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Q9Y6Q6

- TNR11_HUMAN

UniProt

Q9Y6Q6 - TNR11_HUMAN

Protein

Tumor necrosis factor receptor superfamily member 11A

Gene

TNFRSF11A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi133 – 1331Sodium; via carbonyl oxygenBy similarity
    Metal bindingi134 – 1341Sodium; via carbonyl oxygenBy similarity
    Metal bindingi160 – 1601Sodium; via carbonyl oxygenBy similarity

    GO - Molecular functioni

    1. cytokine binding Source: BHF-UCL
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB
    4. receptor activity Source: ProtInc
    5. transmembrane signaling receptor activity Source: BHF-UCL
    6. tumor necrosis factor-activated receptor activity Source: BHF-UCL

    GO - Biological processi

    1. adaptive immune response Source: BHF-UCL
    2. cell-cell signaling Source: ProtInc
    3. circadian temperature homeostasis Source: BHF-UCL
    4. lymph node development Source: Ensembl
    5. mammary gland alveolus development Source: Ensembl
    6. monocyte chemotaxis Source: BHF-UCL
    7. ossification Source: Ensembl
    8. osteoclast differentiation Source: BHF-UCL
    9. positive regulation of cell proliferation Source: ProtInc
    10. positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling Source: BHF-UCL
    11. positive regulation of fever generation by positive regulation of prostaglandin secretion Source: BHF-UCL
    12. positive regulation of JUN kinase activity Source: BHF-UCL
    13. positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
    14. positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    15. response to cytokine Source: BHF-UCL
    16. response to interleukin-1 Source: BHF-UCL
    17. response to lipopolysaccharide Source: BHF-UCL
    18. response to radiation Source: Ensembl
    19. response to tumor necrosis factor Source: BHF-UCL
    20. signal transduction Source: ProtInc
    21. TNFSF11-mediated signaling pathway Source: BHF-UCL
    22. tumor necrosis factor-mediated signaling pathway Source: BHF-UCL

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    Metal-binding, Sodium

    Enzyme and pathway databases

    SignaLinkiQ9Y6Q6.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 11A
    Alternative name(s):
    Osteoclast differentiation factor receptor
    Short name:
    ODFR
    Receptor activator of NF-KB
    CD_antigen: CD265
    Gene namesi
    Name:TNFRSF11A
    Synonyms:RANK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:11908. TNFRSF11A.

    Subcellular locationi

    Isoform 1 : Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
    Isoform RANK-e5a : Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication

    GO - Cellular componenti

    1. external side of plasma membrane Source: BHF-UCL
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Familial expansile osteolysis (FEO) [MIM:174810]: Rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. The osteolytic lesions develop usually in the long bones during early adulthood. FEO is often associated with early-onset deafness and loss of dentition.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211L → LLLCALL in FEO. 1 Publication
    VAR_011517
    Paget disease of bone 2 (PDB2) [MIM:602080]: Bone-remodeling disorder with clinical similarities to FEO. Unlike FEO, however, affected individuals have involvement of the axial skeleton with lesions in the spine, pelvis and skull.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211L → LALLLLCALL in PDB2. 1 Publication
    VAR_011516
    Osteopetrosis, autosomal recessive 7 (OPTB7) [MIM:612301]: A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB7 is characterized by paucity of osteoclasts, suggesting a molecular defect in osteoclast development. OPTB7 is associated with hypogammaglobulinemia.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti53 – 531G → R in OPTB7; two patients with osteoclast-poor osteopetrosis. 1 Publication
    VAR_046788
    Natural varianti129 – 1291R → C in OPTB7; a patient with osteoclast-poor osteopetrosis. 1 Publication
    VAR_046789
    Natural varianti170 – 1701R → G in OPTB7; two siblings with osteoclast-poor osteopetrosis. 1 Publication
    VAR_046791
    Natural varianti175 – 1751C → R in OPTB7; two patients with osteoclast-poor osteopetrosis. 1 Publication
    VAR_046792
    Natural varianti244 – 2441A → S in OPTB7; one patient with osteoclast-poor osteopetrosis. 1 Publication
    VAR_046793

