Q9Y6X9 (MORC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
MORC family CW-type zinc finger protein 2

Alternative name(s):
Zinc finger CW-type coiled-coil domain protein 1

Gene names

Name:	MORC2
Synonyms:	KIAA0852, ZCWCC1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1032 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as a transcriptional repressor. Down-regulates CA9 expression. Ref.10 Ref.11
Subunit structure	Interacts with HDAC4. Ref.11
Subcellular location	Nucleus. Cytoplasm › cytosol. Note: Mainly located in the nucleus. Ref.10
Tissue specificity	Highly expressed in smooth muscle, pancreas and testis.
Sequence similarities	Contains 1 CW-type zinc finger.
Sequence caution	The sequence AAC12954.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAA74875.2 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y6X9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q9Y6X9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1032	1032	MORC family CW-type zinc finger protein 2		PRO_0000096537
Regions
	Zinc finger	490 – 544	55	CW-type
	Coiled coil	282 – 362	81	Potential
	Coiled coil	547 – 584	38	Potential
	Coiled coil	741 – 761	21	Potential
	Coiled coil	966 – 1016	51	Potential
Amino acid modifications
	Modified residue	615	1	Phosphoserine Ref.7 Ref.12 Ref.14
	Modified residue	696	1	Phosphoserine Ref.8
	Modified residue	705	1	Phosphoserine Ref.8
	Modified residue	725	1	Phosphoserine Ref.8
	Modified residue	730	1	Phosphoserine Ref.8
	Modified residue	733	1	Phosphothreonine Ref.8
	Modified residue	739	1	Phosphoserine Ref.9 Ref.14
	Modified residue	743	1	Phosphoserine Ref.9 Ref.12 Ref.14
	Modified residue	777	1	Phosphoserine Ref.8 Ref.12 Ref.14
	Modified residue	779	1	Phosphoserine Ref.8 Ref.12 Ref.14
Natural variations
	Alternative sequence	1 – 62	62	Missing in isoform 2.		VSP_041759

