ID   Q9Y6Q6      PRELIMINARY;      PRT;   616 AA.
AC   Q9Y6Q6;
DT   01-NOV-1999 (TrEMBLrel. 12, Created)
DT   01-NOV-1999 (TrEMBLrel. 12, Last sequence update)
DT   01-MAY-2000 (TrEMBLrel. 13, Last annotation update)
DE   RECEPTOR ACTIVATOR OF NF-KAPPA-B PRECURSOR (TNF-RELATED ACTIVATION-
DE   INDUCED CYTOKINE RECEPTOR) (RANK).
GN   TNFRSF11A OR RANK.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 98032977.
RA   Anderson D.M., Maraskovsky E., Billingsley W.L., Dougall W.C.,
RA   Tometsko M.E., Roux E.R., Teepe M.C., DuBose R.F., Cosman D.,
RA   Galibert L.;
RT   "A homologue of the TNF receptor and its ligand enhance T-cell growth
RT   and dendritic-cell function.";
RL   Nature 390:175-179(1997).
CC   -!- FUNCTION: RECEPTOR FOR A CYTOKINE LIGAND KNOWN AS RANKL.
CC   -!- SUBCELLULAR LOCATION: TYPE I MEMBRANE PROTEIN (POTENTIAL).
CC   -!- TISSUE SPECIFICITY: UBIQUITOUS EXPRESSION WITH HIGH LEVELS IN
CC       SKELETAL MUSCLE, THYMUS, LIVER, COLON, SMALL INTESTINE AND ADRENAL
CC       GLAND.
CC   -!- SIMILARITY: CONTAINS A LA-NGFR/TNFR-TYPE CYSTEINE-RICH REGION.
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DR   EMBL; AF018253; AAB86809.1; -.
DR   MIM; 603499; -.
DR   INTERPRO; IPR001368; -.
DR   PFAM; PF00020; TNFR_c6; 4.
DR   PROSITE; PS00652; TNFR_NGFR_1; UNKNOWN_1.
DR   PROSITE; PS50050; TNFR_NGFR_2; 1.
KW   Receptor; Glycoprotein; Transmembrane; Signal; Repeat.
FT   SIGNAL        1     22       POTENTIAL.
FT   CHAIN        23    616       RECEPTOR ACTIVATOR OF NF-KAPPA-B.
FT   DOMAIN       24    212       EXTRACELLULAR (POTENTIAL).
FT   TRANSMEM    213    233       POTENTIAL.
FT   DOMAIN      234    616       CYTOPLASMIC (POTENTIAL).
FT   DOMAIN       33    195       4 X TNFR-CYS.
FT   REPEAT       33     69       TNFR-CYS 1.
FT   REPEAT       70    112       TNFR-CYS 2.
FT   REPEAT      113    152       TNFR-CYS 3.
FT   REPEAT      153    195       TNFR-CYS 4.
FT   DISULFID     34     46       BY SIMILARITY.
FT   DISULFID     47     60       BY SIMILARITY.
FT   DISULFID     50     68       BY SIMILARITY.
FT   DISULFID     71     86       BY SIMILARITY.
FT   DISULFID     92    112       BY SIMILARITY.
FT   DISULFID    114    124       BY SIMILARITY.
FT   DISULFID    126    133       BY SIMILARITY.
FT   DISULFID    127    151       BY SIMILARITY.
FT   DISULFID    154    169       BY SIMILARITY.
FT   DISULFID    175    194       BY SIMILARITY.
FT   CARBOHYD    105    105       N-LINKED (GLCNAC...) (POTENTIAL).
FT   CARBOHYD    174    174       N-LINKED (GLCNAC...) (POTENTIAL).
SQ   SEQUENCE   616 AA;  66033 MW;  E3DE9A7A08196F81 CRC64;
     MAPRARRRRP LFALLLLCAL LARLQVALQI APPCTSEKHY EHLGRCCNKC EPGKYMSSKC
     TTTSDSVCLP CGPDEYLDSW NEEDKCLLHK VCDTGKALVA VVAGNSTTPR RCACTAGYHW
     SQDCECCRRN TECAPGLGAQ HPLQLNKDTV CKPCLAGYFS DAFSSTDKCR PWTNCTFLGK
     RVEHHGTEKS DAVCSSSLPA RKPPNEPHVY LPGLIILLLF ASVALVAAII FGVCYRKKGK
     ALTANLWHWI NEACGRLSGD KESSGDSCVS THTANFGQQG ACEGVLLLTL EEKTFPEDMC
     YPDQGGVCQG TCVGGGPYAQ GEDARMLSLV SKTEIEEDSF RQMPTEDEYM DRPSQPTDQL
     LFLTEPGSKS TPPFSEPLEV GENDSLSQCF TGTQSTVGSE SCNCTEPLCR TDWTPMSSEN
     YLQKEVDSGH CPHWAASPSP NWADVCTGCR NPPGEDCEPL VGSPKRGPLP QCAYGMGLPP
     EEEASRTEAR DQPEDGADGR LPSSARAGAG SGSSPGGQSP ASGNVTGNSN STFISSGQVM
     NFKGDIIVVY VSQTSQEGAA AAAEPMGRPV QEETLARRDS FAGNGPRFPD PCGGPEGLRE
     PEKASRPVQE QGGAKA
//