    Keywords - Diseasei

    Deafness, Disease mutation, Osteopetrosis

    Organism-specific databases

    MIMi174810. phenotype.
    602080. phenotype.
    612301. phenotype.
    Orphaneti85195. Familial expansile osteolysis.
    178389. Osteopetrosis - hypogammaglobulinemia.
    PharmGKBiPA36601.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 616587Tumor necrosis factor receptor superfamily member 11APRO_0000034585Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 46PROSITE-ProRule annotation
    Disulfide bondi47 ↔ 60PROSITE-ProRule annotation
    Disulfide bondi50 ↔ 68PROSITE-ProRule annotation
    Disulfide bondi71 ↔ 86PROSITE-ProRule annotation
    Disulfide bondi92 ↔ 112PROSITE-ProRule annotation
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi114 ↔ 127PROSITE-ProRule annotation
    Disulfide bondi124 ↔ 126PROSITE-ProRule annotation
    Disulfide bondi133 ↔ 151PROSITE-ProRule annotation
    Disulfide bondi154 ↔ 169PROSITE-ProRule annotation
    Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi175 ↔ 194PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ9Y6Q6.
    PaxDbiQ9Y6Q6.
    PRIDEiQ9Y6Q6.

    PTM databases

    PhosphoSiteiQ9Y6Q6.

    Expressioni

    Tissue specificityi

    Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

    Gene expression databases

    ArrayExpressiQ9Y6Q6.
    BgeeiQ9Y6Q6.
    CleanExiHS_TNFRSF11A.
    GenevestigatoriQ9Y6Q6.

    Organism-specific databases

    HPAiCAB010391.
    HPA027728.

    Interactioni

    Subunit structurei

    Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer By similarity. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi114320. 9 interactions.
    IntActiQ9Y6Q6. 4 interactions.
    STRINGi9606.ENSP00000269485.

    Structurei

    Secondary structure

    1
    616
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi345 – 3484

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1LB5X-ray2.40B342-349[»]
    ProteinModelPortaliQ9Y6Q6.
    SMRiQ9Y6Q6. Positions 32-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 212183ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini234 – 616383CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei213 – 23321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati34 – 6835TNFR-Cys 1Add
    BLAST
    Repeati71 – 11242TNFR-Cys 2Add
    BLAST
    Repeati114 – 15138TNFR-Cys 3Add
    BLAST
    Repeati154 – 19441TNFR-Cys 4Add
    BLAST

    Sequence similaritiesi

    Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45473.
    HOGENOMiHOG000154659.
    HOVERGENiHBG079274.
    InParanoidiQ9Y6Q6.
    KOiK05147.
    OMAiCPHWAAS.
    OrthoDBiEOG786H2Q.
    PhylomeDBiQ9Y6Q6.

    Family and domain databases

    InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR022323. TNFR_11.
    IPR022361. TNFR_11A.
    [Graphical view]
    PfamiPF00020. TNFR_c6. 1 hit.
    [Graphical view]
    PRINTSiPR01961. TNFACTORR11.
    PR01974. TNFACTORR11A.
    SMARTiSM00208. TNFR. 4 hits.
    [Graphical view]
    PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
    PS50050. TNFR_NGFR_2. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y6Q6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPRARRRRP LFALLLLCAL LARLQVALQI APPCTSEKHY EHLGRCCNKC    50
    EPGKYMSSKC TTTSDSVCLP CGPDEYLDSW NEEDKCLLHK VCDTGKALVA 100
    VVAGNSTTPR RCACTAGYHW SQDCECCRRN TECAPGLGAQ HPLQLNKDTV 150
    CKPCLAGYFS DAFSSTDKCR PWTNCTFLGK RVEHHGTEKS DAVCSSSLPA 200
    RKPPNEPHVY LPGLIILLLF ASVALVAAII FGVCYRKKGK ALTANLWHWI 250
    NEACGRLSGD KESSGDSCVS THTANFGQQG ACEGVLLLTL EEKTFPEDMC 300
    YPDQGGVCQG TCVGGGPYAQ GEDARMLSLV SKTEIEEDSF RQMPTEDEYM 350
    DRPSQPTDQL LFLTEPGSKS TPPFSEPLEV GENDSLSQCF TGTQSTVGSE 400
    SCNCTEPLCR TDWTPMSSEN YLQKEVDSGH CPHWAASPSP NWADVCTGCR 450
    NPPGEDCEPL VGSPKRGPLP QCAYGMGLPP EEEASRTEAR DQPEDGADGR 500
    LPSSARAGAG SGSSPGGQSP ASGNVTGNSN STFISSGQVM NFKGDIIVVY 550
    VSQTSQEGAA AAAEPMGRPV QEETLARRDS FAGNGPRFPD PCGGPEGLRE 600
    PEKASRPVQE QGGAKA 616
    Length:616
    Mass (Da):66,034
    Last modified:November 1, 1999 - v1
    Checksum:iE3DE9A7A08196F81
    GO
    Isoform 2 (identifier: Q9Y6Q6-2) [UniParc]FASTAAdd to Basket

