Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y6U3

- ADSV_HUMAN

UniProt

Q9Y6U3 - ADSV_HUMAN

Protein

Adseverin

Gene

SCIN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 4 (04 Jan 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Ca2+-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes By similarity.By similarity

    GO - Molecular functioni

    1. 1-phosphatidylinositol binding Source: UniProtKB
    2. actin binding Source: UniProtKB
    3. actin filament binding Source: UniProtKB
    4. calcium ion binding Source: UniProtKB
    5. phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
    6. phosphatidylserine binding Source: UniProtKB

    GO - Biological processi

    1. actin filament capping Source: UniProtKB-KW
    2. actin filament severing Source: UniProtKB
    3. actin nucleation Source: UniProtKB
    4. calcium ion-dependent exocytosis Source: UniProtKB
    5. negative regulation of cell proliferation Source: UniProtKB
    6. positive regulation of apoptotic process Source: UniProtKB
    7. positive regulation of megakaryocyte differentiation Source: UniProtKB
    8. positive regulation of secretion Source: UniProtKB
    9. regulation of chondrocyte differentiation Source: UniProtKB

    Keywords - Molecular functioni

    Actin capping

    Keywords - Ligandi

    Actin-binding, Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adseverin
    Alternative name(s):
    Scinderin
    Gene namesi
    Name:SCIN
    Synonyms:KIAA1905
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21695. SCIN.

    Subcellular locationi

    GO - Cellular componenti

    1. cell cortex Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. cytoskeleton Source: UniProtKB-SubCell
    4. extracellular vesicular exosome Source: UniProt
    5. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi455 – 4551F → D: Loss of actin-binding. 1 Publication

    Organism-specific databases

    PharmGKBiPA134981389.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 715715AdseverinPRO_0000218744Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei102 – 1021PhosphotyrosineBy similarity
    Modified residuei599 – 5991PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y6U3.
    PaxDbiQ9Y6U3.
    PeptideAtlasiQ9Y6U3.
    PRIDEiQ9Y6U3.

    PTM databases

    PhosphoSiteiQ9Y6U3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y6U3.
    BgeeiQ9Y6U3.
    CleanExiHS_SCIN.
    GenevestigatoriQ9Y6U3.

    Organism-specific databases

    HPAiHPA020518.
    HPA022009.
    HPA024264.

    Interactioni

    Protein-protein interaction databases

    BioGridi124552. 2 interactions.
    IntActiQ9Y6U3. 1 interaction.
    MINTiMINT-1141238.
    STRINGi9606.ENSP00000297029.

    Structurei

    Secondary structure

    1
    715
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi397 – 4037
    Beta strandi405 – 4106
    Helixi413 – 4153
    Beta strandi424 – 4307
    Beta strandi435 – 4417
    Helixi447 – 46317
    Beta strandi469 – 4746
    Helixi480 – 4834
    Beta strandi491 – 4933
    Beta strandi511 – 5166
    Beta strandi519 – 5213
    Beta strandi524 – 5285
    Helixi532 – 5343
    Beta strandi539 – 5446
    Beta strandi548 – 5547
    Helixi560 – 57213
    Beta strandi576 – 5816
    Helixi587 – 5926
    Turni603 – 6053
    Beta strandi615 – 6206
    Beta strandi627 – 6304
    Helixi637 – 6393
    Beta strandi644 – 6496
    Beta strandi654 – 6585
    Helixi664 – 67411
    Beta strandi691 – 6955
    Helixi701 – 7044
    Beta strandi707 – 7093

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3FG6X-ray3.00A/B/C/D/E/F/G/H345-715[»]
    ProteinModelPortaliQ9Y6U3.
    SMRiQ9Y6U3. Positions 7-715.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y6U3.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati27 – 7650Gelsolin-like 1Add
    BLAST
    Repeati148 – 18841Gelsolin-like 2Add
    BLAST
    Repeati265 – 30743Gelsolin-like 3Add
    BLAST
    Repeati398 – 45154Gelsolin-like 4Add
    BLAST
    Repeati523 – 56442Gelsolin-like 5Add
    BLAST
    Repeati626 – 66843Gelsolin-like 6Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 363363Actin-severingSequence AnalysisAdd
    BLAST
    Regioni112 – 1198Polyphosphoinositide bindingBy similarity
    Regioni138 – 1469Polyphosphoinositide bindingBy similarity
    Regioni364 – 715352Ca(2+)-dependent actin bindingAdd
    BLAST

    Sequence similaritiesi

    Belongs to the villin/gelsolin family.Curated
    Contains 6 gelsolin-like repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG304849.
    HOGENOMiHOG000233630.
    HOVERGENiHBG004183.
    InParanoidiQ9Y6U3.
    KOiK05768.
    OMAiQVDQNSY.
    OrthoDBiEOG7288RJ.
    PhylomeDBiQ9Y6U3.
    TreeFamiTF313468.

