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Protein

Tumor necrosis factor receptor superfamily member 11A

Gene

TNFRSF11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi133Sodium; via carbonyl oxygenBy similarity1
Metal bindingi134Sodium; via carbonyl oxygenBy similarity1
Metal bindingi160Sodium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

  • cytokine binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW
  • receptor activity Source: ProtInc
  • transmembrane signaling receptor activity Source: BHF-UCL
  • tumor necrosis factor-activated receptor activity Source: BHF-UCL

GO - Biological processi

  • adaptive immune response Source: BHF-UCL
  • apoptotic signaling pathway Source: GO_Central
  • cell-cell signaling Source: ProtInc
  • circadian temperature homeostasis Source: BHF-UCL
  • inflammatory response Source: GO_Central
  • lymph node development Source: Ensembl
  • mammary gland alveolus development Source: Ensembl
  • monocyte chemotaxis Source: BHF-UCL
  • ossification Source: Ensembl
  • osteoclast differentiation Source: BHF-UCL
  • positive regulation of cell proliferation Source: ProtInc
  • positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling Source: BHF-UCL
  • positive regulation of fever generation by positive regulation of prostaglandin secretion Source: BHF-UCL
  • positive regulation of JUN kinase activity Source: BHF-UCL
  • positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  • regulation of apoptotic process Source: GO_Central
  • response to cytokine Source: BHF-UCL
  • response to interleukin-1 Source: BHF-UCL
  • response to lipopolysaccharide Source: BHF-UCL
  • response to radiation Source: Ensembl
  • response to tumor necrosis factor Source: BHF-UCL
  • signal transduction Source: ProtInc
  • TNFSF11-mediated signaling pathway Source: BHF-UCL
  • tumor necrosis factor-mediated signaling pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Metal-binding, Sodium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141655-MONOMER.
ReactomeiR-HSA-5668541. TNFR2 non-canonical NF-kB pathway.
R-HSA-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
SignaLinkiQ9Y6Q6.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 11A
Alternative name(s):
Osteoclast differentiation factor receptor
Short name:
ODFR
Receptor activator of NF-KB
CD_antigen: CD265
Gene namesi
Name:TNFRSF11A
Synonyms:RANK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:11908. TNFRSF11A.

Subcellular locationi

Isoform 1 :
Isoform RANK-e5a :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 212ExtracellularSequence analysisAdd BLAST183
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 616CytoplasmicSequence analysisAdd BLAST383

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Familial expansile osteolysis (FEO)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. The osteolytic lesions develop usually in the long bones during early adulthood. FEO is often associated with early-onset deafness and loss of dentition.
See also OMIM:174810
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01151721L → LLLCALL in FEO. 1 Publication1
Paget disease of bone 2, early-onset (PDB2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Paget disease, a disorder of bone remodeling characterized by increased bone turnover affecting one or more sites throughout the skeleton, primarily the axial skeleton. Osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone.
See also OMIM:602080
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01151621L → LALLLLCALL in PDB2. 1 Publication1
Osteopetrosis, autosomal recessive 7 (OPTB7)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB7 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development. OPTB7 is associated with hypogammaglobulinemia.
See also OMIM:612301
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04678853G → R in OPTB7; two patients with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant rs121908659dbSNPEnsembl.1
Natural variantiVAR_046789129R → C in OPTB7; a patient with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant rs121908657dbSNPEnsembl.1
Natural variantiVAR_046791170R → G in OPTB7; two siblings with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant rs121908655dbSNPEnsembl.1
Natural variantiVAR_046792175C → R in OPTB7; two patients with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant rs121908656dbSNPEnsembl.1
Natural variantiVAR_046793244A → S in OPTB7; one patient with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant rs121908658dbSNPEnsembl.1

Keywords - Diseasei

Deafness, Disease mutation, Osteopetrosis

Organism-specific databases

DisGeNETi8792.
MalaCardsiTNFRSF11A.
MIMi174810. phenotype.
602080. phenotype.
612301. phenotype.
OpenTargetsiENSG00000141655.
Orphaneti85195. Familial expansile osteolysis.
178389. Osteopetrosis - hypogammaglobulinemia.
PharmGKBiPA36601.