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: 7BEFA46E4150ABF5	FASTA	1,032	117,823
	10 20 30 40 50 60 MAFTNYSSLN RAQLTFEYLH TNSTTHEFLF GALAELVDNA RDADATRIDI YAERREDLRG 70 80 90 100 110 120 GFMLCFLDDG AGMDPSDAAS VIQFGKSAKR TPESTQIGQY GNGLKSGSMR IGKDFILFTK 130 140 150 160 170 180 KEDTMTCLFL SRTFHEEEGI DEVIVPLPTW NARTREPVTD NVEKFAIETE LIYKYSPFRT 190 200 210 220 230 240 EEEVMTQFMK IPGDSGTLVI IFNLKLMDNG EPELDIISNP RDIQMAETSP EGTKPERRSF 250 260 270 280 290 300 RAYAAVLYID PRMRIFIHGH KVQTKRLSCC LYKPRMYKYT SSRFKTRAEQ EVKKAEHVAR 310 320 330 340 350 360 IAEEKAREAE SKARTLEVRL GGDLTRDSRV MLRQVQNRAI TLRREADVKK RIKEAKQRAL 370 380 390 400 410 420 KEPKELNFVF GVNIEHRDLD GMFIYNCSRL IKMYEKVGPQ LEGGMACGGV VGVVDVPYLV 430 440 450 460 470 480 LEPTHNKQDF ADAKEYRHLL RAMGEHLAQY WKDIAIAQRG IIKFWDEFGY LSANWNQPPS 490 500 510 520 530 540 SELRYKRRRA MEIPTTIQCD LCLKWRTLPF QLSSVEKDYP DTWVCSMNPD PEQDRCEASE 550 560 570 580 590 600 QKQKVPLGTF RKDMKTQEEK QKQLTEKIRQ QQEKLEALQK TTPIRSQADL KKLPLEVTTR 610 620 630 640 650 660 PSTEEPVRRP QRPRSPPLPA VIRNAPSRPP SLPTPRPASQ PRKAPVISST PKLPALAARE 670 680 690 700 710 720 EASTSRLLQP PEAPRKPANT LVKTASRPAP LVQQLSPSLL PNSKSPREVP SPKVIKTPVV 730 740 750 760 770 780 KKTESPIKLS PATPSRKRSV AVSDEEEVEE EAERRKERCK RGRFVVKEEK KDSNELSDSA 790 800 810 820 830 840 GEEDSADLKR AQKDKGLHVE VRVNREWYTG RVTAVEVGKH VVRWKVKFDY VPTDTTPRDR 850 860 870 880 890 900 WVEKGSEDVR LMKPPSPEHQ SLDTQQEGGE EEVGPVAQQA IAVAEPSTSE CLRIEPDTTA 910 920 930 940 950 960 LSTNHETIDL LVQILRNCLR YFLPPSFPIS KKQLSAMNSD ELISFPLKEY FKQYEVGLQN 970 980 990 1000 1010 1020 LCNSYQSRAD SRAKASEESL RTSERKLRET EEKLQKLRTN IVALLQKVQE DIDINTDDEL 1030 DAYIEDLITK GD
	Isoform 2 [UniParc]. Checksum: 459161807B8B53F6	FASTA	970	110,724
	10 20 30 40 50 60 MLCFLDDGAG MDPSDAASVI QFGKSAKRTP ESTQIGQYGN GLKSGSMRIG KDFILFTKKE 70 80 90 100 110 120 DTMTCLFLSR TFHEEEGIDE VIVPLPTWNA RTREPVTDNV EKFAIETELI YKYSPFRTEE 130 140 150 160 170 180 EVMTQFMKIP GDSGTLVIIF NLKLMDNGEP ELDIISNPRD IQMAETSPEG TKPERRSFRA 190 200 210 220 230 240 YAAVLYIDPR MRIFIHGHKV QTKRLSCCLY KPRMYKYTSS RFKTRAEQEV KKAEHVARIA 250 260 270 280 290 300 EEKAREAESK ARTLEVRLGG DLTRDSRVML RQVQNRAITL RREADVKKRI KEAKQRALKE 310 320 330 340 350 360 PKELNFVFGV NIEHRDLDGM FIYNCSRLIK MYEKVGPQLE GGMACGGVVG VVDVPYLVLE 370 380 390 400 410 420 PTHNKQDFAD AKEYRHLLRA MGEHLAQYWK DIAIAQRGII KFWDEFGYLS ANWNQPPSSE 430 440 450 460 470 480 LRYKRRRAME IPTTIQCDLC LKWRTLPFQL SSVEKDYPDT WVCSMNPDPE QDRCEASEQK 490 500 510 520 530 540 QKVPLGTFRK DMKTQEEKQK QLTEKIRQQQ EKLEALQKTT PIRSQADLKK LPLEVTTRPS 550 560 570 580 590 600 TEEPVRRPQR PRSPPLPAVI RNAPSRPPSL PTPRPASQPR KAPVISSTPK LPALAAREEA 610 620 630 640 650 660 STSRLLQPPE APRKPANTLV KTASRPAPLV QQLSPSLLPN SKSPREVPSP KVIKTPVVKK 670 680 690 700 710 720 TESPIKLSPA TPSRKRSVAV SDEEEVEEEA ERRKERCKRG RFVVKEEKKD SNELSDSAGE 730 740 750 760 770 780 EDSADLKRAQ KDKGLHVEVR VNREWYTGRV TAVEVGKHVV RWKVKFDYVP TDTTPRDRWV 790 800 810 820 830 840 EKGSEDVRLM KPPSPEHQSL DTQQEGGEEE VGPVAQQAIA VAEPSTSECL RIEPDTTALS 850 860 870 880 890 900 TNHETIDLLV QILRNCLRYF LPPSFPISKK QLSAMNSDEL ISFPLKEYFK QYEVGLQNLC 910 920 930 940 950 960 NSYQSRADSR AKASEESLRT SERKLRETEE KLQKLRTNIV ALLQKVQEDI DINTDDELDA 970 YIEDLITKGD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"A genome annotation-driven approach to cloning the human ORFeome." Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A., Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J., Beare D.M., Dunham I. Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"The DNA sequence of human chromosome 22." Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M. , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H. Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Cerebellum and Neuroblastoma.
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 712-1032. Tissue: Testis.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-615, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-696; SER-705; SER-725; SER-730; THR-733; SER-777 AND SER-779, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-739 AND SER-743, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[10]	"Identification and expression analysis of a novel CW-type zinc finger protein MORC2 in cancer cells." Wang G.L., Wang C.Y., Cai X.Z., Chen W., Wang X.H., Li F. Anat. Rec. 293:1002-1009(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[11]	"Involvement of histone deacetylation in MORC2-mediated down-regulation of carbonic anhydrase IX." Shao Y., Li Y., Zhang J., Liu D., Liu F., Zhao Y., Shen T., Li F. Nucleic Acids Res. 38:2813-2824(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH HDAC4.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-615; SER-743; SER-777 AND SER-779, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-615; SER-739; SER-743; SER-777 AND SER-779, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB020659 mRNA. Translation: BAA74875.2. Sequence problems. CR456469 mRNA. Translation: CAG30355.1. AC004542 Genomic DNA. Translation: AAC12954.1. Sequence problems. AL133637 mRNA. Translation: CAB63760.1. CH471095 Genomic DNA. Translation: EAW59921.1. BC019257 mRNA. Translation: AAH19257.3. BC136782 mRNA. Translation: AAI36783.1.
IPI	IPI00455518. IPI00873776.
PIR	T02436. T43455.
RefSeq	NP_055756.1. NM_014941.1.
UniGene	Hs.555918.
3D structure databases
ProteinModelPortal	Q9Y6X9.
SMR	Q9Y6X9. Positions 27-124, 379-470, 491-543.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-4995722.
STRING	9606.ENSP00000215862.
PTM databases
PhosphoSite	Q9Y6X9.
Polymorphism databases
DMDM	114152840.
Proteomic databases
PaxDb	Q9Y6X9.
PRIDE	Q9Y6X9.
Protocols and materials databases
DNASU	22880.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000215862; ENSP00000215862; ENSG00000133422. ENST00000397641; ENSP00000380763; ENSG00000133422.
GeneID	22880.
KEGG	hsa:22880.
UCSC	uc003aje.1. human.
Organism-specific databases
CTD	22880.
GeneCards	GC22M031322.
HGNC	HGNC:23573. MORC2.
HPA	HPA000436.
neXtProt	NX_Q9Y6X9.
PharmGKB	PA134986990.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG308593.
HOGENOM	HOG000060084.
HOVERGEN	HBG056877.
InParanoid	Q9Y6X9.
OMA	RNCLRYF.
OrthoDB	EOG473PQP.
Gene expression databases
ArrayExpress	Q9Y6X9.
Bgee	Q9Y6X9.
CleanEx	HS_MORC2.
Genevestigator	Q9Y6X9.
GermOnline	ENSG00000133422. Homo sapiens.
Family and domain databases
Gene3D	3.30.565.10. 2 hits.
InterPro	IPR003594. HATPase_ATP-bd. IPR011124. Znf_CW. [Graphical view]
Pfam	PF07496. zf-CW. 1 hit. [Graphical view]
SMART	SM00387. HATPase_c. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit.
PROSITE	PS51050. ZF_CW. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	22880.
NextBio	43453.

Entry information

Entry name

MORC2_HUMAN

Accession

Primary (citable) accession number: Q9Y6X9
Secondary accession number(s): B2RNB1, Q9UF28, Q9Y6V2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 26, 2002
Last sequence update:	September 5, 2006
Last modified:	May 29, 2013
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.