    Family and domain databases

    Gene3Di3.40.20.10. 6 hits.
    InterProiIPR029006. ADF-H/Gelsolin-like_dom.
    IPR007123. Gelsolin-like_dom.
    IPR007122. Villin/Gelsolin.
    [Graphical view]
    PANTHERiPTHR11977. PTHR11977. 1 hit.
    PfamiPF00626. Gelsolin. 6 hits.
    [Graphical view]
    PRINTSiPR00597. GELSOLIN.
    SMARTiSM00262. GEL. 6 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y6U3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARELYHEEF ARAGKQAGLQ VWRIEKLELV PVPQSAHGDF YVGDAYLVLH    50
    TAKTSRGFTY HLHFWLGKEC SQDESTAAAI FTVQMDDYLG GKPVQNRELQ 100
    GYESNDFVSY FKGGLKYKAG GVASGLNHVL TNDLTAKRLL HVKGRRVVRA 150
    TEVPLSWDSF NKGDCFIIDL GTEIYQWCGS SCNKYERLKA NQVATGIRYN 200
    ERKGRSELIV VEEGSEPSEL IKVLGEKPEL PDGGDDDDII ADISNRKMAK 250
    LYMVSDASGS MRVTVVAEEN PFSMAMLLSE ECFILDHGAA KQIFVWKGKD 300
    ANPQERKAAM KTAEEFLQQM NYSKNTQIQV LPEGGETPIF KQFFKDWRDK 350
    DQSDGFGKVY VTEKVAQIKQ IPFDASKLHS SPQMAAQHNM VDDGSGKVEI 400
    WRVENNGRIQ VDQNSYGEFY GGDCYIILYT YPRGQIIYTW QGANATRDEL 450
    TTSAFLTVQL DRSLGGQAVQ IRVSQGKEPV HLLSLFKDKP LIIYKNGTSK 500
    KGGQAPAPPT RLFQVRRNLA SITRIVEVDV DANSLNSNDV FVLKLPQNSG 550
    YIWVGKGASQ EEEKGAEYVA SVLKCKTLRI QEGEEPEEFW NSLGGKKDYQ 600
    TSPLLETQAE DHPPRLYGCS NKTGRFVIEE IPGEFTQDDL AEDDVMLLDA 650
    WEQIFIWIGK DANEVEKKES LKSAKMYLET DPSGRDKRTP IVIIKQGHEP 700
    PTFTGWFLGW DSSKW 715
    Length:715
    Mass (Da):80,489
    Last modified:January 4, 2005 - v4
    Checksum:i20420C82DB2E2D24
    GO
    Isoform 2 (identifier: Q9Y6U3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         528-580: VDVDANSLNS...SVLKCKTLRI → RSSGIPLEGK...RFQESSPRMI
         581-715: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:580
    Mass (Da):65,357
    Checksum:i4291B928419AB445
    GO
    Isoform 3 (identifier: Q9Y6U3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-247: Missing.

    Show »
    Length:468
    Mass (Da):52,814
    Checksum:iFB1BAE7D65C7E39F
    GO

    Sequence cautioni

    The sequence BAB67798.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti48 – 481V → M in BAC11416. (PubMed:14702039)Curated
    Sequence conflicti476 – 4761G → D in AAK60494. 1 PublicationCurated
    Sequence conflicti546 – 5461P → S in AAK60494. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti61 – 611H → R.1 Publication
    Corresponds to variant rs2240572 [ dbSNP | Ensembl ].
    VAR_059956
    Natural varianti443 – 4431A → P.
    Corresponds to variant rs35083013 [ dbSNP | Ensembl ].
    VAR_059957
    Natural varianti455 – 4551F → L.
    Corresponds to variant rs17166250 [ dbSNP | Ensembl ].
    VAR_057470
    Natural varianti500 – 5001K → R.
    Corresponds to variant rs35705332 [ dbSNP | Ensembl ].
    VAR_059958
    Natural varianti578 – 5781L → F.
    Corresponds to variant rs1138957 [ dbSNP | Ensembl ].
    VAR_057471

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 247247Missing in isoform 3. 1 PublicationVSP_040548Add
    BLAST
    Alternative sequencei528 – 58053VDVDA…KTLRI → RSSGIPLEGKKTTRPHHYWK PRLKTIHLGFTAALTKLEDL LLKRFQESSPRMI in isoform 2. 1 PublicationVSP_012427Add
    BLAST
    Alternative sequencei581 – 715135Missing in isoform 2. 1 PublicationVSP_012428Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF276507 mRNA. Translation: AAK60494.1.
    AK027778 mRNA. Translation: BAB55361.1.
    AK075123 mRNA. Translation: BAC11416.1.
    AK290363 mRNA. Translation: BAF83052.1.
    AB067492 mRNA. Translation: BAB67798.1. Different initiation.
    AC005281 Genomic DNA. Translation: AAD15423.1.
    CH471073 Genomic DNA. Translation: EAW93647.1.
    BC021090 mRNA. Translation: AAH21090.1.
    BU193785 mRNA. No translation available.
    CCDSiCCDS47545.1. [Q9Y6U3-1]
    CCDS47546.1. [Q9Y6U3-3]
    RefSeqiNP_001106177.1. NM_001112706.2. [Q9Y6U3-1]
    NP_149119.1. NM_033128.3. [Q9Y6U3-3]
    UniGeneiHs.633359.
    Hs.655515.

    Genome annotation databases

    EnsembliENST00000297029; ENSP00000297029; ENSG00000006747. [Q9Y6U3-1]
    ENST00000341757; ENSP00000341375; ENSG00000006747. [Q9Y6U3-2]
    ENST00000519209; ENSP00000430997; ENSG00000006747. [Q9Y6U3-3]
    GeneIDi85477.
    KEGGihsa:85477.
    UCSCiuc003ssn.4. human. [Q9Y6U3-1]

    Polymorphism databases

    DMDMi57015325.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF276507 mRNA. Translation: AAK60494.1 .
    AK027778 mRNA. Translation: BAB55361.1 .
    AK075123 mRNA. Translation: BAC11416.1 .
    AK290363 mRNA. Translation: BAF83052.1 .
    AB067492 mRNA. Translation: BAB67798.1 . Different initiation.
    AC005281 Genomic DNA. Translation: AAD15423.1 .
    CH471073 Genomic DNA. Translation: EAW93647.1 .
    BC021090 mRNA. Translation: AAH21090.1 .
    BU193785 mRNA. No translation available.
    CCDSi CCDS47545.1. [Q9Y6U3-1 ]
    CCDS47546.1. [Q9Y6U3-3 ]
    RefSeqi NP_001106177.1. NM_001112706.2. [Q9Y6U3-1 ]
    NP_149119.1. NM_033128.3. [Q9Y6U3-3 ]
    UniGenei Hs.633359.
    Hs.655515.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3FG6 X-ray 3.00 A/B/C/D/E/F/G/H 345-715 [» ]
    ProteinModelPortali Q9Y6U3.
    SMRi Q9Y6U3. Positions 7-715.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124552. 2 interactions.
    IntActi Q9Y6U3. 1 interaction.
    MINTi MINT-1141238.
    STRINGi 9606.ENSP00000297029.

    PTM databases

    PhosphoSitei Q9Y6U3.

    Polymorphism databases

    DMDMi 57015325.

    Proteomic databases

    MaxQBi Q9Y6U3.
    PaxDbi Q9Y6U3.
    PeptideAtlasi Q9Y6U3.
    PRIDEi Q9Y6U3.

    Protocols and materials databases

    DNASUi 85477.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297029 ; ENSP00000297029 ; ENSG00000006747 . [Q9Y6U3-1 ]
    ENST00000341757 ; ENSP00000341375 ; ENSG00000006747 . [Q9Y6U3-2 ]
    ENST00000519209 ; ENSP00000430997 ; ENSG00000006747 . [Q9Y6U3-3 ]
    GeneIDi 85477.
    KEGGi hsa:85477.
    UCSCi uc003ssn.4. human. [Q9Y6U3-1 ]

    Organism-specific databases

    CTDi 85477.
    GeneCardsi GC07P012610.
    HGNCi HGNC:21695. SCIN.
    HPAi HPA020518.
    HPA022009.
    HPA024264.
    MIMi 613416. gene.
    neXtProti NX_Q9Y6U3.
    PharmGKBi PA134981389.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG304849.
    HOGENOMi HOG000233630.
    HOVERGENi HBG004183.
    InParanoidi Q9Y6U3.
    KOi K05768.
    OMAi QVDQNSY.
    OrthoDBi EOG7288RJ.
    PhylomeDBi Q9Y6U3.
    TreeFami TF313468.

    Miscellaneous databases

    ChiTaRSi SCIN. human.
    EvolutionaryTracei Q9Y6U3.
    GeneWikii SCIN.
    GenomeRNAii 85477.
    NextBioi 76136.
    PROi Q9Y6U3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y6U3.
    Bgeei Q9Y6U3.
    CleanExi HS_SCIN.
    Genevestigatori Q9Y6U3.

    Family and domain databases

    Gene3Di 3.40.20.10. 6 hits.
    InterProi IPR029006. ADF-H/Gelsolin-like_dom.
    IPR007123. Gelsolin-like_dom.
    IPR007122. Villin/Gelsolin.
    [Graphical view ]
    PANTHERi PTHR11977. PTHR11977. 1 hit.
    Pfami PF00626. Gelsolin. 6 hits.
    [Graphical view ]
    PRINTSi PR00597. GELSOLIN.
    SMARTi SM00262. GEL. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of human scinderin."
      Ladislas M.L., Hill S.J., Davis C.W.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta and Tongue.
    3. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
      Nagase T., Kikuno R., Ohara O.
      DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-407 (ISOFORM 3), VARIANT ARG-61.
      Tissue: Melanoma and Skin.
    7. "The crystal structure of the C-terminus of adseverin reveals the actin-binding interface."
      Chumnarnsilpa S., Lee W.L., Nag S., Kannan B., Larsson M., Burtnick L.D., Robinson R.C.
      Proc. Natl. Acad. Sci. U.S.A. 106:13719-13724(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 345-715, MUTAGENESIS OF PHE-455.

    Entry informationi

    Entry nameiADSV_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y6U3
    Secondary accession number(s): A8K2U8
    , Q8NBZ6, Q8WU97, Q96JC7, Q96PY2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 128 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3