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Protein

Zinc finger protein 37 homolog

Gene

ZFP37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri293 – 31523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 36719C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri517 – 53923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri545 – 56723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri573 – 59523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri601 – 62323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 37 homolog
Short name:
Zfp-37
Gene namesi
Name:ZFP37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:12863. ZFP37.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37452.

Polymorphism and mutation databases

BioMutaiZFP37.
DMDMi257051078.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 630630Zinc finger protein 37 homologPRO_0000047293Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y6Q3.
PaxDbiQ9Y6Q3.
PeptideAtlasiQ9Y6Q3.
PRIDEiQ9Y6Q3.

PTM databases

iPTMnetiQ9Y6Q3.
PhosphoSiteiQ9Y6Q3.

Expressioni

Tissue specificityi

Expressed at low level in several tissues including fetal cartilage.

Gene expression databases

BgeeiQ9Y6Q3.
CleanExiHS_ZFP37.
GenevisibleiQ9Y6Q3. HS.

Organism-specific databases

HPAiHPA049112.

Interactioni

Protein-protein interaction databases

BioGridi113371. 1 interaction.
STRINGi9606.ENSP00000363344.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6Q3.
SMRiQ9Y6Q3. Positions 180-623.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 10372KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri293 – 31523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 36719C2H2-type 3; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri377 – 39923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri405 – 42723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri433 – 45523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri461 – 48323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri489 – 51123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri517 – 53923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri545 – 56723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri573 – 59523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri601 – 62323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9Y6Q3.
KOiK09228.
OMAiKHVPSKK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9Y6Q3.
TreeFamiTF350860.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 9 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y6Q3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVSSGVQIL TKPETVDRRR SAETTKEAGR PLEMAVSEPE ASAAEWKQLD
60 70 80 90 100
PAQSNLYNDV MLENYCNQAS MGCQAPKPDM ISKLEKGEAP WLGKGKRPSQ
110 120 130 140 150
GCPSKIARPK QKETDGKVQK DDDQLENIQK SQNKLLREVA VKKKTQAKKN
160 170 180 190 200
GSDCGSLGKK NNLHKKHVPS KKRLLKFESC GKILKQNLDL PDHSRNCVKR
210 220 230 240 250
KSDAAKEHKK SFNHSLSDTR KGKKQTGKKH EKLSSHSSSD KCNKTGKKHD
260 270 280 290 300
KLCCHSSSHI KQDKIQTGEK HEKSPSLSSS TKHEKPQACV KPYECNQCGK
310 320 330 340 350
VLSHKQGLID HQRVHTGEKP YECNECGIAF SQKSHLVVHQ RTHTGEKPYE
360 370 380 390 400
CIQCGKAHGH KHALTDHLRI HTGEKPYECA ECGKTFRHSS NLIQHVRSHT
410 420 430 440 450
GEKPYECKEC GKSFRYNSSL TEHVRTHTGE IPYECNECGK AFKYSSSLTK
460 470 480 490 500
HMRIHTGEKP FECNECGKAF SKKSHLIIHQ RTHTKEKPYK CNECGKAFGH
510 520 530 540 550
SSSLTYHMRT HTGESPFECN QCGKGFKQIE GLTQHQRVHT GEKPYECNEC
560 570 580 590 600
GKAFSQKSHL IVHQRTHTGE KPYECNECEK AFNAKSQLVI HQRSHTGEKP
610 620 630
YECNECGKTF KQNASLTKHV KTHSEDKSHE
Length:630
Mass (Da):71,209
Last modified:September 1, 2009 - v3
Checksum:i91AB6D25BB0B9C9D
GO
Isoform 2 (identifier: Q9Y6Q3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-44: A → AVSVTFKHVTMAFTQK

Note: No experimental confirmation available.
Show »
Length:645
Mass (Da):72,915
Checksum:iCFDC1DA593DFF92B
GO
Isoform 3 (identifier: Q9Y6Q3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-44: A → AK

Note: No experimental confirmation. Gene prediction based on EST data.
Show »
Length:631
Mass (Da):71,338
Checksum:i095BE5E43AB88B58
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601K → KK in BAG62836 (PubMed:14702039).Curated
Sequence conflicti282 – 2821K → R in BAG62836 (PubMed:14702039).Curated
Sequence conflicti311 – 3111H → R in BAG62836 (PubMed:14702039).Curated
Sequence conflicti382 – 3821C → F in BAG62836 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71V → D.2 Publications
Corresponds to variant rs2282076 [ dbSNP | Ensembl ].
VAR_058701

