Q9Y6U3 (ADSV_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adseverin

Alternative name(s):
Scinderin

Gene names

Name:	SCIN
Synonyms:	KIAA1905

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	715 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Ca2+-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes By similarity.
Subcellular location	Cytoplasm › cytoskeleton.
Sequence similarities	Belongs to the villin/gelsolin family. Contains 6 gelsolin-like repeats.
Sequence caution	The sequence BAB67798.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Ligand	Actin-binding Calcium
Molecular function	Actin capping
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	actin filament capping Inferred from electronic annotation. Source: UniProtKB-KW actin filament severing Inferred from mutant phenotype PubMed 11568009. Source: UniProtKB actin nucleation Inferred from sequence or structural similarity. Source: UniProtKB calcium ion-dependent exocytosis Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of cell proliferation Inferred from mutant phenotype PubMed 11568009. Source: UniProtKB positive regulation of apoptotic process Inferred from mutant phenotype PubMed 11568009. Source: UniProtKB positive regulation of megakaryocyte differentiation Inferred from mutant phenotype PubMed 11568009. Source: UniProtKB positive regulation of secretion Inferred from sequence or structural similarity. Source: UniProtKB regulation of chondrocyte differentiation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cell cortex Inferred from sequence or structural similarity. Source: UniProtKB cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	1-phosphatidylinositol binding Traceable author statement PubMed 11568009. Source: UniProtKB actin filament binding Inferred from sequence or structural similarity. Source: UniProtKB calcium ion binding Inferred from sequence or structural similarity. Source: UniProtKB phosphatidylinositol-4,5-bisphosphate binding Inferred from sequence or structural similarity. Source: UniProtKB phosphatidylserine binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y6U3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y6U3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     528-580: VDVDANSLNS...SVLKCKTLRI → RSSGIPLEGK...RFQESSPRMI
     581-715: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9Y6U3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-247: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 715

715

Adseverin

PRO_0000218744

Regions

Repeat

27 – 76

50

Gelsolin-like 1

Repeat

148 – 188

41

Gelsolin-like 2

Repeat

265 – 307

43

Gelsolin-like 3

Repeat

398 – 451

54

Gelsolin-like 4

Repeat

523 – 564

42

Gelsolin-like 5

Repeat

626 – 668

43

Gelsolin-like 6

Region

1 – 363

363

Actin-severing Potential

Region

112 – 119

8

Polyphosphoinositide binding By similarity

Region

138 – 146

9

Polyphosphoinositide binding By similarity

Region

364 – 715

352

Ca(2+)-dependent actin binding

Amino acid modifications

Modified residue

102

1

Phosphotyrosine By similarity

Modified residue

599

1

Phosphotyrosine By similarity

Natural variations

Alternative sequence

1 – 247

247

Missing in isoform 3.

VSP_040548

Alternative sequence

528 – 580

53

VDVDA…KTLRI → RSSGIPLEGKKTTRPHHYWK PRLKTIHLGFTAALTKLEDL LLKRFQESSPRMI in isoform 2.

VSP_012427

Alternative sequence

581 – 715

135

Missing in isoform 2.

VSP_012428

Natural variant

61

1

H → R. Ref.6
Corresponds to variant rs2240572 [ dbSNP | Ensembl ].

VAR_059956

Natural variant

443

1

A → P.
Corresponds to variant rs35083013 [ dbSNP | Ensembl ].

VAR_059957

Natural variant

455

1

F → L.
Corresponds to variant rs17166250 [ dbSNP | Ensembl ].

VAR_057470

Natural variant

500

1

K → R.
Corresponds to variant rs35705332 [ dbSNP | Ensembl ].

VAR_059958

Natural variant

578

1

L → F.
Corresponds to variant rs1138957 [ dbSNP | Ensembl ].

VAR_057471

Experimental info

Mutagenesis

455

1

F → D: Loss of actin-binding. Ref.7

Sequence conflict

48

1

V → M in BAC11416. Ref.2

Sequence conflict

476

1

G → D in AAK60494. Ref.1

Sequence conflict

546

1

P → S in AAK60494. Ref.1

Secondary structure

1

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715

Helix Strand Turn

Details...

Beta strand

397 – 403

7

Beta strand

405 – 410

6

Helix

413 – 415

3

Beta strand

424 – 430

7

Beta strand

435 – 441

7

Helix

447 – 463

17

Beta strand

469 – 474

6

Helix

480 – 483

4

Beta strand

491 – 493

3

Beta strand

511 – 516

6

Beta strand

519 – 521

3

Beta strand

524 – 528

5

Helix

532 – 534

3

Beta strand

539 – 544

6

Beta strand

548 – 554

7

Helix

560 – 572

13

Beta strand

576 – 581

6

Helix

587 – 592

6

Turn

603 – 605

3

Beta strand

615 – 620

6

Beta strand

627 – 630

4

Helix

637 – 639

3

Beta strand

644 – 649

6

Beta strand

654 – 658

5

Helix

664 – 674

11

Beta strand

691 – 695

5

Helix

701 – 704

4

Beta strand

707 – 709

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 4, 2005. Version 4. Checksum: 20420C82DB2E2D24	FASTA	715	80,489
	10 20 30 40 50 60 MARELYHEEF ARAGKQAGLQ VWRIEKLELV PVPQSAHGDF YVGDAYLVLH TAKTSRGFTY 70 80 90 100 110 120 HLHFWLGKEC SQDESTAAAI FTVQMDDYLG GKPVQNRELQ GYESNDFVSY FKGGLKYKAG 130 140 150 160 170 180 GVASGLNHVL TNDLTAKRLL HVKGRRVVRA TEVPLSWDSF NKGDCFIIDL GTEIYQWCGS 190 200 210 220 230 240 SCNKYERLKA NQVATGIRYN ERKGRSELIV VEEGSEPSEL IKVLGEKPEL PDGGDDDDII 250 260 270 280 290 300 ADISNRKMAK LYMVSDASGS MRVTVVAEEN PFSMAMLLSE ECFILDHGAA KQIFVWKGKD 310 320 330 340 350 360 ANPQERKAAM KTAEEFLQQM NYSKNTQIQV LPEGGETPIF KQFFKDWRDK DQSDGFGKVY 370 380 390 400 410 420 VTEKVAQIKQ IPFDASKLHS SPQMAAQHNM VDDGSGKVEI WRVENNGRIQ VDQNSYGEFY 430 440 450 460 470 480 GGDCYIILYT YPRGQIIYTW QGANATRDEL TTSAFLTVQL DRSLGGQAVQ IRVSQGKEPV 490 500 510 520 530 540 HLLSLFKDKP LIIYKNGTSK KGGQAPAPPT RLFQVRRNLA SITRIVEVDV DANSLNSNDV 550 560 570 580 590 600 FVLKLPQNSG YIWVGKGASQ EEEKGAEYVA SVLKCKTLRI QEGEEPEEFW NSLGGKKDYQ 610 620 630 640 650 660 TSPLLETQAE DHPPRLYGCS NKTGRFVIEE IPGEFTQDDL AEDDVMLLDA WEQIFIWIGK 670 680 690 700 710 DANEVEKKES LKSAKMYLET DPSGRDKRTP IVIIKQGHEP PTFTGWFLGW DSSKW
	Isoform 2 [UniParc]. Checksum: 4291B928419AB445	FASTA	580	65,357
	10 20 30 40 50 60 MARELYHEEF ARAGKQAGLQ VWRIEKLELV PVPQSAHGDF YVGDAYLVLH TAKTSRGFTY 70 80 90 100 110 120 HLHFWLGKEC SQDESTAAAI FTVQMDDYLG GKPVQNRELQ GYESNDFVSY FKGGLKYKAG 130 140 150 160 170 180 GVASGLNHVL TNDLTAKRLL HVKGRRVVRA TEVPLSWDSF NKGDCFIIDL GTEIYQWCGS 190 200 210 220 230 240 SCNKYERLKA NQVATGIRYN ERKGRSELIV VEEGSEPSEL IKVLGEKPEL PDGGDDDDII 250 260 270 280 290 300 ADISNRKMAK LYMVSDASGS MRVTVVAEEN PFSMAMLLSE ECFILDHGAA KQIFVWKGKD 310 320 330 340 350 360 ANPQERKAAM KTAEEFLQQM NYSKNTQIQV LPEGGETPIF KQFFKDWRDK DQSDGFGKVY 370 380 390 400 410 420 VTEKVAQIKQ IPFDASKLHS SPQMAAQHNM VDDGSGKVEI WRVENNGRIQ VDQNSYGEFY 430 440 450 460 470 480 GGDCYIILYT YPRGQIIYTW QGANATRDEL TTSAFLTVQL DRSLGGQAVQ IRVSQGKEPV 490 500 510 520 530 540 HLLSLFKDKP LIIYKNGTSK KGGQAPAPPT RLFQVRRNLA SITRIVERSS GIPLEGKKTT 550 560 570 580 RPHHYWKPRL KTIHLGFTAA LTKLEDLLLK RFQESSPRMI
	Isoform 3 [UniParc]. Checksum: FB1BAE7D65C7E39F	FASTA	468	52,814
	10 20 30 40 50 60 MAKLYMVSDA SGSMRVTVVA EENPFSMAML LSEECFILDH GAAKQIFVWK GKDANPQERK 70 80 90 100 110 120 AAMKTAEEFL QQMNYSKNTQ IQVLPEGGET PIFKQFFKDW RDKDQSDGFG KVYVTEKVAQ 130 140 150 160 170 180 IKQIPFDASK LHSSPQMAAQ HNMVDDGSGK VEIWRVENNG RIQVDQNSYG EFYGGDCYII 190 200 210 220 230 240 LYTYPRGQII YTWQGANATR DELTTSAFLT VQLDRSLGGQ AVQIRVSQGK EPVHLLSLFK 250 260 270 280 290 300 DKPLIIYKNG TSKKGGQAPA PPTRLFQVRR NLASITRIVE VDVDANSLNS NDVFVLKLPQ 310 320 330 340 350 360 NSGYIWVGKG ASQEEEKGAE YVASVLKCKT LRIQEGEEPE EFWNSLGGKK DYQTSPLLET 370 380 390 400 410 420 QAEDHPPRLY GCSNKTGRFV IEEIPGEFTQ DDLAEDDVML LDAWEQIFIW IGKDANEVEK 430 440 450 460 KESLKSAKMY LETDPSGRDK RTPIVIIKQG HEPPTFTGWF LGWDSSKW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of human scinderin." Ladislas M.L., Hill S.J., Davis C.W. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta and Tongue.
[3]	"Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins." Nagase T., Kikuno R., Ohara O. DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[4]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-407 (ISOFORM 3), VARIANT ARG-61. Tissue: Melanoma and Skin.
[7]	"The crystal structure of the C-terminus of adseverin reveals the actin-binding interface." Chumnarnsilpa S., Lee W.L., Nag S., Kannan B., Larsson M., Burtnick L.D., Robinson R.C. Proc. Natl. Acad. Sci. U.S.A. 106:13719-13724(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 345-715, MUTAGENESIS OF PHE-455.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF276507 mRNA. Translation: AAK60494.1.
AK027778 mRNA. Translation: BAB55361.1.
AK075123 mRNA. Translation: BAC11416.1.
AK290363 mRNA. Translation: BAF83052.1.
AB067492 mRNA. Translation: BAB67798.1. Different initiation.
AC005281 Genomic DNA. Translation: AAD15423.1.
CH471073 Genomic DNA. Translation: EAW93647.1.
BC021090 mRNA. Translation: AAH21090.1.
BU193785 mRNA. No translation available.

