Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y6Q1

- CAN6_HUMAN

UniProt

Q9Y6Q1 - CAN6_HUMAN

Protein

Calpain-6

Gene

CAPN6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (04 May 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues By similarity.By similarity

    GO - Molecular functioni

    1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome
    2. microtubule binding Source: UniProtKB

    GO - Biological processi

    1. microtubule bundle formation Source: UniProtKB
    2. proteolysis Source: RefGenome
    3. regulation of cytoskeleton organization Source: UniProtKB

    Protein family/group databases

    MEROPSiC02.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calpain-6
    Alternative name(s):
    Calpain-like protease X-linked
    Calpamodulin
    Short name:
    CalpM
    Gene namesi
    Name:CAPN6
    Synonyms:CALPM, CANPX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:1483. CAPN6.

    Subcellular locationi

    Cytoplasmperinuclear region 1 Publication. Cytoplasmcytoskeletonspindle 1 Publication
    Note: During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle.

    GO - Cellular componenti

    1. perinuclear region of cytoplasm Source: UniProtKB
    2. spindle microtubule Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26063.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 641641Calpain-6PRO_0000207717Add
    BLAST

    Proteomic databases

    PaxDbiQ9Y6Q1.
    PRIDEiQ9Y6Q1.

    PTM databases

    PhosphoSiteiQ9Y6Q1.

    Expressioni

    Tissue specificityi

    Expressed only in placenta.

    Gene expression databases

    ArrayExpressiQ9Y6Q1.
    BgeeiQ9Y6Q1.
    CleanExiHS_CAPN6.
    GenevestigatoriQ9Y6Q1.

    Organism-specific databases

    HPAiHPA040383.

    Interactioni

    Subunit structurei

    Interacts (via domain III) with microtubules. Interacts (via domain II) with ARHGEF2 (via the N-terminal zinc finger).By similarity

    Protein-protein interaction databases

    IntActiQ9Y6Q1. 1 interaction.
    MINTiMINT-195834.
    STRINGi9606.ENSP00000317214.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y6Q1.
    SMRiQ9Y6Q1. Positions 8-489, 513-602.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 343318Calpain catalyticPROSITE-ProRule annotationAdd
    BLAST
    Domaini518 – 620103C2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni344 – 495152Domain IIIAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C2 family.Curated
    Contains 1 C2 domain.Curated
    Contains 1 calpain catalytic domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG258770.
    HOGENOMiHOG000232036.
    HOVERGENiHBG001095.
    InParanoidiQ9Y6Q1.
    KOiK08575.
    OMAiFCDQFLG.
    OrthoDBiEOG75J0MJ.
    PhylomeDBiQ9Y6Q1.
    TreeFamiTF314748.

    Family and domain databases

    Gene3Di2.60.40.150. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR029540. CAPN6.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view]
    PANTHERiPTHR10183:SF281. PTHR10183:SF281. 1 hit.
    PfamiPF00168. C2. 1 hit.
    PF01067. Calpain_III. 1 hit.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view]
    PRINTSiPR00704. CALPAIN.
    SMARTiSM00239. C2. 1 hit.
    SM00720. calpain_III. 1 hit.
    SM00230. CysPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF49758. SSF49758. 1 hit.
    PROSITEiPS50203. CALPAIN_CAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y6Q1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPPLKLFKN QKYQELKQEC IKDSRLFCDP TFLPENDSLF YNRLLPGKVV    50
    WKRPQDICDD PHLIVGNISN HQLTQGRLGH KPMVSAFSCL AVQESHWTKT 100
    IPNHKEQEWD PQKTEKYAGI FHFRFWHFGE WTEVVIDDLL PTINGDLVFS 150
    FSTSMNEFWN ALLEKAYAKL LGCYEALDGL TITDIIVDFT GTLAETVDMQ 200
    KGRYTELVEE KYKLFGELYK TFTKGGLICC SIESPNQEEQ EVETDWGLLK 250
    GHTYTMTDIR KIRLGERLVE VFSAEKVYMV RLRNPLGRQE WSGPWSEISE 300
    EWQQLTASDR KNLGLVMSDD GEFWMSLEDF CRNFHKLNVC RNVNNPIFGR 350
    KELESVLGCW TVDDDPLMNR SGGCYNNRDT FLQNPQYIFT VPEDGHKVIM 400
    SLQQKDLRTY RRMGRPDNYI IGFELFKVEM NRKFRLHHLY IQERAGTSTY 450
    IDTRTVFLSK YLKKGNYVLV PTMFQHGRTS EFLLRIFSEV PVQLRELTLD 500
    MPKMSCWNLA RGYPKVVTQI TVHSAEDLEK KYANETVNPY LVIKCGKEEV 550
    RSPVQKNTVH AIFDTQAIFY RRTTDIPIIV QVWNSRKFCD QFLGQVTLDA 600
    DPSDCRDLKS LYLRKKGGPT AKVKQGHISF KVISSDDLTE L 641
    Length:641
    Mass (Da):74,576
    Last modified:May 4, 2001 - v2
    Checksum:iA48E5291169B1028
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421N → F in CAA04051. 1 PublicationCurated
    Sequence conflicti415 – 4162RP → KT in AAB86605. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti277 – 2771V → L.1 Publication
    Corresponds to variant rs12013711 [ dbSNP | Ensembl ].
    VAR_021084
    Natural varianti358 – 3581G → R in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036048
    Natural varianti518 – 5181T → I.
    Corresponds to variant rs12851517 [ dbSNP | Ensembl ].
    VAR_051515

