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Protein

Unconventional myosin-XVI

Gene

MYO16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity).By similarity

GO - Molecular functioni

  • actin filament binding Source: HGNC
  • ATP binding Source: UniProtKB-KW
  • motor activity Source: InterPro

GO - Biological processi

  • cerebellum development Source: HGNC
  • negative regulation of cell proliferation Source: HGNC
  • negative regulation of G1/S transition of mitotic cell cycle Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-XVI
Alternative name(s):
Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3
Unconventional myosin-16
Gene namesi
Name:MYO16Imported
Synonyms:KIAA0865Imported, MYO16BImported, NYAP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:29822. MYO16.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Found in puncta in soma and processes of astrocytes and dissociated cerebellar cells with the morphology of migrating granule cells.By similarity

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • myosin complex Source: UniProtKB-KW
  • nucleoplasm Source: HGNC
  • perinuclear region of cytoplasm Source: HGNC
  • plasma membrane Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162396437.

Polymorphism and mutation databases

BioMutaiMYO16.
DMDMi152112422.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18581858Unconventional myosin-XVIPRO_0000289136Add
BLAST

Post-translational modificationi

Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y6X6.
MaxQBiQ9Y6X6.
PaxDbiQ9Y6X6.
PeptideAtlasiQ9Y6X6.
PRIDEiQ9Y6X6.

PTM databases

iPTMnetiQ9Y6X6.
PhosphoSiteiQ9Y6X6.

Expressioni

Gene expression databases

BgeeiQ9Y6X6.
CleanExiHS_MYO16.
ExpressionAtlasiQ9Y6X6. baseline and differential.
GenevisibleiQ9Y6X6. HS.

Organism-specific databases

HPAiHPA040110.

Interactioni

Subunit structurei

Binds PPP1CA and/or PPP1CC. Binds F-actin in an ATP-sensitive manner. Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity). Interacts with KIRREL3 (PubMed:25902260).By similarity1 Publication