IPI

IPI00002606.
IPI00044745.
IPI00879729.

RefSeq

NP_001106177.1. NM_001112706.2.
NP_149119.1. NM_033128.3.

UniGene

Hs.633359.
Hs.655515.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3FG6	X-ray	3.00	A/B/C/D/E/F/G/H	345-715	[»]

ProteinModelPortal

Q9Y6U3.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9Y6U3. 1 interaction.

MINT

MINT-1141238.

STRING

9606.ENSP00000297029.

PTM databases

PhosphoSite

Q9Y6U3.

Polymorphism databases

DMDM

57015325.

Proteomic databases

PaxDb

Q9Y6U3.

PeptideAtlas

Q9Y6U3.

PRIDE

Q9Y6U3.

Protocols and materials databases

DNASU

85477.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000297029; ENSP00000297029; ENSG00000006747.
ENST00000341757; ENSP00000341375; ENSG00000006747.
ENST00000445618; ENSP00000390189; ENSG00000006747.
ENST00000519209; ENSP00000430997; ENSG00000006747.

GeneID

85477.

KEGG

hsa:85477.

UCSC

uc003ssn.4. human.

Organism-specific databases

CTD

85477.

GeneCards

GC07P012576.

HGNC

HGNC:21695. SCIN.

HPA

HPA020518.
HPA022009.
HPA024264.

MIM

613416. gene.

neXtProt

NX_Q9Y6U3.

PharmGKB

PA134981389.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG304849.

HOGENOM

HOG000233630.

HOVERGEN

HBG004183.

InParanoid

Q9Y6U3.

KO

K05768.

OMA

QVDQNSY.

PhylomeDB

Q9Y6U3.

Gene expression databases

ArrayExpress

Q9Y6U3.

Bgee

Q9Y6U3.

CleanEx

HS_SCIN.

Genevestigator

Q9Y6U3.

GermOnline

ENSG00000006747. Homo sapiens.

Family and domain databases

InterPro

IPR007123. Gelsolin_dom.
IPR007122. Villin/Gelsolin.
[Graphical view]

PANTHER

PTHR11977. PTHR11977. 1 hit.

Pfam

PF00626. Gelsolin. 6 hits.
[Graphical view]

PRINTS

PR00597. GELSOLIN.

SMART

SM00262. GEL. 6 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

SCIN. human.

EvolutionaryTrace

Q9Y6U3.

GenomeRNAi

85477.

NextBio

76136.

SOURCE

Search...

Entry information

Entry name

ADSV_HUMAN

Accession

Primary (citable) accession number: Q9Y6U3
Secondary accession number(s): A8K2U8 , Q8NBZ6, Q8WU97, Q96JC7, Q96PY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	January 4, 2005
Last modified:	May 1, 2013
This is version 116 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.