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Q9Y6Q5

- AP1M2_HUMAN

UniProt

Q9Y6Q5 - AP1M2_HUMAN

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Protein

AP-1 complex subunit mu-2

Gene

AP1M2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
  2. membrane organization Source: Reactome
  3. post-Golgi vesicle-mediated transport Source: Reactome
  4. protein targeting Source: ProtInc
  5. regulation of defense response to virus by virus Source: Reactome
  6. vesicle targeting Source: ProtInc
  7. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_11103. Nef mediated downregulation of MHC class I complex cell surface expression.
REACT_121399. MHC class II antigen presentation.
REACT_19287. Lysosome Vesicle Biogenesis.
REACT_19400. Golgi Associated Vesicle Biogenesis.
SignaLinkiQ9Y6Q5.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit mu-2
Alternative name(s):
AP-mu chain family member mu1B
Adaptor protein complex AP-1 subunit mu-2
Adaptor-related protein complex 1 subunit mu-2
Clathrin assembly protein complex 1 mu-2 medium chain 2
Golgi adaptor HA1/AP1 adaptin mu-2 subunit
Mu-adaptin 2
Mu1B-adaptin
Gene namesi
Name:AP1M2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:558. AP1M2.

Subcellular locationi

Golgi apparatus. Cytoplasmic vesicleclathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side
Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

GO - Cellular componenti

  1. clathrin adaptor complex Source: InterPro
  2. cytoplasmic vesicle membrane Source: Reactome
  3. cytosol Source: Reactome
  4. Golgi membrane Source: Reactome
  5. lysosomal membrane Source: Reactome
  6. trans-Golgi network membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24849.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423AP-1 complex subunit mu-2PRO_0000193772Add
BLAST

Post-translational modificationi

Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y6Q5.
PaxDbiQ9Y6Q5.
PRIDEiQ9Y6Q5.

PTM databases

PhosphoSiteiQ9Y6Q5.

Expressioni

Gene expression databases

BgeeiQ9Y6Q5.
CleanExiHS_AP1M2.
ExpressionAtlasiQ9Y6Q5. baseline and differential.
GenevestigatoriQ9Y6Q5.

Interactioni

Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).

Protein-protein interaction databases

BioGridi115364. 31 interactions.
IntActiQ9Y6Q5. 6 interactions.
MINTiMINT-1448582.
STRINGi9606.ENSP00000250244.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6Q5.
SMRiQ9Y6Q5. Positions 2-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 421254MHDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 MHD (mu homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG315786.
GeneTreeiENSGT00530000062779.
HOGENOMiHOG000173247.
HOVERGENiHBG050516.
InParanoidiQ9Y6Q5.
KOiK12393.
OMAiQHEEEGL.
PhylomeDBiQ9Y6Q5.
TreeFamiTF300393.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR008968. Clathrin_mu_C.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view]
PfamiPF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiPS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y6Q5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSASAVFILD VKGKPLISRN YKGDVAMSKI EHFMPLLVQR EEEGALAPLL
60 70 80 90 100
SHGQVHFLWI KHSNLYLVAT TSKNANASLV YSFLYKTIEV FCEYFKELEE
110 120 130 140 150
ESIRDNFVIV YELLDELMDF GFPQTTDSKI LQEYITQQSN KLETGKSRVP
160 170 180 190 200
PTVTNAVSWR SEGIKYKKNE VFIDVIESVN LLVNANGSVL LSEIVGTIKL
210 220 230 240 250
KVFLSGMPEL RLGLNDRVLF ELTGRSKNKS VELEDVKFHQ CVRLSRFDND
260 270 280 290 300
RTISFIPPDG DFELMSYRLS TQVKPLIWIE SVIEKFSHSR VEIMVKAKGQ
310 320 330 340 350
FKKQSVANGV EISVPVPSDA DSPRFKTSVG SAKYVPERNV VIWSIKSFPG
360 370 380 390 400
GKEYLMRAHF GLPSVEKEEV EGRPPIGVKF EIPYFTVSGI QVRYMKIIEK
410 420
SGYQALPWVR YITQSGDYQL RTS
Length:423
Mass (Da):48,108
Last modified:January 23, 2007 - v4
Checksum:iA3F6FDF8659DD6F7
GO
Isoform 2 (identifier: Q9Y6Q5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-225: R → LSG

Note: No experimental confirmation available.