GO - Molecular functioni

  • actin filament binding Source: HGNC

Protein-protein interaction databases

BioGridi116666. 1 interaction.
IntActiQ9Y6X6. 7 interactions.
MINTiMINT-8307412.
STRINGi9606.ENSP00000349145.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6X6.
SMRiQ9Y6X6. Positions 41-337, 378-1169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati59 – 8830ANK 1Sequence analysisAdd
BLAST
Repeati92 – 12130ANK 2Sequence analysisAdd
BLAST
Repeati125 – 15430ANK 3Sequence analysisAdd
BLAST
Repeati158 – 18932ANK 4Sequence analysisAdd
BLAST
Repeati191 – 21727ANK 5Sequence analysisAdd
BLAST
Repeati221 – 25030ANK 6Sequence analysisAdd
BLAST
Repeati254 – 28330ANK 7Sequence analysisAdd
BLAST
Domaini401 – 1145745Myosin motorAdd
BLAST
Domaini1147 – 117630IQPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1111 – 1377267Involved in CYFIP1- and NCKAP1-bindingBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1389 – 1671283Pro-richSequence analysisAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.Curated
In the C-terminal section; belongs to the NYAP family.Curated
Contains 7 ANK repeats.PROSITE-ProRule annotation
Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IIRW. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOVERGENiHBG108163.
InParanoidiQ9Y6X6.
KOiK17481.
OrthoDBiEOG7ZGX26.
PhylomeDBiQ9Y6X6.
TreeFamiTF332267.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00248. ANK. 5 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9Y6X6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIDQCLLES LPLGQRQRLV KRMRCEQIKA YYEREKAFQK QEGFLKRLKH
60 70 80 90 100
AKNPKVHFNL TDMLQDAIIH HNDKEVLRLL KEGADPHTLV SSGGSLLHLC
110 120 130 140 150
ARYDNAFIAE ILIDRGVNVN HQDEDFWTPM HIACACDNPD IVLLLVLAGA
160 170 180 190 200
NVLLQDVNGN IPLDYAVEGT ESSSILLTYL DENGVDLTSL RQMKLQRPMS
210 220 230 240 250
MLTDVKHFLS SGGNVNEKND EGVTLLHMAC ASGYKEVVSL ILEHGGDLNI
260 270 280 290 300
VDDQYWTPLH LAAKYGQTNL VKLLLMHQAN PHLVNCNEEK ASDIAASEFI
310 320 330 340 350
EEMLLKAEIA WEEKMKEPLS ASTLAQEEPY EEIIHDLPVL SSKLSPLVLP
360 370 380 390 400
IAKQDSLLEK DIMFKDATKG LCKQQSQDSI PENPMMSGST KPEQVKLMPP
410 420 430 440 450
APNDDLATLS ELNDGSLLYE IQKRFGNNQI YTFIGDILLL VNPYKELPIY
460 470 480 490 500
SSMVSQLYFS SSGKLCSSLP PHLFSCVERA FHQLFREQRP QCFILSGERG
510 520 530 540 550
SGKSEASKQI IRHLTCRAGA SRATLDSRFK HVVCILEAFG HAKTTLNDLS
560 570 580 590 600
SCFIKYFELQ FCERKQQLTG ARIYTYLLEK SRLVSQPLGQ SNFLIFYLLM
610 620 630 640 650
DGLSAEEKYG LHLNNLCAHR YLNQTIQDDA STGERSLNRE KLAVLKRALN
660 670 680 690 700
VVGFSSLEVE NLFVILAAIL HLGDIRFTAL NEGNSAFVSD LQLLEQVAGM
710 720 730 740 750
LQVSTDELAS ALTTDIQYFK GDMIIRRHTI QIAEFFRDLL AKSLYSRLFS
760 770 780 790 800
FLVNTMNSCL HSQDEQKSMQ TLDIGILDIF GFEEFQKNEF EQLCVNMTNE
810 820 830 840 850
KMHHYINEVL FLHEQVECVQ EGVTMETAYS PGNQNGVLDF FFQKPSGFLT
860 870 880 890 900
LLDEESQMIW SVESNFPKKL QSLLESSNTN AVYSPMKDGN GNVALKDHGT
910 920 930 940 950
AFTIMHYAGR VMYDVVGAIE KNKDSLSQNL LFVMKTSENV VINHLFQSKL
960 970 980 990 1000
SQTGSLVSAY PSFKFRGHKS ALLSKKMTAS SIIGENKNYL ELSKLLKKKG
1010 1020 1030 1040 1050
TSTFLQRLER GDPVTIASQL RKSLMDIIGK LQKCTPHFIH CIRPNNSKLP
1060 1070 1080 1090 1100
DTFDNFYVSA QLQYIGVLEM VKIFRYGYPV RLSFSDFLSR YKPLADTFLR
1110 1120 1130 1140 1150
EKKEQSAAER CRLVLQQCKL QGWQMGVRKV FLKYWHADQL NDLCLQLQRK
1160 1170 1180 1190 1200
IITCQKVIRG FLARQHLLQR ISIRQQEVTS INSFLQNTED MGLKTYDALV
1210 1220 1230 1240 1250
IQNASDIARE NDRLRSEMNA PYHKEKLEVR NMQEEGSKRT DDKSGPRHFH
1260 1270 1280 1290 1300
PSSMSVCAAV DGLGQCLVGP SIWSPSLHSV FSMDDSSSLP SPRKQPPPKP
1310 1320 1330 1340 1350
KRDPNTRLSA SYEAVSACLS AAREAANEAL ARPRPHSDDY STMKKIPPRK
1360 1370 1380 1390 1400
PKRSPNTKLS GSYEEISGSR PGDARPAGAP GAAARVLTPG TPQCALPPAA
1410 1420 1430 1440 1450
PPGDEDDSEP VYIEMLGHAA RPDSPDPGES VYEEMKCCLP DDGGPGAGSF
1460 1470 1480 1490 1500
LLHGASPPLL HRAPEDEAAG PPGDACDIPP PFPNLLPHRP PLLVFPPTPV
1510 1520 1530 1540 1550
TCSPASDESP LTPLEVKKLP VLETNLKYPV QPEGSSPLSP QYSKSQKGDG
1560 1570 1580 1590 1600
DRPASPGLAL FNGSGRASPP STPPPPPPPP GPPPAPYRPC AHLAFPPEPA
1610 1620 1630 1640 1650
PVNAGKAGPS AEAPKVHPKP NSAPVAGPCS SFPKIPYSPV KATRADARKA
1660 1670 1680 1690 1700
GSSASPPAPY SPPSSRPLSS PLDELASLFN SGRSVLRKSA AGRKIREAEG
1710 1720 1730 1740 1750
FETNMNISSR DDPSTSEITS ETQDRNANNH GIQLSNSLSS AITAENGNSI
1760 1770 1780 1790 1800
SNGLPEEDGY SRLSISGTGT STFQRHRDSH TTQVIHQLRL SENESVALQE
1810 1820 1830 1840 1850
LLDWRRKLCE EGQDWQQILH HAEPRVPPPP PCKKPSLLKK PEGASCNRLP

SELWDTTI
Length:1,858
Mass (Da):206,129
Last modified:May 29, 2007 - v3
Checksum:iB2D821DD53BD109E
GO
Isoform 21 Publication (identifier: Q9Y6X6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1091-1858: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:1,090
Mass (Da):123,160
Checksum:i4245550D45B08F75
GO
Isoform 31 Publication (identifier: Q9Y6X6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     936-940: TSENV → RGRCF
     941-1858: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:940
Mass (Da):106,160
Checksum:i1F22125264CA3ABA
GO
Isoform 41 Publication (identifier: Q9Y6X6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-192: Missing.
     206-225: Missing.
     936-940: TSENV → RGRCF
     941-1858: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:728
Mass (Da):82,275
Checksum:iA290192D126CE028
GO