Polymorphism and mutation databases

DMDMi19924309.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000003458530 – 616Tumor necrosis factor receptor superfamily member 11AAdd BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 46PROSITE-ProRule annotation
Disulfide bondi47 ↔ 60PROSITE-ProRule annotation
Disulfide bondi50 ↔ 68PROSITE-ProRule annotation
Disulfide bondi71 ↔ 86PROSITE-ProRule annotation
Disulfide bondi92 ↔ 112PROSITE-ProRule annotation
Glycosylationi105N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi114 ↔ 127PROSITE-ProRule annotation
Disulfide bondi124 ↔ 126PROSITE-ProRule annotation
Disulfide bondi133 ↔ 151PROSITE-ProRule annotation
Disulfide bondi154 ↔ 169PROSITE-ProRule annotation
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi175 ↔ 194PROSITE-ProRule annotation
Modified residuei580PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9Y6Q6.
PeptideAtlasiQ9Y6Q6.
PRIDEiQ9Y6Q6.

PTM databases

iPTMnetiQ9Y6Q6.
PhosphoSitePlusiQ9Y6Q6.

Expressioni

Tissue specificityi

Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

Gene expression databases

BgeeiENSG00000141655.
CleanExiHS_TNFRSF11A.
GenevisibleiQ9Y6Q6. HS.

Organism-specific databases

HPAiCAB010391.
HPA027728.

Interactioni

Subunit structurei

Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer (By similarity). Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2.By similarity2 Publications

GO - Molecular functioni

  • cytokine binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi114320. 11 interactors.
IntActiQ9Y6Q6. 4 interactors.
STRINGi9606.ENSP00000465500.

Structurei

Secondary structure

1616
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi345 – 348Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LB5X-ray2.40B342-349[»]
ProteinModelPortaliQ9Y6Q6.
SMRiQ9Y6Q6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 68TNFR-Cys 1Add BLAST35
Repeati71 – 112TNFR-Cys 2Add BLAST42
Repeati114 – 151TNFR-Cys 3Add BLAST38
Repeati154 – 194TNFR-Cys 4Add BLAST41

Sequence similaritiesi

Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHUN. Eukaryota.
ENOG41125ED. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000154659.
HOVERGENiHBG079274.
InParanoidiQ9Y6Q6.
KOiK05147.
OMAiCPHWAAS.
OrthoDBiEOG091G03XW.
PhylomeDBiQ9Y6Q6.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022323. TNFR_11.
IPR022361. TNFR_11A.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01961. TNFACTORR11.
PR01974. TNFACTORR11A.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y6Q6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPRARRRRP LFALLLLCAL LARLQVALQI APPCTSEKHY EHLGRCCNKC
60 70 80 90 100
EPGKYMSSKC TTTSDSVCLP CGPDEYLDSW NEEDKCLLHK VCDTGKALVA
110 120 130 140 150
VVAGNSTTPR RCACTAGYHW SQDCECCRRN TECAPGLGAQ HPLQLNKDTV
160 170 180 190 200
CKPCLAGYFS DAFSSTDKCR PWTNCTFLGK RVEHHGTEKS DAVCSSSLPA
210 220 230 240 250
RKPPNEPHVY LPGLIILLLF ASVALVAAII FGVCYRKKGK ALTANLWHWI
260 270 280 290 300
NEACGRLSGD KESSGDSCVS THTANFGQQG ACEGVLLLTL EEKTFPEDMC
310 320 330 340 350
YPDQGGVCQG TCVGGGPYAQ GEDARMLSLV SKTEIEEDSF RQMPTEDEYM
360 370 380 390 400
DRPSQPTDQL LFLTEPGSKS TPPFSEPLEV GENDSLSQCF TGTQSTVGSE
410 420 430 440 450
SCNCTEPLCR TDWTPMSSEN YLQKEVDSGH CPHWAASPSP NWADVCTGCR
460 470 480 490 500
NPPGEDCEPL VGSPKRGPLP QCAYGMGLPP EEEASRTEAR DQPEDGADGR
510 520 530 540 550
LPSSARAGAG SGSSPGGQSP ASGNVTGNSN STFISSGQVM NFKGDIIVVY
560 570 580 590 600
VSQTSQEGAA AAAEPMGRPV QEETLARRDS FAGNGPRFPD PCGGPEGLRE
610
PEKASRPVQE QGGAKA
Length:616
Mass (Da):66,034
Last modified:November 1, 1999 - v1
Checksum:iE3DE9A7A08196F81
GO
Isoform 2 (identifier: Q9Y6Q6-2) [UniParc]FASTAAdd to basket
Also known as: delta7,8,9

The sequence of this isoform differs from the canonical sequence as follows:
     206-522: Missing.

