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Q9Y6X9

- MORC2_HUMAN

UniProt

Q9Y6X9 - MORC2_HUMAN

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Protein
MORC family CW-type zinc finger protein 2
Gene
MORC2, KIAA0852, ZCWCC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May act as a transcriptional repressor. Down-regulates CA9 expression.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri490 – 54455CW-type
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MORC family CW-type zinc finger protein 2
Alternative name(s):
Zinc finger CW-type coiled-coil domain protein 1
Gene namesi
Name:MORC2
Synonyms:KIAA0852, ZCWCC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:23573. MORC2.

Subcellular locationi

Nucleus. Cytoplasmcytosol
Note: Mainly located in the nucleus.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: UniProtKB-SubCell
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134986990.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 10321031MORC family CW-type zinc finger protein 2
PRO_0000096537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei615 – 6151Phosphoserine3 Publications
Modified residuei696 – 6961Phosphoserine1 Publication
Modified residuei705 – 7051Phosphoserine1 Publication
Modified residuei725 – 7251Phosphoserine1 Publication
Modified residuei730 – 7301Phosphoserine1 Publication
Modified residuei733 – 7331Phosphothreonine1 Publication
Modified residuei739 – 7391Phosphoserine2 Publications
Modified residuei743 – 7431Phosphoserine3 Publications
Modified residuei777 – 7771Phosphoserine3 Publications
Modified residuei779 – 7791Phosphoserine3 Publications
Modified residuei856 – 8561Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9Y6X9.
PaxDbiQ9Y6X9.
PRIDEiQ9Y6X9.

PTM databases

PhosphoSiteiQ9Y6X9.

Expressioni

Tissue specificityi

Highly expressed in smooth muscle, pancreas and testis.

Gene expression databases

ArrayExpressiQ9Y6X9.
BgeeiQ9Y6X9.
CleanExiHS_MORC2.
GenevestigatoriQ9Y6X9.

Organism-specific databases

HPAiHPA000436.

Interactioni

Subunit structurei

Interacts with HDAC4.1 Publication

Protein-protein interaction databases

BioGridi116547. 6 interactions.
MINTiMINT-4995722.
STRINGi9606.ENSP00000215862.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6X9.
SMRiQ9Y6X9. Positions 27-86, 494-542.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili282 – 36281 Reviewed prediction
Add
BLAST
Coiled coili547 – 58438 Reviewed prediction
Add
BLAST
Coiled coili741 – 76121 Reviewed prediction
Add
BLAST
Coiled coili966 – 101651 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG308593.
HOGENOMiHOG000060084.
HOVERGENiHBG056877.
InParanoidiQ9Y6X9.
OMAiRNCLRYF.
OrthoDBiEOG71ZP0X.
PhylomeDBiQ9Y6X9.
TreeFamiTF329118.

Family and domain databases

Gene3Di3.30.565.10. 2 hits.
InterProiIPR003594. HATPase_ATP-bd.
IPR011124. Znf_CW.
[Graphical view]
PfamiPF07496. zf-CW. 1 hit.
[Graphical view]
SMARTiSM00387. HATPase_c. 1 hit.
[Graphical view]
SUPFAMi