Q9Y6V0 (PCLO_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein piccolo

Alternative name(s):
Aczonin

Gene names

Name:	PCLO
Synonyms:	ACZ, KIAA0559

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	5065 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking By similarity. UniProtKB Q9QYX7
Subunit structure	Interacts with RABAC1/PRA1, RIMS2 and profilin By similarity.
Subcellular location	Cell junction › synapse By similarity. Note: Concentrated at the presynaptic side of synaptic junctions By similarity.
Domain	C2 domain 1 is involved in binding calcium and phospholipids. Calcium binds with low affinity but with high specificity and induces a large conformational change. UniProtKB Q9JKS6
Sequence similarities	Contains 2 C2 domains. Contains 1 PDZ (DHR) domain.
Sequence caution	The sequence AAB97937.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAD21789.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Cell junction Synapse
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	Calcium Calcium/phospholipid-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cAMP-mediated signaling Inferred from electronic annotation. Source: Compara cytoskeleton organization Inferred from sequence or structural similarity. Source: UniProtKB insulin secretion Inferred from electronic annotation. Source: Compara regulation of exocytosis Inferred from electronic annotation. Source: Compara synaptic vesicle exocytosis Non-traceable author statement Ref.4. Source: UniProtKB
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Non-traceable author statement Ref.4. Source: UniProtKB membrane Inferred from electronic annotation. Source: InterPro synapse Inferred from sequence or structural similarity. Source: UniProtKB synaptic vesicle Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium ion binding Inferred from sequence or structural similarity. Source: UniProtKB calcium-dependent phospholipid binding Inferred from sequence or structural similarity. Source: UniProtKB profilin binding Inferred from sequence or structural similarity. Source: UniProtKB transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q9Y6V0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y6V0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     4440-4440: S → SGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEQTGKLMEG
     4570-4570: K → KPTDGTKVVSHPITGEIQ
     4612-4612: G → GQVMVVQNAS
     4793-4797: TAHKS → SKRRK
     4798-5065: Missing.

Isoform 3 (identifier: Q9Y6V0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-4458: Missing.
     4459-4476: VQSIISQQSGEAEICVRL → MKKFRVSLVSKVGKQKYV
     4570-4570: K → KPTDGTKVVSHPITGEIQ
     4793-4797: TAHKS → SKRRK
     4798-5065: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9Y6V0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     443-490: AKPPSQQPGS...GSAKPSAQQP → HKAPISTAWL...WLSKTLSSTA
     491-5065: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q9Y6V0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     442-442: Q → QQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGS
     1046-1046: E → EIQEWLCL
     1270-1270: Q → QVEPGKEKT
     4440-4440: S → SGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEQTGKLMEG
     4570-4570: K → KPTDGTKVVSHPITGEIQ
     4612-4612: G → GQVMVVQNAS
     4794-4854: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: Q9Y6V0-6)

The sequence of this isoform differs from the canonical sequence as follows:
     442-442: Q → QQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGS
     1046-1046: E → EIQEWLCL
     1270-1270: Q → QVEPGKEKT
     4440-4440: S → SGNGLGIRIVGGKEIPGHSGEIGAYIAKILPGGSAEQTGKLMEG
     4570-4570: K → KPTDGTKVVSHPITGEIQ
     4612-4612: G → GQVMVVQNAS
     4793-4797: TAHKS → SKRRK
     4798-5065: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 5065

5065

Protein piccolo

PRO_0000058250

Regions

Domain

4427 – 4478

52

PDZ

Domain

4565 – 4669

105

C2 1

Domain

4934 – 5039

106

C2 2

Zinc finger

535 – 559

25

C4-type Potential

Zinc finger

1005 – 1028

24

C4-type Potential

Region

397 – 501

105

10 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X

Compositional bias

193 – 499

307

Gln-rich

Compositional bias

209 – 975

767

Pro-rich

Compositional bias

2303 – 2464

162

Pro-rich

Compositional bias

2336 – 2361

26

Poly-Pro

Compositional bias

3141 – 3248

108

Gln-rich

Compositional bias

3792 – 3896

105

Gln-rich

Compositional bias

4215 – 4278

64

Ser-rich

Compositional bias

4699 – 4765

67

Ser-rich

Amino acid modifications

Modified residue

629

1

Phosphoserine By similarity

Modified residue

751

1

Phosphoserine By similarity

Modified residue

868

1

Phosphothreonine By similarity

Modified residue

1335

1

Phosphoserine By similarity

Modified residue

1336

1

Phosphoserine By similarity

Modified residue

1395

1

Phosphoserine By similarity

Modified residue

1453

1

Phosphoserine By similarity

Modified residue

1571

1

Phosphoserine By similarity

Modified residue

1581

1

Phosphoserine By similarity

Modified residue

1756

1

Phosphothreonine By similarity

Modified residue

1759

1

Phosphoserine By similarity

Modified residue

1762

1

Phosphoserine By similarity

Modified residue

1768

1

Phosphoserine By similarity

Modified residue

1804

1

Phosphoserine By similarity

Modified residue

1824

1

Phosphotyrosine By similarity

Modified residue

1825

1

Phosphoserine By similarity

Modified residue

3000

1

Phosphothreonine By similarity

Modified residue

3378

1

Phosphothreonine By similarity

Modified residue

3515

1

Phosphothreonine By similarity

Modified residue

3546

1

Phosphoserine By similarity

Modified residue

3611

1

Phosphoserine By similarity

Modified residue

3617

1

Phosphoserine By similarity

Modified residue

3764

1

Phosphotyrosine By similarity

Modified residue

3766

1

Phosphoserine By similarity

Modified residue

3897

1

Phosphothreonine By similarity

Modified residue

3898

1

Phosphothreonine By similarity

Modified residue

3939

1

Phosphoserine By similarity

Modified residue

3955

1

Phosphoserine By similarity

Modified residue

4289

1

Phosphoserine By similarity

Modified residue

4293

1

Phosphoserine By similarity

Modified residue

4296

1

Phosphoserine By similarity

Modified residue

4328

1

Phosphoserine By similarity

Natural variations

Alternative sequence

1 – 4458

4458

Missing in isoform 3.

VSP_012348

Alternative sequence

442

1

Q → QQPGPGKIPAQQAGPGKTSA QQTGPTKPPSQLPGPAKPPP QQPGPAKPPPQQPGS in isoform 5 and isoform 6.

VSP_041004

Alternative sequence

443 – 490

48

AKPPS…SAQQP → HKAPISTAWLNKTPTSTAWP SKALTSTAWLNKTPISTAWL SKTLSSTA in isoform 4.

VSP_041005

Alternative sequence

491 – 5065

4575

Missing in isoform 4.

VSP_041006

Alternative sequence

1046

1

E → EIQEWLCL in isoform 5 and isoform 6.

VSP_041007

Alternative sequence

1270

1

Q → QVEPGKEKT in isoform 5 and isoform 6.

VSP_041008

Alternative sequence

4440

1

S → SGNGLGIRIVGGKEIPGHSG EIGAYIAKILPGGSAEQTGK LMEG in isoform 2, isoform 5 and isoform 6.

VSP_003923

Alternative sequence

4459 – 4476

18

VQSII…ICVRL → MKKFRVSLVSKVGKQKYV in isoform 3.

VSP_012349

Alternative sequence

4570

1

K → KPTDGTKVVSHPITGEIQ in isoform 2, isoform 3, isoform 5 and isoform 6.

VSP_003924

Alternative sequence

4612

1

G → GQVMVVQNAS in isoform 2, isoform 5 and isoform 6.

VSP_003925

Alternative sequence

4793 – 4797

5

TAHKS → SKRRK in isoform 2, isoform 3 and isoform 6.

VSP_003926

Alternative sequence

4794 – 4854

61

Missing in isoform 5.

VSP_041009

Alternative sequence

4798 – 5065

268

Missing in isoform 2, isoform 3 and isoform 6.

VSP_003927

Natural variant

2602

1

T → P.
Corresponds to variant rs10261848 [ dbSNP | Ensembl ].

VAR_056959

Natural variant

2735

1

A → T.
Corresponds to variant rs976714 [ dbSNP | Ensembl ].

VAR_056960

Experimental info

Sequence conflict

441

1

V → A in CAB60727. Ref.4

Sequence conflict

443

1

A → T in CAB60727. Ref.4

Sequence conflict

447

1

S → P in AAI22566. Ref.3

Sequence conflict

500

1

S → F in CAB60727. Ref.4

Sequence conflict

509

1

S → F in CAB60727. Ref.4

Sequence conflict

578

1

V → A in CAB60727. Ref.4

Sequence conflict

760

1

S → T in CAB60727. Ref.4

Sequence conflict

4676

1

S → A in AAH01304. Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

5065

Helix Strand Turn

Details...