Show »
Length:299
Mass (Da):32,318
Checksum:i0EF38515CF29F18D
GO
Isoform 3 (identifier: Q9Y6Q6-3) [UniParc]FASTAAdd to basket
Also known as: delta8,9

The sequence of this isoform differs from the canonical sequence as follows:
     244-522: Missing.

Show »
Length:337
Mass (Da):36,399
Checksum:i9200CEF495CCF5B3
GO
Isoform 4 (identifier: Q9Y6Q6-4) [UniParc]FASTAAdd to basket
Also known as: delta9

The sequence of this isoform differs from the canonical sequence as follows:
     263-263: S → M
     264-616: Missing.

Show »
Length:263
Mass (Da):28,965
Checksum:iA6E72E8DEFA676C2
GO
Isoform 5 (identifier: Q9Y6Q6-5) [UniParc]FASTAAdd to basket
Also known as: exon9a

The sequence of this isoform differs from the canonical sequence as follows:
     523-616: GNVTGNSNST...PVQEQGGAKA → D

Show »
Length:523
Mass (Da):56,402
Checksum:i653957CFE411BEB5
GO
Isoform RANK-e5a (identifier: Q9Y6Q6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     143-157: LQLNKDTVCKPCLAG → C

Note: Reduced ability to bind RANKL and to activate NF-kappaB as compared to isoform 1.
Show »
Length:602
Mass (Da):64,552
Checksum:i820338A19FAE9D03
GO

Sequence cautioni

The sequence BAD92999 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01151621L → LALLLLCALL in PDB2. 1 Publication1
Natural variantiVAR_01151721L → LLLCALL in FEO. 1 Publication1
Natural variantiVAR_04678853G → R in OPTB7; two patients with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant rs121908659dbSNPEnsembl.1
Natural variantiVAR_046789129R → C in OPTB7; a patient with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant rs121908657dbSNPEnsembl.1
Natural variantiVAR_046790141H → Y.Corresponds to variant rs35211496dbSNPEnsembl.1
Natural variantiVAR_046791170R → G in OPTB7; two siblings with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant rs121908655dbSNPEnsembl.1
Natural variantiVAR_046792175C → R in OPTB7; two patients with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant rs121908656dbSNPEnsembl.1
Natural variantiVAR_011518192A → V.1 PublicationCorresponds to variant rs1805034dbSNPEnsembl.1
Natural variantiVAR_046793244A → S in OPTB7; one patient with osteoclast-poor osteopetrosis. 1 PublicationCorresponds to variant rs121908658dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054179143 – 157LQLNK…PCLAG → C in isoform RANK-e5a. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_046901206 – 522Missing in isoform 2. 2 PublicationsAdd BLAST317
Alternative sequenceiVSP_054180244 – 522Missing in isoform 3. 1 PublicationAdd BLAST279
Alternative sequenceiVSP_054181263S → M in isoform 4. 1 Publication1
Alternative sequenceiVSP_054182264 – 616Missing in isoform 4. 1 PublicationAdd BLAST353
Alternative sequenceiVSP_054183523 – 616GNVTG…GGAKA → D in isoform 5. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018253 mRNA. Translation: AAB86809.1.
HF584702 mRNA. Translation: CCQ44072.1.
HE647782 mRNA. Translation: CCF23032.1.
HE649916 mRNA. Translation: CCF55033.1.
HE649917 mRNA. Translation: CCF55034.1.
HE659518 mRNA. Translation: CCF77738.1.
AB209762 mRNA. Translation: BAD92999.1. Different initiation.
CCDSiCCDS11980.1. [Q9Y6Q6-1]
CCDS59324.1. [Q9Y6Q6-2]
CCDS74227.1. [Q9Y6Q6-4]
CCDS74228.1. [Q9Y6Q6-3]
RefSeqiNP_001257878.1. NM_001270949.1. [Q9Y6Q6-4]
NP_001257879.1. NM_001270950.1. [Q9Y6Q6-3]
NP_001257880.1. NM_001270951.1. [Q9Y6Q6-2]
NP_001265197.1. NM_001278268.1. [Q9Y6Q6-6]
NP_003830.1. NM_003839.3. [Q9Y6Q6-1]
UniGeneiHs.204044.
Hs.621477.