Sequence cautioni

The sequence BAA74888.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC04608.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC87143.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti555 – 5551K → E in CAD39107 (PubMed:17974005).Curated
Sequence conflicti953 – 9531T → A in BAC87143 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti181 – 1811D → E.
Corresponds to variant rs911973 [ dbSNP | Ensembl ].
VAR_050214
Natural varianti339 – 3391V → I.
Corresponds to variant rs405397 [ dbSNP | Ensembl ].
VAR_050215
Natural varianti385 – 3851M → T.1 Publication
Corresponds to variant rs16973313 [ dbSNP | Ensembl ].
VAR_032584
Natural varianti831 – 8311P → A.5 Publications
Corresponds to variant rs3825491 [ dbSNP | Ensembl ].
VAR_032585
Natural varianti1168 – 11681L → H Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064737
Natural varianti1171 – 11711I → M.
Corresponds to variant rs157024 [ dbSNP | Ensembl ].
VAR_050216

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 192192Missing in isoform 4. 1 PublicationVSP_052447Add
BLAST
Alternative sequencei206 – 22520Missing in isoform 4. 1 PublicationVSP_052448Add
BLAST
Alternative sequencei936 – 9405TSENV → RGRCF in isoform 3 and isoform 4. 1 PublicationVSP_052449
Alternative sequencei941 – 1858918Missing in isoform 3 and isoform 4. 1 PublicationVSP_052450Add
BLAST
Alternative sequencei1091 – 1858768Missing in isoform 2. 1 PublicationVSP_052451Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020672 mRNA. Translation: BAA74888.2. Different initiation.
AK095691 mRNA. Translation: BAC04608.1. Different initiation.
AB290159 mRNA. Translation: BAG06713.1.
AL136132
, AL157771, AL161431, AL353143, AL390918 Genomic DNA. Translation: CAH70519.1.
AL136132
, AL157771, AL353143, AL390918 Genomic DNA. Translation: CAH70520.1.
AL136132, AL353143, AL390918 Genomic DNA. Translation: CAH70521.1.
AL157771
, AL136132, AL161431, AL353143, AL390918 Genomic DNA. Translation: CAI16366.1.
AL157771
, AL136132, AL353143, AL390918 Genomic DNA. Translation: CAI16367.1.
AL161431
, AL136132, AL157771, AL353143, AL390918 Genomic DNA. Translation: CAI15548.1.
AL353143
, AL136132, AL157771, AL161431, AL390918 Genomic DNA. Translation: CAH73221.1.
AL353143
, AL136132, AL157771, AL390918 Genomic DNA. Translation: CAH73222.1.
AL353143, AL136132, AL390918 Genomic DNA. Translation: CAH73223.1.
AL390918
, AL136132, AL157771, AL161431, AL353143 Genomic DNA. Translation: CAI15821.1.
AL390918
, AL136132, AL157771, AL353143 Genomic DNA. Translation: CAI15822.1.
AL390918, AL136132, AL353143 Genomic DNA. Translation: CAI15823.1.
AK127806 mRNA. Translation: BAC87143.1. Different initiation.
BC146791 mRNA. Translation: AAI46792.1.
AL834447 mRNA. Translation: CAD39107.2.
CCDSiCCDS32008.1. [Q9Y6X6-1]
RefSeqiNP_001185879.1. NM_001198950.1.
NP_055826.1. NM_015011.1. [Q9Y6X6-1]
XP_011519364.1. XM_011521062.1. [Q9Y6X6-1]
UniGeneiHs.656587.

