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Protein

Soluble lamin-associated protein of 75 kDa

Gene

FAM169A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Soluble lamin-associated protein of 75 kDa
Short name:
SLAP75
Alternative name(s):
Protein FAM169A
Gene namesi
Name:FAM169A
Synonyms:KIAA0888
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:29138. FAM169A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162387117.

Polymorphism and mutation databases

BioMutaiFAM169A.
DMDMi189031482.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Soluble lamin-associated protein of 75 kDaPRO_0000320587Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei350 – 3501PhosphoserineBy similarity
Modified residuei379 – 3791PhosphoserineBy similarity
Modified residuei449 – 4491PhosphoserineCombined sources
Modified residuei515 – 5151PhosphoserineBy similarity
Modified residuei615 – 6151PhosphoserineBy similarity
Modified residuei618 – 6181PhosphoserineBy similarity
Modified residuei635 – 6351PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y6X4.
MaxQBiQ9Y6X4.
PaxDbiQ9Y6X4.
PeptideAtlasiQ9Y6X4.
PRIDEiQ9Y6X4.

PTM databases

iPTMnetiQ9Y6X4.
PhosphoSiteiQ9Y6X4.

Expressioni

Gene expression databases

BgeeiQ9Y6X4.
CleanExiHS_FAM169A.
ExpressionAtlasiQ9Y6X4. baseline and differential.
GenevisibleiQ9Y6X4. HS.

Organism-specific databases

HPAiHPA041574.

Interactioni

Protein-protein interaction databases

BioGridi117512. 4 interactions.
IntActiQ9Y6X4. 1 interaction.
STRINGi9606.ENSP00000373808.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6X4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi377 – 45579Asp/Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the FAM169 family.Curated

Phylogenomic databases

eggNOGiENOG410IK9K. Eukaryota.
ENOG410ZN43. LUCA.
GeneTreeiENSGT00510000048902.
HOGENOMiHOG000112443.
HOVERGENiHBG107873.
InParanoidiQ9Y6X4.
OMAiEKYPGDH.
OrthoDBiEOG741Z22.
PhylomeDBiQ9Y6X4.
TreeFamiTF332578.

Family and domain databases

InterProiIPR029625. FAM169.
IPR029623. FAM169A.
[Graphical view]
PANTHERiPTHR22442. PTHR22442. 1 hit.
PTHR22442:SF3. PTHR22442:SF3. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y6X4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAFPVDMLEN CSHEELENSA EDYMSDLRCG DPENPECFSL LNITIPISLS
60 70 80 90 100
NVGFVPLYGG DQTQKILALF APEDSLTAVA LYLADQWWAI DDIVKTSVPS
110 120 130 140 150
REGLKQVSTL GERVVLYVLN RIIYRKQEME RNEIPFLCHS STDYAKILWK
160 170 180 190 200
KGEAIGFYSV KPTGSICASF LTQSYQLPVL DTMFLRKKYR GKDFGLHMLE
210 220 230 240 250
DFVDSFTEDA LGLRYPLSSL MYTACKQYFE KYPGDHELLW EVEGVGHWYQ
260 270 280 290 300
RIPVTRALQR EALKILALSQ NEPKRPMSGE YGPASVPEYE ARTEDNQSSE
310 320 330 340 350
MQLTIDSLKD AFASTSEGHD KTSVSTHTRS GNLKRPKIGK RFQDSEFSSS
360 370 380 390 400
QGEDEKTSQT SLTASINKLE STARPSESSE EFLEEEPEQR GIEFEDESSD
410 420 430 440 450
RDARPALETQ PQQEKQDGEK ESELEPMNGE IMDDSLKTSL ITEEEDSTSE
460 470 480 490 500
VLDEELKLQP FNSSEDSTNL VPLVVESSKP PEVDAPDKTP RIPDSEMLMD
510 520 530 540 550
EGTSDEKGHM EEKLSLLPRK KAHLGSSDNV ATMSNEERSD GGFPNSVIAE
560 570 580 590 600
FSEEPVSENL SPNTTSSLED QGEEGVSEPQ ETSTALPQSS LIEVELEDVP
610 620 630 640 650
FSQNAGQKNQ SEEQSEASSE QLDQFTQSAE KAVDSSSEEI EVEVPVVDRR
660 670
NLRRKAKGHK GPAKKKAKLT
Length:670
Mass (Da):74,955
Last modified:February 26, 2008 - v2
Checksum:i735D8883DA82C3F2
GO
Isoform 2 (identifier: Q9Y6X4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     107-127: VSTLGERVVLYVLNRIIYRKQ → EAYVPLFLPKVTNCQFLIQCF
     128-670: Missing.