Genome annotation databases

EnsembliENST00000269485; ENSP00000269485; ENSG00000141655. [Q9Y6Q6-2]
ENST00000586569; ENSP00000465500; ENSG00000141655. [Q9Y6Q6-1]
ENST00000616710; ENSP00000479567; ENSG00000141655. [Q9Y6Q6-4]
ENST00000617039; ENSP00000482466; ENSG00000141655. [Q9Y6Q6-3]
GeneIDi8792.
KEGGihsa:8792.
UCSCiuc002lin.5. human. [Q9Y6Q6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF018253 mRNA. Translation: AAB86809.1.
HF584702 mRNA. Translation: CCQ44072.1.
HE647782 mRNA. Translation: CCF23032.1.
HE649916 mRNA. Translation: CCF55033.1.
HE649917 mRNA. Translation: CCF55034.1.
HE659518 mRNA. Translation: CCF77738.1.
AB209762 mRNA. Translation: BAD92999.1. Different initiation.
CCDSiCCDS11980.1. [Q9Y6Q6-1]
CCDS59324.1. [Q9Y6Q6-2]
CCDS74227.1. [Q9Y6Q6-4]
CCDS74228.1. [Q9Y6Q6-3]
RefSeqiNP_001257878.1. NM_001270949.1. [Q9Y6Q6-4]
NP_001257879.1. NM_001270950.1. [Q9Y6Q6-3]
NP_001257880.1. NM_001270951.1. [Q9Y6Q6-2]
NP_001265197.1. NM_001278268.1. [Q9Y6Q6-6]
NP_003830.1. NM_003839.3. [Q9Y6Q6-1]
UniGeneiHs.204044.
Hs.621477.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LB5X-ray2.40B342-349[»]
ProteinModelPortaliQ9Y6Q6.
SMRiQ9Y6Q6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114320. 11 interactors.
IntActiQ9Y6Q6. 4 interactors.
STRINGi9606.ENSP00000465500.

PTM databases

iPTMnetiQ9Y6Q6.
PhosphoSitePlusiQ9Y6Q6.

Polymorphism and mutation databases

DMDMi19924309.

Proteomic databases

PaxDbiQ9Y6Q6.
PeptideAtlasiQ9Y6Q6.
PRIDEiQ9Y6Q6.

Protocols and materials databases

DNASUi8792.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269485; ENSP00000269485; ENSG00000141655. [Q9Y6Q6-2]
ENST00000586569; ENSP00000465500; ENSG00000141655. [Q9Y6Q6-1]
ENST00000616710; ENSP00000479567; ENSG00000141655. [Q9Y6Q6-4]
ENST00000617039; ENSP00000482466; ENSG00000141655. [Q9Y6Q6-3]
GeneIDi8792.
KEGGihsa:8792.
UCSCiuc002lin.5. human. [Q9Y6Q6-1]

Organism-specific databases

CTDi8792.
DisGeNETi8792.
GeneCardsiTNFRSF11A.
HGNCiHGNC:11908. TNFRSF11A.
HPAiCAB010391.
HPA027728.
MalaCardsiTNFRSF11A.
MIMi174810. phenotype.
602080. phenotype.
603499. gene.
612301. phenotype.
neXtProtiNX_Q9Y6Q6.
OpenTargetsiENSG00000141655.
Orphaneti85195. Familial expansile osteolysis.
178389. Osteopetrosis - hypogammaglobulinemia.
PharmGKBiPA36601.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHUN. Eukaryota.
ENOG41125ED. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000154659.
HOVERGENiHBG079274.
InParanoidiQ9Y6Q6.
KOiK05147.
OMAiCPHWAAS.
OrthoDBiEOG091G03XW.
PhylomeDBiQ9Y6Q6.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141655-MONOMER.
ReactomeiR-HSA-5668541. TNFR2 non-canonical NF-kB pathway.
R-HSA-5676594. TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
SignaLinkiQ9Y6Q6.

Miscellaneous databases

ChiTaRSiTNFRSF11A. human.
GeneWikiiRANK.
GenomeRNAii8792.
PROiQ9Y6Q6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141655.
CleanExiHS_TNFRSF11A.
GenevisibleiQ9Y6Q6. HS.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022323. TNFR_11.
IPR022361. TNFR_11A.
[Graphical view]
PfamiPF00020. TNFR_c6. 1 hit.
[Graphical view]
PRINTSiPR01961. TNFACTORR11.
PR01974. TNFACTORR11A.
SMARTiSM00208. TNFR. 4 hits.
[Graphical view]
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR11_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6Q6
Secondary accession number(s): I4EC36
, I4EC38, I4EC39, I7JE63, N0GVH0, Q59EP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.