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Protein

Calpain-7

Gene

CAPN7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease.By similarity

Catalytic activityi

Broad endopeptidase specificity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei290PROSITE-ProRule annotation1
Active sitei458PROSITE-ProRule annotation1
Active sitei478PROSITE-ProRule annotation1

GO - Molecular functioni

  • calcium-dependent cysteine-type endopeptidase activity Source: GO_Central
  • endopeptidase activity Source: UniProtKB
  • MIT domain binding Source: UniProtKB

GO - Biological processi

  • positive regulation of epithelial cell migration Source: UniProtKB
  • self proteolysis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131375-MONOMER.
BRENDAi3.4.22.B27. 2681.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.

Protein family/group databases

MEROPSiC02.029.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-7 (EC:3.4.22.-)
Alternative name(s):
PalB homolog
Short name:
PalBH
Gene namesi
Name:CAPN7
Synonyms:PALBH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:1484. CAPN7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • extracellular exosome Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23473.
OpenTargetsiENSG00000131375.
PharmGKBiPA26064.

Polymorphism and mutation databases

BioMutaiCAPN7.
DMDMi33112239.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002077201 – 813Calpain-7Add BLAST813

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei95PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y6W3.
MaxQBiQ9Y6W3.
PaxDbiQ9Y6W3.
PeptideAtlasiQ9Y6W3.
PRIDEiQ9Y6W3.

PTM databases

iPTMnetiQ9Y6W3.
PhosphoSitePlusiQ9Y6W3.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000131375.
CleanExiHS_CAPN7.
ExpressionAtlasiQ9Y6W3. baseline and differential.
GenevisibleiQ9Y6W3. HS.

Organism-specific databases

HPAiHPA046617.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IST1P539906EBI-1765641,EBI-945994

GO - Molecular functioni

  • MIT domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117033. 12 interactors.
IntActiQ9Y6W3. 22 interactors.
STRINGi9606.ENSP00000253693.

Structurei

Secondary structure

1813
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi688 – 696Combined sources9
Helixi698 – 700Combined sources3
Turni708 – 710Combined sources3
Helixi711 – 713Combined sources3
Beta strandi717 – 723Combined sources7
Beta strandi725 – 732Combined sources8
Beta strandi737 – 747Combined sources11
Beta strandi758 – 761Combined sources4
Beta strandi766 – 777Combined sources12
Beta strandi779 – 790Combined sources12
Beta strandi795 – 805Combined sources11
Beta strandi808 – 811Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QFEX-ray1.45A684-813[»]
ProteinModelPortaliQ9Y6W3.
SMRiQ9Y6W3.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y6W3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini232 – 540Calpain catalyticPROSITE-ProRule annotationAdd BLAST309

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni541 – 701Domain IIIAdd BLAST161
Regioni702 – 813Domain NAdd BLAST112