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF029232 mRNA. Translation: AAB86605.1.
    AJ000388 mRNA. Translation: CAA04051.1.
    AY800242 Genomic DNA. Translation: AAV41896.1.
    AL031117 Genomic DNA. Translation: CAA19965.1.
    CH471120 Genomic DNA. Translation: EAX02650.1.
    CH471120 Genomic DNA. Translation: EAX02651.1.
    BC000730 mRNA. Translation: AAH00730.1.
    CCDSiCCDS14555.1.
    RefSeqiNP_055104.2. NM_014289.3.
    UniGeneiHs.496593.

    Genome annotation databases

    EnsembliENST00000324068; ENSP00000317214; ENSG00000077274.
    GeneIDi827.
    KEGGihsa:827.
    UCSCiuc004epc.2. human.

    Polymorphism databases

    DMDMi13959315.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF029232 mRNA. Translation: AAB86605.1 .
    AJ000388 mRNA. Translation: CAA04051.1 .
    AY800242 Genomic DNA. Translation: AAV41896.1 .
    AL031117 Genomic DNA. Translation: CAA19965.1 .
    CH471120 Genomic DNA. Translation: EAX02650.1 .
    CH471120 Genomic DNA. Translation: EAX02651.1 .
    BC000730 mRNA. Translation: AAH00730.1 .
    CCDSi CCDS14555.1.
    RefSeqi NP_055104.2. NM_014289.3.
    UniGenei Hs.496593.

    3D structure databases

    ProteinModelPortali Q9Y6Q1.
    SMRi Q9Y6Q1. Positions 8-489, 513-602.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9Y6Q1. 1 interaction.
    MINTi MINT-195834.
    STRINGi 9606.ENSP00000317214.

    Protein family/group databases

    MEROPSi C02.971.

    PTM databases

    PhosphoSitei Q9Y6Q1.

    Polymorphism databases

    DMDMi 13959315.

    Proteomic databases

    PaxDbi Q9Y6Q1.
    PRIDEi Q9Y6Q1.

    Protocols and materials databases

    DNASUi 827.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000324068 ; ENSP00000317214 ; ENSG00000077274 .
    GeneIDi 827.
    KEGGi hsa:827.
    UCSCi uc004epc.2. human.

    Organism-specific databases

    CTDi 827.
    GeneCardsi GC0XM110488.
    HGNCi HGNC:1483. CAPN6.
    HPAi HPA040383.
    MIMi 300146. gene.
    neXtProti NX_Q9Y6Q1.
    PharmGKBi PA26063.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG258770.
    HOGENOMi HOG000232036.
    HOVERGENi HBG001095.
    InParanoidi Q9Y6Q1.
    KOi K08575.
    OMAi FCDQFLG.
    OrthoDBi EOG75J0MJ.
    PhylomeDBi Q9Y6Q1.
    TreeFami TF314748.

    Miscellaneous databases

    ChiTaRSi CAPN6. human.
    GenomeRNAii 827.
    NextBioi 3404.
    PROi Q9Y6Q1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y6Q1.
    Bgeei Q9Y6Q1.
    CleanExi HS_CAPN6.
    Genevestigatori Q9Y6Q1.

    Family and domain databases

    Gene3Di 2.60.40.150. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR029540. CAPN6.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view ]
    PANTHERi PTHR10183:SF281. PTHR10183:SF281. 1 hit.
    Pfami PF00168. C2. 1 hit.
    PF01067. Calpain_III. 1 hit.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view ]
    PRINTSi PR00704. CALPAIN.
    SMARTi SM00239. C2. 1 hit.
    SM00720. calpain_III. 1 hit.
    SM00230. CysPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF49758. SSF49758. 1 hit.
    PROSITEi PS50203. CALPAIN_CAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution."
      Dear T.N., Matena K., Vingron M., Boehm T.
      Genomics 45:175-184(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Crotty P.L.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    3. "A novel X-linked calpain-like protease."
      Belsito A., Piluso G., Nigro V.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. NIEHS SNPs program
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT LEU-277.
    5. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    8. "Calpain 6 is involved in microtubule stabilization and cytoskeletal organization."
      Tonami K., Kurihara Y., Aburatani H., Uchijima Y., Asano T., Kurihara H.
      Mol. Cell. Biol. 27:2548-2561(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, FUNCTION, INTERACTION WITH MICROTUBULE.
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-358.

    Entry informationi

    Entry nameiCAN6_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y6Q1
    Secondary accession number(s): D3DUY7, Q9UEQ1, Q9UJA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 4, 2001
    Last sequence update: May 4, 2001
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3