Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Stress-associated endoplasmic reticulum protein 1

Gene

SERP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-381038. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Stress-associated endoplasmic reticulum protein 1
Alternative name(s):
Ribosome-attached membrane protein 4
Gene namesi
Name:SERP1
Synonyms:RAMP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:10759. SERP1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838CytoplasmicSequence analysisAdd
BLAST
Transmembranei39 – 5921Helical; Anchor for type IV membrane proteinSequence analysisAdd
BLAST
Topological domaini60 – 667ExtracellularSequence analysis

GO - Cellular componenti

  • cytoplasmic microtubule Source: UniProtKB
  • cytosol Source: Reactome
  • endoplasmic reticulum Source: ProtInc
  • endoplasmic reticulum membrane Source: Reactome
  • integral component of membrane Source: UniProtKB-KW
  • ribosome Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162402942.

Polymorphism and mutation databases

BioMutaiSERP1.
DMDMi74721555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6666Stress-associated endoplasmic reticulum protein 1PRO_0000274794Add
BLAST

Proteomic databases

EPDiQ9Y6X1.
PaxDbiQ9Y6X1.
PRIDEiQ9Y6X1.
TopDownProteomicsiQ9Y6X1.

PTM databases

iPTMnetiQ9Y6X1.
PhosphoSiteiQ9Y6X1.

Expressioni

Gene expression databases

BgeeiQ9Y6X1.
CleanExiHS_SERP1.
ExpressionAtlasiQ9Y6X1. baseline and differential.
GenevisibleiQ9Y6X1. HS.

Organism-specific databases

HPAiHPA038970.

Interactioni

Subunit structurei

Interacts with SEC61B, SEC61A1 and the SEC61 complex. Interacts with CANX (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
TMEM79Q9BSE23EBI-10329948,EBI-8649725

Protein-protein interaction databases

BioGridi118079. 13 interactions.
IntActiQ9Y6X1. 1 interaction.
MINTiMINT-4721772.
STRINGi9606.ENSP00000239944.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6X1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RAMP4 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3491. Eukaryota.
ENOG411221U. LUCA.
GeneTreeiENSGT00390000012245.
HOVERGENiHBG058555.
InParanoidiQ9Y6X1.
OMAiKNVNNRG.
OrthoDBiEOG7RNK3C.
PhylomeDBiQ9Y6X1.
TreeFamiTF313229.

Family and domain databases

InterProiIPR010580. ER_stress-assoc.
[Graphical view]
PANTHERiPTHR15601. PTHR15601. 1 hit.
PfamiPF06624. RAMP4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y6X1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAKQRIRMA NEKHSKNITQ RGNVAKTSRN APEEKASVGP WLLALFIFVV
60
CGSAIFQIIQ SIRMGM
Length:66
Mass (Da):7,374
Last modified:November 1, 1999 - v1
Checksum:iDC15C0143AAE0D91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022427 mRNA. Translation: BAA81895.1.
AF136975 mRNA. Translation: AAG49436.1.
AL136807 mRNA. Translation: CAB66741.1.
CR533472 mRNA. Translation: CAG38503.1.
CH471052 Genomic DNA. Translation: EAW78834.1.
CH471052 Genomic DNA. Translation: EAW78835.1.
CH471052 Genomic DNA. Translation: EAW78836.1.
BC108314 mRNA. Translation: AAI08315.1.
BC112364 mRNA. Translation: AAI12365.1.
BC112365 mRNA. Translation: AAI12366.1.
CCDSiCCDS3150.1.
RefSeqiNP_055260.1. NM_014445.3.
XP_011511000.1. XM_011512698.1.
UniGeneiHs.518326.
Hs.713956.

Genome annotation databases

EnsembliENST00000239944; ENSP00000239944; ENSG00000120742.
ENST00000479209; ENSP00000420076; ENSG00000120742.
GeneIDi27230.
KEGGihsa:27230.
UCSCiuc003exy.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022427 mRNA. Translation: BAA81895.1.
AF136975 mRNA. Translation: AAG49436.1.
AL136807 mRNA. Translation: CAB66741.1.
CR533472 mRNA. Translation: CAG38503.1.
CH471052 Genomic DNA. Translation: EAW78834.1.
CH471052 Genomic DNA. Translation: EAW78835.1.
CH471052 Genomic DNA. Translation: EAW78836.1.
BC108314 mRNA. Translation: AAI08315.1.
BC112364 mRNA. Translation: AAI12365.1.
BC112365 mRNA. Translation: AAI12366.1.
CCDSiCCDS3150.1.
RefSeqiNP_055260.1. NM_014445.3.
XP_011511000.1. XM_011512698.1.
UniGeneiHs.518326.
Hs.713956.

3D structure databases

ProteinModelPortaliQ9Y6X1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118079. 13 interactions.
IntActiQ9Y6X1. 1 interaction.
MINTiMINT-4721772.
STRINGi9606.ENSP00000239944.

PTM databases

iPTMnetiQ9Y6X1.
PhosphoSiteiQ9Y6X1.

Polymorphism and mutation databases

BioMutaiSERP1.
DMDMi74721555.

Proteomic databases

EPDiQ9Y6X1.
PaxDbiQ9Y6X1.
PRIDEiQ9Y6X1.
TopDownProteomicsiQ9Y6X1.

Protocols and materials databases

DNASUi27230.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239944; ENSP00000239944; ENSG00000120742.
ENST00000479209; ENSP00000420076; ENSG00000120742.
GeneIDi27230.
KEGGihsa:27230.
UCSCiuc003exy.4. human.

Organism-specific databases

CTDi27230.
GeneCardsiSERP1.
HGNCiHGNC:10759. SERP1.
HPAiHPA038970.
neXtProtiNX_Q9Y6X1.
PharmGKBiPA162402942.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3491. Eukaryota.
ENOG411221U. LUCA.
GeneTreeiENSGT00390000012245.
HOVERGENiHBG058555.
InParanoidiQ9Y6X1.
OMAiKNVNNRG.
OrthoDBiEOG7RNK3C.
PhylomeDBiQ9Y6X1.
TreeFamiTF313229.

Enzyme and pathway databases

ReactomeiR-HSA-381038. XBP1(S) activates chaperone genes.

Miscellaneous databases

ChiTaRSiSERP1. human.
GeneWikiiSERP1.
GenomeRNAii27230.
NextBioi50084.
PROiQ9Y6X1.

Gene expression databases

BgeeiQ9Y6X1.
CleanExiHS_SERP1.
ExpressionAtlasiQ9Y6X1. baseline and differential.
GenevisibleiQ9Y6X1. HS.

Family and domain databases

InterProiIPR010580. ER_stress-assoc.
[Graphical view]
PANTHERiPTHR15601. PTHR15601. 1 hit.
PfamiPF06624. RAMP4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human SERP1."
    Yamaguchi A., Hori O., Ogawa S.
    Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adrenal gland.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiSERP1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6X1
Secondary accession number(s): D3DNI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.