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Q9Y6R0

- NUMBL_HUMAN

UniProt

Q9Y6R0 - NUMBL_HUMAN

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Protein

Numb-like protein

Gene
NUMBL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.2 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. adherens junction organization Source: Ensembl
  2. axonogenesis Source: Ensembl
  3. cytokine-mediated signaling pathway Source: UniProtKB
  4. lateral ventricle development Source: UniProtKB
  5. nervous system development Source: ProtInc
  6. neuroblast division in subventricular zone Source: UniProtKB
  7. positive regulation of dendrite morphogenesis Source: Ensembl
  8. positive regulation of neurogenesis Source: UniProtKB
  9. protein metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Neurogenesis, Ubl conjugation pathway

Enzyme and pathway databases

SignaLinkiQ9Y6R0.

Names & Taxonomyi

Protein namesi
Recommended name:
Numb-like protein
Alternative name(s):
Numb-related protein
Short name:
Numb-R
Gene namesi
Name:NUMBL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:8061. NUMBL.

Subcellular locationi

Cytoplasm By similarity
Note: Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS By similarity.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31846.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 609609Numb-like proteinPRO_0000057999Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei279 – 2791Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y6R0.
PaxDbiQ9Y6R0.
PRIDEiQ9Y6R0.

PTM databases

PhosphoSiteiQ9Y6R0.

Expressioni

Gene expression databases

ArrayExpressiQ9Y6R0.
BgeeiQ9Y6R0.
CleanExiHS_NUMBL.
GenevestigatoriQ9Y6R0.

Organism-specific databases

HPAiHPA058251.
HPA058380.

Interactioni

Subunit structurei

Interacts (via PTB domain) with MAP3K7IP2 (via C-terminal). Interacts (via C-terminal) with TRAF6 (via TRAF domains). Associates with EPS15 and NOTCH1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RBFOX1Q9NWB12EBI-945925,EBI-945906

Protein-protein interaction databases

BioGridi114677. 20 interactions.
IntActiQ9Y6R0. 18 interactions.
MINTiMINT-1497553.
STRINGi9606.ENSP00000252891.

Structurei

Secondary structure

1
609
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni64 – 663
Helixi67 – 748
Beta strandi78 – 9114
Helixi96 – 10712
Beta strandi114 – 1207
Beta strandi122 – 1298
Turni130 – 1323
Beta strandi135 – 1406
Helixi141 – 1433
Beta strandi144 – 1496
Beta strandi156 – 1638
Turni164 – 1674
Beta strandi168 – 17912
Helixi181 – 20121

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3F0WX-ray2.70A60-204[»]
ProteinModelPortaliQ9Y6R0.
SMRiQ9Y6R0. Positions 60-202.

Miscellaneous databases

EvolutionaryTraceiQ9Y6R0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 223150PIDAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi427 – 44620Poly-GlnAdd
BLAST

Domaini

The PTB domain is necessary for the inhibition of MAP3K7IP2-mediated activation of NF-kappa-B.

Sequence similaritiesi

Contains 1 PID domain.

Phylogenomic databases

eggNOGiNOG331167.
HOGENOMiHOG000220819.
HOVERGENiHBG006672.
InParanoidiQ9Y6R0.
KOiK06057.
OMAiPEQHLPP.
OrthoDBiEOG7MKW5J.
PhylomeDBiQ9Y6R0.
TreeFamiTF314159.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR016698. Numb/numb-like.
IPR010449. Numb_domain.
IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view]
PfamiPF06311. NumbF. 1 hit.
PF00640. PID. 1 hit.
[Graphical view]
PIRSFiPIRSF017607. Numb/numb-like. 1 hit.
SMARTiSM00462. PTB. 1 hit.
[Graphical view]
PROSITEiPS01179. PID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y6R0-1 [UniParc]FASTAAdd to Basket

« Hide

MSRSAAASGG PRRPERHLPP APCGAPGPPE TCRTEPDGAG TMNKLRQSLR    50
RRKPAYVPEA SRPHQWQADE DAVRKGTCSF PVRYLGHVEV EESRGMHVCE 100
DAVKKLKAMG RKSVKSVLWV SADGLRVVDD KTKDLLVDQT IEKVSFCAPD 150
RNLDKAFSYI CRDGTTRRWI CHCFLALKDS GERLSHAVGC AFAACLERKQ 200
RREKECGVTA AFDASRTSFA REGSFRLSGG GRPAEREAPD KKKAEAAAAP 250
TVAPGPAQPG HVSPTPATTS PGEKGEAGTP VAAGTTAAAI PRRHAPLEQL 300
VRQGSFRGFP ALSQKNSPFK RQLSLRLNEL PSTLQRRTDF QVKGTVPEME 350
PPGAGDSDSI NALCTQISSS FASAGAPAPG PPPATTGTSA WGEPSVPPAA 400
AFQPGHKRTP SEAERWLEEV SQVAKAQQQQ QQQQQQQQQQ QQQQQQAASV 450
APVPTMPPAL QPFPAPVGPF DAAPAQVAVF LPPPHMQPPF VPAYPGLGYP 500
PMPRVPVVGI TPSQMVANAF CSAAQLQPQP ATLLGKAGAF PPPAIPSAPG 550
SQARPRPNGA PWPPEPAPAP APELDPFEAQ WAALEGKATV EKPSNPFSGD 600
LQKTFEIEL 609
Length:609
Mass (Da):64,891
Last modified:November 1, 1999 - v1
Checksum:i69458D161B60F4B4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF015041 mRNA. Translation: AAD01549.1.
BC001794 mRNA. No translation available.
BT009807 mRNA. Translation: AAP88809.1.
CCDSiCCDS12561.1.
RefSeqiNP_001276908.1. NM_001289979.1.
NP_001276909.1. NM_001289980.1.
NP_004747.1. NM_004756.4.
UniGeneiHs.326953.

