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Q9Y6U3 (ADSV_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adseverin
Alternative name(s):
Scinderin
Gene names
Name:SCIN
Synonyms:KIAA1905
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length715 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Ca2+-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes By similarity.

Subcellular location

Cytoplasmcytoskeleton.

Sequence similarities

Belongs to the villin/gelsolin family.

Contains 6 gelsolin-like repeats.

Sequence caution

The sequence BAB67798.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
   LigandActin-binding
Calcium
   Molecular functionActin capping
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin filament capping

Inferred from electronic annotation. Source: UniProtKB-KW

actin filament severing

Inferred from mutant phenotype PubMed 11568009. Source: UniProtKB

actin nucleation

Inferred from sequence or structural similarity. Source: UniProtKB

calcium ion-dependent exocytosis

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of cell proliferation

Inferred from mutant phenotype PubMed 11568009. Source: UniProtKB

positive regulation of apoptotic process

Inferred from mutant phenotype PubMed 11568009. Source: UniProtKB

positive regulation of megakaryocyte differentiation

Inferred from mutant phenotype PubMed 11568009. Source: UniProtKB

positive regulation of secretion

Inferred from sequence or structural similarity. Source: UniProtKB

regulation of chondrocyte differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcell cortex

Inferred from sequence or structural similarity. Source: UniProtKB

cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

extracellular vesicular exosome

Inferred from direct assay PubMed 19056867PubMed 23376485. Source: UniProt

protein complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_function1-phosphatidylinositol binding

Traceable author statement PubMed 11568009. Source: UniProtKB

actin binding

Inferred from sequence or structural similarity. Source: UniProtKB

actin filament binding

Inferred from sequence or structural similarity. Source: UniProtKB

calcium ion binding

Inferred from sequence or structural similarity. Source: UniProtKB

phosphatidylinositol-4,5-bisphosphate binding

Inferred from sequence or structural similarity. Source: UniProtKB

phosphatidylserine binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y6U3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y6U3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     528-580: VDVDANSLNS...SVLKCKTLRI → RSSGIPLEGK...RFQESSPRMI
     581-715: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9Y6U3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-247: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 715715Adseverin
PRO_0000218744

Regions

Repeat27 – 7650Gelsolin-like 1
Repeat148 – 18841Gelsolin-like 2
Repeat265 – 30743Gelsolin-like 3
Repeat398 – 45154Gelsolin-like 4
Repeat523 – 56442Gelsolin-like 5
Repeat626 – 66843Gelsolin-like 6
Region1 – 363363Actin-severing Potential
Region112 – 1198Polyphosphoinositide binding By similarity
Region138 – 1469Polyphosphoinositide binding By similarity
Region364 – 715352Ca(2+)-dependent actin binding

Amino acid modifications

Modified residue1021Phosphotyrosine By similarity
Modified residue5991Phosphotyrosine By similarity

Natural variations

Alternative sequence1 – 247247Missing in isoform 3.
VSP_040548
Alternative sequence528 – 58053VDVDA…KTLRI → RSSGIPLEGKKTTRPHHYWK PRLKTIHLGFTAALTKLEDL LLKRFQESSPRMI in isoform 2.
VSP_012427
Alternative sequence581 – 715135Missing in isoform 2.
VSP_012428
Natural variant611H → R. Ref.6
Corresponds to variant rs2240572 [ dbSNP | Ensembl ].
VAR_059956
Natural variant4431A → P.
Corresponds to variant rs35083013 [ dbSNP | Ensembl ].
VAR_059957
Natural variant4551F → L.
Corresponds to variant rs17166250 [ dbSNP | Ensembl ].
VAR_057470
Natural variant5001K → R.
Corresponds to variant rs35705332 [ dbSNP | Ensembl ].
VAR_059958
Natural variant5781L → F.
Corresponds to variant rs1138957 [ dbSNP | Ensembl ].
VAR_057471

Experimental info

Mutagenesis4551F → D: Loss of actin-binding. Ref.7
Sequence conflict481V → M in BAC11416. Ref.2
Sequence conflict4761G → D in AAK60494. Ref.1
Sequence conflict5461P → S in AAK60494. Ref.1

Secondary structure

......................................................... 715
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 4, 2005. Version 4.
Checksum: 20420C82DB2E2D24

FASTA71580,489
        10         20         30         40         50         60 
MARELYHEEF ARAGKQAGLQ VWRIEKLELV PVPQSAHGDF YVGDAYLVLH TAKTSRGFTY 

        70         80         90        100        110        120 
HLHFWLGKEC SQDESTAAAI FTVQMDDYLG GKPVQNRELQ GYESNDFVSY FKGGLKYKAG 

       130        140        150        160        170        180 
GVASGLNHVL TNDLTAKRLL HVKGRRVVRA TEVPLSWDSF NKGDCFIIDL GTEIYQWCGS 

       190        200        210        220        230        240 
SCNKYERLKA NQVATGIRYN ERKGRSELIV VEEGSEPSEL IKVLGEKPEL PDGGDDDDII 

       250        260        270        280        290        300 
ADISNRKMAK LYMVSDASGS MRVTVVAEEN PFSMAMLLSE ECFILDHGAA KQIFVWKGKD 

       310        320        330        340        350        360 
ANPQERKAAM KTAEEFLQQM NYSKNTQIQV LPEGGETPIF KQFFKDWRDK DQSDGFGKVY 

       370        380        390        400        410        420 
VTEKVAQIKQ IPFDASKLHS SPQMAAQHNM VDDGSGKVEI WRVENNGRIQ VDQNSYGEFY 

