Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 780B

Gene

ZNF780B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri165 – 18723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri193 – 21523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri221 – 24323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri249 – 27123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 29923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri417 – 43923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri445 – 46723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri473 – 49523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri501 – 52323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri529 – 55123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri557 – 57923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri585 – 60723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri613 – 63523C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri641 – 66323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri669 – 69123C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri697 – 71923C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri725 – 74723C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri753 – 77523C2H2-type 22; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri781 – 80323C2H2-type 23; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 780B
Alternative name(s):
Zinc finger protein 779
Gene namesi
Name:ZNF780B
Synonyms:ZNF779
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componentsi: Chromosome 1, Chromosome 19

Organism-specific databases

HGNCiHGNC:33109. ZNF780B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410426.

Polymorphism and mutation databases

BioMutaiZNF780B.
DMDMi74762083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 833833Zinc finger protein 780BPRO_0000263088Add
BLAST

Proteomic databases

MaxQBiQ9Y6R6.
PaxDbiQ9Y6R6.
PeptideAtlasiQ9Y6R6.
PRIDEiQ9Y6R6.

PTM databases

iPTMnetiQ9Y6R6.
PhosphoSiteiQ9Y6R6.

Expressioni

Gene expression databases

BgeeiQ9Y6R6.
CleanExiHS_ZNF780B.
ExpressionAtlasiQ9Y6R6. baseline and differential.
GenevisibleiQ9Y6R6. HS.

Organism-specific databases

HPAiHPA003311.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000391641.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6R6.
SMRiQ9Y6R6. Positions 163-810.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7772KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 23 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri165 – 18723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri193 – 21523C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri221 – 24323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri249 – 27123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 29923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri417 – 43923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri445 – 46723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri473 – 49523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri501 – 52323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri529 – 55123C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri557 – 57923C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri585 – 60723C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri613 – 63523C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri641 – 66323C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri669 – 69123C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri697 – 71923C2H2-type 20PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri725 – 74723C2H2-type 21PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri753 – 77523C2H2-type 22; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri781 – 80323C2H2-type 23; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129692.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9Y6R6.
KOiK09228.
OMAiHQEGYIN.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9Y6R6.
TreeFamiTF343410.

Family and domain databases

Gene3Di3.30.160.60. 23 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 23 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 21 hits.
PS50157. ZINC_FINGER_C2H2_2. 23 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y6R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHGSVTFRD VAIDFSQEEW ECLQPDQRTL YRDVMLENYS HLISLGSSIS
60 70 80 90 100
KPDVITLLEQ EKEPWIVVSK ETSRWYPDLE SKYGPEKISP ENDIFEINLP
110 120 130 140 150
KHVIKQISKT LGLEAFYFRN DSEYRSRFEG RQGHQEGYIN QKIISYEEMP
160 170 180 190 200
AYTHASPIHN THKPYECKEC GKYFSCGSNL IQHQSIHTGE KPYKCKECGK
210 220 230 240 250
AFQLHIQLTR HQKFHTGEKT FECKECGKAF NLPTQLNRHK NIHTVKKLFE
260 270 280 290 300
CKECGKSFNR SSNLTQHQSI HAGVKPYQCK ECGKAFNRGS NLIQHQKIHS
310 320 330 340 350
NEKPFVCREC EMAFRYHYQL IEHCRIHTGE KPFECKECRK AFTLLTKLVR
360 370 380 390 400
HQKIHMGEKP FECRECGKAF SLLNQLNRHK NIHTGEKPFE CKECGKSFNR
410 420 430 440 450
SSNLIQHQSI HADVKPYECK ECGKGFNRGA NLIQHQKIHS NEKPFVCREC
460 470 480 490 500
EMAFRYHYQL IQHCQIHTGG KPFECKECGK AFSLLTQLAR HKNIHTGEKP
510 520 530 540 550
FECKDCGKAF NRGSNLVQHQ SIHTGEKPYE CKECGKAFRL HLQLSQHEKT
560 570 580 590 600
HTGEKPFECK ECGKFFRRGS NLNQHRSIHT GKKPFECKEC GKAFRLHMHL
610 620 630 640 650
IRHQKFHTGE KPFECKECGK AFSLHTQLNH HKNIHTGEKP FKCKECGKSF
660 670 680 690 700
NRVSNLVQHQ SIHAGVKPYE CKECGKGFSR VSNLIQHQKT HSSAKPFVCK
710 720 730 740 750
ECRKTFRYHY QLTEHYRIHT GEKPFECKEC GKAFGLLTQL AQHQIIHTGE
760 770 780 790 800
KPFKCKECGK AFNRGSNLVQ PQSIHTGEKP YECKECGKAF RLHLQLSLHQ
810 820 830
KLVQVRNPLN VRNVGQPSDI SSNLLNIRKF ILG
Length:833
Mass (Da):96,807
Last modified:November 1, 1999 - v1
Checksum:i2A354BA8B633B54A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007842 Genomic DNA. Translation: AAD39268.1.
CH471126 Genomic DNA. Translation: EAW56932.1.
BC136960 mRNA. Translation: AAI36961.1.
CCDSiCCDS46077.1.
RefSeqiNP_001005851.1. NM_001005851.2.
XP_005258650.1. XM_005258593.1.
XP_011547099.1. XM_011548797.1.
UniGeneiHs.101139.

Genome annotation databases

EnsembliENST00000434248; ENSP00000391641; ENSG00000128000.
ENST00000617676; ENSP00000484593; ENSG00000128000.
ENST00000625684; ENSP00000487572; ENSG00000281601.
ENST00000627167; ENSP00000487499; ENSG00000281601.
GeneIDi163131.
KEGGihsa:163131.
UCSCiuc002omu.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC007842 Genomic DNA. Translation: AAD39268.1.
CH471126 Genomic DNA. Translation: EAW56932.1.
BC136960 mRNA. Translation: AAI36961.1.
CCDSiCCDS46077.1.
RefSeqiNP_001005851.1. NM_001005851.2.
XP_005258650.1. XM_005258593.1.
XP_011547099.1. XM_011548797.1.
UniGeneiHs.101139.

3D structure databases

ProteinModelPortaliQ9Y6R6.
SMRiQ9Y6R6. Positions 163-810.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000391641.

PTM databases

iPTMnetiQ9Y6R6.
PhosphoSiteiQ9Y6R6.

Polymorphism and mutation databases

BioMutaiZNF780B.
DMDMi74762083.

Proteomic databases

MaxQBiQ9Y6R6.
PaxDbiQ9Y6R6.
PeptideAtlasiQ9Y6R6.
PRIDEiQ9Y6R6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000434248; ENSP00000391641; ENSG00000128000.
ENST00000617676; ENSP00000484593; ENSG00000128000.
ENST00000625684; ENSP00000487572; ENSG00000281601.
ENST00000627167; ENSP00000487499; ENSG00000281601.
GeneIDi163131.
KEGGihsa:163131.
UCSCiuc002omu.3. human.

Organism-specific databases

CTDi163131.
GeneCardsiZNF780B.
HGNCiHGNC:33109. ZNF780B.
HPAiHPA003311.
neXtProtiNX_Q9Y6R6.
PharmGKBiPA162410426.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129692.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9Y6R6.
KOiK09228.
OMAiHQEGYIN.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9Y6R6.
TreeFamiTF343410.

Miscellaneous databases

GenomeRNAii163131.
PROiQ9Y6R6.

Gene expression databases

BgeeiQ9Y6R6.
CleanExiHS_ZNF780B.
ExpressionAtlasiQ9Y6R6. baseline and differential.
GenevisibleiQ9Y6R6. HS.

Family and domain databases

Gene3Di3.30.160.60. 23 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 23 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 21 hits.
PS50157. ZINC_FINGER_C2H2_2. 23 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiZ780B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6R6
Secondary accession number(s): B9EH00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.