Genome annotation databases

EnsembliENST00000252891; ENSP00000252891; ENSG00000105245.
ENST00000540131; ENSP00000442759; ENSG00000105245.
ENST00000598779; ENSP00000472400; ENSG00000105245.
GeneIDi9253.
KEGGihsa:9253.
UCSCiuc002oon.3. human.

Polymorphism databases

DMDMi14194976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF015041 mRNA. Translation: AAD01549.1 .
BC001794 mRNA. No translation available.
BT009807 mRNA. Translation: AAP88809.1 .
CCDSi CCDS12561.1.
RefSeqi NP_001276908.1. NM_001289979.1.
NP_001276909.1. NM_001289980.1.
NP_004747.1. NM_004756.4.
UniGenei Hs.326953.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3F0W X-ray 2.70 A 60-204 [» ]
ProteinModelPortali Q9Y6R0.
SMRi Q9Y6R0. Positions 60-202.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114677. 20 interactions.
IntActi Q9Y6R0. 18 interactions.
MINTi MINT-1497553.
STRINGi 9606.ENSP00000252891.

PTM databases

PhosphoSitei Q9Y6R0.

Polymorphism databases

DMDMi 14194976.

Proteomic databases

MaxQBi Q9Y6R0.
PaxDbi Q9Y6R0.
PRIDEi Q9Y6R0.

Protocols and materials databases

DNASUi 9253.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252891 ; ENSP00000252891 ; ENSG00000105245 .
ENST00000540131 ; ENSP00000442759 ; ENSG00000105245 .
ENST00000598779 ; ENSP00000472400 ; ENSG00000105245 .
GeneIDi 9253.
KEGGi hsa:9253.
UCSCi uc002oon.3. human.

Organism-specific databases

CTDi 9253.
GeneCardsi GC19M041171.
HGNCi HGNC:8061. NUMBL.
HPAi HPA058251.
HPA058380.
MIMi 604018. gene.
neXtProti NX_Q9Y6R0.
PharmGKBi PA31846.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG331167.
HOGENOMi HOG000220819.
HOVERGENi HBG006672.
InParanoidi Q9Y6R0.
KOi K06057.
OMAi PEQHLPP.
OrthoDBi EOG7MKW5J.
PhylomeDBi Q9Y6R0.
TreeFami TF314159.

Enzyme and pathway databases

SignaLinki Q9Y6R0.

Miscellaneous databases

ChiTaRSi NUMBL. human.
EvolutionaryTracei Q9Y6R0.
GeneWikii NUMBL.
GenomeRNAii 9253.
NextBioi 34685.
PROi Q9Y6R0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y6R0.
Bgeei Q9Y6R0.
CleanExi HS_NUMBL.
Genevestigatori Q9Y6R0.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR016698. Numb/numb-like.
IPR010449. Numb_domain.
IPR011993. PH_like_dom.
IPR006020. PTB/PI_dom.
[Graphical view ]
Pfami PF06311. NumbF. 1 hit.
PF00640. PID. 1 hit.
[Graphical view ]
PIRSFi PIRSF017607. Numb/numb-like. 1 hit.
SMARTi SM00462. PTB. 1 hit.
[Graphical view ]
PROSITEi PS01179. PID. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module."
    Salcini A.E., Confalonieri S., Doria M., Santolini E., Tassi E., Minenkova O., Cesareni G., Pelicci P.G., Di Fiore P.P.
    Genes Dev. 11:2239-2249(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-609.
    Tissue: Eye.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-609.
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation."
    Ma Q., Zhou L., Shi H., Huo K.
    Cell. Signal. 20:1044-1051(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MAP3K7IP2, SUBCELLULAR LOCATION.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-279, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "NUMBL interacts with TRAF6 and promotes the degradation of TRAF6."
    Zhou L., Ma Q., Shi H., Huo K.
    Biochem. Biophys. Res. Commun. 392:409-414(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TRAF6.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Human numb-like protein, phosphotyrosine interaction domain."
    Structural genomics consortium (SGC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 60-204.

Entry informationi

Entry nameiNUMBL_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6R0
Secondary accession number(s): Q7Z4J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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