Beta strand

4425 – 4430

6

Beta strand

4434 – 4437

4

Beta strand

4442 – 4446

5

Helix

4456 – 4463

8

Beta strand

4470 – 4477

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 3, 2011. Version 4. Checksum: 0CE4F2990F74AFFF	FASTA	5,065	553,277
	10 20 30 40 50 60 MGNEASLEGE GLPEGLAAAA AAGGGASGAG SPSHTAIPAG MEADLSQLSE EERRQIAAVM 70 80 90 100 110 120 SRAQGLPKGS VPPAAAESPS MHRKQELDSS HPPKQSGRPP DPGRPAQPGL SKSRTTDTFR 130 140 150 160 170 180 SEQKLPGRSP STISLKESKS RTDLKEEHKS SMMPGFLSEV NALSAVSSVV NKFNPFDLIS 190 200 210 220 230 240 DSEASQEETT KKQKVVQKEQ GKPEGIIKPP LQQQPPKPIP KQQGPGRDPL QQDGTPKSIS 250 260 270 280 290 300 SQQPEKIKSQ PPGTGKPIQG PTQTPQTDHA KLPLQRDASR PQTKQADIVR GESVKPSLPS 310 320 330 340 350 360 PSKPPIQQPT PGKPPAQQPG HEKSQPGPAK PPAQPSGLTK PLAQQPGTVK PPVQPPGTTK 370 380 390 400 410 420 PPAQPLGPAK PPAQQTGSEK PSSEQPGPKA LAQPPGVGKT PAQQPGPAKP PTQQVGTPKP 430 440 450 460 470 480 LAQQPGLQSP AKAPGPTKTP VQAKPPSQQP GSTKPPPQQP GPAKPSPQQP GSTKPPSQQP 490 500 510 520 530 540 GSAKPSAQQP SPAKPSAQQS TKPVSQTGSG KPLQPPTVSP SAKQPPSQGL PKTICPLCNT 550 560 570 580 590 600 TELLLHVPEK ANFNTCTECQ TTVCSLCGFN PNPHLTEVKE WLCLNCQMKR ALGGDLAPVP 610 620 630 640 650 660 SSPQPKLKTA PVTTTSAVSK SSPQPQQTSP KKDAAPKQDL SKAPEPKKPP PLVKQPTLHG 670 680 690 700 710 720 SPSAKAKQPP EADSLSKPAP PKEPSVPSEQ DKAPVADDKP KQPKMVKPTT DLVSSSSATT 730 740 750 760 770 780 KPDIPSSKVQ SQAEEKTTPP LKTDSAKPSQ SFPPTGEKVS PFDSKAIPRP ASDSKIISHP 790 800 810 820 830 840 GPSSESKGQK QVDPVQKKEE PKKAQTKMSP KPDAKPMPKG SPTPPGPRPT AGQTVPTPQQ 850 860 870 880 890 900 SPKPQEQSRR FSLNLGSITD APKSQPTTPQ ETVTGKLFGF GASIFSQASN LISTAGQPGP 910 920 930 940 950 960 HSQSGPGAPM KQAPAPSQPP TSQGPPKSTG QAPPAPAKSI PVKKETKAPA AEKLEPKAEQ 970 980 990 1000 1010 1020 APTVKRTETE KKPPPIKDSK SLTAEPQKAV LPTKLEKSPK PESTCPLCKT ELNIGSKDPP 1030 1040 1050 1060 1070 1080 NFNTCTECKN QVCNLCGFNP TPHLTENCQT QRAISGQLGD IRKMPPAPSG PKASPMPVPT 1090 1100 1110 1120 1130 1140 ESSSQKTAVP PQVKLVKKQE QEVKTEAEKV ILEKVKETLS MEKIPPMVTT DQKQEESKLE 1150 1160 1170 1180 1190 1200 KDKASALQEK KPLPEEKKLI PEEEKIRSEE KKPLLEEKKP TPEDKKLLPE AKTSAPEEQK 1210 1220 1230 1240 1250 1260 HDLLKSQVQI AEEKLEGRVA PKTVQEGKQP QTKMEGLPSG TPQSLPKEDD KTTKTIKEQP 1270 1280 1290 1300 1310 1320 QPPCTAKPDQ EKEDDKSDTS SSQQPKSPQG LSDTGYSSDG ISSSLGEIPS LIPTDEKDIL 1330 1340 1350 1360 1370 1380 KGLKKDSFSQ ESSPSSPSDL AKLESTVLSI LEAQASTLAD EKSEKKTQPH EVSPEQPKDQ 1390 1400 1410 1420 1430 1440 EKTQSLSETL EITISEEEIK ESQEERKDTF KKDSQQDIPS SKDHKEKSEF VDDITTRREP 1450 1460 1470 1480 1490 1500 YDSVEESSES ENSPVPQRKR RTSVGSSSSD EYKQEDSQGS GEEEDFIRKQ IIEMSADEDA 1510 1520 1530 1540 1550 1560 SGSEDDEFIR NQLKEISSST ESQKKEETKG KGKITAGKHR RLTRKSSTSI DEDAGRRHSW 1570 1580 1590 1600 1610 1620 HDEDDEAFDE SPELKYRETK SQESEELVVT GGGGLRRFKT IELNSTIADK YSAESSQKKT 1630 1640 1650 1660 1670 1680 SLYFDEEPEL EMESLTDSPE DRSRGEGSSS LHASSFTPGT SPTSVSSLDE DSDSSPSHKK 1690 1700 1710 1720 1730 1740 GESKQQRKAR HRPHGPLLPT IEDSSEEEEL REEEELLKEQ EKQREIEQQQ RKSSSKKSKK 1750 1760 1770 1780 1790 1800 DKDELRAQRR RERPKTPPSN LSPIEDASPT EELRQAAEME ELHRSSCSEY SPSIESDPEG 1810 1820 1830 1840 1850 1860 FEISPEKIIE VQKVYKLPTA VSLYSPTDEQ SIMQKEGSQK ALKSAEEMYE EMMHKTHKYK 1870 1880 1890 1900 1910 1920 AFPAANERDE VFEKEPLYGG MLIEDYIYES LVEDTYNGSV DGSLLTRQEE ENGFMQQKGR 1930 1940 1950 1960 1970 1980 EQKIRLSEQI YEDPMQKITD LQKEFYELES LHSVVPQEDI VSSSFIIPES HEIVDLGTMV 1990 2000 2010 2020 2030 2040 TSTEEERKLL DADAAYEELM KRQQMQLTPG SSPTQAPIGE DMTESTMDFD RMPDASLTSS 2050 2060 2070 2080 2090 2100 VLSGASLTDS TSSATLSIPD VKITQHFSTE EIEDEYVTDY TREIQEIIAH ESLILTYSEP 2110 2120 2130 2140 2150 2160 SESATSVPPS DTPSLTSSVS SVCTTDSSSP ITTLDSITTV YTEPVDMITK FEDSEEISSS 2170 2180 2190 2200 2210 2220 TYFPGSIIDY PEEISVSLDR TAPPDGRASA DHIVISLSDM ASSIIESVVP KPEGPVADTV 2230 2240 2250 2260 2270 2280 STDLLISEKD PVKKAKKETG NGIILEVLEA YRDKKELEAE RTKSSLSETV FDHPPSSVIA 2290 2300 2310 2320 2330 2340 LPMKEQLSTT YFTSGETFGQ EKPASQLPSG SPSVSSLPAK PRPFFRSSSL DISAQPPPPP 2350 2360 2370 2380 2390 2400 PPPPPPPPPP PPPPPPPLPP PTSPKPTILP KKKLTVASPV TTATPLFDAV TTLETTAVLR 2410 2420 2430 2440 2450 2460 SNGLPVTRIC TTAPPPVPPK PSSIPSGLVF THRPEPSKPP IAPKPVIPQL PTTTQKPTDI 2470 2480 2490 2500 2510 2520 HPKPTGLSLT SSMTLNLVTS ADYKLPSPTS PLSPHSNKSS PRFSKSLTET YVVITLPSEP 2530 2540 2550 2560 2570 2580 GTPTDSSASQ AITSWPLGSP SKDLVSVEPV FSVVPPVTAV EIPISSEQTF YISGALQTFS 2590 2600 2610 2620 2630 2640 ATPVTAPSSF QAAPTSVTQF LTTEVSKTEV SATRSTAPSV GLSSISITIP PEPLALDNIH 2650 2660 2670 2680 2690 2700 LEKPQYKEDG KLQLVGDVID LRTVPKVEVK TTDKCIDLSA STMDVKRQIT ANEVYGKQIS 2710 2720 2730 2740 2750 2760 AVQPSIINLS VTSSIVTPVS LATETVTFVT CTASASYTTG TESLVGAEHA MTTPLQLTTS 2770 2780 2790 2800 2810 2820 KHAEPPYRIP SDQVFPIARE EAPINLSLGT PAHAVTLAIT KPVTVPPVGV TNGWTDSTVS 2830 2840 2850 2860 2870 2880 QGITDGEVVD LSTTKSHRTV VTMDESTSSV MTKIIEDEKP VDLTAGRRAV CCDVVYKLPF 2890 2900 2910 2920 2930 2940 GRSCTAQQPA TTLPEDRFGY RDDHYQYDRS GPYGYRGIGG MKPSMSDTNL AEAGHFFYKS 2950 2960 2970 2980 2990 3000 KNAFDYSEGT DTAVDLTSGR VTTGEVMDYS SKTTGPYPET RQVISGAGIS TPQYSTARMT 3010 3020 3030 3040 3050 3060 PPPGPQYCVG SVLRSSNGVV YSSVATPTPS TFAITTQPGS IFSTTVRDLS GIHTADAVTS 3070 3080 3090 3100 3110 3120 LPAMHHSQPM PRSYFITTGA SETDIAVTGI DISASLQTIT MESLTAETID SVPTLTTASE 3130 3140 3150 3160 3170 3180 VFPEVVGDES ALLIVPEEDK QQQQLDLERE LLELEKIKQQ RFAEELEWER QEIQRFREQE 3190 3200 3210 3220 3230 3240 KIMVQKKLEE LQSMKQHLLF QQEEERQAQF MMRQETLAQQ QLQLEQIQQL QQQLHQQLEE 3250 3260 3270 3280 3290 3300 QKIRQIYQYN YDPSGTASPQ TTTEQAILEG QYAALEGSQF WATEDATTTA SAVVAIEIPQ 3310 3320 3330 3340 3350 3360 SQGWYTVQSD GVTQYIAPPG ILSTVSEIPL TDVVVKEEKQ PKKRSSGAKV RGQYDDMGEN 3370 3380 3390 3400 3410 3420 MTDDPRSFKK IVDSGVQTDD EDATDRSYVS RRRRTKKSVD TSVQTDDEDQ DEWDMPTRSR 3430 3440 3450 3460 3470 3480 RKARVGKYGD SMTEADKTKP LSKVSSIAVQ TVAEISVQTE PVGTIRTPSI RARVDAKVEI 3490 3500 3510 3520 3530 3540 IKHISAPEKT YKGGSLGCQT EADSDTQSPQ YLSATSPPKD KKRPTPLEIG