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Q9Y6R4

- M3K4_HUMAN

UniProt

Q9Y6R4 - M3K4_HUMAN

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Protein

Mitogen-activated protein kinase kinase kinase 4

Gene

MAP3K4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Enzyme regulationi

N-terminal autoinhibitory domain interacts with the C-terminal kinase domain, inhibiting kinase activity, and preventing interaction with its substrate, MAP2K6. The GADD45 proteins activate the kinase by binding to the N-terminal domain. Activated by phosphorylation on Thr-1505.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1372 – 13721ATPPROSITE-ProRule annotation
Active sitei1463 – 14631Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1349 – 13579ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase kinase kinase activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. activation of MAPKK activity Source: UniProtKB
  2. chorionic trophoblast cell differentiation Source: Ensembl
  3. intracellular signal transduction Source: UniProtKB
  4. male germ-line sex determination Source: Ensembl
  5. MAPK cascade Source: GOC
  6. placenta development Source: Ensembl
  7. positive regulation of JUN kinase activity Source: UniProtKB
  8. positive regulation of p38MAPK cascade Source: UniProtKB
  9. regulation of gene expression Source: Ensembl
  10. response to UV-C Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.12.2. 2681.
SignaLinkiQ9Y6R4.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 4 (EC:2.7.11.25)
Alternative name(s):
MAP three kinase 1
MAPK/ERK kinase kinase 4
Short name:
MEK kinase 4
Short name:
MEKK 4
Gene namesi
Name:MAP3K4
Synonyms:KIAA0213, MAPKKK4, MEKK4, MTK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:6856. MAP3K4.

Subcellular locationi

Cytoplasmperinuclear region By similarity
Note: Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1372 – 13721K → R: Loss of activity. 2 Publications

Organism-specific databases

PharmGKBiPA30600.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16081608Mitogen-activated protein kinase kinase kinase 4PRO_0000086247Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei456 – 4561Phosphoserine1 Publication
Modified residuei457 – 4571Phosphoserine1 Publication
Modified residuei458 – 4581Phosphothreonine1 Publication
Modified residuei461 – 4611Phosphoserine1 Publication
Modified residuei499 – 4991Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y6R4.
PaxDbiQ9Y6R4.
PRIDEiQ9Y6R4.

PTM databases

PhosphoSiteiQ9Y6R4.

Expressioni

Tissue specificityi

Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues.1 Publication

Gene expression databases

BgeeiQ9Y6R4.
CleanExiHS_MAP3K4.
ExpressionAtlasiQ9Y6R4. baseline and differential.
GenevestigatoriQ9Y6R4.

Organism-specific databases

HPAiHPA007625.

Interactioni

Subunit structurei

Monomer and homodimer. Homodimerization enhances kinase activity. Interacts with TRAF4; this promotes homodimerization (By similarity). Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with AXIN1 and DIXDC1; interaction with DIXDC1 prevents interaction with AXIN1.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FLNBO753692EBI-448104,EBI-352089
GADD45BO752932EBI-448104,EBI-448187
MAP2K6P525642EBI-448104,EBI-448135
SH3KBP1Q96B975EBI-448104,EBI-346595
UBCP0CG482EBI-448104,EBI-3390054

Protein-protein interaction databases

BioGridi110380. 22 interactions.
IntActiQ9Y6R4. 13 interactions.
MINTiMINT-1213156.
STRINGi9606.ENSP00000375986.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6R4.
SMRiQ9Y6R4. Positions 1301-1603.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1343 – 1601259Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 74Poly-Ala
Compositional biasi25 – 3814Poly-ProAdd
BLAST
Compositional biasi1190 – 120213Poly-AlaAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00590000083157.
HOVERGENiHBG006304.
InParanoidiQ9Y6R4.
KOiK04428.
OMAiFVKVCTD.
OrthoDBiEOG7P5T02.
PhylomeDBiQ9Y6R4.
TreeFamiTF105114.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y6R4-1) [UniParc]FASTAAdd to Basket

