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Protein

Zinc finger protein 780B

Gene

ZNF780B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 187C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri193 – 215C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 523C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri557 – 579C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri585 – 607C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri613 – 635C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri641 – 663C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri669 – 691C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri697 – 719C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri725 – 747C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri753 – 775C2H2-type 22; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri781 – 803C2H2-type 23; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 780B
Alternative name(s):
Zinc finger protein 779
Gene namesi
Name:ZNF780B
Synonyms:ZNF779
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000128000.15
HGNCiHGNC:33109 ZNF780B
neXtProtiNX_Q9Y6R6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi163131
OpenTargetsiENSG00000128000
PharmGKBiPA162410426

Polymorphism and mutation databases

BioMutaiZNF780B
DMDMi74762083

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002630881 – 833Zinc finger protein 780BAdd BLAST833

Proteomic databases

MaxQBiQ9Y6R6
PaxDbiQ9Y6R6
PeptideAtlasiQ9Y6R6
PRIDEiQ9Y6R6

PTM databases

iPTMnetiQ9Y6R6
PhosphoSitePlusiQ9Y6R6

Expressioni

Gene expression databases

BgeeiENSG00000128000
CleanExiHS_ZNF780B
ExpressionAtlasiQ9Y6R6 baseline and differential
GenevisibleiQ9Y6R6 HS

Organism-specific databases

HPAiHPA003311

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000391641

Structurei

3D structure databases

ProteinModelPortaliQ9Y6R6
SMRiQ9Y6R6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 77KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 187C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri193 – 215C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri221 – 243C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri249 – 271C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri277 – 299C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 439C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri445 – 467C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri473 – 495C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri501 – 523C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri529 – 551C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri557 – 579C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri585 – 607C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri613 – 635C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri641 – 663C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri669 – 691C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri697 – 719C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri725 – 747C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri753 – 775C2H2-type 22; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri781 – 803C2H2-type 23; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144167
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9Y6R6
KOiK09228
OMAiEINLPKH
OrthoDBiEOG091G02KC
PhylomeDBiQ9Y6R6
TreeFamiTF343410

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 23 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 21 hits
PS50157 ZINC_FINGER_C2H2_2, 23 hits

Sequencei

Sequence statusi: Complete.

Q9Y6R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHGSVTFRD VAIDFSQEEW ECLQPDQRTL YRDVMLENYS HLISLGSSIS
60 70 80 90 100
KPDVITLLEQ EKEPWIVVSK ETSRWYPDLE SKYGPEKISP ENDIFEINLP
110 120 130 140 150
KHVIKQISKT LGLEAFYFRN DSEYRSRFEG RQGHQEGYIN QKIISYEEMP
160 170 180 190 200
AYTHASPIHN THKPYECKEC GKYFSCGSNL IQHQSIHTGE KPYKCKECGK
210 220 230 240 250
AFQLHIQLTR HQKFHTGEKT FECKECGKAF NLPTQLNRHK NIHTVKKLFE
260 270 280 290 300
CKECGKSFNR SSNLTQHQSI HAGVKPYQCK ECGKAFNRGS NLIQHQKIHS
310 320 330 340 350
NEKPFVCREC EMAFRYHYQL IEHCRIHTGE KPFECKECRK AFTLLTKLVR
360 370 380 390 400
HQKIHMGEKP FECRECGKAF SLLNQLNRHK NIHTGEKPFE CKECGKSFNR
410 420 430 440 450
SSNLIQHQSI HADVKPYECK ECGKGFNRGA NLIQHQKIHS NEKPFVCREC
460 470 480 490 500
EMAFRYHYQL IQHCQIHTGG KPFECKECGK AFSLLTQLAR HKNIHTGEKP
510 520 530 540 550
FECKDCGKAF NRGSNLVQHQ SIHTGEKPYE CKECGKAFRL HLQLSQHEKT
560 570 580 590 600
HTGEKPFECK ECGKFFRRGS NLNQHRSIHT GKKPFECKEC GKAFRLHMHL
610 620 630 640 650
IRHQKFHTGE KPFECKECGK AFSLHTQLNH HKNIHTGEKP FKCKECGKSF
660 670 680 690 700
NRVSNLVQHQ SIHAGVKPYE CKECGKGFSR VSNLIQHQKT HSSAKPFVCK
710 720 730 740 750
ECRKTFRYHY QLTEHYRIHT GEKPFECKEC GKAFGLLTQL AQHQIIHTGE
760 770 780 790 800
KPFKCKECGK AFNRGSNLVQ PQSIHTGEKP YECKECGKAF RLHLQLSLHQ
810 820 830
KLVQVRNPLN VRNVGQPSDI SSNLLNIRKF ILG
Length:833
Mass (Da):96,807
Last modified:November 1, 1999 - v1
Checksum:i2A354BA8B633B54A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007842 Genomic DNA Translation: AAD39268.1
CH471126 Genomic DNA Translation: EAW56932.1
BC136960 mRNA Translation: AAI36961.1
CCDSiCCDS46077.1
RefSeqiNP_001005851.1, NM_001005851.2
XP_005258650.1, XM_005258593.2
XP_016881914.1, XM_017026425.1
XP_016881915.1, XM_017026426.1
XP_016881916.1, XM_017026427.1
UniGeneiHs.101139

Genome annotation databases

EnsembliENST00000434248; ENSP00000391641; ENSG00000128000
ENST00000617676; ENSP00000484593; ENSG00000128000
ENST00000625684; ENSP00000487572; ENSG00000281601
ENST00000627167; ENSP00000487499; ENSG00000281601
GeneIDi163131
KEGGihsa:163131
UCSCiuc002omu.3 human

Similar proteinsi

Entry informationi

Entry nameiZ780B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6R6
Secondary accession number(s): B9EH00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1999
Last modified: February 28, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome