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Protein

Mitogen-activated protein kinase kinase kinase 4

Gene

MAP3K4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Enzyme regulationi

N-terminal autoinhibitory domain interacts with the C-terminal kinase domain, inhibiting kinase activity, and preventing interaction with its substrate, MAP2K6. The GADD45 proteins activate the kinase by binding to the N-terminal domain. Activated by phosphorylation on Thr-1505.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1372ATPPROSITE-ProRule annotation1
Active sitei1463Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1349 – 1357ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase kinase kinase activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • activation of MAPKK activity Source: UniProtKB
  • chorionic trophoblast cell differentiation Source: Ensembl
  • intracellular signal transduction Source: UniProtKB
  • male germ-line sex determination Source: Ensembl
  • placenta development Source: Ensembl
  • positive regulation of JUN kinase activity Source: UniProtKB
  • positive regulation of p38MAPK cascade Source: UniProtKB
  • positive regulation of telomerase activity Source: BHF-UCL
  • positive regulation of telomere capping Source: BHF-UCL
  • positive regulation of telomere maintenance via telomerase Source: BHF-UCL
  • regulation of gene expression Source: Ensembl
  • response to UV-C Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS01498-MONOMER.
BRENDAi2.7.12.2. 2681.
SignaLinkiQ9Y6R4.
SIGNORiQ9Y6R4.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 4 (EC:2.7.11.25)
Alternative name(s):
MAP three kinase 1
MAPK/ERK kinase kinase 4
Short name:
MEK kinase 4
Short name:
MEKK 4
Gene namesi
Name:MAP3K4
Synonyms:KIAA0213, MAPKKK4, MEKK4, MTK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:6856. MAP3K4.

Subcellular locationi

  • Cytoplasmperinuclear region By similarity

  • Note: Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1372K → R: Loss of activity. 2 Publications1

Organism-specific databases

DisGeNETi4216.
OpenTargetsiENSG00000085511.
PharmGKBiPA30600.

Chemistry databases

ChEMBLiCHEMBL4853.
GuidetoPHARMACOLOGYi2079.

Polymorphism and mutation databases

BioMutaiMAP3K4.
DMDMi296434576.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000862471 – 1608Mitogen-activated protein kinase kinase kinase 4Add BLAST1608

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84PhosphoserineBy similarity1
Modified residuei431PhosphoserineCombined sources1
Modified residuei447PhosphothreonineCombined sources1
Modified residuei456PhosphoserineCombined sources1
Modified residuei457PhosphoserineCombined sources1
Modified residuei458PhosphothreonineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei481PhosphoserineCombined sources1
Modified residuei499PhosphoserineCombined sources1
Modified residuei1252PhosphoserineCombined sources1
Modified residuei1274PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y6R4.
PaxDbiQ9Y6R4.
PeptideAtlasiQ9Y6R4.
PRIDEiQ9Y6R4.

PTM databases

iPTMnetiQ9Y6R4.
PhosphoSitePlusiQ9Y6R4.

Expressioni

Tissue specificityi

Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues.1 Publication

Gene expression databases

BgeeiENSG00000085511.
CleanExiHS_MAP3K4.
ExpressionAtlasiQ9Y6R4. baseline and differential.
GenevisibleiQ9Y6R4. HS.

Organism-specific databases

HPAiHPA007625.

Interactioni

Subunit structurei

Monomer and homodimer. Homodimerization enhances kinase activity. Interacts with TRAF4; this promotes homodimerization (PubMed:16157600). Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with AXIN1 and DIXDC1; interaction with DIXDC1 prevents interaction with AXIN1 (PubMed:15262978). Interacts with GADD45 and MAP2K6 (PubMed:12052864). Interacts with ZFP36; this interaction enhances the association with SH3KBP1/CIN85 (PubMed:20221403). Interacts with SH3KBP1; this interaction enhances the association with ZFP36 (PubMed:20221403). Interacts with CDC42 (By similarity).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FLNBO753692EBI-448104,EBI-352089
GADD45BO752932EBI-448104,EBI-448187
MAP2K6P525642EBI-448104,EBI-448135
SH3KBP1Q96B975EBI-448104,EBI-346595
UBCP0CG482EBI-448104,EBI-3390054

Protein-protein interaction databases

BioGridi110380. 48 interactors.
IntActiQ9Y6R4. 13 interactors.
MINTiMINT-1213156.
STRINGi9606.ENSP00000375986.

Chemistry databases

BindingDBiQ9Y6R4.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6R4.
SMRiQ9Y6R4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1343 – 1601Protein kinasePROSITE-ProRule annotationAdd BLAST259

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 7Poly-Ala4
Compositional biasi25 – 38Poly-ProAdd BLAST14
Compositional biasi1190 – 1202Poly-AlaAdd BLAST13

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4645. Eukaryota.
ENOG410XQZE. LUCA.
GeneTreeiENSGT00590000083157.
HOVERGENiHBG006304.
InParanoidiQ9Y6R4.
KOiK04428.
OMAiHYIRGGE.
OrthoDBiEOG091G00SM.
PhylomeDBiQ9Y6R4.
TreeFamiTF105114.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y6R4-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MREAAAALVP PPAFAVTPAA AMEEPPPPPP PPPPPPEPET ESEPECCLAA
60 70 80 90 100
RQEGTLGDSA CKSPESDLED FSDETNTENL YGTSPPSTPR QMKRMSTKHQ
110 120 130 140 150
RNNVGRPASR SNLKEKMNAP NQPPHKDTGK TVENVEEYSY KQEKKIRAAL
160 170 180 190 200
RTTERDRKKN VQCSFMLDSV GGSLPKKSIP DVDLNKPYLS LGCSNAKLPV
210 220 230 240 250
SVPMPIARPA RQTSRTDCPA DRLKFFETLR LLLKLTSVSK KKDREQRGQE
260 270 280 290 300
NTSGFWLNRS NELIWLELQA WHAGRTINDQ DFFLYTARQA IPDIINEILT
310 320 330 340 350
FKVDYGSFAF VRDRAGFNGT SVEGQCKATP GTKIVGYSTH HEHLQRQRVS
360 370 380 390 400
FEQVKRIMEL LEYIEALYPS LQALQKDYEK YAAKDFQDRV QALCLWLNIT
410 420 430 440 450
KDLNQKLRIM GTVLGIKNLS DIGWPVFEIP SPRPSKGNEP EYEGDDTEGE
460 470 480 490 500
LKELESSTDE SEEEQISDPR VPEIRQPIDN SFDIQSRDCI SKKLERLESE
510 520 530 540 550
DDSLGWGAPD WSTEAGFSRH CLTSIYRPFV DKALKQMGLR KLILRLHKLM
560 570 580 590 600
DGSLQRARIA LVKNDRPVEF SEFPDPMWGS DYVQLSRTPP SSEEKCSAVS
610 620 630 640 650
WEELKAMDLP SFEPAFLVLC RVLLNVIHEC LKLRLEQRPA GEPSLLSIKQ
660 670 680 690 700
LVRECKEVLK GGLLMKQYYQ FMLQEVLEDL EKPDCNIDAF EEDLHKMLMV
710 720 730 740 750
YFDYMRSWIQ MLQQLPQASH SLKNLLEEEW NFTKEITHYI RGGEAQAGKL
760 770 780 790 800
FCDIAGMLLK STGSFLEFGL QESCAEFWTS ADDSSASDEI RRSVIEISRA
810 820 830 840 850
LKELFHEARE RASKALGFAK MLRKDLEIAA EFRLSAPVRD LLDVLKSKQY
860 870 880 890 900
VKVQIPGLEN LQMFVPDTLA EEKSIILQLL NAAAGKDCSK DSDDVLIDAY
910 920 930 940 950
LLLTKHGDRA RDSEDSWGTW EAQPVKVVPQ VETVDTLRSM QVDNLLLVVM
960 970 980 990 1000
QSAHLTIQRK AFQQSIEGLM TLCQEQTSSQ PVIAKALQQL KNDALELCNR
1010 1020 1030 1040 1050
ISNAIDRVDH MFTSEFDAEV DESESVTLQQ YYREAMIQGY NFGFEYHKEV
1060 1070 1080 1090 1100
VRLMSGEFRQ KIGDKYISFA RKWMNYVLTK CESGRGTRPR WATQGFDFLQ
1110 1120 1130 1140 1150
AIEPAFISAL PEDDFLSLQA LMNECIGHVI GKPHSPVTGL YLAIHRNSPR
1160 1170 1180 1190 1200
PMKVPRCHSD PPNPHLIIPT PEGFSTRSMP SDARSHGSPA AAAAAAAAAV
1210 1220 1230 1240 1250
AASRPSPSGG DSVLPKSISS AHDTRGSSVP ENDRLASIAA ELQFRSLSRH
1260 1270 1280 1290 1300
SSPTEERDEP AYPRGDSSGS TRRSWELRTL ISQSKDTASK LGPIEAIQKS
1310 1320 1330 1340 1350
VRLFEEKRYR EMRRKNIIGQ VCDTPKSYDN VMHVGLRKVT FKWQRGNKIG
1360 1370 1380 1390 1400
EGQYGKVYTC ISVDTGELMA MKEIRFQPND HKTIKETADE LKIFEGIKHP
1410 1420 1430 1440 1450
NLVRYFGVEL HREEMYIFME YCDEGTLEEV SRLGLQEHVI RLYSKQITIA
1460 1470 1480 1490 1500
INVLHEHGIV HRDIKGANIF LTSSGLIKLG DFGCSVKLKN NAQTMPGEVN
1510 1520 1530 1540 1550
STLGTAAYMA PEVITRAKGE GHGRAADIWS LGCVVIEMVT GKRPWHEYEH
1560 1570 1580 1590 1600
NFQIMYKVGM GHKPPIPERL SPEGKDFLSH CLESDPKMRW TASQLLDHSF

VKVCTDEE
Length:1,608
Mass (Da):181,685
Last modified:May 18, 2010 - v2
Checksum:iC22294914945EA91
GO
Isoform 2 (identifier: Q9Y6R4-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1175-1224: Missing.

Show »
Length:1,558
Mass (Da):177,014
Checksum:i4F94E9CF82E88354
GO

Sequence cautioni

The sequence BAA13204 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAC12766 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAH70639 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAH70640 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20815 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI20816 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI21477 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41309 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41310 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35P → PP in AAI36277 (PubMed:15489334).Curated1
Sequence conflicti500E → D in AAI46771 (PubMed:15489334).Curated1
Sequence conflicti791R → I in AAB68804 (PubMed:9305639).Curated1
Sequence conflicti1190Missing in EAW47587 (Ref. 5) Curated1
Sequence conflicti1190Missing in AAI43736 (PubMed:15489334).Curated1
Sequence conflicti1190Missing in AAI36277 (PubMed:15489334).Curated1
Sequence conflicti1199Missing in AAB68804 (PubMed:9305639).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059767157R → H.1 PublicationCorresponds to variant rs4559074dbSNPEnsembl.1
Natural variantiVAR_040686294I → T.1 PublicationCorresponds to variant rs35842248dbSNPEnsembl.1
Natural variantiVAR_040687335V → I.1 PublicationCorresponds to variant rs35730939dbSNPEnsembl.1
Natural variantiVAR_040688566R → H.1 PublicationCorresponds to variant rs55765351dbSNPEnsembl.1
Natural variantiVAR_040689584Q → H.1 PublicationCorresponds to variant rs34018542dbSNPEnsembl.1
Natural variantiVAR_040690906H → P.1 PublicationCorresponds to variant rs35533223dbSNPEnsembl.1
Natural variantiVAR_0406911413E → Q in an ovarian serous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0406921492A → V.1 PublicationCorresponds to variant rs41267837dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0048841175 – 1224Missing in isoform 2. 2 PublicationsAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002715 mRNA. Translation: AAB68804.1.
D86968 mRNA. Translation: BAA13204.2. Different initiation.
AL109942
, AL139393, AL591045, AL596452 Genomic DNA. Translation: CAC12766.2. Sequence problems.
AL109942
, AL139393, AL591045, AL596452 Genomic DNA. Translation: CAI21477.1. Sequence problems.
AL139393
, AL109942, AL591045, AL596452 Genomic DNA. Translation: CAI20815.1. Sequence problems.
AL139393
, AL109942, AL591045, AL596452 Genomic DNA. Translation: CAI20816.1. Sequence problems.
AL591045
, AL109942, AL139393, AL596452 Genomic DNA. Translation: CAH70639.1. Sequence problems.
AL591045
, AL109942, AL139393, AL596452 Genomic DNA. Translation: CAH70640.1. Sequence problems.
AL596452
, AL109942, AL139393, AL591045 Genomic DNA. Translation: CAI41309.1. Sequence problems.
AL596452
, AL109942, AL139393, AL591045 Genomic DNA. Translation: CAI41310.1. Sequence problems.
CH471051 Genomic DNA. Translation: EAW47587.1.
BC136276 mRNA. Translation: AAI36277.1.
BC143735 mRNA. Translation: AAI43736.1.
BC146770 mRNA. Translation: AAI46771.1.
CCDSiCCDS34565.1. [Q9Y6R4-1]
CCDS34566.1. [Q9Y6R4-2]
PIRiT03022.
RefSeqiNP_001278887.1. NM_001291958.1.
NP_001288001.1. NM_001301072.1.
NP_005913.2. NM_005922.3.
NP_006715.2. NM_006724.3.
UniGeneiHs.390428.