    Also known as: delta7,8,9

    The sequence of this isoform differs from the canonical sequence as follows:
         206-522: Missing.

    Show »
    Length:299
    Mass (Da):32,318
    Checksum:i0EF38515CF29F18D
    GO
    Isoform 3 (identifier: Q9Y6Q6-3) [UniParc]FASTAAdd to Basket

    Also known as: delta8,9

    The sequence of this isoform differs from the canonical sequence as follows:
         244-522: Missing.

    Show »
    Length:337
    Mass (Da):36,399
    Checksum:i9200CEF495CCF5B3
    GO
    Isoform 4 (identifier: Q9Y6Q6-4) [UniParc]FASTAAdd to Basket

    Also known as: delta9

    The sequence of this isoform differs from the canonical sequence as follows:
         263-263: S → M
         264-616: Missing.

    Show »
    Length:263
    Mass (Da):28,965
    Checksum:iA6E72E8DEFA676C2
    GO
    Isoform 5 (identifier: Q9Y6Q6-5) [UniParc]FASTAAdd to Basket

    Also known as: exon9a

    The sequence of this isoform differs from the canonical sequence as follows:
         523-616: GNVTGNSNST...PVQEQGGAKA → D

    Show »
    Length:523
    Mass (Da):56,402
    Checksum:i653957CFE411BEB5
    GO
    Isoform RANK-e5a (identifier: Q9Y6Q6-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         143-157: LQLNKDTVCKPCLAG → C

    Note: Reduced abilitity to bind RANKL and to activate NF-kappaB as compared to isoform 1.

    Show »
    Length:602
    Mass (Da):64,552
    Checksum:i820338A19FAE9D03
    GO

    Sequence cautioni

    The sequence BAD92999.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211L → LALLLLCALL in PDB2. 1 Publication
    VAR_011516
    Natural varianti21 – 211L → LLLCALL in FEO. 1 Publication
    VAR_011517
    Natural varianti53 – 531G → R in OPTB7; two patients with osteoclast-poor osteopetrosis. 1 Publication
    VAR_046788
    Natural varianti129 – 1291R → C in OPTB7; a patient with osteoclast-poor osteopetrosis. 1 Publication
    VAR_046789
    Natural varianti141 – 1411H → Y.
    Corresponds to variant rs35211496 [ dbSNP | Ensembl ].
    VAR_046790
    Natural varianti170 – 1701R → G in OPTB7; two siblings with osteoclast-poor osteopetrosis. 1 Publication
    VAR_046791
    Natural varianti175 – 1751C → R in OPTB7; two patients with osteoclast-poor osteopetrosis. 1 Publication
    VAR_046792
    Natural varianti192 – 1921A → V.1 Publication
    Corresponds to variant rs1805034 [ dbSNP | Ensembl ].
    VAR_011518
    Natural varianti244 – 2441A → S in OPTB7; one patient with osteoclast-poor osteopetrosis. 1 Publication
    VAR_046793

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei143 – 15715LQLNK…PCLAG → C in isoform RANK-e5a. 1 PublicationVSP_054179Add
    BLAST
    Alternative sequencei206 – 522317Missing in isoform 2. 2 PublicationsVSP_046901Add
    BLAST
    Alternative sequencei244 – 522279Missing in isoform 3. 1 PublicationVSP_054180Add
    BLAST
    Alternative sequencei263 – 2631S → M in isoform 4. 1 PublicationVSP_054181
    Alternative sequencei264 – 616353Missing in isoform 4. 1 PublicationVSP_054182Add
    BLAST
    Alternative sequencei523 – 61694GNVTG…GGAKA → D in isoform 5. 1 PublicationVSP_054183Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF018253 mRNA. Translation: AAB86809.1.
    HF584702 mRNA. Translation: CCQ44072.1.
    HE647782 mRNA. Translation: CCF23032.1.
    HE649916 mRNA. Translation: CCF55033.1.
    HE649917 mRNA. Translation: CCF55034.1.
    HE659518 mRNA. Translation: CCF77738.1.
    AB209762 mRNA. Translation: BAD92999.1. Different initiation.
    CCDSiCCDS11980.1. [Q9Y6Q6-1]
    CCDS59324.1. [Q9Y6Q6-2]
    RefSeqiNP_001257878.1. NM_001270949.1. [Q9Y6Q6-4]
    NP_001257879.1. NM_001270950.1. [Q9Y6Q6-3]
    NP_001257880.1. NM_001270951.1. [Q9Y6Q6-2]
    NP_001265197.1. NM_001278268.1. [Q9Y6Q6-6]
    NP_003830.1. NM_003839.3. [Q9Y6Q6-1]
    XP_005266834.1. XM_005266777.1. [Q9Y6Q6-5]
    UniGeneiHs.204044.
    Hs.621477.

    Genome annotation databases

    EnsembliENST00000269485; ENSP00000269485; ENSG00000141655. [Q9Y6Q6-2]
    ENST00000586569; ENSP00000465500; ENSG00000141655. [Q9Y6Q6-1]
    GeneIDi8792.
    KEGGihsa:8792.
    UCSCiuc002lin.4. human. [Q9Y6Q6-1]

    Polymorphism databases

    DMDMi19924309.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF018253 mRNA. Translation: AAB86809.1 .
    HF584702 mRNA. Translation: CCQ44072.1 .
    HE647782 mRNA. Translation: CCF23032.1 .
    HE649916 mRNA. Translation: CCF55033.1 .
    HE649917 mRNA. Translation: CCF55034.1 .
    HE659518 mRNA. Translation: CCF77738.1 .
    AB209762 mRNA. Translation: BAD92999.1 . Different initiation.
    CCDSi CCDS11980.1. [Q9Y6Q6-1 ]
    CCDS59324.1. [Q9Y6Q6-2 ]
    RefSeqi NP_001257878.1. NM_001270949.1. [Q9Y6Q6-4 ]
    NP_001257879.1. NM_001270950.1. [Q9Y6Q6-3 ]
    NP_001257880.1. NM_001270951.1. [Q9Y6Q6-2 ]
    NP_001265197.1. NM_001278268.1. [Q9Y6Q6-6 ]
    NP_003830.1. NM_003839.3. [Q9Y6Q6-1 ]
    XP_005266834.1. XM_005266777.1. [Q9Y6Q6-5 ]
    UniGenei Hs.204044.
    Hs.621477.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1LB5 X-ray 2.40 B 342-349 [» ]
    ProteinModelPortali Q9Y6Q6.
    SMRi Q9Y6Q6. Positions 32-198.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114320. 9 interactions.
    IntActi Q9Y6Q6. 4 interactions.
    STRINGi 9606.ENSP00000269485.

    Chemistry

    GuidetoPHARMACOLOGYi 1881.

    PTM databases

    PhosphoSitei Q9Y6Q6.

    Polymorphism databases

    DMDMi 19924309.

    Proteomic databases

    MaxQBi Q9Y6Q6.
    PaxDbi Q9Y6Q6.
    PRIDEi Q9Y6Q6.

