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Protein

Zinc finger protein 780B

Gene

ZNF780B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 187C2H2-type 1Add BLAST23
Zinc fingeri193 – 215C2H2-type 2Add BLAST23
Zinc fingeri221 – 243C2H2-type 3Add BLAST23
Zinc fingeri249 – 271C2H2-type 4Add BLAST23
Zinc fingeri277 – 299C2H2-type 5Add BLAST23
Zinc fingeri305 – 327C2H2-type 6Add BLAST23
Zinc fingeri333 – 355C2H2-type 7Add BLAST23
Zinc fingeri361 – 383C2H2-type 8Add BLAST23
Zinc fingeri389 – 411C2H2-type 9Add BLAST23
Zinc fingeri417 – 439C2H2-type 10Add BLAST23
Zinc fingeri445 – 467C2H2-type 11Add BLAST23
Zinc fingeri473 – 495C2H2-type 12Add BLAST23
Zinc fingeri501 – 523C2H2-type 13Add BLAST23
Zinc fingeri529 – 551C2H2-type 14Add BLAST23
Zinc fingeri557 – 579C2H2-type 15Add BLAST23
Zinc fingeri585 – 607C2H2-type 16Add BLAST23
Zinc fingeri613 – 635C2H2-type 17Add BLAST23
Zinc fingeri641 – 663C2H2-type 18Add BLAST23
Zinc fingeri669 – 691C2H2-type 19Add BLAST23
Zinc fingeri697 – 719C2H2-type 20Add BLAST23
Zinc fingeri725 – 747C2H2-type 21Add BLAST23
Zinc fingeri753 – 775C2H2-type 22; degenerateAdd BLAST23
Zinc fingeri781 – 803C2H2-type 23; degenerateAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 780B
Alternative name(s):
Zinc finger protein 779
Gene namesi
Name:ZNF780B
Synonyms:ZNF779
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000128000.15.
HGNCiHGNC:33109. ZNF780B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi163131.
OpenTargetsiENSG00000128000.
PharmGKBiPA162410426.

Polymorphism and mutation databases

BioMutaiZNF780B.
DMDMi74762083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002630881 – 833Zinc finger protein 780BAdd BLAST833

Proteomic databases

MaxQBiQ9Y6R6.
PaxDbiQ9Y6R6.
PeptideAtlasiQ9Y6R6.
PRIDEiQ9Y6R6.

PTM databases

iPTMnetiQ9Y6R6.
PhosphoSitePlusiQ9Y6R6.

Expressioni

Gene expression databases

BgeeiENSG00000128000.
CleanExiHS_ZNF780B.
ExpressionAtlasiQ9Y6R6. baseline and differential.
GenevisibleiQ9Y6R6. HS.

Organism-specific databases

HPAiHPA003311.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000391641.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6R6.
SMRiQ9Y6R6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 77KRABAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri165 – 187C2H2-type 1Add BLAST23
Zinc fingeri193 – 215C2H2-type 2Add BLAST23
Zinc fingeri221 – 243C2H2-type 3Add BLAST23
Zinc fingeri249 – 271C2H2-type 4Add BLAST23
Zinc fingeri277 – 299C2H2-type 5Add BLAST23
Zinc fingeri305 – 327C2H2-type 6Add BLAST23
Zinc fingeri333 – 355C2H2-type 7Add BLAST23
Zinc fingeri361 – 383C2H2-type 8Add BLAST23
Zinc fingeri389 – 411C2H2-type 9Add BLAST23
Zinc fingeri417 – 439C2H2-type 10Add BLAST23
Zinc fingeri445 – 467C2H2-type 11Add BLAST23
Zinc fingeri473 – 495C2H2-type 12Add BLAST23
Zinc fingeri501 – 523C2H2-type 13Add BLAST23
Zinc fingeri529 – 551C2H2-type 14Add BLAST23
Zinc fingeri557 – 579C2H2-type 15Add BLAST23
Zinc fingeri585 – 607C2H2-type 16Add BLAST23
Zinc fingeri613 – 635C2H2-type 17Add BLAST23
Zinc fingeri641 – 663C2H2-type 18Add BLAST23
Zinc fingeri669 – 691C2H2-type 19Add BLAST23
Zinc fingeri697 – 719C2H2-type 20Add BLAST23
Zinc fingeri725 – 747C2H2-type 21Add BLAST23
Zinc fingeri753 – 775C2H2-type 22; degenerateAdd BLAST23
Zinc fingeri781 – 803C2H2-type 23; degenerateAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00900000141086.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9Y6R6.
KOiK09228.
OMAiEINLPKH.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9Y6R6.
TreeFamiTF343410.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 3 hits.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 23 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 12 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 21 hits.
PS50157. ZINC_FINGER_C2H2_2. 23 hits.

Sequencei

Sequence statusi: Complete.

Q9Y6R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHGSVTFRD VAIDFSQEEW ECLQPDQRTL YRDVMLENYS HLISLGSSIS
60 70 80 90 100
KPDVITLLEQ EKEPWIVVSK ETSRWYPDLE SKYGPEKISP ENDIFEINLP
110 120 130 140 150
KHVIKQISKT LGLEAFYFRN DSEYRSRFEG RQGHQEGYIN QKIISYEEMP
160 170 180 190 200
AYTHASPIHN THKPYECKEC GKYFSCGSNL IQHQSIHTGE KPYKCKECGK
210 220 230 240 250
AFQLHIQLTR HQKFHTGEKT FECKECGKAF NLPTQLNRHK NIHTVKKLFE
260 270 280 290 300
CKECGKSFNR SSNLTQHQSI HAGVKPYQCK ECGKAFNRGS NLIQHQKIHS
310 320 330 340 350
NEKPFVCREC EMAFRYHYQL IEHCRIHTGE KPFECKECRK AFTLLTKLVR
360 370 380 390 400
HQKIHMGEKP FECRECGKAF SLLNQLNRHK NIHTGEKPFE CKECGKSFNR
410 420 430 440 450
SSNLIQHQSI HADVKPYECK ECGKGFNRGA NLIQHQKIHS NEKPFVCREC
460 470 480 490 500
EMAFRYHYQL IQHCQIHTGG KPFECKECGK AFSLLTQLAR HKNIHTGEKP
510 520 530 540 550
FECKDCGKAF NRGSNLVQHQ SIHTGEKPYE CKECGKAFRL HLQLSQHEKT
560 570 580 590 600
HTGEKPFECK ECGKFFRRGS NLNQHRSIHT GKKPFECKEC GKAFRLHMHL
610 620 630 640 650
IRHQKFHTGE KPFECKECGK AFSLHTQLNH HKNIHTGEKP FKCKECGKSF
660 670 680 690 700
NRVSNLVQHQ SIHAGVKPYE CKECGKGFSR VSNLIQHQKT HSSAKPFVCK
710 720 730 740 750
ECRKTFRYHY QLTEHYRIHT GEKPFECKEC GKAFGLLTQL AQHQIIHTGE
760 770 780 790 800
KPFKCKECGK AFNRGSNLVQ PQSIHTGEKP YECKECGKAF RLHLQLSLHQ
810 820 830
KLVQVRNPLN VRNVGQPSDI SSNLLNIRKF ILG
Length:833
Mass (Da):96,807
Last modified:November 1, 1999 - v1
Checksum:i2A354BA8B633B54A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007842 Genomic DNA. Translation: AAD39268.1.
CH471126 Genomic DNA. Translation: EAW56932.1.
BC136960 mRNA. Translation: AAI36961.1.
CCDSiCCDS46077.1.
RefSeqiNP_001005851.1. NM_001005851.2.
XP_005258650.1. XM_005258593.2.
XP_016881914.1. XM_017026425.1.
XP_016881915.1. XM_017026426.1.
XP_016881916.1. XM_017026427.1.
UniGeneiHs.101139.

Genome annotation databases

EnsembliENST00000434248; ENSP00000391641; ENSG00000128000.
ENST00000617676; ENSP00000484593; ENSG00000128000.
ENST00000625684; ENSP00000487572; ENSG00000281601.
ENST00000627167; ENSP00000487499; ENSG00000281601.
GeneIDi163131.
KEGGihsa:163131.
UCSCiuc002omu.3. human.

Similar proteinsi

Entry informationi

Entry nameiZ780B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6R6
Secondary accession number(s): B9EH00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1999
Last modified: November 22, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families