Genome annotation databases

EnsembliENST00000366919; ENSP00000355886; ENSG00000085511. [Q9Y6R4-2]
ENST00000392142; ENSP00000375986; ENSG00000085511. [Q9Y6R4-1]
GeneIDi4216.
KEGGihsa:4216.
UCSCiuc003qtn.4. human. [Q9Y6R4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002715 mRNA. Translation: AAB68804.1.
D86968 mRNA. Translation: BAA13204.2. Different initiation.
AL109942
, AL139393, AL591045, AL596452 Genomic DNA. Translation: CAC12766.2. Sequence problems.
AL109942
, AL139393, AL591045, AL596452 Genomic DNA. Translation: CAI21477.1. Sequence problems.
AL139393
, AL109942, AL591045, AL596452 Genomic DNA. Translation: CAI20815.1. Sequence problems.
AL139393
, AL109942, AL591045, AL596452 Genomic DNA. Translation: CAI20816.1. Sequence problems.
AL591045
, AL109942, AL139393, AL596452 Genomic DNA. Translation: CAH70639.1. Sequence problems.
AL591045
, AL109942, AL139393, AL596452 Genomic DNA. Translation: CAH70640.1. Sequence problems.
AL596452
, AL109942, AL139393, AL591045 Genomic DNA. Translation: CAI41309.1. Sequence problems.
AL596452
, AL109942, AL139393, AL591045 Genomic DNA. Translation: CAI41310.1. Sequence problems.
CH471051 Genomic DNA. Translation: EAW47587.1.
BC136276 mRNA. Translation: AAI36277.1.
BC143735 mRNA. Translation: AAI43736.1.
BC146770 mRNA. Translation: AAI46771.1.
CCDSiCCDS34565.1. [Q9Y6R4-1]
CCDS34566.1. [Q9Y6R4-2]
PIRiT03022.
RefSeqiNP_001278887.1. NM_001291958.1.
NP_001288001.1. NM_001301072.1.
NP_005913.2. NM_005922.3.
NP_006715.2. NM_006724.3.
UniGeneiHs.390428.

3D structure databases

ProteinModelPortaliQ9Y6R4.
SMRiQ9Y6R4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110380. 48 interactors.
IntActiQ9Y6R4. 13 interactors.
MINTiMINT-1213156.
STRINGi9606.ENSP00000375986.

Chemistry databases

BindingDBiQ9Y6R4.
ChEMBLiCHEMBL4853.
GuidetoPHARMACOLOGYi2079.

PTM databases

iPTMnetiQ9Y6R4.
PhosphoSitePlusiQ9Y6R4.

Polymorphism and mutation databases

BioMutaiMAP3K4.
DMDMi296434576.

Proteomic databases

EPDiQ9Y6R4.
PaxDbiQ9Y6R4.
PeptideAtlasiQ9Y6R4.
PRIDEiQ9Y6R4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366919; ENSP00000355886; ENSG00000085511. [Q9Y6R4-2]
ENST00000392142; ENSP00000375986; ENSG00000085511. [Q9Y6R4-1]
GeneIDi4216.
KEGGihsa:4216.
UCSCiuc003qtn.4. human. [Q9Y6R4-1]

Organism-specific databases

CTDi4216.
DisGeNETi4216.
GeneCardsiMAP3K4.
H-InvDBHIX0151295.
HGNCiHGNC:6856. MAP3K4.
HPAiHPA007625.
MIMi602425. gene.
neXtProtiNX_Q9Y6R4.
OpenTargetsiENSG00000085511.
PharmGKBiPA30600.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4645. Eukaryota.
ENOG410XQZE. LUCA.
GeneTreeiENSGT00590000083157.
HOVERGENiHBG006304.
InParanoidiQ9Y6R4.
KOiK04428.
OMAiHYIRGGE.
OrthoDBiEOG091G00SM.
PhylomeDBiQ9Y6R4.
TreeFamiTF105114.

Enzyme and pathway databases

BioCyciZFISH:HS01498-MONOMER.
BRENDAi2.7.12.2. 2681.
SignaLinkiQ9Y6R4.
SIGNORiQ9Y6R4.

Miscellaneous databases

ChiTaRSiMAP3K4. human.
GeneWikiiMAP3K4.
GenomeRNAii4216.
PROiQ9Y6R4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000085511.
CleanExiHS_MAP3K4.
ExpressionAtlasiQ9Y6R4. baseline and differential.
GenevisibleiQ9Y6R4. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiM3K4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6R4
Secondary accession number(s): A6H8W0
, B7ZLD3, B9EG75, Q5VTT8, Q5VTT9, Q92612, Q9H408
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 162 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.