YSSHLRADST 3550 3560 3570 3580 3590 3600 VQLAPSPPKS PKVLYSPISP LSPGKALESA FVPYEKPLPD DISPQKVLHP DMAKVPPASP 3610 3620 3630 3640 3650 3660 KTAKMMQRSM SDPKPLSPTA DESSRAPFQY TEGYTTKGSQ TMTSSGAQKK VKRTLPNPPP 3670 3680 3690 3700 3710 3720 EEISTGTQST FSTMGTVSRR RICRTNTMAR AKILQDIDRE LDLVERESAK LRKKQAELDE 3730 3740 3750 3760 3770 3780 EEKEIDAKLR YLEMGINRRK EALLKEREKR ERAYLQGVAE DRDYMSDSEV SSTRPTRIES 3790 3800 3810 3820 3830 3840 QHGIERPRTA PQTEFSQFIP PQTQTESQLV PPTSPYTQYQ YSSPALPTQA PTSYTQQSHF 3850 3860 3870 3880 3890 3900 EQQTLYHQQV SPYQTQPTFQ AVATMSFTPQ VQPTPTPQPS YQLPSQMMVI QQKPRQTTLY 3910 3920 3930 3940 3950 3960 LEPKITSNYE VIRNQPLMIA PVSTDNTFAV SHLGSKYNSL DLRIGLEERS SMASSPISSI 3970 3980 3990 4000 4010 4020 SADSFYADID HHTPRNYVLI DDIGEITKGT AALSTAFSLH EKDLSKTDRL LRTTETRRSQ 4030 4040 4050 4060 4070 4080 EVTDFLAPLQ SSSRLHSYVK AEEDPMEDPY ELKLLKHQIK QEFRRGTESL DHLAGLSHYY 4090 4100 4110 4120 4130 4140 HADTSYRHFP KSEKYSISRL TLEKQAAKQL PAAILYQKQS KHKKSLIDPK MSKFSPIQES 4150 4160 4170 4180 4190 4200 RDLEPDYSSY MTSSTSSIGG ISSRARLLQD DITFGLRKNI TDQQKFMGSS LGTGLGTLGN 4210 4220 4230 4240 4250 4260 TIRSALQDEA DKPYSSGSRS RPSSRPSSVY GLDLSIKRDS SSSSLRLKAQ EAEALDVSFS 4270 4280 4290 4300 4310 4320 HASSSARTKP TSLPISQSRG RIPIVAQNSE EESPLSPVGQ PMGMARAAAG PLPPISADTR 4330 4340 4350 4360 4370 4380 DQFGSSHSLP EVQQHMREES RTRGYDRDIA FIMDDFQHAM SDSEAYHLRR EETDWFDKPR 4390 4400 4410 4420 4430 4440 ESRLENGHGL DRKLPERLVH SRPLSQHQEQ IIQMNGKTMH YIFPHARIKI TRDSKDHTVS 4450 4460 4470 4480 4490 4500 MQVLEWNGIP LTSKTYEEVQ SIISQQSGEA EICVRLDLNM LSDSENSQHL ELHEPPKAVD 4510 4520 4530 4540 4550 4560 KAKSPGVDPK QLAAELQKVS LQQSPLVLSS VVEKGSHVHS GPTSAGSSSV PSPGQPGSPS 4570 4580 4590 4600 4610 4620 VSKKKHGSSK LQINYDLGNL IIHILQARNL VPRDNNGYSD PFVKVYLLPG RGAEYKRRTK 4630 4640 4650 4660 4670 4680 HVQKSLNPEW NQTVIYKSIS MEQLKKKTLE VTVWDYDRFS SNDFLGEVLI DLSSTSHLDN 4690 4700 4710 4720 4730 4740 TPRWYPLKEQ TESIDHGKSH SSQSSQQSPK PSVIKSRSHG IFPDPSKDMQ VPTIEKSHSS 4750 4760 4770 4780 4790 4800 PGSSKSSSEG HLRSHGPSRS QSKTSVTQTH LEDAGAAIAA AEAAVQQLRI QPTAHKSGQS 4810 4820 4830 4840 4850 4860 NHARKQHRHS IAGVLPIQRT QSDNLPPPAN GNQDQSQLAL RKVMSDGPVK PEGAKPPNHR 4870 4880 4890 4900 4910 4920 PAESSVSTGS SGSSFGSGYS VDSEGSSSTA GETNLFPIPR IGKMGQNGQE PVKQPGVGVG 4930 4940 4950 4960 4970 4980 LADTEAKTQV MGEIKIALKK EMKTDGEQLI VEILQCRNIT YKFKSPDHLP DLYVKIYVMN 4990 5000 5010 5020 5030 5040 ISTQKKVIKK KTRVCRHDRE PSFNETFRFS LSPAGHSLQI LLFSNGGKFM KKTLIGEACI 5050 5060 WLDKVDLRKR IVNWHKLLVS PTQTH
	Isoform 2 [UniParc]. Checksum: C9939ED01362785E	FASTA	4,866	530,858
	10 20 30 40 50 60 MGNEASLEGE GLPEGLAAAA AAGGGASGAG SPSHTAIPAG MEADLSQLSE EERRQIAAVM 70 80 90 100 110 120 SRAQGLPKGS VPPAAAESPS MHRKQELDSS HPPKQSGRPP DPGRPAQPGL SKSRTTDTFR 130 140 150 160 170 180 SEQKLPGRSP STISLKESKS RTDLKEEHKS SMMPGFLSEV NALSAVSSVV NKFNPFDLIS 190 200 210 220 230 240 DSEASQEETT KKQKVVQKEQ GKPEGIIKPP LQQQPPKPIP KQQGPGRDPL QQDGTPKSIS 250 260 270 280 290 300 SQQPEKIKSQ PPGTGKPIQG PTQTPQTDHA KLPLQRDASR PQTKQADIVR GESVKPSLPS 310 320 330 340 350 360 PSKPPIQQPT PGKPPAQQPG HEKSQPGPAK PPAQPSGLTK PLAQQPGTVK PPVQPPGTTK 370 380 390 400 410 420 PPAQPLGPAK PPAQQTGSEK PSSEQPGPKA LAQPPGVGKT PAQQPGPAKP PTQQVGTPKP 430 440 450 460 470 480 LAQQPGLQSP AKAPGPTKTP VQAKPPSQQP GSTKPPPQQP GPAKPSPQQP GSTKPPSQQP 490 500 510 520 530 540 GSAKPSAQQP SPAKPSAQQS TKPVSQTGSG KPLQPPTVSP SAKQPPSQGL PKTICPLCNT 550 560 570 580 590 600 TELLLHVPEK ANFNTCTECQ TTVCSLCGFN PNPHLTEVKE WLCLNCQMKR ALGGDLAPVP 610 620 630 640 650 660 SSPQPKLKTA PVTTTSAVSK SSPQPQQTSP KKDAAPKQDL SKAPEPKKPP PLVKQPTLHG 670 680 690 700 710 720 SPSAKAKQPP EADSLSKPAP PKEPSVPSEQ DKAPVADDKP KQPKMVKPTT DLVSSSSATT 730 740 750 760 770 780 KPDIPSSKVQ SQAEEKTTPP LKTDSAKPSQ SFPPTGEKVS PFDSKAIPRP ASDSKIISHP 790 800 810 820 830 840 GPSSESKGQK QVDPVQKKEE PKKAQTKMSP KPDAKPMPKG SPTPPGPRPT AGQTVPTPQQ 850 860 870 880 890 900 SPKPQEQSRR FSLNLGSITD APKSQPTTPQ ETVTGKLFGF GASIFSQASN LISTAGQPGP 910 920 930 940 950 960 HSQSGPGAPM KQAPAPSQPP TSQGPPKSTG QAPPAPAKSI PVKKETKAPA AEKLEPKAEQ 970 980 990 1000 1010 1020 APTVKRTETE KKPPPIKDSK SLTAEPQKAV LPTKLEKSPK PESTCPLCKT ELNIGSKDPP 1030 1040 1050 1060 1070 1080 NFNTCTECKN QVCNLCGFNP TPHLTENCQT QRAISGQLGD IRKMPPAPSG PKASPMPVPT 1090 1100 1110 1120 1130 1140 ESSSQKTAVP PQVKLVKKQE QEVKTEAEKV ILEKVKETLS MEKIPPMVTT DQKQEESKLE 1150 1160 1170 1180 1190 1200 KDKASALQEK KPLPEEKKLI PEEEKIRSEE KKPLLEEKKP TPEDKKLLPE AKTSAPEEQK 1210 1220 1230 1240 1250 1260 HDLLKSQVQI AEEKLEGRVA PKTVQEGKQP QTKMEGLPSG TPQSLPKEDD KTTKTIKEQP 1270 1280 1290 1300 1310 1320 QPPCTAKPDQ EKEDDKSDTS SSQQPKSPQG LSDTGYSSDG ISSSLGEIPS LIPTDEKDIL 1330 1340 1350 1360 1370 1380 KGLKKDSFSQ ESSPSSPSDL AKLESTVLSI LEAQASTLAD EKSEKKTQPH EVSPEQPKDQ 1390 1400 1410 1420 1430 1440 EKTQSLSETL EITISEEEIK ESQEERKDTF KKDSQQDIPS SKDHKEKSEF VDDITTRREP 1450 1460 1470 1480 1490 1500 YDSVEESSES ENSPVPQRKR RTSVGSSSSD EYKQEDSQGS GEEEDFIRKQ IIEMSADEDA 1510 1520 1530 1540 1550 1560 SGSEDDEFIR NQLKEISSST ESQKKEETKG KGKITAGKHR RLTRKSSTSI DEDAGRRHSW 1570 1580 1590 1600 1610 1620 HDEDDEAFDE SPELKYRETK SQESEELVVT GGGGLRRFKT IELNSTIADK YSAESSQKKT 1630 1640 1650 1660 1670 1680 SLYFDEEPEL EMESLTDSPE DRSRGEGSSS LHASSFTPGT SPTSVSSLDE DSDSSPSHKK 1690 1700 1710 1720 1730 1740 GESKQQRKAR HRPHGPLLPT IEDSSEEEEL REEEELLKEQ EKQREIEQQQ RKSSSKKSKK 1750 1760 1770 1780 1790 1800 DKDELRAQRR RERPKTPPSN LSPIEDASPT EELRQAAEME ELHRSSCSEY SPSIESDPEG 1810 1820 1830 1840 1850 1860 FEISPEKIIE VQKVYKLPTA VSLYSPTDEQ SIMQKEGSQK ALKSAEEMYE EMMHKTHKYK 1870 1880 1890 1900 1910 1920 AFPAANERDE VFEKEPLYGG MLIEDYIYES LVEDTYNGSV DGSLLTRQEE ENGFMQQKGR 1930 1940 1950 1960 1970 1980 EQKIRLSEQI YEDPMQKITD LQKEFYELES LHSVVPQEDI VSSSFIIPES HEIVDLGTMV 1990 2000 2010 2020 2030 2040 TSTEEERKLL DADAAYEELM KRQQMQLTPG SSPTQAPIGE DMTESTMDFD RMPDASLTSS 2050 2060 2070 2080 2090 2100 VLSGASLTDS TSSATLSIPD VKITQHFSTE EIEDEYVTDY TREIQEIIAH ESLILTYSEP 2110 2120 2130 2140 2150 2160 SESATSVPPS DTPSLTSSVS SVCTTDSSSP ITTLDSITTV YTEPVDMITK FEDSEEISSS 2170 2180 2190 2200 2210 2220 TYFPGSIIDY PEEISVSLDR TAPPDGRASA DHIVISLSDM ASSIIESVVP KPEGPVADTV 2230 2240 2250 2260 2270 2280 STDLLISEKD PVKKAKKETG NGIILEVLEA YRDKKELEAE RTKSSLSETV FDHPPSSVIA 2290 2300 2310 2320 2330 2340 LPMKEQLSTT YFTSGETFGQ EKPASQLPSG SPSVSSLPAK PRPFFRSSSL DISAQPPPPP 2350 2360 2370 2380 2390 2400 PPPPPPPPPP PPPPPPPLPP PTSPKPTILP KKKLTVASPV TTATPLFDAV TTLETTAVLR 2410 2420 2430 2440 2450 2460 SNGLPVTRIC TTAPPPVPPK PSSIPSGLVF THRPEPSKPP IAPKPVIPQL PTTTQKPTDI 2470 2480 2490 2500 2510 2520 HPKPTGLSLT SSMTLNLVTS ADYKLPSPTS PLSPHSNKSS PRFSKSLTET YVVITLPSEP 2530 2540 2550 2560 2570 2580 GTPTDSSASQ AITSWPLGSP SKDLVSVEPV FSVVPPVTAV EIPISSEQTF YISGALQTFS 2590 2600 2610 2620 2630 2640 ATPVTAPSSF QAAPTSVTQF LTTEVSKTEV SATRSTAPSV GLSSISITIP PEPLALDNIH 2650 2660 2670 2680 2690 2700 LEKPQYKEDG KLQLVGDVID LRTVPKVEVK TTDKCIDLSA STMDVKRQIT ANEVYGKQIS 2710 2720 2730 2740 2750 2760 AVQPSIINLS VTSSIVTPVS LATETVTFVT CTASASYTTG TESLVGAEHA MTTPLQLTTS 2770 2780 2790 2800 2810 2820 KHAEPPYRIP SDQVFPIARE EAPINLSLGT PAHAVTLAIT KPVTVPPVGV TNGWTDSTVS 2830 2840 2850 2860 2870 2880 QGITDGEVVD LSTTKSHRTV VTMDESTSSV MTKIIEDEKP VDLTAGRRAV CCDVVYKLPF 2890 2900 2910 2920 2930 2940 GRSCTAQQPA TTLPEDRFGY RDDHYQYDRS GPYGYRGIGG MKPSMSDTNL AEAGHFFYKS 2950 2960 2970 2980 2990 3000 KNAFDYSEGT DTAVDLTSGR VTTGEVMDYS SKTTGPYPET RQVISGAGIS TPQYSTARMT 3010 3020 3030 3040 3050 3060 PPPGPQYCVG SVLRSSNGVV YSSVATPTPS TFAITTQPGS IFSTTVRDLS GIHTADAVTS 3070 3080 3090 3100 3110 3120 LPAMHHSQPM PRSYFITTGA SETDIAVTGI DISASLQTIT MESLTAETID SVPTLTTASE 3130 3140 3150 3160 3170 3180 VFPEVVGDES ALLIVPEEDK QQQQLDLERE LLELEKIKQQ RFAEELEWER QEIQRFREQE 3190 3200 3210 3220 3230 3240 KIMVQKKLEE LQSMKQHLLF QQEEERQAQF MMRQETLAQQ QLQLEQIQQL QQQLHQQLEE 3250 3260 3270 3280 3290 3300 QKIRQIYQYN YDPSGTASPQ TTTEQAILEG QYAALEGSQF WATEDATTTA SAVVAIEIPQ 3310 3320 3330 3340 3350 3360 SQGWYTVQSD GVTQYIAPPG ILSTVSEIPL TDVVVKEEKQ PKKRSSGAKV RGQYDDMGEN 3370 3380 3390 3400 3410 3420 MTDDPRSFKK IVDSGVQTDD EDATDRSYVS RRRRTKKSVD TSVQTDDEDQ DEWDMPTRSR 3430 3440 3450 3460 3470 3480 RKARVGKYGD SMTEADKTKP LSKVSSIAVQ TVAEISVQTE PVGTIRTPSI RARVDAKVEI 3490 3500 3510 3520 3530 3540 IKHISAPEKT YKGGSLGCQT EADSDTQSPQ YLSATSPPKD KKRPTPLEIG YSSHLRADST 3550 3560 3570 3580 3590 3600 VQLAPSPPKS PKVLYSPISP LSPGKALESA FVPYEKPLPD DISPQKVLHP DMAKVPPASP 3610 3620 3630 3640 3650 3660 KTAKMMQRSM SDPKPLSPTA DESSRAPFQY TEGYTTKGSQ TMTSSGAQKK VKRTLPNPPP 3670 3680 3690 3700 3710 3720 EEISTGTQST FSTMGTVSRR RICRTNTMAR AKILQDIDRE LDLVERESAK LRKKQAELDE 3730 3740 3750 3760 3770 3780 EEKEIDAKLR YLEMGINRRK EALLKEREKR ERAYLQGVAE DRDYMSDSEV SSTRPTRIES 3790 3800 3810 3820 3830 3840 QHGIERPRTA PQTEFSQFIP PQTQTESQLV PPTSPYTQYQ YSSPALPTQA PTSYTQQSHF 3850 3860 3870 3880 3890 3900 EQQTLYHQQV SPYQTQPTFQ AVATMSFTPQ VQPTPTPQPS YQLPSQMMVI QQKPRQTTLY 3910 3920 3930 3940 3950 3960 LEPKITSNYE VIRNQPLMIA PVSTDNTFAV SHLGSKYNSL DLRIGLEERS SMASSPISSI 3970 3980 3990 4000 4010 4020 SADSFYADID HHTPRNYVLI DDIGEITKGT AALSTAFSLH EKDLSKTDRL LRTTETRRSQ 4030 4040 4050 4060 4070 4080 EVTDFLAPLQ SSSRLHSYVK AEEDPMEDPY ELKLLKHQIK QEFRRGTESL DHLAGLSHYY 4090 4100 4110 4120 4130 4140 HADTSYRHFP KSEKYSISRL TLEKQAAKQL PAAILYQKQS KHKKSLIDPK MSKFSPIQES 4150 4160 4170 4180 4190 4200 RDLEPDYSSY MTSSTSSIGG ISSRARLLQD DITFGLRKNI TDQQKFMGSS LGTGLGTLGN 4210 4220 4230 4240 4250 4260 TIRSALQDEA DKPYSSGSRS RPSSRPSSVY GLDLSIKRDS SSSSLRLKAQ EAEALDVSFS 4270 4280 4290 4300 4310 4320 HASSSARTKP TSLPISQSRG RIPIVAQNSE EESPLSPVGQ PMGMARAAAG PLPPISADTR 4330 4340 4350 4360 4370 4380 DQFGSSHSLP EVQQHMREES RTRGYDRDIA FIMDDFQHAM SDSEAYHLRR EETDWFDKPR 4390 4400 4410 4420 4430 4440 ESRLENGHGL DRKLPERLVH SRPLSQHQEQ IIQMNGKTMH YIFPHARIKI TRDSKDHTVS 4450 4460 4470 4480 4490 4500 GNGLGIRIVG GKEIPGHSGE IGAYIAKILP GGSAEQTGKL MEGMQVLEWN GIPLTSKTYE 4510 4520 4530 4540 4550 4560 EVQSIISQQS GEAEICVRLD LNMLSDSENS QHLELHEPPK AVDKAKSPGV DPKQLAAELQ 4570 4580 4590 4600 4610 4620 KVSLQQSPLV LSSVVEKGSH VHSGPTSAGS SSVPSPGQPG SPSVSKKKHG SSKPTDGTKV 4630 4640 4650 4660 4670 4680 VSHPITGEIQ LQINYDLGNL IIHILQARNL VPRDNNGYSD PFVKVYLLPG RGQVMVVQNA 4690 4700 4710 4720 4730 4740 SAEYKRRTKH VQKSLNPEWN QTVIYKSISM EQLKKKTLEV TVWDYDRFSS NDFLGEVLID 4750 4760 4770 4780 4790 4800 LSSTSHLDNT PRWYPLKEQT ESIDHGKSHS SQSSQQSPKP SVIKSRSHGI FPDPSKDMQV 4810 4820 4830 4840 4850 4860 PTIEKSHSSP GSSKSSSEGH LRSHGPSRSQ SKTSVTQTHL EDAGAAIAAA EAAVQQLRIQ PSKRRK
	Isoform 3 [UniParc]. Checksum: B515BD682ECC0154	FASTA	356	39,047
	10 20 30 40 50 60 MKKFRVSLVS KVGKQKYVDL NMLSDSENSQ HLELHEPPKA VDKAKSPGVD PKQLAAELQK 70 80 90 100 110 120 VSLQQSPLVL SSVVEKGSHV HSGPTSAGSS SVPSPGQPGS PSVSKKKHGS SKPTDGTKVV 130 140 150 160 170 180 SHPITGEIQL QINYDLGNLI IHILQARNLV PRDNNGYSDP FVKVYLLPGR GAEYKRRTKH 190 200 210 220 230 240 VQKSLNPEWN QTVIYKSISM EQLKKKTLEV TVWDYDRFSS NDFLGEVLID LSSTSHLDNT 250 260 270 280 290 300 PRWYPLKEQT ESIDHGKSHS SQSSQQSPKP SVIKSRSHGI FPDPSKDMQV PTIEKSHSSP 310 320 330 340 350 GSSKSSSEGH LRSHGPSRSQ SKTSVTQTHL EDAGAAIAAA EAAVQQLRIQ PSKRRK
	Isoform 4 [UniParc]. Checksum: 6F57A26F73587277	FASTA	490	51,012
	10 20 30 40 50 60 MGNEASLEGE GLPEGLAAAA AAGGGASGAG SPSHTAIPAG MEADLSQLSE EERRQIAAVM 70 80 90 100 110 120 SRAQGLPKGS VPPAAAESPS MHRKQELDSS HPPKQSGRPP DPGRPAQPGL SKSRTTDTFR 130 140 150 160 170 180 SEQKLPGRSP STISLKESKS RTDLKEEHKS SMMPGFLSEV NALSAVSSVV NKFNPFDLIS 190 200 210 220 230 240 DSEASQEETT KKQKVVQKEQ GKPEGIIKPP LQQQPPKPIP KQQGPGRDPL QQDGTPKSIS 250 260 270 280 290 300 SQQPEKIKSQ PPGTGKPIQG PTQTPQTDHA KLPLQRDASR PQTKQADIVR GESVKPSLPS 310 320 330 340 350 360 PSKPPIQQPT PGKPPAQQPG HEKSQPGPAK PPAQPSGLTK PLAQQPGTVK PPVQPPGTTK 370 380 390 400 410 420 PPAQPLGPAK PPAQQTGSEK PSSEQPGPKA LAQPPGVGKT PAQQPGPAKP PTQQVGTPKP 430 440 450 460 470 480 LAQQPGLQSP AKAPGPTKTP VQHKAPISTA WLNKTPTSTA WPSKALTSTA WLNKTPISTA 490 WLSKTLSSTA