Also known as: A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MREAAAALVP PPAFAVTPAA AMEEPPPPPP PPPPPPEPET ESEPECCLAA
60 70 80 90 100
RQEGTLGDSA CKSPESDLED FSDETNTENL YGTSPPSTPR QMKRMSTKHQ
110 120 130 140 150
RNNVGRPASR SNLKEKMNAP NQPPHKDTGK TVENVEEYSY KQEKKIRAAL
160 170 180 190 200
RTTERDRKKN VQCSFMLDSV GGSLPKKSIP DVDLNKPYLS LGCSNAKLPV
210 220 230 240 250
SVPMPIARPA RQTSRTDCPA DRLKFFETLR LLLKLTSVSK KKDREQRGQE
260 270 280 290 300
NTSGFWLNRS NELIWLELQA WHAGRTINDQ DFFLYTARQA IPDIINEILT
310 320 330 340 350
FKVDYGSFAF VRDRAGFNGT SVEGQCKATP GTKIVGYSTH HEHLQRQRVS
360 370 380 390 400
FEQVKRIMEL LEYIEALYPS LQALQKDYEK YAAKDFQDRV QALCLWLNIT
410 420 430 440 450
KDLNQKLRIM GTVLGIKNLS DIGWPVFEIP SPRPSKGNEP EYEGDDTEGE
460 470 480 490 500
LKELESSTDE SEEEQISDPR VPEIRQPIDN SFDIQSRDCI SKKLERLESE
510 520 530 540 550
DDSLGWGAPD WSTEAGFSRH CLTSIYRPFV DKALKQMGLR KLILRLHKLM
560 570 580 590 600
DGSLQRARIA LVKNDRPVEF SEFPDPMWGS DYVQLSRTPP SSEEKCSAVS
610 620 630 640 650
WEELKAMDLP SFEPAFLVLC RVLLNVIHEC LKLRLEQRPA GEPSLLSIKQ
660 670 680 690 700
LVRECKEVLK GGLLMKQYYQ FMLQEVLEDL EKPDCNIDAF EEDLHKMLMV
710 720 730 740 750
YFDYMRSWIQ MLQQLPQASH SLKNLLEEEW NFTKEITHYI RGGEAQAGKL
760 770 780 790 800
FCDIAGMLLK STGSFLEFGL QESCAEFWTS ADDSSASDEI RRSVIEISRA
810 820 830 840 850
LKELFHEARE RASKALGFAK MLRKDLEIAA EFRLSAPVRD LLDVLKSKQY
860 870 880 890 900
VKVQIPGLEN LQMFVPDTLA EEKSIILQLL NAAAGKDCSK DSDDVLIDAY
910 920 930 940 950
LLLTKHGDRA RDSEDSWGTW EAQPVKVVPQ VETVDTLRSM QVDNLLLVVM
960 970 980 990 1000
QSAHLTIQRK AFQQSIEGLM TLCQEQTSSQ PVIAKALQQL KNDALELCNR
1010 1020 1030 1040 1050
ISNAIDRVDH MFTSEFDAEV DESESVTLQQ YYREAMIQGY NFGFEYHKEV
1060 1070 1080 1090 1100
VRLMSGEFRQ KIGDKYISFA RKWMNYVLTK CESGRGTRPR WATQGFDFLQ
1110 1120 1130 1140 1150
AIEPAFISAL PEDDFLSLQA LMNECIGHVI GKPHSPVTGL YLAIHRNSPR
1160 1170 1180 1190 1200
PMKVPRCHSD PPNPHLIIPT PEGFSTRSMP SDARSHGSPA AAAAAAAAAV
1210 1220 1230 1240 1250
AASRPSPSGG DSVLPKSISS AHDTRGSSVP ENDRLASIAA ELQFRSLSRH
1260 1270 1280 1290 1300
SSPTEERDEP AYPRGDSSGS TRRSWELRTL ISQSKDTASK LGPIEAIQKS
1310 1320 1330 1340 1350
VRLFEEKRYR EMRRKNIIGQ VCDTPKSYDN VMHVGLRKVT FKWQRGNKIG
1360 1370 1380 1390 1400
EGQYGKVYTC ISVDTGELMA MKEIRFQPND HKTIKETADE LKIFEGIKHP
1410 1420 1430 1440 1450
NLVRYFGVEL HREEMYIFME YCDEGTLEEV SRLGLQEHVI RLYSKQITIA
1460 1470 1480 1490 1500
INVLHEHGIV HRDIKGANIF LTSSGLIKLG DFGCSVKLKN NAQTMPGEVN
1510 1520 1530 1540 1550
STLGTAAYMA PEVITRAKGE GHGRAADIWS LGCVVIEMVT GKRPWHEYEH
1560 1570 1580 1590 1600
NFQIMYKVGM GHKPPIPERL SPEGKDFLSH CLESDPKMRW TASQLLDHSF

VKVCTDEE
Length:1,608
Mass (Da):181,685
Last modified:May 18, 2010 - v2
Checksum:iC22294914945EA91
GO
Isoform 2 (identifier: Q9Y6R4-2) [UniParc]FASTAAdd to Basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1175-1224: Missing.

Show »
Length:1,558
Mass (Da):177,014
Checksum:i4F94E9CF82E88354
GO

Sequence cautioni

The sequence BAA13204.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAC12766.2 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAH70639.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAH70640.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI20815.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI20816.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI21477.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI41309.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI41310.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351P → PP in AAI36277. (PubMed:15489334)Curated
Sequence conflicti500 – 5001E → D in AAI46771. (PubMed:15489334)Curated
Sequence conflicti791 – 7911R → I in AAB68804. (PubMed:9305639)Curated
Sequence conflicti1190 – 11901Missing in EAW47587. 1 PublicationCurated
Sequence conflicti1190 – 11901Missing in AAI43736. (PubMed:15489334)Curated
Sequence conflicti1190 – 11901Missing in AAI36277. (PubMed:15489334)Curated
Sequence conflicti1199 – 11991Missing in AAB68804. (PubMed:9305639)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti157 – 1571R → H.1 Publication
Corresponds to variant rs4559074 [ dbSNP | Ensembl ].
VAR_059767
Natural varianti294 – 2941I → T.1 Publication
Corresponds to variant rs35842248 [ dbSNP | Ensembl ].
VAR_040686
Natural varianti335 – 3351V → I.1 Publication
Corresponds to variant rs35730939 [ dbSNP | Ensembl ].
VAR_040687
Natural varianti566 – 5661R → H.1 Publication
Corresponds to variant rs55765351 [ dbSNP | Ensembl ].
VAR_040688
Natural varianti584 – 5841Q → H.1 Publication
Corresponds to variant rs34018542 [ dbSNP | Ensembl ].
VAR_040689
Natural varianti906 – 9061H → P.1 Publication
Corresponds to variant rs35533223 [ dbSNP | Ensembl ].
VAR_040690
Natural varianti1413 – 14131E → Q in an ovarian serous carcinoma sample; somatic mutation. 1 Publication
VAR_040691
Natural varianti1492 – 14921A → V.1 Publication
Corresponds to variant rs41267837 [ dbSNP | Ensembl ].
VAR_040692

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1175 – 122450Missing in isoform 2. 2 PublicationsVSP_004884Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002715 mRNA. Translation: AAB68804.1.
D86968 mRNA. Translation: BAA13204.2. Different initiation.
AL109942
, AL139393, AL591045, AL596452 Genomic DNA. Translation: CAC12766.2. Sequence problems.
AL109942
, AL139393, AL591045, AL596452 Genomic DNA. Translation: CAI21477.1. Sequence problems.
AL139393
, AL109942, AL591045, AL596452 Genomic DNA. Translation: CAI20815.1. Sequence problems.
AL139393
, AL109942, AL591045, AL596452 Genomic DNA. Translation: CAI20816.1. Sequence problems.
AL591045
, AL109942, AL139393, AL596452 Genomic DNA. Translation: CAH70639.1. Sequence problems.
AL591045
, AL109942, AL139393, AL596452 Genomic DNA. Translation: CAH70640.1. Sequence problems.
AL596452
, AL109942, AL139393, AL591045 Genomic DNA. Translation: CAI41309.1. Sequence problems.
AL596452
, AL109942, AL139393, AL591045 Genomic DNA. Translation: CAI41310.1. Sequence problems.
CH471051 Genomic DNA. Translation: EAW47587.1.
BC136276 mRNA. Translation: AAI36277.1.
BC143735 mRNA. Translation: AAI43736.1.
BC146770 mRNA. Translation: AAI46771.1.
CCDSiCCDS34565.1. [Q9Y6R4-1]
CCDS34566.1. [Q9Y6R4-2]
PIRiT03022.
RefSeqiNP_001278887.1. NM_001291958.1.
NP_001288001.1. NM_001301072.1.
NP_005913.2. NM_005922.3.
NP_006715.2. NM_006724.3.
UniGeneiHs.390428.

Genome annotation databases

EnsembliENST00000366919; ENSP00000355886; ENSG00000085511. [Q9Y6R4-2]
ENST00000392142; ENSP00000375986; ENSG00000085511. [Q9Y6R4-1]
GeneIDi4216.
KEGGihsa:4216.
UCSCiuc003qtn.3. human. [Q9Y6R4-1]
uc003qto.3. human. [Q9Y6R4-2]

Polymorphism databases

DMDMi296434576.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF002715 mRNA. Translation: AAB68804.1 .
D86968 mRNA. Translation: BAA13204.2 . Different initiation.
AL109942
, AL139393 , AL591045 , AL596452 Genomic DNA. Translation: CAC12766.2 . Sequence problems.
AL109942
, AL139393 , AL591045 , AL596452 Genomic DNA. Translation: CAI21477.1 . Sequence problems.
AL139393
, AL109942 , AL591045 , AL596452 Genomic DNA. Translation: CAI20815.1 . Sequence problems.
AL139393
, AL109942 , AL591045 , AL596452 Genomic DNA. Translation: CAI20816.1 . Sequence problems.
AL591045
, AL109942 , AL139393 , AL596452 Genomic DNA. Translation: CAH70639.1 . Sequence problems.
AL591045
, AL109942 , AL139393 , AL596452 Genomic DNA. Translation: CAH70640.1 . Sequence problems.
AL596452
, AL109942 , AL139393 , AL591045 Genomic DNA. Translation: CAI41309.1 . Sequence problems.
AL596452
, AL109942 , AL139393 , AL591045 Genomic DNA. Translation: CAI41310.1 . Sequence problems.
CH471051 Genomic DNA. Translation: EAW47587.1 .
BC136276 mRNA. Translation: AAI36277.1 .
BC143735 mRNA. Translation: AAI43736.1 .
BC146770 mRNA. Translation: AAI46771.1 .
CCDSi CCDS34565.1. [Q9Y6R4-1 ]
CCDS34566.1. [Q9Y6R4-2 ]
PIRi T03022.
RefSeqi NP_001278887.1. NM_001291958.1.
NP_001288001.1. NM_001301072.1.
NP_005913.2. NM_005922.3.
NP_006715.2. NM_006724.3.
UniGenei Hs.390428.

3D structure databases

ProteinModelPortali Q9Y6R4.
SMRi Q9Y6R4. Positions 1301-1603.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110380. 22 interactions.
IntActi Q9Y6R4. 13 interactions.
MINTi MINT-1213156.
STRINGi 9606.ENSP00000375986.

Chemistry

BindingDBi Q9Y6R4.
ChEMBLi CHEMBL4853.
GuidetoPHARMACOLOGYi 2079.

PTM databases

PhosphoSitei Q9Y6R4.

Polymorphism databases

DMDMi 296434576.

Proteomic databases

MaxQBi Q9Y6R4.
PaxDbi Q9Y6R4.
PRIDEi Q9Y6R4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000366919 ; ENSP00000355886 ; ENSG00000085511 . [Q9Y6R4-2 ]
ENST00000392142 ; ENSP00000375986 ; ENSG00000085511 . [Q9Y6R4-1 ]
GeneIDi 4216.
KEGGi hsa:4216.
UCSCi uc003qtn.3. human. [Q9Y6R4-1 ]
uc003qto.3. human. [Q9Y6R4-2 ]

Organism-specific databases

CTDi 4216.
GeneCardsi GC06P161412.
H-InvDB HIX0151295.
HGNCi HGNC:6856. MAP3K4.
HPAi HPA007625.
MIMi 602425. gene.
neXtProti NX_Q9Y6R4.
PharmGKBi PA30600.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00590000083157.
HOVERGENi HBG006304.
InParanoidi Q9Y6R4.
KOi K04428.
OMAi FVKVCTD.
OrthoDBi EOG7P5T02.
PhylomeDBi Q9Y6R4.
TreeFami TF105114.

Enzyme and pathway databases

BRENDAi 2.7.12.2. 2681.
SignaLinki Q9Y6R4.

Miscellaneous databases

ChiTaRSi MAP3K4. human.
GeneWikii MAP3K4.
GenomeRNAii 4216.
NextBioi 16627.
PROi Q9Y6R4.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y6R4.
CleanExi HS_MAP3K4.
ExpressionAtlasi Q9Y6R4. baseline and differential.
Genevestigatori Q9Y6R4.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways."
    Takekawa M., Posas F., Saito H.
    EMBO J. 16:4973-4982(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, ALTERNATIVE SPLICING, MUTAGENESIS OF LYS-1372.
    Tissue: Fetal liver and Skeletal muscle.
  2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Bone marrow.
  3. Ohara O., Nagase T., Kikuno R., Nomura N.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT HIS-157.
    Tissue: Cerebellum.
  7. "Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding."
    Mita H., Tsutsui J., Takekawa M., Witten E.A., Saito H.
    Mol. Cell. Biol. 22:4544-4555(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME REGULATION, INTERACTION WITH GADD45 AND MAP2K6, MUTAGENESIS OF LYS-1372.
  8. "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms."
    Wong C.K., Luo W., Deng Y., Zou H., Ye Z., Lin S.-C.
    J. Biol. Chem. 279:39366-39373(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AXIN1 AND DIXDC1.
  9. "MEKK4 is an effector of the embryonic TRAF4 for JNK activation."
    Abell A.N., Johnson G.L.
    J. Biol. Chem. 280:35793-35796(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TRAF4.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-499, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-456; SER-457; THR-458 AND SER-461, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-294; ILE-335; HIS-566; HIS-584; PRO-906; GLN-1413 AND VAL-1492.

Entry informationi

Entry nameiM3K4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6R4
Secondary accession number(s): A6H8W0
, B7ZLD3, B9EG75, Q5VTT8, Q5VTT9, Q92612, Q9H408
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3