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei44 – 441A → AVSVTFKHVTMAFTQK in isoform 2. 1 PublicationVSP_037941
Alternative sequencei44 – 441A → AK in isoform 3. CuratedVSP_055044

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022158 mRNA. Translation: AAC28425.1.
AK301275 mRNA. Translation: BAG62836.1.
AL162588 Genomic DNA. No translation available.
CH878453 Genomic DNA. Translation: EAW50556.1.
BC126390 mRNA. Translation: AAI26391.1.
CCDSiCCDS65109.1. [Q9Y6Q3-3]
CCDS65110.1. [Q9Y6Q3-2]
CCDS6787.1. [Q9Y6Q3-1]
RefSeqiNP_001269444.1. NM_001282515.1. [Q9Y6Q3-2]
NP_001269447.1. NM_001282518.1. [Q9Y6Q3-3]
NP_003399.1. NM_003408.2. [Q9Y6Q3-1]
UniGeneiHs.150406.

Genome annotation databases

EnsembliENST00000374227; ENSP00000363344; ENSG00000136866. [Q9Y6Q3-1]
ENST00000553380; ENSP00000452552; ENSG00000136866. [Q9Y6Q3-2]
ENST00000555206; ENSP00000451310; ENSG00000136866. [Q9Y6Q3-3]
GeneIDi7539.
KEGGihsa:7539.
UCSCiuc004bgm.3. human. [Q9Y6Q3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022158 mRNA. Translation: AAC28425.1.
AK301275 mRNA. Translation: BAG62836.1.
AL162588 Genomic DNA. No translation available.
CH878453 Genomic DNA. Translation: EAW50556.1.
BC126390 mRNA. Translation: AAI26391.1.
CCDSiCCDS65109.1. [Q9Y6Q3-3]
CCDS65110.1. [Q9Y6Q3-2]
CCDS6787.1. [Q9Y6Q3-1]
RefSeqiNP_001269444.1. NM_001282515.1. [Q9Y6Q3-2]
NP_001269447.1. NM_001282518.1. [Q9Y6Q3-3]
NP_003399.1. NM_003408.2. [Q9Y6Q3-1]
UniGeneiHs.150406.

3D structure databases

ProteinModelPortaliQ9Y6Q3.
SMRiQ9Y6Q3. Positions 180-623.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113371. 1 interaction.
STRINGi9606.ENSP00000363344.

PTM databases

iPTMnetiQ9Y6Q3.
PhosphoSiteiQ9Y6Q3.

Polymorphism and mutation databases

BioMutaiZFP37.
DMDMi257051078.

Proteomic databases

MaxQBiQ9Y6Q3.
PaxDbiQ9Y6Q3.
PeptideAtlasiQ9Y6Q3.
PRIDEiQ9Y6Q3.

Protocols and materials databases

DNASUi7539.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374227; ENSP00000363344; ENSG00000136866. [Q9Y6Q3-1]
ENST00000553380; ENSP00000452552; ENSG00000136866. [Q9Y6Q3-2]
ENST00000555206; ENSP00000451310; ENSG00000136866. [Q9Y6Q3-3]
GeneIDi7539.
KEGGihsa:7539.
UCSCiuc004bgm.3. human. [Q9Y6Q3-1]

Organism-specific databases

CTDi7539.
GeneCardsiZFP37.
HGNCiHGNC:12863. ZFP37.
HPAiHPA049112.
MIMi602951. gene.
neXtProtiNX_Q9Y6Q3.
PharmGKBiPA37452.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129694.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9Y6Q3.
KOiK09228.
OMAiKHVPSKK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9Y6Q3.
TreeFamiTF350860.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7539.
PROiQ9Y6Q3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y6Q3.
CleanExiHS_ZFP37.
GenevisibleiQ9Y6Q3. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 9 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization, and chromosomal assignment of the human ortholog of murine Zfp-37, a candidate gene for Nager syndrome."
    Dreyer S.D., Zhou L., Machado M.A., Horton W.A., Zabel B., Winterpacht A., Lee B.
    Mamm. Genome 9:458-462(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Cartilage.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASP-7.
    Tissue: Spleen.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ASP-7.
    Tissue: Brain.

Entry informationi

Entry nameiZFP37_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6Q3
Secondary accession number(s): A0AVJ9
, B4DVX4, G3V3L7, Q5T7Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 1, 2009
Last modified: July 6, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-34 is the initiator. Orthologous sequences start at a downstream Met.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.