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Protein

Calpain-7

Gene

CAPN7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei290PROSITE-ProRule annotation1
Active sitei458PROSITE-ProRule annotation1
Active sitei478PROSITE-ProRule annotation1

GO - Molecular functioni

  • calcium-dependent cysteine-type endopeptidase activity Source: GO_Central
  • endopeptidase activity Source: UniProtKB
  • MIT domain binding Source: UniProtKB

GO - Biological processi

  • positive regulation of epithelial cell migration Source: UniProtKB
  • self proteolysis Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.B27 2681
ReactomeiR-HSA-1474228 Degradation of the extracellular matrix

Protein family/group databases

MEROPSiC02.029

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-7 (EC:3.4.22.-)
Alternative name(s):
PalB homolog
Short name:
PalBH
Gene namesi
Name:CAPN7
Synonyms:PALBH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000131375.9
HGNCiHGNC:1484 CAPN7
MIMi606400 gene
neXtProtiNX_Q9Y6W3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131375
PharmGKBiPA26064

Polymorphism and mutation databases

BioMutaiCAPN7
DMDMi33112239

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002077201 – 813Calpain-7Add BLAST813

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei95PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y6W3
MaxQBiQ9Y6W3
PaxDbiQ9Y6W3
PeptideAtlasiQ9Y6W3
PRIDEiQ9Y6W3
ProteomicsDBi86800

PTM databases

iPTMnetiQ9Y6W3
PhosphoSitePlusiQ9Y6W3

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000131375
CleanExiHS_CAPN7
ExpressionAtlasiQ9Y6W3 baseline and differential
GenevisibleiQ9Y6W3 HS

Organism-specific databases

HPAiHPA046617

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • MIT domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117033, 12 interactors
IntActiQ9Y6W3, 23 interactors
MINTiQ9Y6W3
STRINGi9606.ENSP00000253693

Structurei

Secondary structure

1813
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi688 – 696Combined sources9
Helixi698 – 700Combined sources3
Turni708 – 710Combined sources3
Helixi711 – 713Combined sources3
Beta strandi717 – 723Combined sources7
Beta strandi725 – 732Combined sources8
Beta strandi737 – 747Combined sources11
Beta strandi758 – 761Combined sources4
Beta strandi766 – 777Combined sources12
Beta strandi779 – 790Combined sources12
Beta strandi795 – 805Combined sources11
Beta strandi808 – 811Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QFEX-ray1.45A684-813[»]
ProteinModelPortaliQ9Y6W3
SMRiQ9Y6W3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y6W3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini232 – 540Calpain catalyticPROSITE-ProRule annotationAdd BLAST309

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni541 – 701Domain IIIAdd BLAST161
Regioni702 – 813Domain NAdd BLAST112

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00750000117668
HOGENOMiHOG000006940
HOVERGENiHBG036832
InParanoidiQ9Y6W3
KOiK08576
OMAiHYTVRVY
OrthoDBiEOG091G023Z
PhylomeDBiQ9Y6W3
TreeFamiTF322245

Family and domain databases

CDDicd00214 Calpain_III, 1 hit
cd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR007330 MIT
IPR036181 MIT_dom_sf
IPR038765 Papain_like_cys_pep_sf
IPR001300 Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF01067 Calpain_III, 1 hit
PF04212 MIT, 2 hits
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit
SM00745 MIT, 2 hits
SUPFAMiSSF116846 SSF116846, 2 hits
SSF49758 SSF49758, 2 hits
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y6W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDATALERDA VQFARLAVQR DHEGRYSEAV FYYKEAAQAL IYAEMAGSSL
60 70 80 90 100
ENIQEKITEY LERVQALHSA VQSKSADPLK SKHQLDLERA HFLVTQAFDE
110 120 130 140 150
DEKENVEDAI ELYTEAVDLC LKTSYETADK VLQNKLKQLA RQALDRAEAL
160 170 180 190 200
SEPLTKPVGK ISSTSVKPKP PPVRAHFPLG ANPFLERPQS FISPQSCDAQ
210 220 230 240 250
GQRYTAEEIE VLRTTSKING IEYVPFMNVD LRERFAYPMP FCDRWGKLPL
260 270 280 290 300
SPKQKTTFSK WVRPEDLTNN PTMIYTVSSF SIKQTIVSDC SFVASLAISA
310 320 330 340 350
AYERRFNKKL ITGIIYPQNK DGEPEYNPCG KYMVKLHLNG VPRKVIIDDQ
360 370 380 390 400
LPVDHKGELL CSYSNNKSEL WVSLIEKAYM KVMGGYDFPG SNSNIDLHAL
410 420 430 440 450
TGWIPERIAM HSDSQTFSKD NSFRMLYQRF HKGDVLITAS TGMMTEAEGE
460 470 480 490 500
KWGLVPTHAY AVLDIREFKG LRFIQLKNPW SHLRWKGRYS ENDVKNWTPE
510 520 530 540 550
LQKYLNFDPR TAQKIDNGIF WISWDDLCQY YDVIYLSWNP GLFKESTCIH
560 570 580 590 600
STWDAKQGPV KDAYSLANNP QYKLEVQCPQ GGAAVWVLLS RHITDKDDFA
610 620 630 640 650
NNREFITMVV YKTDGKKVYY PADPPPYIDG IRINSPHYLT KIKLTTPGTH
660 670 680 690 700
TFTLVVSQYE KQNTIHYTVR VYSACSFTFS KIPSPYTLSK RINGKWSGQS
710 720 730 740 750
AGGCGNFQET HKNNPIYQFH IEKTGPLLIE LRGPRQYSVG FEVVTVSTLG
760 770 780 790 800
DPGPHGFLRK SSGDYRCGFC YLELENIPSG IFNIIPSTFL PKQEGPFFLD
810
FNSIIPIKIT QLQ
Length:813
Mass (Da):92,652
Last modified:November 1, 1999 - v1
Checksum:i814769611360D281
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028639 mRNA Translation: BAA78730.1
CCDSiCCDS2624.1
RefSeqiNP_055111.1, NM_014296.2
UniGeneiHs.595234

Genome annotation databases

EnsembliENST00000253693; ENSP00000253693; ENSG00000131375
GeneIDi23473
KEGGihsa:23473
UCSCiuc003bzn.4 human

Similar proteinsi

Entry informationi

Entry nameiCAN7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6W3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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