    Protocols and materials databases

    DNASUi 8792.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000269485 ; ENSP00000269485 ; ENSG00000141655 . [Q9Y6Q6-2 ]
    ENST00000586569 ; ENSP00000465500 ; ENSG00000141655 . [Q9Y6Q6-1 ]
    GeneIDi 8792.
    KEGGi hsa:8792.
    UCSCi uc002lin.4. human. [Q9Y6Q6-1 ]

    Organism-specific databases

    CTDi 8792.
    GeneCardsi GC18P059992.
    HGNCi HGNC:11908. TNFRSF11A.
    HPAi CAB010391.
    HPA027728.
    MIMi 174810. phenotype.
    602080. phenotype.
    603499. gene.
    612301. phenotype.
    neXtProti NX_Q9Y6Q6.
    Orphaneti 85195. Familial expansile osteolysis.
    178389. Osteopetrosis - hypogammaglobulinemia.
    PharmGKBi PA36601.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45473.
    HOGENOMi HOG000154659.
    HOVERGENi HBG079274.
    InParanoidi Q9Y6Q6.
    KOi K05147.
    OMAi CPHWAAS.
    OrthoDBi EOG786H2Q.
    PhylomeDBi Q9Y6Q6.

    Enzyme and pathway databases

    SignaLinki Q9Y6Q6.

    Miscellaneous databases

    GeneWikii RANK.
    GenomeRNAii 8792.
    NextBioi 32972.
    PROi Q9Y6Q6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y6Q6.
    Bgeei Q9Y6Q6.
    CleanExi HS_TNFRSF11A.
    Genevestigatori Q9Y6Q6.

    Family and domain databases

    InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR022323. TNFR_11.
    IPR022361. TNFR_11A.
    [Graphical view ]
    Pfami PF00020. TNFR_c6. 1 hit.
    [Graphical view ]
    PRINTSi PR01961. TNFACTORR11.
    PR01974. TNFACTORR11A.
    SMARTi SM00208. TNFR. 4 hits.
    [Graphical view ]
    PROSITEi PS00652. TNFR_NGFR_1. 1 hit.
    PS50050. TNFR_NGFR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function."
      Anderson D.M., Maraskovsky E., Billingsley W.L., Dougall W.C., Tometsko M.E., Roux E.R., Teepe M.C., DuBose R.F., Cosman D., Galibert L.
      Nature 390:175-179(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Dendritic cell.
    2. "Alternative splicing generates a truncated isoform of human TNFRSF11A (RANK) with an altered capacity to activate NF-kappaB."
      Sirinian C., Papanastasiou A.D., Zarkadis I.K., Kalofonos H.P.
      Gene 525:124-129(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM RANK-E5A), SUBCELLULAR LOCATION (ISOFORMS 1 AND RANK-E5A), ALTERNATIVE SPLICING.
      Tissue: Blood.
    3. "Alternative splicing generates multiple human TNFRSF11A (RANK) isoforms."
      Papanastasiou A.D., Sirinian C., Kalofonos H.P.
      Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), NUCLEOTIDE SEQUENCE [MRNA] OF 159-523 (ISOFORM 5), ALTERNATIVE SPLICING.
      Tissue: Blood.
    4. "Homo sapiens protein coding cDNA."
      Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    5. "RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis."
      Nakagawa N., Kinosaki M., Yamaguchi K., Shima N., Yasuda H., Yano K., Morinaga T., Higashio K.
      Biochem. Biophys. Res. Commun. 253:395-400(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor."
      Wong B.R., Josien R., Lee S.Y., Vologodskaia M., Steinman R.M., Choi Y.
      J. Biol. Chem. 273:28355-28359(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRAF1; TRAF2; TRAF3; TRAF5 AND TRAF6.
    7. "The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis."
      Wada T., Nakashima T., Oliveira-dos-Santos A.J., Gasser J., Hara H., Schett G., Penninger J.M.
      Nat. Med. 11:394-399(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH GAB2.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis."
      Hughes A.E., Ralston S.H., Marken J., Bell C., MacPherson H., Wallace R.G.H., van Hul W., Whyte M.P., Nakatsuka K., Hovy L., Anderson D.M.
      Nat. Genet. 24:45-48(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT FEO LEU-LEU-CYS-ALA-LEU-LEU-21 INS, VARIANT PDB2 ALA-LEU-LEU-LEU-LEU-CYS-ALA-LEU-LEU-21 INS, VARIANT VAL-192.
    10. Cited for: VARIANTS OPTB7 ARG-53; CYS-129; GLY-170; ARG-175 AND SER-244.

    Entry informationi

    Entry nameiTNR11_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y6Q6
    Secondary accession number(s): I4EC36
    , I4EC38, I4EC39, I7JE63, N0GVH0, Q59EP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3