Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear receptor coactivator 3

Gene

NCOA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.

Miscellaneous

NCOA3 is frequently amplified or overexpressed in breast and ovarian cancers.

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.1 Publication

Enzyme regulationi

Coactivator activity on nuclear receptors and NF-kappa-B pathways is enhanced by various hormones, and the TNF cytokine, respectively. TNF stimulation probably enhances phosphorylation, which in turn activates coactivator function. In contrast, acetylation by CREBBP apparently suppresses coactivation of target genes by disrupting its association with nuclear receptors. Binds to CSNK1D.

GO - Molecular functioni

  • androgen receptor binding Source: UniProtKB
  • disordered domain specific binding Source: CAFA
  • histone acetyltransferase activity Source: UniProtKB
  • ligand-dependent nuclear receptor binding Source: UniProtKB
  • ligand-dependent nuclear receptor transcription coactivator activity Source: GO_Central
  • nuclear hormone receptor binding Source: UniProtKB
  • protein heterodimerization activity Source: CAFA
  • protein N-terminus binding Source: UniProtKB
  • thyroid hormone receptor binding Source: UniProtKB
  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

  • androgen receptor signaling pathway Source: UniProtKB
  • cellular response to estradiol stimulus Source: BHF-UCL
  • cellular response to hormone stimulus Source: GO_Central
  • intracellular receptor signaling pathway Source: GO_Central
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of keratinocyte differentiation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • receptor transactivation Source: UniProtKB
  • regulation of RNA biosynthetic process Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Acyltransferase, Transferase
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1989781. PPARA activates gene expression.
R-HSA-381340. Transcriptional regulation of white adipocyte differentiation.
R-HSA-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.
R-HSA-5687128. MAPK6/MAPK4 signaling.
SignaLinkiQ9Y6Q9.
SIGNORiQ9Y6Q9.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivator 3 (EC:2.3.1.48)
Short name:
NCoA-3
Alternative name(s):
ACTR
Amplified in breast cancer 1 protein
Short name:
AIB-1
CBP-interacting protein
Short name:
pCIP
Class E basic helix-loop-helix protein 42
Short name:
bHLHe42
Receptor-associated coactivator 3
Short name:
RAC-3
Steroid receptor coactivator protein 3
Short name:
SRC-3
Thyroid hormone receptor activator molecule 1
Short name:
TRAM-1
Gene namesi
Name:NCOA3
Synonyms:AIB1, BHLHE42, RAC3, TRAM1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:7670. NCOA3.

Subcellular locationi

  • Cytoplasm
  • Nucleus

  • Note: Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: HPA
  • extracellular exosome Source: UniProtKB
  • nuclear chromatin Source: BHF-UCL
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • protein complex Source: CAFA

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi616K → Q: Strongly reduces acetylation by CREBBP. 1 Publication1
Mutagenesisi619 – 620KK → QQ: Abolishes acetylation by CREBBP. 1 Publication2
Mutagenesisi647K → Q: Does not affect acetylation by CREBBP. 1 Publication1
Mutagenesisi681K → Q: Does not affect acetylation by CREBBP. 1 Publication1
Mutagenesisi687K → Q: Does not affect acetylation by CREBBP. 1 Publication1
Mutagenesisi700K → Q: Does not affect acetylation by CREBBP. 1 Publication1
Mutagenesisi708K → Q: Does not affect acetylation by CREBBP. 1 Publication1

Organism-specific databases

DisGeNETi8202.
OpenTargetsiENSG00000124151.
PharmGKBiPA31472.

Chemistry databases

ChEMBLiCHEMBL1615382.

Polymorphism and mutation databases

BioMutaiNCOA3.
DMDMi23396777.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000944062 – 1424Nuclear receptor coactivator 3Add BLAST1423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei214PhosphoserineCombined sources1
Modified residuei551PhosphoserineCombined sources1
Modified residuei569PhosphoserineBy similarity1
Modified residuei601Phosphoserine; by CK11 Publication1
Modified residuei616N6-acetyllysine; by CREBBP1 Publication1
Modified residuei619N6-acetyllysine; by CREBBP1 Publication1
Modified residuei620N6-acetyllysine; by CREBBP1 Publication1
Modified residuei687N6-acetyllysineCombined sources1
Modified residuei694PhosphoserineCombined sources1
Modified residuei728PhosphoserineCombined sources1
Modified residuei857PhosphoserineCombined sources1
Modified residuei860PhosphoserineBy similarity1
Modified residuei867PhosphoserineCombined sources1
Modified residuei1033PhosphoserineCombined sources1
Modified residuei1171Asymmetric dimethylarginineCombined sources1
Modified residuei1177Asymmetric dimethylarginineCombined sources1
Modified residuei1188Asymmetric dimethylarginineCombined sources1
Modified residuei1330PhosphoserineCombined sources1

Post-translational modificationi

Acetylated by CREBBP. Acetylation occurs in the RID domain, and disrupts the interaction with nuclear receptors and regulates its function.1 Publication
Methylated by CARM1.By similarity
Phosphorylated by IKK complex. Regulated its function. Phosphorylation at Ser-601 by CK1 promotes coactivator function.2 Publications

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9Y6Q9.
PaxDbiQ9Y6Q9.
PeptideAtlasiQ9Y6Q9.
PRIDEiQ9Y6Q9.

PTM databases

iPTMnetiQ9Y6Q9.
PhosphoSitePlusiQ9Y6Q9.
SwissPalmiQ9Y6Q9.

Expressioni

Tissue specificityi

Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.

Gene expression databases

BgeeiENSG00000124151.
CleanExiHS_NCOA3.
HS_RAC3.
HS_TRAM1.
GenevisibleiQ9Y6Q9. HS.

Organism-specific databases

HPAiCAB009800.
HPA024210.

Interactioni

Subunit structurei

Interacts with CARM1 (By similarity). Present in a complex containing NCOA2, IKKA, IKKB, IKBKG and the histone acetyltransferase protein CREBBP. Interacts with CASP8AP2, NR3C1 and PCAF. Interacts with ATAD2 and this interaction is enhanced by estradiol. Found in a complex containing NCOA3, AR and MAK. Interacts with DDX5. Interacts with PSMB9. Interacts with NPAS2. Interacts with NR4A3 (By similarity). Interacts with ESRRB; mediates the interaction between ESRRB and RNA polymerase II complexes and allows NCOA3 corecruitment to ESRRB, KLF4, NANOG, and SOX2 enhancer regions to trigger ESRRB-dependent gene activation involved in self-renewal and pluripotency (By similarity).By similarity13 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • androgen receptor binding Source: UniProtKB
  • disordered domain specific binding Source: CAFA
  • ligand-dependent nuclear receptor binding Source: UniProtKB
  • nuclear hormone receptor binding Source: UniProtKB
  • protein heterodimerization activity Source: CAFA
  • protein N-terminus binding Source: UniProtKB
  • thyroid hormone receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi113841. 109 interactors.
DIPiDIP-30876N.
IntActiQ9Y6Q9. 50 interactors.
MINTiMINT-231818.
STRINGi9606.ENSP00000361066.

Chemistry databases

BindingDBiQ9Y6Q9.

Structurei

Secondary structure

11424
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi619 – 626Combined sources8
Helixi736 – 743Combined sources8
Helixi1049 – 1060Combined sources12
Helixi1069 – 1075Combined sources7
Helixi1078 – 1084Combined sources7
Helixi1086 – 1088Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KBHNMR-A1045-1091[»]
3L3XX-ray1.55B618-629[»]
3L3ZX-ray2.00B735-746[»]
DisProtiDP00343.
ProteinModelPortaliQ9Y6Q9.
SMRiQ9Y6Q9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y6Q9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 82bHLHPROSITE-ProRule annotationAdd BLAST58
Domaini110 – 180PASPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1023 – 1093Interaction with CREBBP1 PublicationAdd BLAST71
Regioni1097 – 1304AcetyltransferaseAdd BLAST208

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi685 – 689LXXLL motif 15
Motifi738 – 742LXXLL motif 25
Motifi1057 – 1061LXXLL motif 35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi505 – 671Ser-richAdd BLAST167
Compositional biasi976 – 980Poly-Gln5
Compositional biasi1248 – 1278Poly-GlnAdd BLAST31
Compositional biasi1392 – 1417Met-richAdd BLAST26

Domaini

Contains three Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. Motifs 1 and 2 are essential for the association with nuclear receptors, and constitute the RID domain (Receptor-interacting domain).

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IQ5R. Eukaryota.
ENOG410ZDZC. LUCA.
GeneTreeiENSGT00530000063109.
HOVERGENiHBG052583.
InParanoidiQ9Y6Q9.
KOiK11256.
OMAiMQCFALS.
OrthoDBiEOG091G152H.
PhylomeDBiQ9Y6Q9.
TreeFamiTF332652.

Family and domain databases

CDDicd00083. HLH. 1 hit.
cd00130. PAS. 1 hit.
Gene3Di1.10.287.1070. 1 hit.
2.130.10.10. 1 hit.
4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR010011. DUF1518.
IPR032565. DUF4927.
IPR028818. NCOA3.
IPR009110. Nuc_rcpt_coact.
IPR014920. Nuc_rcpt_coact_Ncoa-typ.
IPR017426. Nuclear_rcpt_coactivator.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR014935. SRC/p160_LXXLL.
IPR015943. WD40/YVTN_repeat-like_dom.
PANTHERiPTHR10684. PTHR10684. 1 hit.
PTHR10684:SF6. PTHR10684:SF6. 1 hit.
PfamiView protein in Pfam
PF07469. DUF1518. 1 hit.
PF16279. DUF4927. 1 hit.
PF08815. Nuc_rec_co-act. 1 hit.
PF00989. PAS. 1 hit.
PF08832. SRC-1. 1 hit.
PIRSFiPIRSF038181. Nuclear_receptor_coactivator. 1 hit.
SMARTiView protein in SMART
SM01151. DUF1518. 1 hit.
SM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
SSF69125. SSF69125. 1 hit.
PROSITEiView protein in PROSITE
PS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q9Y6Q9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGLGENLDP LASDSRKRKL PCDTPGQGLT CSGEKRRREQ ESKYIEELAE
60 70 80 90 100
LISANLSDID NFNVKPDKCA ILKETVRQIR QIKEQGKTIS NDDDVQKADV
110 120 130 140 150
SSTGQGVIDK DSLGPLLLQA LDGFLFVVNR DGNIVFVSEN VTQYLQYKQE
160 170 180 190 200
DLVNTSVYNI LHEEDRKDFL KNLPKSTVNG VSWTNETQRQ KSHTFNCRML
210 220 230 240 250
MKTPHDILED INASPEMRQR YETMQCFALS QPRAMMEEGE DLQSCMICVA
260 270 280 290 300
RRITTGERTF PSNPESFITR HDLSGKVVNI DTNSLRSSMR PGFEDIIRRC
310 320 330 340 350
IQRFFSLNDG QSWSQKRHYQ EAYLNGHAET PVYRFSLADG TIVTAQTKSK
360 370 380 390 400
LFRNPVTNDR HGFVSTHFLQ REQNGYRPNP NPVGQGIRPP MAGCNSSVGG
410 420 430 440 450
MSMSPNQGLQ MPSSRAYGLA DPSTTGQMSG ARYGGSSNIA SLTPGPGMQS
460 470 480 490 500
PSSYQNNNYG LNMSSPPHGS PGLAPNQQNI MISPRNRGSP KIASHQFSPV
510 520 530 540 550
AGVHSPMASS GNTGNHSFSS SSLSALQAIS EGVGTSLLST LSSPGPKLDN
560 570 580 590 600
SPNMNITQPS KVSNQDSKSP LGFYCDQNPV ESSMCQSNSR DHLSDKESKE
610 620 630 640 650
SSVEGAENQR GPLESKGHKK LLQLLTCSSD DRGHSSLTNS PLDSSCKESS
660 670 680 690 700
VSVTSPSGVS SSTSGGVSST SNMHGSLLQE KHRILHKLLQ NGNSPAEVAK
710 720 730 740 750
ITAEATGKDT SSITSCGDGN VVKQEQLSPK KKENNALLRY LLDRDDPSDA
760 770 780 790 800
LSKELQPQVE GVDNKMSQCT SSTIPSSSQE KDPKIKTETS EEGSGDLDNL
810 820 830 840 850
DAILGDLTSS DFYNNSISSN GSHLGTKQQV FQGTNSLGLK SSQSVQSIRP
860 870 880 890 900
PYNRAVSLDS PVSVGSSPPV KNISAFPMLP KQPMLGGNPR MMDSQENYGS
910 920 930 940 950
SMGGPNRNVT VTQTPSSGDW GLPNSKAGRM EPMNSNSMGR PGGDYNTSLP
960 970 980 990 1000
RPALGGSIPT LPLRSNSIPG ARPVLQQQQQ MLQMRPGEIP MGMGANPYGQ
1010 1020 1030 1040 1050
AAASNQLGSW PDGMLSMEQV SHGTQNRPLL RNSLDDLVGP PSNLEGQSDE
1060 1070 1080 1090 1100
RALLDQLHTL LSNTDATGLE EIDRALGIPE LVNQGQALEP KQDAFQGQEA
1110 1120 1130 1140 1150
AVMMDQKAGL YGQTYPAQGP PMQGGFHLQG QSPSFNSMMN QMNQQGNFPL
1160 1170 1180 1190 1200
QGMHPRANIM RPRTNTPKQL RMQLQQRLQG QQFLNQSRQA LELKMENPTA
1210 1220 1230 1240 1250
GGAAVMRPMM QPQVSSQQGF LNAQMVAQRS RELLSHHFRQ QRVAMMMQQQ
1260 1270 1280 1290 1300
QQQQQQQQQQ QQQQQQQQQQ QQQQQQTQAF SPPPNVTASP SMDGLLAGPT
1310 1320 1330 1340 1350
MPQAPPQQFP YQPNYGMGQQ PDPAFGRVSS PPNAMMSSRM GPSQNPMMQH
1360 1370 1380 1390 1400
PQAASIYQSS EMKGWPSGNL ARNSSFSQQQ FAHQGNPAVY SMVHMNGSSG
1410 1420
HMGQMNMNPM PMSGMPMGPD QKYC
Length:1,424
Mass (Da):155,293
Last modified:November 1, 1999 - v1
Checksum:i732CDF0423161679
GO
Isoform 2 (identifier: Q9Y6Q9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     903-917: Missing.

Show »
Length:1,409
Mass (Da):153,797
Checksum:i04B4DF09150BD916
GO
Isoform 3 (identifier: Q9Y6Q9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-321: E → EVTSDGIFSPT
     903-917: Missing.
     1214-1217: Missing.

Show »
Length:1,415
Mass (Da):154,400
Checksum:i4A162AB05BA34062
GO
Isoform 4 (identifier: Q9Y6Q9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-321: E → EVTSDGIFSPT
     837-901: Missing.
     903-917: Missing.
     1214-1217: Missing.

Show »
Length:1,350
Mass (Da):147,499
Checksum:iF75584B329A892C4
GO
Isoform 5 (identifier: Q9Y6Q9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1214-1217: Missing.

Show »
Length:1,420
Mass (Da):154,892
Checksum:i654343CEA0855C60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti131 – 132DG → EA in AAC51663 (PubMed:9238002).Curated2

Polymorphismi

The length of the poly-Gln region is polymorphic in the normal population.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053527218R → C1 PublicationCorresponds to variant dbSNP:rs6094752Ensembl.1
Natural variantiVAR_060695220R → I1 PublicationCorresponds to variant dbSNP:rs72645252Ensembl.1
Natural variantiVAR_053528369L → F. Corresponds to variant dbSNP:rs6094756Ensembl.1
Natural variantiVAR_013831460G → R. Corresponds to variant dbSNP:rs1052765Ensembl.1
Natural variantiVAR_060696556I → V1 PublicationCorresponds to variant dbSNP:rs72645272Ensembl.1
Natural variantiVAR_013832559P → S1 PublicationCorresponds to variant dbSNP:rs2230781Ensembl.1
Natural variantiVAR_013833586Q → H1 PublicationCorresponds to variant dbSNP:rs2230782Ensembl.1
Natural variantiVAR_053529777S → A1 PublicationCorresponds to variant dbSNP:rs2230783Ensembl.1
Natural variantiVAR_0606971247M → K1 PublicationCorresponds to variant dbSNP:rs72645299Ensembl.1
Natural variantiVAR_0606981247M → L1 PublicationCorresponds to variant dbSNP:rs72645298Ensembl.1
Natural variantiVAR_0138341248 – 1250Missing 2 Publications3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003405321E → EVTSDGIFSPT in isoform 3 and isoform 4. 1 Publication1
Alternative sequenceiVSP_003406837 – 901Missing in isoform 4. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_003407903 – 917Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_0034081214 – 1217Missing in isoform 3, isoform 4 and isoform 5. 4 Publications4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016031 mRNA. Translation: AAC51849.1.
AF036892 mRNA. Translation: AAB92368.1.
AF012108 mRNA. Translation: AAC51677.1.
AF010227 mRNA. Translation: AAC51663.1.
EF488684 Genomic DNA. Translation: ABO43042.1.
AL034418 Genomic DNA. Translation: CAB40662.1.
AL034418 Genomic DNA. Translation: CAC17693.1.
AL034418 Genomic DNA. Translation: CAI42141.1.
CH471077 Genomic DNA. Translation: EAW75698.1.
CH471077 Genomic DNA. Translation: EAW75702.1.
BC119001 mRNA. Translation: AAI19002.1.
CCDSiCCDS13406.1. [Q9Y6Q9-5]
CCDS13407.1. [Q9Y6Q9-1]
CCDS54472.1. [Q9Y6Q9-3]
PIRiT03851.
RefSeqiNP_001167559.1. NM_001174088.1. [Q9Y6Q9-3]
NP_006525.2. NM_006534.3. [Q9Y6Q9-5]
NP_858045.1. NM_181659.2. [Q9Y6Q9-1]
UniGeneiHs.592142.

Genome annotation databases

EnsembliENST00000371997; ENSP00000361065; ENSG00000124151. [Q9Y6Q9-3]
ENST00000371998; ENSP00000361066; ENSG00000124151. [Q9Y6Q9-1]
ENST00000372004; ENSP00000361073; ENSG00000124151. [Q9Y6Q9-5]
GeneIDi8202.
KEGGihsa:8202.
UCSCiuc002xtk.4. human. [Q9Y6Q9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiNCOA3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6Q9
Secondary accession number(s): A4LAZ5
, Q0VF45, Q5JYD9, Q5JYE0, Q9BR49, Q9UPC9, Q9UPG4, Q9UPG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 1, 1999
Last modified: June 7, 2017
This is version 189 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families