Show »
Length:425
Mass (Da):48,210
Checksum:i93CA6C8D3A74ABBF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti364 – 3641S → R in AAH05021. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei225 – 2251R → LSG in isoform 2. 1 PublicationVSP_000169

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF020797 mRNA. Translation: AAD25870.2.
AK315689 mRNA. Translation: BAG38052.1.
CH471106 Genomic DNA. Translation: EAW84124.1.
BC003387 mRNA. Translation: AAH03387.1.
BC003612 mRNA. Translation: AAH03612.1.
BC005021 mRNA. Translation: AAH05021.1.
CCDSiCCDS45964.1. [Q9Y6Q5-1]
RefSeqiNP_005489.2. NM_005498.4. [Q9Y6Q5-1]
XP_005259758.1. XM_005259701.1. [Q9Y6Q5-2]
UniGeneiHs.18894.

Genome annotation databases

EnsembliENST00000250244; ENSP00000250244; ENSG00000129354. [Q9Y6Q5-1]
ENST00000590923; ENSP00000465685; ENSG00000129354. [Q9Y6Q5-2]
GeneIDi10053.
KEGGihsa:10053.
UCSCiuc002mpc.3. human. [Q9Y6Q5-1]
uc002mpd.3. human. [Q9Y6Q5-2]

Polymorphism databases

DMDMi13123953.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF020797 mRNA. Translation: AAD25870.2 .
AK315689 mRNA. Translation: BAG38052.1 .
CH471106 Genomic DNA. Translation: EAW84124.1 .
BC003387 mRNA. Translation: AAH03387.1 .
BC003612 mRNA. Translation: AAH03612.1 .
BC005021 mRNA. Translation: AAH05021.1 .
CCDSi CCDS45964.1. [Q9Y6Q5-1 ]
RefSeqi NP_005489.2. NM_005498.4. [Q9Y6Q5-1 ]
XP_005259758.1. XM_005259701.1. [Q9Y6Q5-2 ]
UniGenei Hs.18894.

3D structure databases

ProteinModelPortali Q9Y6Q5.
SMRi Q9Y6Q5. Positions 2-422.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115364. 31 interactions.
IntActi Q9Y6Q5. 6 interactions.
MINTi MINT-1448582.
STRINGi 9606.ENSP00000250244.

PTM databases

PhosphoSitei Q9Y6Q5.

Polymorphism databases

DMDMi 13123953.

Proteomic databases

MaxQBi Q9Y6Q5.
PaxDbi Q9Y6Q5.
PRIDEi Q9Y6Q5.

Protocols and materials databases

DNASUi 10053.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000250244 ; ENSP00000250244 ; ENSG00000129354 . [Q9Y6Q5-1 ]
ENST00000590923 ; ENSP00000465685 ; ENSG00000129354 . [Q9Y6Q5-2 ]
GeneIDi 10053.
KEGGi hsa:10053.
UCSCi uc002mpc.3. human. [Q9Y6Q5-1 ]
uc002mpd.3. human. [Q9Y6Q5-2 ]

Organism-specific databases

CTDi 10053.
GeneCardsi GC19M010683.
HGNCi HGNC:558. AP1M2.
MIMi 607309. gene.
neXtProti NX_Q9Y6Q5.
PharmGKBi PA24849.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG315786.
GeneTreei ENSGT00530000062779.
HOGENOMi HOG000173247.
HOVERGENi HBG050516.
InParanoidi Q9Y6Q5.
KOi K12393.
OMAi QHEEEGL.
PhylomeDBi Q9Y6Q5.
TreeFami TF300393.

Enzyme and pathway databases

Reactomei REACT_11103. Nef mediated downregulation of MHC class I complex cell surface expression.
REACT_121399. MHC class II antigen presentation.
REACT_19287. Lysosome Vesicle Biogenesis.
REACT_19400. Golgi Associated Vesicle Biogenesis.
SignaLinki Q9Y6Q5.

Miscellaneous databases

GeneWikii AP1M2.
GenomeRNAii 10053.
NextBioi 37981.
PROi Q9Y6Q5.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y6Q5.
CleanExi HS_AP1M2.
ExpressionAtlasi Q9Y6Q5. baseline and differential.
Genevestigatori Q9Y6Q5.

Family and domain databases

InterProi IPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR008968. Clathrin_mu_C.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
[Graphical view ]
Pfami PF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
[Graphical view ]
PIRSFi PIRSF005992. Clathrin_mu. 1 hit.
PRINTSi PR00314. CLATHRINADPT.
SUPFAMi SSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEi PS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Colon and Placenta.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAP1M2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6Q5
Secondary accession number(s): B2RDV5, Q9BSI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 127 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3