Note: No experimental confirmation available.
Show »
Length:127
Mass (Da):14,209
Checksum:i0FD56BA3B050262C
GO

Sequence cautioni

The sequence BAA74911.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB14344.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAE45948.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti275 – 2751R → G in BAF82693 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei107 – 12721VSTLG…IYRKQ → EAYVPLFLPKVTNCQFLIQC F in isoform 2. 1 PublicationVSP_031670Add
BLAST
Alternative sequencei128 – 670543Missing in isoform 2. 1 PublicationVSP_031671Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020695 mRNA. Translation: BAA74911.1. Different initiation.
AK022981 mRNA. Translation: BAB14344.1. Different initiation.
AK290004 mRNA. Translation: BAF82693.1.
BX640902 mRNA. Translation: CAE45948.1. Different initiation.
CCDSiCCDS43330.1. [Q9Y6X4-1]
RefSeqiNP_056381.1. NM_015566.2. [Q9Y6X4-1]
XP_005248537.1. XM_005248480.1. [Q9Y6X4-1]
XP_011541608.1. XM_011543306.1. [Q9Y6X4-1]
XP_011541609.1. XM_011543307.1. [Q9Y6X4-1]
UniGeneiHs.91662.

Genome annotation databases

EnsembliENST00000389156; ENSP00000373808; ENSG00000198780. [Q9Y6X4-1]
ENST00000510609; ENSP00000423905; ENSG00000198780. [Q9Y6X4-2]
ENST00000514215; ENSP00000425319; ENSG00000198780. [Q9Y6X4-2]
GeneIDi26049.
KEGGihsa:26049.
UCSCiuc003kdm.4. human. [Q9Y6X4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020695 mRNA. Translation: BAA74911.1. Different initiation.
AK022981 mRNA. Translation: BAB14344.1. Different initiation.
AK290004 mRNA. Translation: BAF82693.1.
BX640902 mRNA. Translation: CAE45948.1. Different initiation.
CCDSiCCDS43330.1. [Q9Y6X4-1]
RefSeqiNP_056381.1. NM_015566.2. [Q9Y6X4-1]
XP_005248537.1. XM_005248480.1. [Q9Y6X4-1]
XP_011541608.1. XM_011543306.1. [Q9Y6X4-1]
XP_011541609.1. XM_011543307.1. [Q9Y6X4-1]
UniGeneiHs.91662.

3D structure databases

ProteinModelPortaliQ9Y6X4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117512. 4 interactions.
IntActiQ9Y6X4. 1 interaction.
STRINGi9606.ENSP00000373808.

PTM databases

iPTMnetiQ9Y6X4.
PhosphoSiteiQ9Y6X4.

Polymorphism and mutation databases

BioMutaiFAM169A.
DMDMi189031482.

Proteomic databases

EPDiQ9Y6X4.
MaxQBiQ9Y6X4.
PaxDbiQ9Y6X4.
PeptideAtlasiQ9Y6X4.
PRIDEiQ9Y6X4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389156; ENSP00000373808; ENSG00000198780. [Q9Y6X4-1]
ENST00000510609; ENSP00000423905; ENSG00000198780. [Q9Y6X4-2]
ENST00000514215; ENSP00000425319; ENSG00000198780. [Q9Y6X4-2]
GeneIDi26049.
KEGGihsa:26049.
UCSCiuc003kdm.4. human. [Q9Y6X4-1]

Organism-specific databases

CTDi26049.
GeneCardsiFAM169A.
H-InvDBHIX0004952.
HGNCiHGNC:29138. FAM169A.
HPAiHPA041574.
MIMi615769. gene.
neXtProtiNX_Q9Y6X4.
PharmGKBiPA162387117.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK9K. Eukaryota.
ENOG410ZN43. LUCA.
GeneTreeiENSGT00510000048902.
HOGENOMiHOG000112443.
HOVERGENiHBG107873.
InParanoidiQ9Y6X4.
OMAiEKYPGDH.
OrthoDBiEOG741Z22.
PhylomeDBiQ9Y6X4.
TreeFamiTF332578.

Miscellaneous databases

ChiTaRSiFAM169A. human.
GenomeRNAii26049.
NextBioi47899.
PROiQ9Y6X4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y6X4.
CleanExiHS_FAM169A.
ExpressionAtlasiQ9Y6X4. baseline and differential.
GenevisibleiQ9Y6X4. HS.

Family and domain databases

InterProiIPR029625. FAM169.
IPR029623. FAM169A.
[Graphical view]
PANTHERiPTHR22442. PTHR22442. 1 hit.
PTHR22442:SF3. PTHR22442:SF3. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hippocampus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Endometrium.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-449, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-635, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells."
    Roux K.J., Kim D.I., Raida M., Burke B.
    J. Cell Biol. 196:801-810(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiF169A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6X4
Secondary accession number(s): A8K1T9, Q6MZT0, Q9H989
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: April 13, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.