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated
Contains 1 calpain catalytic domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00750000117668.
HOGENOMiHOG000006940.
HOVERGENiHBG036832.
InParanoidiQ9Y6W3.
KOiK08576.
OMAiPIYQFHI.
OrthoDBiEOG091G023Z.
PhylomeDBiQ9Y6W3.
TreeFamiTF322245.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
Gene3Di1.20.58.280. 2 hits.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR007330. MIT.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF04212. MIT. 2 hits.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00745. MIT. 2 hits.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 2 hits.
SSF49758. SSF49758. 2 hits.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y6W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDATALERDA VQFARLAVQR DHEGRYSEAV FYYKEAAQAL IYAEMAGSSL
60 70 80 90 100
ENIQEKITEY LERVQALHSA VQSKSADPLK SKHQLDLERA HFLVTQAFDE
110 120 130 140 150
DEKENVEDAI ELYTEAVDLC LKTSYETADK VLQNKLKQLA RQALDRAEAL
160 170 180 190 200
SEPLTKPVGK ISSTSVKPKP PPVRAHFPLG ANPFLERPQS FISPQSCDAQ
210 220 230 240 250
GQRYTAEEIE VLRTTSKING IEYVPFMNVD LRERFAYPMP FCDRWGKLPL
260 270 280 290 300
SPKQKTTFSK WVRPEDLTNN PTMIYTVSSF SIKQTIVSDC SFVASLAISA
310 320 330 340 350
AYERRFNKKL ITGIIYPQNK DGEPEYNPCG KYMVKLHLNG VPRKVIIDDQ
360 370 380 390 400
LPVDHKGELL CSYSNNKSEL WVSLIEKAYM KVMGGYDFPG SNSNIDLHAL
410 420 430 440 450
TGWIPERIAM HSDSQTFSKD NSFRMLYQRF HKGDVLITAS TGMMTEAEGE
460 470 480 490 500
KWGLVPTHAY AVLDIREFKG LRFIQLKNPW SHLRWKGRYS ENDVKNWTPE
510 520 530 540 550
LQKYLNFDPR TAQKIDNGIF WISWDDLCQY YDVIYLSWNP GLFKESTCIH
560 570 580 590 600
STWDAKQGPV KDAYSLANNP QYKLEVQCPQ GGAAVWVLLS RHITDKDDFA
610 620 630 640 650
NNREFITMVV YKTDGKKVYY PADPPPYIDG IRINSPHYLT KIKLTTPGTH
660 670 680 690 700
TFTLVVSQYE KQNTIHYTVR VYSACSFTFS KIPSPYTLSK RINGKWSGQS
710 720 730 740 750
AGGCGNFQET HKNNPIYQFH IEKTGPLLIE LRGPRQYSVG FEVVTVSTLG
760 770 780 790 800
DPGPHGFLRK SSGDYRCGFC YLELENIPSG IFNIIPSTFL PKQEGPFFLD
810
FNSIIPIKIT QLQ
Length:813
Mass (Da):92,652
Last modified:November 1, 1999 - v1
Checksum:i814769611360D281
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028639 mRNA. Translation: BAA78730.1.
CCDSiCCDS2624.1.
RefSeqiNP_055111.1. NM_014296.2.
UniGeneiHs.595234.

Genome annotation databases

EnsembliENST00000253693; ENSP00000253693; ENSG00000131375.
GeneIDi23473.
KEGGihsa:23473.
UCSCiuc003bzn.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028639 mRNA. Translation: BAA78730.1.
CCDSiCCDS2624.1.
RefSeqiNP_055111.1. NM_014296.2.
UniGeneiHs.595234.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2QFEX-ray1.45A684-813[»]
ProteinModelPortaliQ9Y6W3.
SMRiQ9Y6W3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117033. 12 interactors.
IntActiQ9Y6W3. 22 interactors.
STRINGi9606.ENSP00000253693.

Protein family/group databases

MEROPSiC02.029.

PTM databases

iPTMnetiQ9Y6W3.
PhosphoSitePlusiQ9Y6W3.

Polymorphism and mutation databases

BioMutaiCAPN7.
DMDMi33112239.

Proteomic databases

EPDiQ9Y6W3.
MaxQBiQ9Y6W3.
PaxDbiQ9Y6W3.
PeptideAtlasiQ9Y6W3.
PRIDEiQ9Y6W3.

Protocols and materials databases

DNASUi23473.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253693; ENSP00000253693; ENSG00000131375.
GeneIDi23473.
KEGGihsa:23473.
UCSCiuc003bzn.4. human.

Organism-specific databases

CTDi23473.
DisGeNETi23473.
GeneCardsiCAPN7.
HGNCiHGNC:1484. CAPN7.
HPAiHPA046617.
MIMi606400. gene.
neXtProtiNX_Q9Y6W3.
OpenTargetsiENSG00000131375.
PharmGKBiPA26064.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00750000117668.
HOGENOMiHOG000006940.
HOVERGENiHBG036832.
InParanoidiQ9Y6W3.
KOiK08576.
OMAiPIYQFHI.
OrthoDBiEOG091G023Z.
PhylomeDBiQ9Y6W3.
TreeFamiTF322245.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131375-MONOMER.
BRENDAi3.4.22.B27. 2681.
ReactomeiR-HSA-1474228. Degradation of the extracellular matrix.

Miscellaneous databases

ChiTaRSiCAPN7. human.
EvolutionaryTraceiQ9Y6W3.
GenomeRNAii23473.
PROiQ9Y6W3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131375.
CleanExiHS_CAPN7.
ExpressionAtlasiQ9Y6W3. baseline and differential.
GenevisibleiQ9Y6W3. HS.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
Gene3Di1.20.58.280. 2 hits.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR007330. MIT.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF04212. MIT. 2 hits.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00745. MIT. 2 hits.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 2 hits.
SSF49758. SSF49758. 2 hits.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAN7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.