	Isoform 5 [UniParc]. Checksum: 18F145349952C935	FASTA	5,142	560,699
	10 20 30 40 50 60 MGNEASLEGE GLPEGLAAAA AAGGGASGAG SPSHTAIPAG MEADLSQLSE EERRQIAAVM 70 80 90 100 110 120 SRAQGLPKGS VPPAAAESPS MHRKQELDSS HPPKQSGRPP DPGRPAQPGL SKSRTTDTFR 130 140 150 160 170 180 SEQKLPGRSP STISLKESKS RTDLKEEHKS SMMPGFLSEV NALSAVSSVV NKFNPFDLIS 190 200 210 220 230 240 DSEASQEETT KKQKVVQKEQ GKPEGIIKPP LQQQPPKPIP KQQGPGRDPL QQDGTPKSIS 250 260 270 280 290 300 SQQPEKIKSQ PPGTGKPIQG PTQTPQTDHA KLPLQRDASR PQTKQADIVR GESVKPSLPS 310 320 330 340 350 360 PSKPPIQQPT PGKPPAQQPG HEKSQPGPAK PPAQPSGLTK PLAQQPGTVK PPVQPPGTTK 370 380 390 400 410 420 PPAQPLGPAK PPAQQTGSEK PSSEQPGPKA LAQPPGVGKT PAQQPGPAKP PTQQVGTPKP 430 440 450 460 470 480 LAQQPGLQSP AKAPGPTKTP VQQPGPGKIP AQQAGPGKTS AQQTGPTKPP SQLPGPAKPP 490 500 510 520 530 540 PQQPGPAKPP PQQPGSAKPP SQQPGSTKPP PQQPGPAKPS PQQPGSTKPP SQQPGSAKPS 550 560 570 580 590 600 AQQPSPAKPS AQQSTKPVSQ TGSGKPLQPP TVSPSAKQPP SQGLPKTICP LCNTTELLLH 610 620 630 640 650 660 VPEKANFNTC TECQTTVCSL CGFNPNPHLT EVKEWLCLNC QMKRALGGDL APVPSSPQPK 670 680 690 700 710 720 LKTAPVTTTS AVSKSSPQPQ QTSPKKDAAP KQDLSKAPEP KKPPPLVKQP TLHGSPSAKA 730 740 750 760 770 780 KQPPEADSLS KPAPPKEPSV PSEQDKAPVA DDKPKQPKMV KPTTDLVSSS SATTKPDIPS 790 800 810 820 830 840 SKVQSQAEEK TTPPLKTDSA KPSQSFPPTG EKVSPFDSKA IPRPASDSKI ISHPGPSSES 850 860 870 880 890 900 KGQKQVDPVQ KKEEPKKAQT KMSPKPDAKP MPKGSPTPPG PRPTAGQTVP TPQQSPKPQE 910 920 930 940 950 960 QSRRFSLNLG SITDAPKSQP TTPQETVTGK LFGFGASIFS QASNLISTAG QPGPHSQSGP 970 980 990 1000 1010 1020 GAPMKQAPAP SQPPTSQGPP KSTGQAPPAP AKSIPVKKET KAPAAEKLEP KAEQAPTVKR 1030 1040 1050 1060 1070 1080 TETEKKPPPI KDSKSLTAEP QKAVLPTKLE KSPKPESTCP LCKTELNIGS KDPPNFNTCT 1090 1100 1110 1120 1130 1140 ECKNQVCNLC GFNPTPHLTE IQEWLCLNCQ TQRAISGQLG DIRKMPPAPS GPKASPMPVP 1150 1160 1170 1180 1190 1200 TESSSQKTAV PPQVKLVKKQ EQEVKTEAEK VILEKVKETL SMEKIPPMVT TDQKQEESKL 1210 1220 1230 1240 1250 1260 EKDKASALQE KKPLPEEKKL IPEEEKIRSE EKKPLLEEKK PTPEDKKLLP EAKTSAPEEQ 1270 1280 1290 1300 1310 1320 KHDLLKSQVQ IAEEKLEGRV APKTVQEGKQ PQTKMEGLPS GTPQSLPKED DKTTKTIKEQ 1330 1340 1350 1360 1370 1380 PQPPCTAKPD QVEPGKEKTE KEDDKSDTSS SQQPKSPQGL SDTGYSSDGI SSSLGEIPSL 1390 1400 1410 1420 1430 1440 IPTDEKDILK GLKKDSFSQE SSPSSPSDLA KLESTVLSIL EAQASTLADE KSEKKTQPHE 1450 1460 1470 1480 1490 1500 VSPEQPKDQE KTQSLSETLE ITISEEEIKE SQEERKDTFK KDSQQDIPSS KDHKEKSEFV 1510 1520 1530 1540 1550 1560 DDITTRREPY DSVEESSESE NSPVPQRKRR TSVGSSSSDE YKQEDSQGSG EEEDFIRKQI 1570 1580 1590 1600 1610 1620 IEMSADEDAS GSEDDEFIRN QLKEISSSTE SQKKEETKGK GKITAGKHRR LTRKSSTSID 1630 1640 1650 1660 1670 1680 EDAGRRHSWH DEDDEAFDES PELKYRETKS QESEELVVTG GGGLRRFKTI ELNSTIADKY 1690 1700 1710 1720 1730 1740 SAESSQKKTS LYFDEEPELE MESLTDSPED RSRGEGSSSL HASSFTPGTS PTSVSSLDED 1750 1760 1770 1780 1790 1800 SDSSPSHKKG ESKQQRKARH RPHGPLLPTI EDSSEEEELR EEEELLKEQE KQREIEQQQR 1810 1820 1830 1840 1850 1860 KSSSKKSKKD KDELRAQRRR ERPKTPPSNL SPIEDASPTE ELRQAAEMEE LHRSSCSEYS 1870 1880 1890 1900 1910 1920 PSIESDPEGF EISPEKIIEV QKVYKLPTAV SLYSPTDEQS IMQKEGSQKA LKSAEEMYEE 1930 1940 1950 1960 1970 1980 MMHKTHKYKA FPAANERDEV FEKEPLYGGM LIEDYIYESL VEDTYNGSVD GSLLTRQEEE 1990 2000 2010 2020 2030 2040 NGFMQQKGRE QKIRLSEQIY EDPMQKITDL QKEFYELESL HSVVPQEDIV SSSFIIPESH 2050 2060 2070 2080 2090 2100 EIVDLGTMVT STEEERKLLD ADAAYEELMK RQQMQLTPGS SPTQAPIGED MTESTMDFDR 2110 2120 2130 2140 2150 2160 MPDASLTSSV LSGASLTDST SSATLSIPDV KITQHFSTEE IEDEYVTDYT REIQEIIAHE 2170 2180 2190 2200 2210 2220 SLILTYSEPS ESATSVPPSD TPSLTSSVSS VCTTDSSSPI TTLDSITTVY TEPVDMITKF 2230 2240 2250 2260 2270 2280 EDSEEISSST YFPGSIIDYP EEISVSLDRT APPDGRASAD HIVISLSDMA SSIIESVVPK 2290 2300 2310 2320 2330 2340 PEGPVADTVS TDLLISEKDP VKKAKKETGN GIILEVLEAY RDKKELEAER TKSSLSETVF 2350 2360 2370 2380 2390 2400 DHPPSSVIAL PMKEQLSTTY FTSGETFGQE KPASQLPSGS PSVSSLPAKP RPFFRSSSLD 2410 2420 2430 2440 2450 2460 ISAQPPPPPP PPPPPPPPPP PPPPPPLPPP TSPKPTILPK KKLTVASPVT TATPLFDAVT 2470 2480 2490 2500 2510 2520 TLETTAVLRS NGLPVTRICT TAPPPVPPKP SSIPSGLVFT HRPEPSKPPI APKPVIPQLP 2530 2540 2550 2560 2570 2580 TTTQKPTDIH PKPTGLSLTS SMTLNLVTSA DYKLPSPTSP LSPHSNKSSP RFSKSLTETY 2590 2600 2610 2620 2630 2640 VVITLPSEPG TPTDSSASQA ITSWPLGSPS KDLVSVEPVF SVVPPVTAVE IPISSEQTFY 2650 2660 2670 2680 2690 2700 ISGALQTFSA TPVTAPSSFQ AAPTSVTQFL TTEVSKTEVS ATRSTAPSVG LSSISITIPP 2710 2720 2730 2740 2750 2760 EPLALDNIHL EKPQYKEDGK LQLVGDVIDL RTVPKVEVKT TDKCIDLSAS TMDVKRQITA 2770 2780 2790 2800 2810 2820 NEVYGKQISA VQPSIINLSV TSSIVTPVSL ATETVTFVTC TASASYTTGT ESLVGAEHAM 2830 2840 2850 2860 2870 2880 TTPLQLTTSK HAEPPYRIPS DQVFPIAREE APINLSLGTP AHAVTLAITK PVTVPPVGVT 2890 2900 2910 2920 2930 2940 NGWTDSTVSQ GITDGEVVDL STTKSHRTVV TMDESTSSVM TKIIEDEKPV DLTAGRRAVC 2950 2960 2970 2980 2990 3000 CDVVYKLPFG RSCTAQQPAT TLPEDRFGYR DDHYQYDRSG PYGYRGIGGM KPSMSDTNLA 3010 3020 3030 3040 3050 3060 EAGHFFYKSK NAFDYSEGTD TAVDLTSGRV TTGEVMDYSS KTTGPYPETR QVISGAGIST 3070 3080 3090 3100 3110 3120 PQYSTARMTP PPGPQYCVGS VLRSSNGVVY SSVATPTPST FAITTQPGSI FSTTVRDLSG 3130 3140 3150 3160 3170 3180 IHTADAVTSL PAMHHSQPMP RSYFITTGAS ETDIAVTGID ISASLQTITM ESLTAETIDS 3190 3200 3210 3220 3230 3240 VPTLTTASEV FPEVVGDESA LLIVPEEDKQ QQQLDLEREL LELEKIKQQR FAEELEWERQ 3250 3260 3270 3280 3290 3300 EIQRFREQEK IMVQKKLEEL QSMKQHLLFQ QEEERQAQFM MRQETLAQQQ LQLEQIQQLQ 3310 3320 3330 3340 3350 3360 QQLHQQLEEQ KIRQIYQYNY DPSGTASPQT TTEQAILEGQ YAALEGSQFW ATEDATTTAS 3370 3380 3390 3400 3410 3420 AVVAIEIPQS QGWYTVQSDG VTQYIAPPGI LSTVSEIPLT DVVVKEEKQP KKRSSGAKVR 3430 3440 3450 3460 3470 3480 GQYDDMGENM TDDPRSFKKI VDSGVQTDDE DATDRSYVSR RRRTKKSVDT SVQTDDEDQD 3490 3500 3510 3520 3530 3540 EWDMPTRSRR KARVGKYGDS MTEADKTKPL SKVSSIAVQT VAEISVQTEP VGTIRTPSIR 3550 3560 3570 3580 3590 3600 ARVDAKVEII KHISAPEKTY KGGSLGCQTE ADSDTQSPQY LSATSPPKDK KRPTPLEIGY 3610 3620 3630 3640 3650 3660 SSHLRADSTV QLAPSPPKSP KVLYSPISPL SPGKALESAF VPYEKPLPDD ISPQKVLHPD 3670 3680 3690 3700 3710 3720 MAKVPPASPK TAKMMQRSMS DPKPLSPTAD ESSRAPFQYT EGYTTKGSQT MTSSGAQKKV 3730 3740 3750 3760 3770 3780 KRTLPNPPPE EISTGTQSTF STMGTVSRRR ICRTNTMARA KILQDIDREL DLVERESAKL 3790 3800 3810 3820 3830 3840 RKKQAELDEE EKEIDAKLRY LEMGINRRKE ALLKEREKRE RAYLQGVAED RDYMSDSEVS 3850 3860 3870 3880 3890 3900 STRPTRIESQ HGIERPRTAP QTEFSQFIPP QTQTESQLVP PTSPYTQYQY SSPALPTQAP 3910 3920 3930 3940 3950 3960 TSYTQQSHFE QQTLYHQQVS PYQTQPTFQA VATMSFTPQV QPTPTPQPSY QLPSQMMVIQ 3970 3980 3990 4000 4010 4020 QKPRQTTLYL EPKITSNYEV IRNQPLMIAP VSTDNTFAVS HLGSKYNSLD LRIGLEERSS 4030 4040 4050 4060 4070 4080 MASSPISSIS ADSFYADIDH HTPRNYVLID DIGEITKGTA ALSTAFSLHE KDLSKTDRLL 4090 4100 4110 4120 4130 4140 RTTETRRSQE VTDFLAPLQS SSRLHSYVKA EEDPMEDPYE LKLLKHQIKQ EFRRGTESLD 4150 4160 4170 4180 4190 4200 HLAGLSHYYH ADTSYRHFPK SEKYSISRLT LEKQAAKQLP AAILYQKQSK HKKSLIDPKM 4210 4220 4230 4240 4250 4260 SKFSPIQESR DLEPDYSSYM TSSTSSIGGI SSRARLLQDD ITFGLRKNIT DQQKFMGSSL 4270 4280 4290 4300 4310 4320 GTGLGTLGNT IRSALQDEAD KPYSSGSRSR PSSRPSSVYG LDLSIKRDSS SSSLRLKAQE 4330 4340 4350 4360 4370 4380 AEALDVSFSH ASSSARTKPT SLPISQSRGR IPIVAQNSEE ESPLSPVGQP MGMARAAAGP 4390 4400 4410 4420 4430 4440 LPPISADTRD QFGSSHSLPE VQQHMREESR TRGYDRDIAF IMDDFQHAMS DSEAYHLRRE 4450 4460 4470 4480 4490 4500 ETDWFDKPRE SRLENGHGLD RKLPERLVHS RPLSQHQEQI IQMNGKTMHY IFPHARIKIT 4510 4520 4530 4540 4550 4560 RDSKDHTVSG NGLGIRIVGG KEIPGHSGEI GAYIAKILPG GSAEQTGKLM EGMQVLEWNG 4570 4580 4590 4600 4610 4620 IPLTSKTYEE VQSIISQQSG EAEICVRLDL NMLSDSENSQ HLELHEPPKA VDKAKSPGVD 4630 4640 4650 4660 4670 4680 PKQLAAELQK VSLQQSPLVL SSVVEKGSHV HSGPTSAGSS SVPSPGQPGS PSVSKKKHGS 4690 4700 4710 4720 4730 4740 SKPTDGTKVV SHPITGEIQL QINYDLGNLI IHILQARNLV PRDNNGYSDP FVKVYLLPGR 4750 4760 4770 4780 4790 4800 GQVMVVQNAS AEYKRRTKHV QKSLNPEWNQ TVIYKSISME QLKKKTLEVT VWDYDRFSSN 4810 4820 4830 4840 4850 4860 DFLGEVLIDL SSTSHLDNTP RWYPLKEQTE SIDHGKSHSS QSSQQSPKPS VIKSRSHGIF 4870 4880 4890 4900 4910 4920 PDPSKDMQVP TIEKSHSSPG SSKSSSEGHL RSHGPSRSQS KTSVTQTHLE DAGAAIAAAE 4930 4940 4950 4960 4970 4980 AAVQQLRIQP TKPPNHRPAE SSVSTGSSGS SFGSGYSVDS EGSSSTAGET NLFPIPRIGK 4990 5000 5010 5020 5030 5040 MGQNGQEPVK QPGVGVGLAD TEAKTQVMGE IKIALKKEMK TDGEQLIVEI LQCRNITYKF 5050 5060 5070 5080 5090 5100 KSPDHLPDLY VKIYVMNIST QKKVIKKKTR VCRHDREPSF NETFRFSLSP AGHSLQILLF 5110 5120 5130 5140 SNGGKFMKKT LIGEACIWLD KVDLRKRIVN WHKLLVSPTQ TH
	Isoform 6 [UniParc]. Checksum: E9D027F9FB9879F2	FASTA	4,935	537,886
	10 20 30 40 50 60 MGNEASLEGE GLPEGLAAAA AAGGGASGAG SPSHTAIPAG MEADLSQLSE EERRQIAAVM 70 80 90 100 110 120 SRAQGLPKGS VPPAAAESPS MHRKQELDSS HPPKQSGRPP DPGRPAQPGL SKSRTTDTFR 130 140 150 160 170 180 SEQKLPGRSP STISLKESKS RTDLKEEHKS SMMPGFLSEV NALSAVSSVV NKFNPFDLIS 190 200 210 220 230 240 DSEASQEETT KKQKVVQKEQ GKPEGIIKPP LQQQPPKPIP KQQGPGRDPL QQDGTPKSIS 250 260 270 280 290 300 SQQPEKIKSQ PPGTGKPIQG PTQTPQTDHA KLPLQRDASR PQTKQADIVR GESVKPSLPS 310 320 330 340 350 360 PSKPPIQQPT PGKPPAQQPG HEKSQPGPAK PPAQPSGLTK PLAQQPGTVK PPVQPPGTTK 370 380 390 400 410 420 PPAQPLGPAK PPAQQTGSEK PSSEQPGPKA LAQPPGVGKT PAQQPGPAKP PTQQVGTPKP 430 440 450 460 470 480 LAQQPGLQSP AKAPGPTKTP VQQPGPGKIP AQQAGPGKTS AQQTGPTKPP SQLPGPAKPP 490 500 510 520 530 540 PQQPGPAKPP PQQPGSAKPP SQQPGSTKPP PQQPGPAKPS PQQPGSTKPP SQQPGSAKPS 550 560 570 580 590 600 AQQPSPAKPS AQQSTKPVSQ TGSGKPLQPP TVSPSAKQPP SQGLPKTICP LCNTTELLLH 610 620 630 640 650 660 VPEKANFNTC TECQTTVCSL CGFNPNPHLT EVKEWLCLNC QMKRALGGDL APVPSSPQPK 670 680 690 700 710 720 LKTAPVTTTS AVSKSSPQPQ QTSPKKDAAP KQDLSKAPEP KKPPPLVKQP TLHGSPSAKA 730 740 750 760 770 780 KQPPEADSLS KPAPPKEPSV PSEQDKAPVA DDKPKQPKMV KPTTDLVSSS SATTKPDIPS 790 800 810 820 830 840 SKVQSQAEEK TTPPLKTDSA KPSQSFPPTG EKVSPFDSKA IPRPASDSKI ISHPGPSSES 850 860 870 880 890 900 KGQKQVDPVQ KKEEPKKAQT KMSPKPDAKP MPKGSPTPPG PRPTAGQTVP TPQQSPKPQE 910 920 930 940 950 960 QSRRFSLNLG SITDAPKSQP TTPQETVTGK LFGFGASIFS QASNLISTAG QPGPHSQSGP 970 980 990 1000 1010 1020 GAPMKQAPAP SQPPTSQGPP KSTGQAPPAP AKSIPVKKET KAPAAEKLEP KAEQAPTVKR 1030 1040 1050 1060 1070 1080 TETEKKPPPI KDSKSLTAEP QKAVLPTKLE KSPKPESTCP LCKTELNIGS KDPPNFNTCT 1090 1100 1110 1120 1130 1140 ECKNQVCNLC GFNPTPHLTE IQEWLCLNCQ TQRAISGQLG DIRKMPPAPS GPKASPMPVP 1150 1160 1170 1180 1190 1200 TESSSQKTAV PPQVKLVKKQ EQEVKTEAEK VILEKVKETL SMEKIPPMVT TDQKQEESKL 1210 1220 1230 1240 1250 1260 EKDKASALQE KKPLPEEKKL IPEEEKIRSE EKKPLLEEKK PTPEDKKLLP EAKTSAPEEQ 1270 1280 1290 1300 1310 1320 KHDLLKSQVQ IAEEKLEGRV APKTVQEGKQ PQTKMEGLPS GTPQSLPKED DKTTKTIKEQ 1330 1340 1350 1360 1370 1380 PQPPCTAKPD QVEPGKEKTE KEDDKSDTSS SQQPKSPQGL SDTGYSSDGI SSSLGEIPSL 1390 1400 1410 1420 1430 1440 IPTDEKDILK GLKKDSFSQE SSPSSPSDLA KLESTVLSIL EAQASTLADE KSEKKTQPHE 1450 1460 1470 1480 1490 1500 VSPEQPKDQE KTQSLSETLE ITISEEEIKE SQEERKDTFK KDSQQDIPSS KDHKEKSEFV 1510 1520 1530 1540 1550 1560 DDITTRREPY DSVEESSESE NSPVPQRKRR TSVGSSSSDE YKQEDSQGSG EEEDFIRKQI 1570 1580 1590 1600 1610 1620 IEMSADEDAS GSEDDEFIRN QLKEISSSTE SQKKEETKGK GKITAGKHRR LTRKSSTSID 1630 1640 1650 1660 1670 1680 EDAGRRHSWH DEDDEAFDES PELKYRETKS QESEELVVTG GGGLRRFKTI ELNSTIADKY 1690 1700 1710 1720 1730 1740 SAESSQKKTS LYFDEEPELE MESLTDSPED RSRGEGSSSL HASSFTPGTS PTSVSSLDED 1750 1760 1770 1780 1790 1800 SDSSPSHKKG ESKQQRKARH RPHGPLLPTI EDSSEEEELR EEEELLKEQE KQREIEQQQR 1810 1820 1830 1840 1850 1860 KSSSKKSKKD KDELRAQRRR ERPKTPPSNL SPIEDASPTE ELRQAAEMEE LHRSSCSEYS 1870 1880 1890 1900 1910 1920 PSIESDPEGF EISPEKIIEV QKVYKLPTAV SLYSPTDEQS IMQKEGSQKA LKSAEEMYEE 1930 1940 1950 1960 1970 1980 MMHKTHKYKA FPAANERDEV FEKEPLYGGM LIEDYIYESL VEDTYNGSVD GSLLTRQEEE 1990 2000 2010 2020 2030 2040 NGFMQQKGRE QKIRLSEQIY EDPMQKITDL QKEFYELESL HSVVPQEDIV SSSFIIPESH 2050 2060 2070 2080 2090 2100 EIVDLGTMVT STEEERKLLD ADAAYEELMK RQQMQLTPGS SPTQAPIGED MTESTMDFDR 2110 2120 2130 2140 2150 2160 MPDASLTSSV LSGASLTDST SSATLSIPDV KITQHFSTEE IEDEYVTDYT REIQEIIAHE 2170 2180 2190 