Genome annotation databases

EnsembliENST00000251041; ENSP00000251041; ENSG00000041515. [Q9Y6X6-3]
ENST00000356711; ENSP00000349145; ENSG00000041515. [Q9Y6X6-1]
ENST00000357550; ENSP00000350160; ENSG00000041515. [Q9Y6X6-1]
GeneIDi23026.
KEGGihsa:23026.
UCSCiuc001vqt.1. human. [Q9Y6X6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020672 mRNA. Translation: BAA74888.2. Different initiation.
AK095691 mRNA. Translation: BAC04608.1. Different initiation.
AB290159 mRNA. Translation: BAG06713.1.
AL136132
, AL157771, AL161431, AL353143, AL390918 Genomic DNA. Translation: CAH70519.1.
AL136132
, AL157771, AL353143, AL390918 Genomic DNA. Translation: CAH70520.1.
AL136132, AL353143, AL390918 Genomic DNA. Translation: CAH70521.1.
AL157771
, AL136132, AL161431, AL353143, AL390918 Genomic DNA. Translation: CAI16366.1.
AL157771
, AL136132, AL353143, AL390918 Genomic DNA. Translation: CAI16367.1.
AL161431
, AL136132, AL157771, AL353143, AL390918 Genomic DNA. Translation: CAI15548.1.
AL353143
, AL136132, AL157771, AL161431, AL390918 Genomic DNA. Translation: CAH73221.1.
AL353143
, AL136132, AL157771, AL390918 Genomic DNA. Translation: CAH73222.1.
AL353143, AL136132, AL390918 Genomic DNA. Translation: CAH73223.1.
AL390918
, AL136132, AL157771, AL161431, AL353143 Genomic DNA. Translation: CAI15821.1.
AL390918
, AL136132, AL157771, AL353143 Genomic DNA. Translation: CAI15822.1.
AL390918, AL136132, AL353143 Genomic DNA. Translation: CAI15823.1.
AK127806 mRNA. Translation: BAC87143.1. Different initiation.
BC146791 mRNA. Translation: AAI46792.1.
AL834447 mRNA. Translation: CAD39107.2.
CCDSiCCDS32008.1. [Q9Y6X6-1]
RefSeqiNP_001185879.1. NM_001198950.1.
NP_055826.1. NM_015011.1. [Q9Y6X6-1]
XP_011519364.1. XM_011521062.1. [Q9Y6X6-1]
UniGeneiHs.656587.

3D structure databases

ProteinModelPortaliQ9Y6X6.
SMRiQ9Y6X6. Positions 41-337, 378-1169.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116666. 1 interaction.
IntActiQ9Y6X6. 7 interactions.
MINTiMINT-8307412.
STRINGi9606.ENSP00000349145.

PTM databases

iPTMnetiQ9Y6X6.
PhosphoSiteiQ9Y6X6.

Polymorphism and mutation databases

BioMutaiMYO16.
DMDMi152112422.

Proteomic databases

EPDiQ9Y6X6.
MaxQBiQ9Y6X6.
PaxDbiQ9Y6X6.
PeptideAtlasiQ9Y6X6.
PRIDEiQ9Y6X6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251041; ENSP00000251041; ENSG00000041515. [Q9Y6X6-3]
ENST00000356711; ENSP00000349145; ENSG00000041515. [Q9Y6X6-1]
ENST00000357550; ENSP00000350160; ENSG00000041515. [Q9Y6X6-1]
GeneIDi23026.
KEGGihsa:23026.
UCSCiuc001vqt.1. human. [Q9Y6X6-1]

Organism-specific databases

CTDi23026.
GeneCardsiMYO16.
H-InvDBHIX0019753.
HGNCiHGNC:29822. MYO16.
HPAiHPA040110.
MIMi615479. gene.
neXtProtiNX_Q9Y6X6.
PharmGKBiPA162396437.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIRW. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOVERGENiHBG108163.
InParanoidiQ9Y6X6.
KOiK17481.
OrthoDBiEOG7ZGX26.
PhylomeDBiQ9Y6X6.
TreeFamiTF332267.

Miscellaneous databases

GenomeRNAii23026.
NextBioi43994.
PROiQ9Y6X6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y6X6.
CleanExiHS_MYO16.
ExpressionAtlasiQ9Y6X6. baseline and differential.
GenevisibleiQ9Y6X6. HS.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF12796. Ank_2. 2 hits.
PF00063. Myosin_head. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00248. ANK. 5 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
PS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-831.
    Tissue: BrainImported.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-995 (ISOFORMS 1/3), VARIANTS THR-385 AND ALA-831.
    Tissue: BrainImported.
  3. "Multiplex amplification and cloning of 5'-ends of cDNA by ligase-free recombination: preparation of full-length cDNA clones encoding motor proteins."
    Yamakawa H., Kikuno R.F., Nagase T., Ohara O.
    Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-831.
    Tissue: Brain.
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ALA-831.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-935 (ISOFORMS 1/2/3), VARIANT ALA-831.
    Tissue: Amygdala.
  7. "Autism and intellectual disability-associated KIRREL3 interacts with neuronal proteins MAP1B and MYO16 with potential roles in neurodevelopment."
    Liu Y.F., Sowell S.M., Luo Y., Chaubey A., Cameron R.S., Kim H.G., Srivastava A.K.
    PLoS ONE 10:E0123106-E0123106(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KIRREL3.
  8. Cited for: VARIANT HIS-1168.

Entry informationi

Entry nameiMYO16_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6X6
Secondary accession number(s): A6H8Y0
, A8MTX3, Q5VYX4, Q5VYX5, Q5VYX6, Q6ZS13, Q8N3C2, Q8N948
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: May 11, 2016
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.