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Protein

IgGFc-binding protein

Gene

FCGBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.1 Publication

Protein family/group databases

MEROPSiI08.954.

Names & Taxonomyi

Protein namesi
Recommended name:
IgGFc-binding protein
Alternative name(s):
Fcgamma-binding protein antigen
Short name:
FcgammaBP
Gene namesi
Name:FCGBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:13572. FCGBP.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28059.

Polymorphism and mutation databases

BioMutaiFCGBP.
DMDMi224471888.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 54055382IgGFc-binding proteinPRO_0000256698Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)1 Publication
Glycosylationi91 – 911N-linked (GlcNAc...)1 Publication
Disulfide bondi494 ↔ 502PROSITE-ProRule annotation
Disulfide bondi886 ↔ 894PROSITE-ProRule annotation
Disulfide bondi1274 ↔ 1282PROSITE-ProRule annotation
Glycosylationi1317 – 13171N-linked (GlcNAc...) (complex)1 Publication
Disulfide bondi1695 ↔ 1704PROSITE-ProRule annotation
Glycosylationi1743 – 17431N-linked (GlcNAc...)1 Publication
Disulfide bondi2094 ↔ 2102PROSITE-ProRule annotation
Glycosylationi2138 – 21381N-linked (GlcNAc...)1 Publication
Disulfide bondi2475 ↔ 2483PROSITE-ProRule annotation
Glycosylationi2518 – 25181N-linked (GlcNAc...)2 Publications
Disulfide bondi2896 ↔ 2905PROSITE-ProRule annotation
Disulfide bondi3295 ↔ 3303PROSITE-ProRule annotation
Disulfide bondi3676 ↔ 3684PROSITE-ProRule annotation
Glycosylationi3719 – 37191N-linked (GlcNAc...)1 Publication
Disulfide bondi4097 ↔ 4106PROSITE-ProRule annotation
Glycosylationi4145 – 41451N-linked (GlcNAc...)Sequence analysis
Disulfide bondi4496 ↔ 4504PROSITE-ProRule annotation
Glycosylationi4540 – 45401N-linked (GlcNAc...)Sequence analysis
Disulfide bondi4878 ↔ 4886PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9Y6R7.
PaxDbiQ9Y6R7.
PRIDEiQ9Y6R7.

PTM databases

PhosphoSiteiQ9Y6R7.

Expressioni

Tissue specificityi

Mainly expressed in placenta and colon epithelium. Expressed in thyroid, and down-regulated in thyroid carcinomas. Present in serum, with higher levels in patients with various autoimmune diseases (at protein level).3 Publications

Gene expression databases

BgeeiQ9Y6R7.
CleanExiHS_FCGBP.

Organism-specific databases

HPAiHPA003517.
HPA003564.

Interactioni

Subunit structurei

Interacts with the Fc portion of IgG and with MUC2.2 Publications

Protein-protein interaction databases

BioGridi114381. 2 interactions.
IntActiQ9Y6R7. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini471 – 690220VWFD 1PROSITE-ProRule annotationAdd
BLAST
Domaini745 – 79955TIL 1Add
BLAST
Domaini863 – 1081219VWFD 2PROSITE-ProRule annotationAdd
BLAST
Domaini1136 – 118954TIL 2Add
BLAST
Domaini1251 – 1477227VWFD 3PROSITE-ProRule annotationAdd
BLAST
Domaini1532 – 158554TIL 3Add
BLAST
Domaini1672 – 1895224VWFD 4PROSITE-ProRule annotationAdd
BLAST
Domaini1950 – 200758TIL 4Add
BLAST
Domaini2071 – 2282212VWFD 5PROSITE-ProRule annotationAdd
BLAST
Domaini2337 – 239054TIL 5Add
BLAST
Domaini2452 – 2678227VWFD 6PROSITE-ProRule annotationAdd
BLAST
Domaini2733 – 278654TIL 6Add
BLAST
Domaini2873 – 3096224VWFD 7PROSITE-ProRule annotationAdd
BLAST
Domaini3151 – 320858TIL 7Add
BLAST
Domaini3272 – 3483212VWFD 8PROSITE-ProRule annotationAdd
BLAST
Domaini3538 – 359154TIL 8Add
BLAST
Domaini3653 – 3879227VWFD 9PROSITE-ProRule annotationAdd
BLAST
Domaini3934 – 398754TIL 9Add
BLAST
Domaini4074 – 4297224VWFD 10PROSITE-ProRule annotationAdd
BLAST
Domaini4352 – 440958TIL 10Add
BLAST
Domaini4473 – 4684212VWFD 11PROSITE-ProRule annotationAdd
BLAST
Domaini4739 – 479254TIL 11Add
BLAST
Domaini4855 – 5066212VWFD 12PROSITE-ProRule annotationAdd
BLAST
Domaini5121 – 517454TIL 12Add
BLAST
Domaini5234 – 5405172VWFD 13PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 450427IgGFc-bindingAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi741 – 847107Cys-richAdd
BLAST
Compositional biasi1132 – 1235104Cys-richAdd
BLAST
Compositional biasi1528 – 1656129Cys-richAdd
BLAST
Compositional biasi2333 – 2436104Cys-richAdd
BLAST
Compositional biasi2729 – 2857129Cys-richAdd
BLAST
Compositional biasi3534 – 3637104Cys-richAdd
BLAST
Compositional biasi3930 – 4058129Cys-richAdd
BLAST
Compositional biasi5117 – 5219103Cys-richAdd
BLAST

Domaini

The N-terminal IgGFc-binding region is primate-specific.

Sequence similaritiesi

Contains 13 VWFD domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR8B. Eukaryota.
ENOG410XSFB. LUCA.
HOGENOMiHOG000112559.
InParanoidiQ9Y6R7.
OMAiCKEACEC.
OrthoDBiEOG7SJD3N.
PhylomeDBiQ9Y6R7.
TreeFamiTF316399.

Family and domain databases

InterProiIPR000742. EGF-like_dom.
IPR003645. Fol_N.
IPR002919. TIL_dom.
IPR025615. TILa_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 12 hits.
PF01826. TIL. 12 hits.
PF12714. TILa. 12 hits.
PF00094. VWD. 13 hits.
[Graphical view]
SMARTiSM00832. C8. 12 hits.
SM00181. EGF. 7 hits.
SM00274. FOLN. 9 hits.
SM00214. VWC. 7 hits.
SM00215. VWC_out. 11 hits.
SM00216. VWD. 13 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 12 hits.
PROSITEiPS51233. VWFD. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGALWSWWIL WAGATLLWGL TQEASVDLKN TGREEFLTAF LQNYQLAYSK
60 70 80 90 100
AYPRLLISSL SESPASVSIL SQADNTSKKV TVRPGESVMV NISAKAEMIG
110 120 130 140 150
SKIFQHAVVI HSDYAISVQA LNAKPDTAEL TLLRPIQALG TEYFVLTPPG
160 170 180 190 200
TSARNVKEFA VVAGAAGASV SVTLKGSVTF NGKFYPAGDV LRVTLQPYNV
210 220 230 240 250
AQLQSSVDLS GSKVTASSPV AVLSGHSCAQ KHTTCNHVVE QLLPTSAWGT
260 270 280 290 300
HYVVPTLASQ SRYDLAFVVA SQATKLTYNH GGITGSRGLQ AGDVVEFEVR
310 320 330 340 350
PSWPLYLSAN VGIQVLLFGT GAIRNEVTYD PYLVLIPDVA AYCPAYVVKS
360 370 380 390 400
VPGCEGVALV VAQTKAISGL TIDGHAVGAK LTWEAVPGSE FSYAEVELGT
410 420 430 440 450
ADMIHTAEAT TNLGLLTFGL AKAIGYATAA DCGRTVLSPV EPSCEGMQCA
460 470 480 490 500
AGQRCQVVGG KAGCVAESTA VCRAQGDPHY TTFDGRRYDM MGTCSYTMVE
510 520 530 540 550
LCSEDDTLPA FSVEAKNEHR GSRRVSYVGL VTVRAYSHSV SLTRGEVGFV
560 570 580 590 600
LVDNQRSRLP VSLSEGRLRV YQSGPRAVVE LVFGLVVTYD WDCQLALSLP
610 620 630 640 650
ARFQDQVCGL CGNYNGDPAD DFLTPDGALA PDAVEFASSW KLDDGDYLCE
660 670 680 690 700
DGCQNNCPAC TPGQAQHYEG DRLCGMLTKL DGPFAVCHDT LDPRPFLEQC
710 720 730 740 750
VYDLCVVGGE RLSLCRGLSA YAQACLELGI SVGDWRSPAN CPLSCPANSR
760 770 780 790 800
YELCGPACPT SCNGAAAPSN CSGRPCVEGC VCLPGFVASG GACVPASSCG
810 820 830 840 850
CTFQGLQLAP GQEVWADELC QRRCTCNGAT HQVTCRDKQS CPAGERCSVQ
860 870 880 890 900
NGLLGCYPDR FGTCQGSGDP HYVSFDGRRF DFMGTCTYLL VGSCGQNAAL
910 920 930 940 950
PAFRVLVENE HRGSQTVSYT RAVRVEARGV KVAVRREYPG QVLVDDVLQY
960 970 980 990 1000
LPFQAADGQV QVFRQGRDAV VRTDFGLTVT YDWNARVTAK VPSSYAEALC
1010 1020 1030 1040 1050
GLCGNFNGDP ADDLALRGGG QAANALAFGN SWQEETRPGC GATEPGDCPK
1060 1070 1080 1090 1100
LDSLVAQQLQ SKNECGILAD PKGPFRECHS KLDPQGAVRD CVYDRCLLPG
1110 1120 1130 1140 1150
QSGPLCDALA TYAAACQAAG ATVHPWRSEE LCPLSCPPHS HYEACSYGCP
1160 1170 1180 1190 1200
LSCGDLPVPG GCGSECHEGC VCDEGFALSG ESCLPLASCG CVHQGTYHPP
1210 1220 1230 1240 1250
GQTFYPGPGC DSLCHCQEGG LVSCESSSCG PHEACQPSGG SLGCVAVGSS
1260 1270 1280 1290 1300
TCQASGDPHY TTFDGRRFDF MGTCVYVLAQ TCGTRPGLHR FAVLQENVAW
1310 1320 1330 1340 1350
GNGRVSVTRV ITVQVANFTL RLEQRQWKVT VNGVDMKLPV VLANGQIRAS
1360 1370 1380 1390 1400
QHGSDVVIET DFGLRVAYDL VYYVRVTVPG NYYQQMCGLC GNYNGDPKDD
1410 1420 1430 1440 1450
FQKPNGSQAG NANEFGNSWE EVVPDSPCLP PTPCPPGSED CIPSHKCPPE
1460 1470 1480 1490 1500
LEKKYQKEEF CGLLSSPTGP LSSCHKLVDP QGPLKDCIFD LCLGGGNLSI
1510 1520 1530 1540 1550
LCSNIHAYVS ACQAAGGHVE PWRTETFCPM ECPPNSHYEL CADTCSLGCS
1560 1570 1580 1590 1600
ALSAPPQCQD GCAEGCQCDS GFLYNGQACV PIQQCGCYHN GVYYEPEQTV
1610 1620 1630 1640 1650
LIDNCRQQCT CHAGKGMVCQ EHSCKPGQVC QPSGGILSCV TKDPCHGVTC
1660 1670 1680 1690 1700
RPQETCKEQG GQGVCLPNYE ATCWLWGDPH YHSFDGRKFD FQGTCNYVLA
1710 1720 1730 1740 1750
TTGCPGVSTQ GLTPFTVTTK NQNRGNPAVS YVRVVTVAAL GTNISIHKDE
1760 1770 1780 1790 1800
IGKVRVNGVL TALPVSVADG RISVTQGASK ALLVADFGLQ VSYDWNWRVD
1810 1820 1830 1840 1850
VTLPSSYHGA VCGLCGNMDR NPNNDQVFPN GTLAPSIPIW GGSWRAPGWD
1860 1870 1880 1890 1900
PLCWDECRGS CPTCPEDRLE QYEGPGFCGP LAPGTGGPFT TCHAHVPPES
1910 1920 1930 1940 1950
FFKGCVLDVC MGGGDRDILC KALASYVAAC QAAGVVIEDW RAQVGCEITC
1960 1970 1980 1990 2000
PENSHYEVCG SPCPASCPSP APLTTPAVCE GPCVEGCQCD AGFVLSADRC
2010 2020 2030 2040 2050
VPLNNGCGCW ANGTYHEAGS EFWADGTCSQ WCRCGPGGGS LVCTPASCGL
2060 2070 2080 2090 2100
GEVCGLLPSG QHGCQPVSTA ECQAWGDPHY VTLDGHRFNF QGTCEYLLSA
2110 2120 2130 2140 2150
PCHGPPLGAE NFTVTVANEH RGSQAVSYTR SVTLQIYNHS LTLSARWPRK
2160 2170 2180 2190 2200
LQVDGVFVTL PFQLDSLLHA HLSGADVVVT TTSGLSLAFD GDSFVRLRVP
2210 2220 2230 2240 2250
AAYAGSLCGL CGNYNQDPAD DLKAVGGKPA GWQVGGAQGC GECVSKPCPS
2260 2270 2280 2290 2300
PCTPEQQESF GGPDACGVIS ATDGPLAPCH GLVPPAQYFQ GCLLDACQVQ
2310 2320 2330 2340 2350
GHPGGLCPAV ATYVAACQAA GAQLREWRRP DFCPFQCPAH SHYELCGDSC
2360 2370 2380 2390 2400
PGSCPSLSAP EGCESACREG CVCDAGFVLS GDTCVPVGQC GCLHDDRYYP
2410 2420 2430 2440 2450
LGQTFYPGPG CDSLCRCREG GEVSCEPSSC GPHETCRPSG GSLGCVAVGS
2460 2470 2480 2490 2500
TTCQASGDPH YTTFDGRRFD FMGTCVYVLA QTCGTRPGLH RFAVLQENVA
2510 2520 2530 2540 2550
WGNGRVSVTR VITVQVANFT LRLEQRQWKV TVNGVDMKLP VVLANGQIRA
2560 2570 2580 2590 2600
SQHGSDVVIE TDFGLRVAYD LVYYVRVTVP GNYYQLMCGL CGNYNGDPKD
2610 2620 2630 2640 2650
DFQKPNGSQA GNANEFGNSW EEVVPDSPCL PPPTCPPGSE GCIPSEECPP
2660 2670 2680 2690 2700
ELEKKYQKEE FCGLLSSPTG PLSSCHKLVD PQGPLKDCIF DLCLGGGNLS
2710 2720 2730 2740 2750
ILCSNIHAYV SACQAAGGQV EPWRNETFCP MECPQNSHYE LCADTCSLGC
2760 2770 2780 2790 2800
SALSAPLQCP DGCAEGCQCD SGFLYNGQAC VPIQQCGCYH NGAYYEPEQT
2810 2820 2830 2840 2850
VLIDNCRQQC TCHVGKVVVC QEHSCKPGQV CQPSGGILSC VNKDPCHGVT
2860 2870 2880 2890 2900
CRPQETCKEQ GGQGVCLPNY EATCWLWGDP HYHSFDGRKF DFQGTCNYVL
2910 2920 2930 2940 2950
ATTGCPGVST QGLTPFTVTT KNQNRGNPAV SYVRVVTVAA LGTNISIHKD
2960 2970 2980 2990 3000
EIGKVRVNGV LTALPVSVAD GRISVTQGAS KALLVADFGL QVSYDWNWRV
3010 3020 3030 3040 3050
DVTLPSSYHG AVCGLCGNMD RNPNNDQVFP NGTLAPSIPI WGGSWRAPGW
3060 3070 3080 3090 3100
DPLCWDECRG SCPTCPEDRL EQYEGPGFCG PLAPGTGGPF TTCHAHVPPE
3110 3120 3130 3140 3150
SFFKGCVLDV CMGGGDRDIL CKALASYVAA CQAAGVVIED WRAQVGCEIT
3160 3170 3180 3190 3200
CPENSHYEVC GPPCPASCPS PAPLTTPAVC EGPCVEGCQC DAGFVLSADR
3210 3220 3230 3240 3250
CVPLNNGCGC WANGTYHEAG SEFWADGTCS QWCRCGPGGG SLVCTPASCG
3260 3270 3280 3290 3300
LGEVCGLLPS GQHGCQPVST AECQAWGDPH YVTLDGHRFD FQGTCEYLLS
3310 3320 3330 3340 3350
APCHGPPLGA ENFTVTVANE HRGSQAVSYT RSVTLQIYNH SLTLSARWPR
3360 3370 3380 3390 3400
KLQVDGVFVT LPFQLDSLLH AHLSGADVVV TTTSGLSLAF DGDSFVRLRV
3410 3420 3430 3440 3450
PAAYAGSLCG LCGNYNQDPA DDLKAVGGKP AGWQVGGAQG CGECVSKPCP
3460 3470 3480 3490 3500
SPCTPEQQES FGGPDACGVI SATDGPLAPC HGLVPPAQYF QGCLLDACQV
3510 3520 3530 3540 3550
QGHPGGLCPA VATYVAACQA AGAQLREWRR PDFCPFQCPA HSHYELCGDS
3560 3570 3580 3590 3600
CPGSCPSLSA PEGCESACRE GCVCDAGFVL SGDTCVPVGQ CGCLHDDRYY
3610 3620 3630 3640 3650
PLGQTFYPGP GCDSLCRCRE GGEVSCEPSS CGPHETCRPS GGSLGCVAVG
3660 3670 3680 3690 3700
STTCQASGDP HYTTFDGHRF DFMGTCVYVL AQTCGTRPGL HRFAVLQENV
3710 3720 3730 3740 3750
AWGNGRVSVT RVITVQVANF TLRLEQRQWK VTVNGVDMKL PVVLANGQIR
3760 3770 3780 3790 3800
ASQHGSDVVI ETDFGLRVAY DLVYYVRVTV PGNYYQLMCG LCGNYNGDPK
3810 3820 3830 3840 3850
DDFQKPNGSQ AGNANEFGNS WEEVVPDSPC LPPPTCPPGS AGCIPSDKCP
3860 3870 3880 3890 3900
PELEKKYQKE EFCGLLSSPT GPLSSCHKLV DPQGPLKDCI FDLCLGGGNL
3910 3920 3930 3940 3950
SILCSNIHAY VSACQAAGGH VEPWRNETFC PMECPQNSHY ELCADTCSLG
3960 3970 3980 3990 4000
CSALSAPLQC PDGCAEGCQC DSGFLYNGQA CVPIQQCGCY HNGVYYEPEQ
4010 4020 4030 4040 4050
TVLIDNCRQQ CTCHVGKVVV CQEHSCKPGQ VCQPSGGILS CVTKDPCHGV
4060 4070 4080 4090 4100
TCRPQETCKE QGGQGVCLPN YEATCWLWGD PHYHSFDGRK FDFQGTCNYV
4110 4120 4130 4140 4150
LATTGCPGVS TQGLTPFTVT TKNQNRGNPA VSYVRVVTVA ALGTNISIHK
4160 4170 4180 4190 4200
DEIGKVRVNG VLTALPVSVA DGRISVAQGA SKALLVADFG LQVSYDWNWR
4210 4220 4230 4240 4250
VDVTLPSSYH GAVCGLCGNM DRNPNNDQVF PNGTLAPSIP IWGGSWRAPG
4260 4270 4280 4290 4300
WDPLCWDECR GSCPTCPEDR LEQYEGPGFC GPLSSGTGGP FTTCHAHVPP
4310 4320 4330 4340 4350
ESFFKGCVLD VCMGGGDRDI LCKALASYVA ACQAAGVVIE DWRAQVGCEI
4360 4370 4380 4390 4400
TCPENSHYEV CGPPCPASCP SPAPLTTPAV CEGPCVEGCQ CDAGFVLSAD
4410 4420 4430 4440 4450
RCVPLNNGCG CWANGTYHEA GSEFWADGTC SQWCRCGPGG GSLVCTPASC
4460 4470 4480 4490 4500
GLGEVCGLLP SGQHGCQPVS TAECQAWGDP HYVTLDGHRF DFQGTCEYLL
4510 4520 4530 4540 4550
SAPCHGPPLG AENFTVTVAN EHRGSQAVSY TRSVTLQIYN HSLTLSARWP
4560 4570 4580 4590 4600
RKLQVDGVFV ALPFQLDSLL HAHLSGADVV VTTTSGLSLA FDGDSFVRLR
4610 4620 4630 4640 4650
VPAAYAASLC GLCGNYNQDP ADDLKAVGGK PAGWQVGGAQ GCGECVSKPC
4660 4670 4680 4690 4700
PSPCTPEQQE SFGGPDACGV ISATDGPLAP CHGLVPPAQY FQGCLLDACQ
4710 4720 4730 4740 4750
VQGHPGGLCP AVATYVAACQ AAGAQLGEWR RPDFCPLQCP AHSHYELCGD
4760 4770 4780 4790 4800
SCPVSCPSLS APEGCESACR EGCVCDAGFV LSGDTCVPVG QCGCLHDGRY
4810 4820 4830 4840 4850
YPLGEVFYPG PECERRCECG PGGHVTCQEG AACGPHEECR LEDGVQACHA
4860 4870 4880 4890 4900
TGCGRCLANG GIHYITLDGR VYDLHGSCSY VLAQVCHPKP GDEDFSIVLE
4910 4920 4930 4940 4950
KNAAGDLQRL LVTVAGQVVS LAQGQQVTVD GEAVALPVAV GRVRVTAEGR
4960 4970 4980 4990 5000
NMVLQTTKGL RLLFDGDAHL LMSIPSPFRG RLCGLCGNFN GNWSDDFVLP
5010 5020 5030 5040 5050
NGSAASSVET FGAAWRAPGS SKGCGEGCGP QGCPVCLAEE TAPYESNEAC
5060 5070 5080 5090 5100
GQLRNPQGPF ATCQAVLSPS EYFRQCVYDL CAQKGDKAFL CRSLAAYTAA
5110 5120 5130 5140 5150
CQAAGVAVKP WRTDSFCPLH CPAHSHYSIC TRTCQGSCAA LSGLTGCTTR
5160 5170 5180 5190 5200
CFEGCECDDR FLLSQGVCIP VQDCGCTHNG RYLPVNSSLL TSDCSERCSC
5210 5220 5230 5240 5250
SSSSGLTCQA AGCPPGRVCE VKAEARNCWA TRGLCVLSVG ANLTTFDGAR
5260 5270 5280 5290 5300
GATTSPGVYE LSSRCPGLQN TIPWYRVVAE VQICHGKTEA VGQVHIFFQD
5310 5320 5330 5340 5350
GMVTLTPNKG VWVNGLRVDL PAEKLASVSV SRTPDGSLLV RQKAGVQVWL
5360 5370 5380 5390 5400
GANGKVAVIV SNDHAGKLCG ACGNFDGDQT NDWHDSQEKP AMEKWRAQDF

SPCYG
Length:5,405
Mass (Da):572,017
Last modified:March 3, 2009 - v3
Checksum:i6E502F782261355F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1961 – 19611S → P in BAA19526 (PubMed:9182547).Curated
Sequence conflicti2719 – 27191Q → H in BAA19526 (PubMed:9182547).Curated
Sequence conflicti2842 – 28421N → T in BAA19526 (PubMed:9182547).Curated
Sequence conflicti2976 – 29761T → A in BAA19526 (PubMed:9182547).Curated
Sequence conflicti3117 – 31171R → H in BAA19526 (PubMed:9182547).Curated
Sequence conflicti3668 – 36681H → R in BAA19526 (PubMed:9182547).Curated
Sequence conflicti3841 – 38411A → E in BAA19526 (PubMed:9182547).Curated
Sequence conflicti3847 – 38482DK → EE in BAA19526 (PubMed:9182547).Curated
Sequence conflicti4043 – 40431T → N in BAA19526 (PubMed:9182547).Curated
Sequence conflicti4284 – 42841S → A in BAA19526 (PubMed:9182547).Curated
Sequence conflicti4318 – 43181R → H in BAA19526 (PubMed:9182547).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti732 – 7321V → A.
Corresponds to variant rs34181317 [ dbSNP | Ensembl ].
VAR_054490
Natural varianti770 – 7701N → S.
Corresponds to variant rs34939346 [ dbSNP | Ensembl ].
VAR_054491
Natural varianti929 – 9291G → R.
Corresponds to variant rs35338934 [ dbSNP | Ensembl ].
VAR_054492
Natural varianti971 – 9711V → M.
Corresponds to variant rs35922811 [ dbSNP | Ensembl ].
VAR_054493
Natural varianti1019 – 10191G → R.
Corresponds to variant rs34254649 [ dbSNP | Ensembl ].
VAR_054494
Natural varianti1340 – 13401V → L.
Corresponds to variant rs11083543 [ dbSNP | Ensembl ].
VAR_028903
Natural varianti1436 – 14361P → L.
Corresponds to variant rs36106401 [ dbSNP | Ensembl ].
VAR_054495
Natural varianti1445 – 14451H → D.
Corresponds to variant rs2909229 [ dbSNP | Ensembl ].
VAR_054496
Natural varianti1524 – 15241T → N.
Corresponds to variant rs34938990 [ dbSNP | Ensembl ].
VAR_054497
Natural varianti1616 – 16161G → V.
Corresponds to variant rs7248839 [ dbSNP | Ensembl ].
VAR_028904
Natural varianti1617 – 16171M → V.
Corresponds to variant rs7249743 [ dbSNP | Ensembl ].
VAR_028905
Natural varianti2089 – 20891N → D.
Corresponds to variant rs885723 [ dbSNP | Ensembl ].
VAR_028906
Natural varianti2646 – 26461E → D.
Corresponds to variant rs2542320 [ dbSNP | Ensembl ].
VAR_028907
Natural varianti2647 – 26471E → K.
Corresponds to variant rs2542319 [ dbSNP | Ensembl ].
VAR_028908
Natural varianti2793 – 27931A → V.
Corresponds to variant rs2542316 [ dbSNP | Ensembl ].
VAR_028909
Natural varianti2814 – 28141V → A.1 Publication
Corresponds to variant rs3746009 [ dbSNP | Ensembl ].
VAR_028910
Natural varianti3264 – 32641G → S.
Corresponds to variant rs6508919 [ dbSNP | Ensembl ].
VAR_028911
Natural varianti3920 – 39201H → Q.
Corresponds to variant rs2542318 [ dbSNP | Ensembl ].
VAR_028912
Natural varianti4015 – 40151V → A.
Corresponds to variant rs3746009 [ dbSNP | Ensembl ].
VAR_028913
Natural varianti4095 – 40951G → D.
Corresponds to variant rs1975181 [ dbSNP | Ensembl ].
VAR_028914
Natural varianti4465 – 44651G → S.1 Publication
Corresponds to variant rs6508919 [ dbSNP | Ensembl ].
VAR_028915
Natural varianti4906 – 49061D → H.1 Publication
Corresponds to variant rs3746013 [ dbSNP | Ensembl ].
VAR_028916
Natural varianti5017 – 50171A → V.1 Publication
Corresponds to variant rs741143 [ dbSNP | Ensembl ].
VAR_054498

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84239 mRNA. Translation: BAA19526.1.
AC006950 Genomic DNA. Translation: AAD15624.1.
AC007842 Genomic DNA. Translation: AAD39266.1.
AC011536 Genomic DNA. No translation available.
RefSeqiNP_003881.2. NM_003890.2.
XP_011547112.1. XM_011548810.1.
XP_011547113.1. XM_011548811.1.
UniGeneiHs.111732.

Genome annotation databases

EnsembliENST00000628705; ENSP00000487490; ENSG00000281123.
GeneIDi8857.
KEGGihsa:8857.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84239 mRNA. Translation: BAA19526.1.
AC006950 Genomic DNA. Translation: AAD15624.1.
AC007842 Genomic DNA. Translation: AAD39266.1.
AC011536 Genomic DNA. No translation available.
RefSeqiNP_003881.2. NM_003890.2.
XP_011547112.1. XM_011548810.1.
XP_011547113.1. XM_011548811.1.
UniGeneiHs.111732.

3D structure databases

ProteinModelPortaliQ9Y6R7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114381. 2 interactions.
IntActiQ9Y6R7. 4 interactions.

Protein family/group databases

MEROPSiI08.954.

PTM databases

PhosphoSiteiQ9Y6R7.

Polymorphism and mutation databases

BioMutaiFCGBP.
DMDMi224471888.

Proteomic databases

MaxQBiQ9Y6R7.
PaxDbiQ9Y6R7.
PRIDEiQ9Y6R7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000628705; ENSP00000487490; ENSG00000281123.
GeneIDi8857.
KEGGihsa:8857.

Organism-specific databases

CTDi8857.
GeneCardsiFCGBP.
H-InvDBHIX0040147.
HGNCiHGNC:13572. FCGBP.
HPAiHPA003517.
HPA003564.
neXtProtiNX_Q9Y6R7.
PharmGKBiPA28059.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR8B. Eukaryota.
ENOG410XSFB. LUCA.
HOGENOMiHOG000112559.
InParanoidiQ9Y6R7.
OMAiCKEACEC.
OrthoDBiEOG7SJD3N.
PhylomeDBiQ9Y6R7.
TreeFamiTF316399.

Miscellaneous databases

ChiTaRSiFCGBP. human.
GeneWikiiFCGBP.
GenomeRNAii8857.
NextBioi33257.
PROiQ9Y6R7.

Gene expression databases

BgeeiQ9Y6R7.
CleanExiHS_FCGBP.

Family and domain databases

InterProiIPR000742. EGF-like_dom.
IPR003645. Fol_N.
IPR002919. TIL_dom.
IPR025615. TILa_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_dom.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF08742. C8. 12 hits.
PF01826. TIL. 12 hits.
PF12714. TILa. 12 hits.
PF00094. VWD. 13 hits.
[Graphical view]
SMARTiSM00832. C8. 12 hits.
SM00181. EGF. 7 hits.
SM00274. FOLN. 9 hits.
SM00214. VWC. 7 hits.
SM00215. VWC_out. 11 hits.
SM00216. VWD. 13 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 12 hits.
PROSITEiPS51233. VWFD. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human IgGFc binding protein (FcgammaBP) in colonic epithelial cells exhibits mucin-like structure."
    Harada N., Iijima S., Kobayashi K., Yoshida T., Brown W.R., Hibi T., Oshima A., Morikawa M.
    J. Biol. Chem. 272:15232-15241(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ALA-2814; SER-4465; HIS-4906 AND VAL-5017, FUNCTION, INTERACTION WITH IGG, TISSUE SPECIFICITY.
    Tissue: Colon epithelium.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Detection of Fcgamma binding protein antigen in human sera and its relation with autoimmune diseases."
    Kobayashi K., Yagasaki M., Harada N., Chichibu K., Hibi T., Yoshida T., Brown W.R., Morikawa M.
    Immunol. Lett. 79:229-235(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Differential expression of IgG Fc binding protein (FcgammaBP) in human normal thyroid tissue, thyroid adenomas and thyroid carcinomas."
    O'Donovan N., Fischer A., Abdo E.-M., Simon F., Peter H.J., Gerber H., Buergi U., Marti U.
    J. Endocrinol. 174:517-524(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-3719.
    Tissue: Bile.
  6. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-75; ASN-91; ASN-1743; ASN-2138 AND ASN-2518.
    Tissue: Plasma.
  7. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2518.
    Tissue: Saliva.
  8. "Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein."
    Johansson M.E.V., Thomsson K.A., Hansson G.C.
    J. Proteome Res. 8:3549-3557(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MUC2.
  9. Cited for: GLYCOSYLATION AT ASN-1317.

Entry informationi

Entry nameiFCGBP_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6R7
Secondary accession number(s): O95784
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 3, 2009
Last modified: May 11, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.