2200 2210 2220 SLILTYSEPS ESATSVPPSD TPSLTSSVSS VCTTDSSSPI TTLDSITTVY TEPVDMITKF 2230 2240 2250 2260 2270 2280 EDSEEISSST YFPGSIIDYP EEISVSLDRT APPDGRASAD HIVISLSDMA SSIIESVVPK 2290 2300 2310 2320 2330 2340 PEGPVADTVS TDLLISEKDP VKKAKKETGN GIILEVLEAY RDKKELEAER TKSSLSETVF 2350 2360 2370 2380 2390 2400 DHPPSSVIAL PMKEQLSTTY FTSGETFGQE KPASQLPSGS PSVSSLPAKP RPFFRSSSLD 2410 2420 2430 2440 2450 2460 ISAQPPPPPP PPPPPPPPPP PPPPPPLPPP TSPKPTILPK KKLTVASPVT TATPLFDAVT 2470 2480 2490 2500 2510 2520 TLETTAVLRS NGLPVTRICT TAPPPVPPKP SSIPSGLVFT HRPEPSKPPI APKPVIPQLP 2530 2540 2550 2560 2570 2580 TTTQKPTDIH PKPTGLSLTS SMTLNLVTSA DYKLPSPTSP LSPHSNKSSP RFSKSLTETY 2590 2600 2610 2620 2630 2640 VVITLPSEPG TPTDSSASQA ITSWPLGSPS KDLVSVEPVF SVVPPVTAVE IPISSEQTFY 2650 2660 2670 2680 2690 2700 ISGALQTFSA TPVTAPSSFQ AAPTSVTQFL TTEVSKTEVS ATRSTAPSVG LSSISITIPP 2710 2720 2730 2740 2750 2760 EPLALDNIHL EKPQYKEDGK LQLVGDVIDL RTVPKVEVKT TDKCIDLSAS TMDVKRQITA 2770 2780 2790 2800 2810 2820 NEVYGKQISA VQPSIINLSV TSSIVTPVSL ATETVTFVTC TASASYTTGT ESLVGAEHAM 2830 2840 2850 2860 2870 2880 TTPLQLTTSK HAEPPYRIPS DQVFPIAREE APINLSLGTP AHAVTLAITK PVTVPPVGVT 2890 2900 2910 2920 2930 2940 NGWTDSTVSQ GITDGEVVDL STTKSHRTVV TMDESTSSVM TKIIEDEKPV DLTAGRRAVC 2950 2960 2970 2980 2990 3000 CDVVYKLPFG RSCTAQQPAT TLPEDRFGYR DDHYQYDRSG PYGYRGIGGM KPSMSDTNLA 3010 3020 3030 3040 3050 3060 EAGHFFYKSK NAFDYSEGTD TAVDLTSGRV TTGEVMDYSS KTTGPYPETR QVISGAGIST 3070 3080 3090 3100 3110 3120 PQYSTARMTP PPGPQYCVGS VLRSSNGVVY SSVATPTPST FAITTQPGSI FSTTVRDLSG 3130 3140 3150 3160 3170 3180 IHTADAVTSL PAMHHSQPMP RSYFITTGAS ETDIAVTGID ISASLQTITM ESLTAETIDS 3190 3200 3210 3220 3230 3240 VPTLTTASEV FPEVVGDESA LLIVPEEDKQ QQQLDLEREL LELEKIKQQR FAEELEWERQ 3250 3260 3270 3280 3290 3300 EIQRFREQEK IMVQKKLEEL QSMKQHLLFQ QEEERQAQFM MRQETLAQQQ LQLEQIQQLQ 3310 3320 3330 3340 3350 3360 QQLHQQLEEQ KIRQIYQYNY DPSGTASPQT TTEQAILEGQ YAALEGSQFW ATEDATTTAS 3370 3380 3390 3400 3410 3420 AVVAIEIPQS QGWYTVQSDG VTQYIAPPGI LSTVSEIPLT DVVVKEEKQP KKRSSGAKVR 3430 3440 3450 3460 3470 3480 GQYDDMGENM TDDPRSFKKI VDSGVQTDDE DATDRSYVSR RRRTKKSVDT SVQTDDEDQD 3490 3500 3510 3520 3530 3540 EWDMPTRSRR KARVGKYGDS MTEADKTKPL SKVSSIAVQT VAEISVQTEP VGTIRTPSIR 3550 3560 3570 3580 3590 3600 ARVDAKVEII KHISAPEKTY KGGSLGCQTE ADSDTQSPQY LSATSPPKDK KRPTPLEIGY 3610 3620 3630 3640 3650 3660 SSHLRADSTV QLAPSPPKSP KVLYSPISPL SPGKALESAF VPYEKPLPDD ISPQKVLHPD 3670 3680 3690 3700 3710 3720 MAKVPPASPK TAKMMQRSMS DPKPLSPTAD ESSRAPFQYT EGYTTKGSQT MTSSGAQKKV 3730 3740 3750 3760 3770 3780 KRTLPNPPPE EISTGTQSTF STMGTVSRRR ICRTNTMARA KILQDIDREL DLVERESAKL 3790 3800 3810 3820 3830 3840 RKKQAELDEE EKEIDAKLRY LEMGINRRKE ALLKEREKRE RAYLQGVAED RDYMSDSEVS 3850 3860 3870 3880 3890 3900 STRPTRIESQ HGIERPRTAP QTEFSQFIPP QTQTESQLVP PTSPYTQYQY SSPALPTQAP 3910 3920 3930 3940 3950 3960 TSYTQQSHFE QQTLYHQQVS PYQTQPTFQA VATMSFTPQV QPTPTPQPSY QLPSQMMVIQ 3970 3980 3990 4000 4010 4020 QKPRQTTLYL EPKITSNYEV IRNQPLMIAP VSTDNTFAVS HLGSKYNSLD LRIGLEERSS 4030 4040 4050 4060 4070 4080 MASSPISSIS ADSFYADIDH HTPRNYVLID DIGEITKGTA ALSTAFSLHE KDLSKTDRLL 4090 4100 4110 4120 4130 4140 RTTETRRSQE VTDFLAPLQS SSRLHSYVKA EEDPMEDPYE LKLLKHQIKQ EFRRGTESLD 4150 4160 4170 4180 4190 4200 HLAGLSHYYH ADTSYRHFPK SEKYSISRLT LEKQAAKQLP AAILYQKQSK HKKSLIDPKM 4210 4220 4230 4240 4250 4260 SKFSPIQESR DLEPDYSSYM TSSTSSIGGI SSRARLLQDD ITFGLRKNIT DQQKFMGSSL 4270 4280 4290 4300 4310 4320 GTGLGTLGNT IRSALQDEAD KPYSSGSRSR PSSRPSSVYG LDLSIKRDSS SSSLRLKAQE 4330 4340 4350 4360 4370 4380 AEALDVSFSH ASSSARTKPT SLPISQSRGR IPIVAQNSEE ESPLSPVGQP MGMARAAAGP 4390 4400 4410 4420 4430 4440 LPPISADTRD QFGSSHSLPE VQQHMREESR TRGYDRDIAF IMDDFQHAMS DSEAYHLRRE 4450 4460 4470 4480 4490 4500 ETDWFDKPRE SRLENGHGLD RKLPERLVHS RPLSQHQEQI IQMNGKTMHY IFPHARIKIT 4510 4520 4530 4540 4550 4560 RDSKDHTVSG NGLGIRIVGG KEIPGHSGEI GAYIAKILPG GSAEQTGKLM EGMQVLEWNG 4570 4580 4590 4600 4610 4620 IPLTSKTYEE VQSIISQQSG EAEICVRLDL NMLSDSENSQ HLELHEPPKA VDKAKSPGVD 4630 4640 4650 4660 4670 4680 PKQLAAELQK VSLQQSPLVL SSVVEKGSHV HSGPTSAGSS SVPSPGQPGS PSVSKKKHGS 4690 4700 4710 4720 4730 4740 SKPTDGTKVV SHPITGEIQL QINYDLGNLI IHILQARNLV PRDNNGYSDP FVKVYLLPGR 4750 4760 4770 4780 4790 4800 GQVMVVQNAS AEYKRRTKHV QKSLNPEWNQ TVIYKSISME QLKKKTLEVT VWDYDRFSSN 4810 4820 4830 4840 4850 4860 DFLGEVLIDL SSTSHLDNTP RWYPLKEQTE SIDHGKSHSS QSSQQSPKPS VIKSRSHGIF 4870 4880 4890 4900 4910 4920 PDPSKDMQVP TIEKSHSSPG SSKSSSEGHL RSHGPSRSQS KTSVTQTHLE DAGAAIAAAE 4930 AAVQQLRIQP SKRRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 21-607 (ISOFORMS 5/6). Tissue: Placenta.
[4]	"Aczonin, a 550-kd putative scaffolding protein of presynaptic active zones, shares homology regions with rim and bassoon and binds profilin." Wang X., Kibschull M., Laue M.M., Lichte B., Petrasch-Parwez E., Kilimann M.W. J. Cell Biol. 147:151-162(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-795 (ISOFORMS 1/2). Tissue: Brain.
[5]	"Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3655-5065 (ISOFORM 2). Tissue: Brain.
[6]	"Solution structure of RSGI RUH-003, a PDZ domain of hypothetical KIAA0559 protein from human." RIKEN structural genomics initiative (RSGI) Submitted (JAN-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 4390-4480.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AC004006 Genomic DNA. No translation available.
AC004082 Genomic DNA. Translation: AAB97937.1. Sequence problems.
AC080093 Genomic DNA. No translation available.
AC004886 Genomic DNA. Translation: AAD21789.2. Sequence problems.
AC004903 Genomic DNA. No translation available.
AC093461 Genomic DNA. No translation available.
CH236949 Genomic DNA. Translation: EAL24187.1.
BC001304 mRNA. Translation: AAH01304.2.
BC122565 mRNA. Translation: AAI22566.1.
BC125271 mRNA. Translation: AAI25272.1.
Y19188 mRNA. Translation: CAB60727.1.
AB011131 mRNA. Translation: BAA25485.1.

IPI

IPI00411656.
IPI00515102.
IPI00789624.
IPI00843855.
IPI00968106.
IPI01014960.

PIR

T00332.
T00634.

RefSeq

NP_055325.2. NM_014510.2.
NP_149015.2. NM_033026.5.

UniGene

Hs.12376.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1UJD	NMR	-	A	4420-4480	[»]

ProteinModelPortal

Q9Y6V0.

SMR

Q9Y6V0. Positions 4567-4693.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000411633.

PTM databases

PhosphoSite

Q9Y6V0.

Polymorphism databases

DMDM

41019528.

Proteomic databases

PaxDb

Q9Y6V0.

PRIDE

Q9Y6V0.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000333891; ENSP00000334319; ENSG00000186472.
ENST00000423517; ENSP00000388393; ENSG00000186472.

GeneID

27445.

KEGG

hsa:27445.

UCSC

uc003uhu.1. human.
uc003uhv.2. human.
uc003uhx.2. human.

Organism-specific databases

CTD

27445.

GeneCards

GC07M082383.

HGNC

HGNC:13406. PCLO.

HPA

HPA015858.
HPA029579.

MIM

604918. gene.

neXtProt

NX_Q9Y6V0.

PharmGKB

PA33072.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG12793.

HOVERGEN

HBG074340.

InParanoid

Q9Y6V0.

OMA

YSVDSEG.

Gene expression databases

ArrayExpress

Q9Y6V0.

Bgee

Q9Y6V0.

CleanEx

HS_PCLO.

Genevestigator

Q9Y6V0.

Family and domain databases

Gene3D

3.30.40.10. 1 hit.

InterPro

IPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR020477. C2_dom.
IPR018029. C2_membr_targeting.
IPR001565. Synaptotagmin.
IPR011011. Znf_FYVE_PHD.
IPR008899. Znf_piccolo.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Pfam

PF00168. C2. 2 hits.
PF05715. zf-piccolo. 2 hits.
[Graphical view]

PRINTS

PR00360. C2DOMAIN.
PR00399. SYNAPTOTAGMN.

SMART

SM00239. C2. 2 hits.
[Graphical view]

SUPFAM

SSF49562. C2_CaLB. 2 hits.
SSF57903. FYVE_PHD_ZnF. 2 hits.

PROSITE

PS50004. C2. 2 hits.
PS50106. PDZ. False negative.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

PCLO. human.

EvolutionaryTrace

Q9Y6V0.

GenomeRNAi

27445.

NextBio

50526.

SOURCE

Search...

Entry information

Entry name

PCLO_HUMAN

Accession

Primary (citable) accession number: Q9Y6V0
Secondary accession number(s): A4D1A7 , A6NNX9, O43373, O60305, Q08E72, Q9BVC8, Q9UIV2, Q9Y6U9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	May 3, 2011
Last modified:	April 3, 2013
This is version 129 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.