       430        440        450        460        470        480 
GGDCYIILYT YPRGQIIYTW QGANATRDEL TTSAFLTVQL DRSLGGQAVQ IRVSQGKEPV 

       490        500        510        520        530        540 
HLLSLFKDKP LIIYKNGTSK KGGQAPAPPT RLFQVRRNLA SITRIVEVDV DANSLNSNDV 

       550        560        570        580        590        600 
FVLKLPQNSG YIWVGKGASQ EEEKGAEYVA SVLKCKTLRI QEGEEPEEFW NSLGGKKDYQ 

       610        620        630        640        650        660 
TSPLLETQAE DHPPRLYGCS NKTGRFVIEE IPGEFTQDDL AEDDVMLLDA WEQIFIWIGK 

       670        680        690        700        710 
DANEVEKKES LKSAKMYLET DPSGRDKRTP IVIIKQGHEP PTFTGWFLGW DSSKW 

« Hide

Isoform 2 [UniParc].

Checksum: 4291B928419AB445
Show »

FASTA58065,357
Isoform 3 [UniParc].

Checksum: FB1BAE7D65C7E39F
Show »

FASTA46852,814

References

« Hide 'large scale' references
[1]"Isolation and characterization of human scinderin."
Ladislas M.L., Hill S.J., Davis C.W.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta and Tongue.
[3]"Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
Nagase T., Kikuno R., Ohara O.
DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[4]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-407 (ISOFORM 3), VARIANT ARG-61.
Tissue: Melanoma and Skin.
[7]"The crystal structure of the C-terminus of adseverin reveals the actin-binding interface."
Chumnarnsilpa S., Lee W.L., Nag S., Kannan B., Larsson M., Burtnick L.D., Robinson R.C.
Proc. Natl. Acad. Sci. U.S.A. 106:13719-13724(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 345-715, MUTAGENESIS OF PHE-455.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF276507 mRNA. Translation: AAK60494.1.
AK027778 mRNA. Translation: BAB55361.1.
AK075123 mRNA. Translation: BAC11416.1.
AK290363 mRNA. Translation: BAF83052.1.
AB067492 mRNA. Translation: BAB67798.1. Different initiation.
AC005281 Genomic DNA. Translation: AAD15423.1.
CH471073 Genomic DNA. Translation: EAW93647.1.
BC021090 mRNA. Translation: AAH21090.1.
BU193785 mRNA. No translation available.
CCDSCCDS47545.1. [Q9Y6U3-1]
CCDS47546.1. [Q9Y6U3-3]
RefSeqNP_001106177.1. NM_001112706.2. [Q9Y6U3-1]
NP_149119.1. NM_033128.3. [Q9Y6U3-3]
UniGeneHs.633359.
Hs.655515.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3FG6X-ray3.00A/B/C/D/E/F/G/H345-715[»]
ProteinModelPortalQ9Y6U3.
SMRQ9Y6U3. Positions 7-715.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124552. 2 interactions.
IntActQ9Y6U3. 1 interaction.
MINTMINT-1141238.
STRING9606.ENSP00000297029.

PTM databases

PhosphoSiteQ9Y6U3.

Polymorphism databases

DMDM57015325.

Proteomic databases

MaxQBQ9Y6U3.
PaxDbQ9Y6U3.
PeptideAtlasQ9Y6U3.
PRIDEQ9Y6U3.

Protocols and materials databases

DNASU85477.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000297029; ENSP00000297029; ENSG00000006747. [Q9Y6U3-1]
ENST00000341757; ENSP00000341375; ENSG00000006747. [Q9Y6U3-2]
ENST00000445618; ENSP00000390189; ENSG00000006747. [Q9Y6U3-3]
ENST00000519209; ENSP00000430997; ENSG00000006747. [Q9Y6U3-3]
GeneID85477.
KEGGhsa:85477.
UCSCuc003ssn.4. human. [Q9Y6U3-1]

Organism-specific databases

CTD85477.
GeneCardsGC07P012610.
HGNCHGNC:21695. SCIN.
HPAHPA020518.
HPA022009.
HPA024264.
MIM613416. gene.
neXtProtNX_Q9Y6U3.
PharmGKBPA134981389.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG304849.
HOGENOMHOG000233630.
HOVERGENHBG004183.
InParanoidQ9Y6U3.
KOK05768.
OMAQVDQNSY.
OrthoDBEOG7288RJ.
PhylomeDBQ9Y6U3.
TreeFamTF313468.

Gene expression databases

ArrayExpressQ9Y6U3.
BgeeQ9Y6U3.
CleanExHS_SCIN.
GenevestigatorQ9Y6U3.

Family and domain databases

Gene3D3.40.20.10. 6 hits.
InterProIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR007122. Villin/Gelsolin.
[Graphical view]
PANTHERPTHR11977. PTHR11977. 1 hit.
PfamPF00626. Gelsolin. 6 hits.
[Graphical view]
PRINTSPR00597. GELSOLIN.
SMARTSM00262. GEL. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSCIN. human.
EvolutionaryTraceQ9Y6U3.
GeneWikiSCIN.
GenomeRNAi85477.
NextBio76136.
PROQ9Y6U3.
SOURCESearch...

Entry information

Entry nameADSV_HUMAN
AccessionPrimary (citable) accession number: Q9Y6U3
Secondary accession number(s): A8K2U8 expand/collapse secondary AC list , Q8NBZ6, Q8WU97, Q96JC7, Q96PY2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 4, 2005
Last modified: July 9, 2014
This is version 127 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM