##gff-version 3 Q9Y6R1 UniProtKB Chain 1 1079 . . . ID=PRO_0000079227;Note=Electrogenic sodium bicarbonate cotransporter 1 Q9Y6R1 UniProtKB Topological domain 1 466 . . . Note=Cytoplasmic;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Transmembrane 467 491 . . . Note=Helical%3B Name%3D1;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Topological domain 492 501 . . . Note=Extracellular;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Transmembrane 502 520 . . . Note=Helical%3B Name%3D2;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Topological domain 521 521 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Transmembrane 522 542 . . . Note=Discontinuously helical%3B Name%3D3;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:29500354;Dbxref=PMID:29500354 Q9Y6R1 UniProtKB Topological domain 543 550 . . . Note=Extracellular;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Transmembrane 551 571 . . . Note=Helical%3B Name%3D4;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Topological domain 572 585 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Transmembrane 586 609 . . . Note=Helical%3B Name%3D5;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:29500354;Dbxref=PMID:29500354 Q9Y6R1 UniProtKB Topological domain 610 692 . . . Note=Extracellular;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Transmembrane 693 710 . . . Note=Helical%3B Name%3D6;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Topological domain 711 725 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Transmembrane 726 745 . . . Note=Helical%3B Name%3D7;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Topological domain 746 779 . . . Note=Extracellular;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Transmembrane 780 807 . . . Note=Helical%3B Name%3D8;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Topological domain 808 819 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Transmembrane 820 836 . . . Note=Helical%3B Name%3D9;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Topological domain 837 837 . . . Note=Extracellular;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Transmembrane 838 855 . . . Note=Discontinuously helical%3B Name%3D10;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:29500354;Dbxref=PMID:29500354 Q9Y6R1 UniProtKB Topological domain 856 877 . . . Note=Cytoplasmic;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Transmembrane 878 894 . . . Note=Helical%3B Name%3D11;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Topological domain 895 901 . . . Note=Extracellular;Ontology_term=ECO:0000305,ECO:0000305;evidence=ECO:0000305|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Transmembrane 902 918 . . . Note=Helical%3B Name%3D12;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:29500354;Dbxref=PMID:29500354 Q9Y6R1 UniProtKB Topological domain 919 960 . . . Note=Cytoplasmic;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Intramembrane 961 986 . . . Note=Discontinuously helical;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:29500354;Dbxref=PMID:29500354 Q9Y6R1 UniProtKB Topological domain 987 1079 . . . Note=Cytoplasmic;Ontology_term=ECO:0000269,ECO:0000305;evidence=ECO:0000269|PubMed:12534288,ECO:0000305|PubMed:29500354;Dbxref=PMID:12534288,PMID:29500354 Q9Y6R1 UniProtKB Region 1 62 . . . Note=Required for interaction with AHCYL1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16769890;Dbxref=PMID:16769890 Q9Y6R1 UniProtKB Region 39 78 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y6R1 UniProtKB Region 238 265 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y6R1 UniProtKB Region 748 779 . . . Note=Interaction with CA4 Q9Y6R1 UniProtKB Region 1002 1004 . . . Note=CA2-binding Q9Y6R1 UniProtKB Region 1012 1079 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y6R1 UniProtKB Region 1030 1033 . . . Note=CA2-binding Q9Y6R1 UniProtKB Region 1057 1059 . . . Note=Required for basolateral targeting Q9Y6R1 UniProtKB Compositional bias 39 53 . . . Note=Basic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y6R1 UniProtKB Compositional bias 54 73 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y6R1 UniProtKB Compositional bias 238 260 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y6R1 UniProtKB Compositional bias 1012 1039 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y6R1 UniProtKB Compositional bias 1060 1079 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y6R1 UniProtKB Modified residue 30 30 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88343 Q9Y6R1 UniProtKB Modified residue 49 49 . . . Note=Phosphothreonine%3B by PKA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12730338;Dbxref=PMID:12730338 Q9Y6R1 UniProtKB Modified residue 61 61 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88343 Q9Y6R1 UniProtKB Modified residue 65 65 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88343 Q9Y6R1 UniProtKB Modified residue 68 68 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88343 Q9Y6R1 UniProtKB Modified residue 223 223 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88343 Q9Y6R1 UniProtKB Modified residue 232 232 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88343 Q9Y6R1 UniProtKB Modified residue 233 233 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88343 Q9Y6R1 UniProtKB Modified residue 245 245 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88343 Q9Y6R1 UniProtKB Modified residue 249 249 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JI66 Q9Y6R1 UniProtKB Modified residue 254 254 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q9Y6R1 UniProtKB Modified residue 256 256 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88343 Q9Y6R1 UniProtKB Modified residue 257 257 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q9Y6R1 UniProtKB Modified residue 262 262 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88343 Q9Y6R1 UniProtKB Modified residue 1026 1026 . . . Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11744745,ECO:0000269|PubMed:12411514,ECO:0000269|PubMed:12730338;Dbxref=PMID:11744745,PMID:12411514,PMID:12730338 Q9Y6R1 UniProtKB Modified residue 1029 1029 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88343 Q9Y6R1 UniProtKB Modified residue 1034 1034 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q9Y6R1 UniProtKB Modified residue 1044 1044 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O88343 Q9Y6R1 UniProtKB Modified residue 1069 1069 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9JI66 Q9Y6R1 UniProtKB Alternative sequence 1 44 . . . ID=VSP_016704;Note=In isoform 2 and isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9235899;Dbxref=PMID:15489334,PMID:9235899 Q9Y6R1 UniProtKB Alternative sequence 45 85 . . . ID=VSP_016705;Note=In isoform 2 and isoform 3. HKRKTGHKEKKEKERISENYSDKSDIENADESSSSILKPLI->MSTENVEGKPSNLGERGRARSSTFLRVVQPMFNHSIFTSAV;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9235899;Dbxref=PMID:15489334,PMID:9235899 Q9Y6R1 UniProtKB Alternative sequence 635 690 . . . ID=VSP_016706;Note=In isoform 3. ANISISNDTTLAPEYLPTMSSTDMYHNTTFDWAFLSKKECSKYGGNLVGNNCNFVP->GEGITLCVYARFVFGGRCRLHACKFSTCCHGPQELVLFFSLKNSATEFDVSLPEVF;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9Y6R1 UniProtKB Alternative sequence 691 1079 . . . ID=VSP_016707;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9Y6R1 UniProtKB Alternative sequence 813 896 . . . ID=VSP_016708;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.5 Q9Y6R1 UniProtKB Alternative sequence 1034 1079 . . . ID=VSP_041003;Note=In isoform 5. SDCPYSEKVPSIKIPMDIMEQQPFLSDSKPSDRERSPTFLERHTSC->EKDHQHSLNATHHADKIPFLQSLGMPSPPRTPVKVVPQIRIELEPEDNDYFWRSKGTETTL;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.6 Q9Y6R1 UniProtKB Natural variant 342 342 . . . ID=VAR_024751;Note=In pRTA-OA%3B decreased localization to the basolateral membrane%3B mistargeting to the apical membrane probably explains the loss of the cotransporter activity. R->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000303;evidence=ECO:0000269|PubMed:10545938,ECO:0000269|PubMed:15713912,ECO:0000269|PubMed:15930088,ECO:0000303|PubMed:17661077;Dbxref=dbSNP:rs121908856,PMID:10545938,PMID:15713912,PMID:15930088,PMID:17661077 Q9Y6R1 UniProtKB Natural variant 471 471 . . . ID=VAR_024752;Note=In pRTA-OA%3B mistargeting to the apical membrane and altered function. S->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:15471865,ECO:0000269|PubMed:15713912;Dbxref=PMID:15471865,PMID:15713912 Q9Y6R1 UniProtKB Natural variant 529 529 . . . ID=VAR_024753;Note=In pRTA-OA%3B decreased cotransporter activity%3B mediates electroneutral sodium/bicarbonate cotransport rather than electrogenic sodium/bicarbonate cotransport%3B no effect on cell membrane localization. T->S;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000303;evidence=ECO:0000269|PubMed:15930088,ECO:0000269|PubMed:23636456,ECO:0000303|PubMed:17661077;Dbxref=PMID:15930088,PMID:17661077,PMID:23636456 Q9Y6R1 UniProtKB Natural variant 530 530 . . . ID=VAR_071661;Note=In pRTA-OA%3B decreased cotransporter activity%3B no effect on localization to the basolateral membrane. G->R;Ontology_term=ECO:0000269,ECO:0000303;evidence=ECO:0000269|PubMed:23636456,ECO:0000303|PubMed:17661077;Dbxref=PMID:17661077,PMID:23636456 Q9Y6R1 UniProtKB Natural variant 554 554 . . . ID=VAR_024754;Note=In pRTA-OA%3B mistargeting and altered function. R->H;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10545938,ECO:0000269|PubMed:15713912,ECO:0000269|PubMed:15930088;Dbxref=dbSNP:rs121908857,PMID:10545938,PMID:15713912,PMID:15930088 Q9Y6R1 UniProtKB Natural variant 566 566 . . . ID=VAR_071662;Note=In pRTA-OA%3B loss of localization to the plasma membrane%3B the retention in the cytoplasm probably explains the loss of the cotransporter activity. L->P;Ontology_term=ECO:0000269,ECO:0000303;evidence=ECO:0000269|PubMed:16636648,ECO:0000303|PubMed:17661077;Dbxref=PMID:16636648,PMID:17661077 Q9Y6R1 UniProtKB Natural variant 843 843 . . . ID=VAR_024755;Note=In pRTA-OA%3B altered function. A->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15930088;Dbxref=PMID:15930088 Q9Y6R1 UniProtKB Natural variant 925 925 . . . ID=VAR_024756;Note=In pRTA-OA%3B altered function. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15930088;Dbxref=dbSNP:rs1203164637,PMID:15930088 Q9Y6R1 UniProtKB Mutagenesis 49 49 . . . Note=Loss of conductance regulation by cAMP%3B isoform 1. T->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12730338;Dbxref=PMID:12730338 Q9Y6R1 UniProtKB Mutagenesis 49 49 . . . Note=Loss of conductance regulation by cAMP%3B isoform 1. T->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12730338;Dbxref=PMID:12730338 Q9Y6R1 UniProtKB Mutagenesis 135 135 . . . Note=Mistargeting and altered function. E->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15713912;Dbxref=PMID:15713912 Q9Y6R1 UniProtKB Mutagenesis 477 477 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 493 493 . . . Note=Prevents membrane targeting. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 494 494 . . . Note=Prevents membrane targeting. A->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 503 503 . . . Note=Strong reduction of the sodium-dependent ion transport activity. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 504 504 . . . Note=Prevents membrane targeting. S->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 527 529 . . . Note=Confers anion exchange activity%3B when associated with E-798%3B S-842%3B T-844 and R-847. SST->GFS;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29500354;Dbxref=PMID:29500354 Q9Y6R1 UniProtKB Mutagenesis 527 527 . . . Note=Severely reduces transporter activity. S->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29500354;Dbxref=PMID:29500354 Q9Y6R1 UniProtKB Mutagenesis 536 536 . . . Note=Prevents membrane targeting. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 552 552 . . . Note=Prevents membrane targeting. E->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 554 554 . . . Note=Prevents membrane targeting. R->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 582 582 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. R->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 582 582 . . . Note=Strong reduction of the sodium-dependent ion transport activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 586 586 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 599 599 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 600 600 . . . Note=Strong reduction of the sodium-dependent ion transport activity. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 602 602 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 603 603 . . . Note=Strong reduction of the sodium-dependent ion transport activity. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 691 691 . . . Note=Strong reduction of the sodium-dependent ion transport activity. D->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 700 700 . . . Note=Strong reduction of the sodium-dependent ion transport activity. F->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 711 711 . . . Note=Strong reduction of the sodium-dependent ion transport activity. K->E%2CN%2CQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 711 711 . . . Note=No effect on the sodium-dependent ion transport activity. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 712 712 . . . Note=Strong reduction of the sodium-dependent ion transport activity. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 714 714 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 715 715 . . . Note=Strong reduction of the sodium-dependent ion transport activity. T->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 721 721 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. T->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 724 724 . . . Note=Strong reduction of the sodium-dependent ion transport activity. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 725 725 . . . Note=Strong reduction of the sodium-dependent ion transport activity. K->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 728 728 . . . Note=Strong reduction of the sodium-dependent ion transport activity. S->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 729 729 . . . Note=Strong reduction of the sodium-dependent ion transport activity. D->N%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 743 743 . . . Note=Prevents membrane targeting. D->K%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 749 749 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 752 752 . . . Note=Prevents membrane targeting. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 766 766 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. R->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 767 767 . . . Note=Alters interaction with CA4. G->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14567693;Dbxref=PMID:14567693 Q9Y6R1 UniProtKB Mutagenesis 775 775 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. E->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 798 798 . . . Note=Abolishes transporter activity. D->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29500354;Dbxref=PMID:29500354 Q9Y6R1 UniProtKB Mutagenesis 798 798 . . . Note=Severely reduces transporter activity. Confers anion exchange activity%3B when associated with SST-527--529-GFS%3B S-842%3B T-844 and R-847. D->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29500354;Dbxref=PMID:29500354 Q9Y6R1 UniProtKB Mutagenesis 798 798 . . . Note=Strong reduction of the sodium-dependent ion transport activity. D->N%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 802 802 . . . Note=Abolishes transporter activity. T->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29500354;Dbxref=PMID:29500354 Q9Y6R1 UniProtKB Mutagenesis 808 809 . . . Note=Strong reduction of the sodium-dependent ion transport activity. RK->NN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 814 815 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. KK->NN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 820 820 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. H->D%2CN%2CS%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 822 822 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 842 842 . . . Note=Confers anion exchange activity%3B when associated with SST-527--529-GFS%3B D-798%3B T-844 and R-847. V->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29500354;Dbxref=PMID:29500354 Q9Y6R1 UniProtKB Mutagenesis 844 844 . . . Note=Confers anion exchange activity%3B when associated with SST-527--529-GFS%3B D-798%3B S-842 and R-847. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29500354;Dbxref=PMID:29500354 Q9Y6R1 UniProtKB Mutagenesis 845 845 . . . Note=Strongly reduces transporter activity. T->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29500354;Dbxref=PMID:29500354 Q9Y6R1 UniProtKB Mutagenesis 847 847 . . . Note=Abolishes transporter activity. Confers anion exchange activity%3B when associated with SST-527--529-GFS%3B D-798%3B S-842 and T-844. I->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29500354;Dbxref=PMID:29500354 Q9Y6R1 UniProtKB Mutagenesis 851 851 . . . Note=Prevents membrane targeting. H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 853 853 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 858 860 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. ETE->MSK;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 875 877 . . . Note=Prevents membrane targeting. EQR->QQQ;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 875 875 . . . Note=Strong reduction of the sodium-dependent ion transport activity. E->Q Q9Y6R1 UniProtKB Mutagenesis 898 898 . . . Note=Strong reduction of the sodium-dependent ion transport activity. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 925 927 . . . Note=Prevents membrane targeting. RLK->NLN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 948 948 . . . Note=Strong reduction of the sodium-dependent ion transport activity. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 949 949 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 951 951 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. H->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 951 951 . . . Note=Prevents membrane targeting. H->N%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 968 968 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 987 987 . . . Note=Moderate reduction of the sodium-dependent ion transport activity. R->E%2CN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15817634;Dbxref=PMID:15817634 Q9Y6R1 UniProtKB Mutagenesis 1002 1002 . . . Note=Partial loss of interaction with CA2. L->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15218065;Dbxref=PMID:15218065 Q9Y6R1 UniProtKB Mutagenesis 1003 1003 . . . Note=Abolishes interaction with CA2. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15218065;Dbxref=PMID:15218065 Q9Y6R1 UniProtKB Mutagenesis 1004 1004 . . . Note=Partial loss of interaction with CA2. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15218065;Dbxref=PMID:15218065 Q9Y6R1 UniProtKB Mutagenesis 1026 1026 . . . Note=Prevents phosphorylation by PKA. Loss of regulation by cAMP of the transporter stoichiometry. S->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11744745,ECO:0000269|PubMed:12730338;Dbxref=PMID:11744745,PMID:12730338 Q9Y6R1 UniProtKB Mutagenesis 1026 1026 . . . Note=Loss of regulation by cAMP of the transporter stoichiometry. Shifts transporter stoichiometry from 3:1 to 2:1. S->D;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:11744745,ECO:0000269|PubMed:12730338;Dbxref=PMID:11744745,PMID:12730338 Q9Y6R1 UniProtKB Mutagenesis 1030 1033 . . . Note=Abolishes interaction with CA2. DNDD->NNNN;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15218065;Dbxref=PMID:15218065 Q9Y6R1 UniProtKB Mutagenesis 1030 1030 . . . Note=Loss of regulation by cAMP of the transporter stoichiometry. Abolishes interaction with CA2. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12411514;Dbxref=PMID:12411514 Q9Y6R1 UniProtKB Mutagenesis 1032 1032 . . . Note=Loss of regulation by cAMP of the transporter stoichiometry. Partial loss of interaction with CA2. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12411514;Dbxref=PMID:12411514 Q9Y6R1 UniProtKB Mutagenesis 1033 1033 . . . Note=No effect on regulation by cAMP of the transporter stoichiometry. Partial loss of interaction with CA2. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12411514;Dbxref=PMID:12411514 Q9Y6R1 UniProtKB Mutagenesis 1057 1057 . . . Note=Targeting to apical membrane. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15273250;Dbxref=PMID:15273250 Q9Y6R1 UniProtKB Sequence conflict 6 6 . . . Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y6R1 UniProtKB Sequence conflict 49 49 . . . Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y6R1 UniProtKB Sequence conflict 78 78 . . . Note=S->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y6R1 UniProtKB Sequence conflict 256 256 . . . Note=S->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y6R1 UniProtKB Sequence conflict 263 263 . . . Note=D->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y6R1 UniProtKB Sequence conflict 298 298 . . . Note=P->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y6R1 UniProtKB Sequence conflict 364 364 . . . Note=H->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y6R1 UniProtKB Sequence conflict 605 605 . . . Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y6R1 UniProtKB Sequence conflict 654 654 . . . Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y6R1 UniProtKB Sequence conflict 749 749 . . . Note=D->G;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y6R1 UniProtKB Sequence conflict 799 799 . . . Note=Q->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y6R1 UniProtKB Sequence conflict 856 856 . . . Note=K->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y6R1 UniProtKB Sequence conflict 912 912 . . . Note=M->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y6R1 UniProtKB Sequence conflict 913 913 . . . Note=G->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y6R1 UniProtKB Sequence conflict 940 940 . . . Note=I->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y6R1 UniProtKB Sequence conflict 1007 1007 . . . Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y6R1 UniProtKB Sequence conflict 1069 1069 . . . Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y6R1 UniProtKB Glycosylation 597 597 . . . Note=N-linked (GalNAc) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25568315;Dbxref=PMID:25568315 Q9Y6R1 UniProtKB Glycosylation 617 617 . . . Note=N-linked (GalNAc) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25568315;Dbxref=PMID:25568315 Q9Y6R1 UniProtKB Disulfide bond 583 585 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25568315;Dbxref=PMID:25568315 Q9Y6R1 UniProtKB Disulfide bond 630 642 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:25568315;Dbxref=PMID:25568315