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Protein

Soluble lamin-associated protein of 75 kDa

Gene

FAM169A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Soluble lamin-associated protein of 75 kDa
Short name:
SLAP75
Alternative name(s):
Protein FAM169A
Gene namesi
Name:FAM169A
Synonyms:KIAA0888
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000198780.11
HGNCiHGNC:29138 FAM169A
MIMi615769 gene
neXtProtiNX_Q9Y6X4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198780
PharmGKBiPA162387117

Polymorphism and mutation databases

BioMutaiFAM169A
DMDMi189031482

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003205871 – 670Soluble lamin-associated protein of 75 kDaAdd BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei350PhosphoserineBy similarity1
Modified residuei379PhosphoserineBy similarity1
Modified residuei449PhosphoserineCombined sources1
Modified residuei515PhosphoserineBy similarity1
Modified residuei615PhosphoserineBy similarity1
Modified residuei618PhosphoserineBy similarity1
Modified residuei635PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y6X4
PaxDbiQ9Y6X4
PeptideAtlasiQ9Y6X4
PRIDEiQ9Y6X4

PTM databases

iPTMnetiQ9Y6X4
PhosphoSitePlusiQ9Y6X4

Expressioni

Gene expression databases

BgeeiENSG00000198780
CleanExiHS_FAM169A
ExpressionAtlasiQ9Y6X4 baseline and differential
GenevisibleiQ9Y6X4 HS

Organism-specific databases

HPAiHPA041574

Interactioni

Protein-protein interaction databases

BioGridi117512, 4 interactors
IntActiQ9Y6X4, 3 interactors
STRINGi9606.ENSP00000373808

Structurei

3D structure databases

ProteinModelPortaliQ9Y6X4
SMRiQ9Y6X4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi377 – 455Asp/Glu-richAdd BLAST79

Sequence similaritiesi

Belongs to the FAM169 family.Curated

Phylogenomic databases

eggNOGiENOG410IK9K Eukaryota
ENOG410ZN43 LUCA
GeneTreeiENSGT00510000048902
HOGENOMiHOG000112443
HOVERGENiHBG107873
InParanoidiQ9Y6X4
OMAiEKYPGDH
OrthoDBiEOG091G0JCF
PhylomeDBiQ9Y6X4
TreeFamiTF332578

Family and domain databases

InterProiView protein in InterPro
IPR029625 FAM169
IPR029623 FAM169A
PANTHERiPTHR22442 PTHR22442, 1 hit
PTHR22442:SF3 PTHR22442:SF3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y6X4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFPVDMLEN CSHEELENSA EDYMSDLRCG DPENPECFSL LNITIPISLS
60 70 80 90 100
NVGFVPLYGG DQTQKILALF APEDSLTAVA LYLADQWWAI DDIVKTSVPS
110 120 130 140 150
REGLKQVSTL GERVVLYVLN RIIYRKQEME RNEIPFLCHS STDYAKILWK
160 170 180 190 200
KGEAIGFYSV KPTGSICASF LTQSYQLPVL DTMFLRKKYR GKDFGLHMLE
210 220 230 240 250
DFVDSFTEDA LGLRYPLSSL MYTACKQYFE KYPGDHELLW EVEGVGHWYQ
260 270 280 290 300
RIPVTRALQR EALKILALSQ NEPKRPMSGE YGPASVPEYE ARTEDNQSSE
310 320 330 340 350
MQLTIDSLKD AFASTSEGHD KTSVSTHTRS GNLKRPKIGK RFQDSEFSSS
360 370 380 390 400
QGEDEKTSQT SLTASINKLE STARPSESSE EFLEEEPEQR GIEFEDESSD
410 420 430 440 450
RDARPALETQ PQQEKQDGEK ESELEPMNGE IMDDSLKTSL ITEEEDSTSE
460 470 480 490 500
VLDEELKLQP FNSSEDSTNL VPLVVESSKP PEVDAPDKTP RIPDSEMLMD
510 520 530 540 550
EGTSDEKGHM EEKLSLLPRK KAHLGSSDNV ATMSNEERSD GGFPNSVIAE
560 570 580 590 600
FSEEPVSENL SPNTTSSLED QGEEGVSEPQ ETSTALPQSS LIEVELEDVP
610 620 630 640 650
FSQNAGQKNQ SEEQSEASSE QLDQFTQSAE KAVDSSSEEI EVEVPVVDRR
660 670
NLRRKAKGHK GPAKKKAKLT
Length:670
Mass (Da):74,955
Last modified:February 26, 2008 - v2
Checksum:i735D8883DA82C3F2
GO
Isoform 2 (identifier: Q9Y6X4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-127: VSTLGERVVLYVLNRIIYRKQ → EAYVPLFLPKVTNCQFLIQCF
     128-670: Missing.

Note: No experimental confirmation available.
Show »
Length:127
Mass (Da):14,209
Checksum:i0FD56BA3B050262C
GO

Sequence cautioni

The sequence BAA74911 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB14344 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAE45948 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti275R → G in BAF82693 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031670107 – 127VSTLG…IYRKQ → EAYVPLFLPKVTNCQFLIQC F in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_031671128 – 670Missing in isoform 2. 1 PublicationAdd BLAST543

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020695 mRNA Translation: BAA74911.1 Different initiation.
AK022981 mRNA Translation: BAB14344.1 Different initiation.
AK290004 mRNA Translation: BAF82693.1
BX640902 mRNA Translation: CAE45948.1 Different initiation.
CCDSiCCDS43330.1 [Q9Y6X4-1]
RefSeqiNP_056381.1, NM_015566.2 [Q9Y6X4-1]
XP_005248537.1, XM_005248480.2 [Q9Y6X4-1]
XP_011541608.1, XM_011543306.2 [Q9Y6X4-1]
XP_011541609.1, XM_011543307.2 [Q9Y6X4-1]
UniGeneiHs.91662

Genome annotation databases

EnsembliENST00000389156; ENSP00000373808; ENSG00000198780 [Q9Y6X4-1]
ENST00000510609; ENSP00000423905; ENSG00000198780 [Q9Y6X4-2]
ENST00000514215; ENSP00000425319; ENSG00000198780 [Q9Y6X4-2]
GeneIDi26049
KEGGihsa:26049
UCSCiuc003kdm.4 human [Q9Y6X4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiF169A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6X4
Secondary accession number(s): A8K1T9, Q6MZT0, Q9H989
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: May 23, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

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