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Protein

Cadherin-10

Gene

CDH10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-10
Alternative name(s):
T2-cadherin
Gene namesi
Name:CDH10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:1749. CDH10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini55 – 613ExtracellularSequence analysisAdd BLAST559
Transmembranei614 – 634HelicalSequence analysisAdd BLAST21
Topological domaini635 – 788CytoplasmicSequence analysisAdd BLAST154

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1008.
OpenTargetsiENSG00000040731.
PharmGKBiPA26283.

Polymorphism and mutation databases

BioMutaiCDH10.
DMDMi116241276.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000000378123 – 54Sequence analysisAdd BLAST32
ChainiPRO_000000378255 – 788Cadherin-10Add BLAST734

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi256N-linked (GlcNAc...)Sequence analysis1
Glycosylationi438N-linked (GlcNAc...)Sequence analysis1
Glycosylationi456N-linked (GlcNAc...)Sequence analysis1
Glycosylationi534N-linked (GlcNAc...)Sequence analysis1
Modified residuei784PhosphoserineCombined sources1
Modified residuei788PhosphoserineBy similarity1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9Y6N8.
PeptideAtlasiQ9Y6N8.
PRIDEiQ9Y6N8.

PTM databases

iPTMnetiQ9Y6N8.
PhosphoSitePlusiQ9Y6N8.

Expressioni

Tissue specificityi

Predominantly expressed in brain. Also found in adult and fetal kidney. Very low levels detected in prostate and fetal lung.1 Publication

Gene expression databases

BgeeiENSG00000040731.
CleanExiHS_CDH10.
ExpressionAtlasiQ9Y6N8. baseline and differential.
GenevisibleiQ9Y6N8. HS.

Organism-specific databases

HPAiHPA010651.

Interactioni

Protein-protein interaction databases

BioGridi107443. 6 interactors.
IntActiQ9Y6N8. 4 interactors.
MINTiMINT-1386628.
STRINGi9606.ENSP00000264463.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6N8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 160Cadherin 1PROSITE-ProRule annotationAdd BLAST106
Domaini161 – 269Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini270 – 384Cadherin 3PROSITE-ProRule annotationAdd BLAST115
Domaini385 – 487Cadherin 4PROSITE-ProRule annotationAdd BLAST103
Domaini488 – 606Cadherin 5PROSITE-ProRule annotationAdd BLAST119

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9Y6N8.
KOiK06802.
OMAiLLWVCLP.
OrthoDBiEOG091G0298.
PhylomeDBiQ9Y6N8.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIHQFLLLF LFWVCLPHFC SPEIMFRRTP VPQQRILSSR VPRSDGKILH
60 70 80 90 100
RQKRGWMWNQ FFLLEEYTGS DYQYVGKLHS DQDKGDGSLK YILSGDGAGT
110 120 130 140 150
LFIIDEKTGD IHATRRIDRE EKAFYTLRAQ AINRRTLRPV EPESEFVIKI
160 170 180 190 200
HDINDNEPTF PEEIYTASVP EMSVVGTSVV QVTATDADDP SYGNSARVIY
210 220 230 240 250
SILQGQPYFS VEPETGIIRT ALPNMNRENR EQYQVVIQAK DMGGQMGGLS
260 270 280 290 300
GTTTVNITLT DVNDNPPRFP QNTIHLRVLE SSPVGTAIGS VKATDADTGK
310 320 330 340 350
NAEVEYRIID GDGTDMFDIV TEKDTQEGII TVKKPLDYES RRLYTLKVEA
360 370 380 390 400
ENTHVDPRFY YLGPFKDTTI VKISIEDVDE PPVFSRSSYL FEVHEDIEVG
410 420 430 440 450
TIIGTVMARD PDSISSPIRF SLDRHTDLDR IFNIHSGNGS LYTSKPLDRE
460 470 480 490 500
LSQWHNLTVI AAEINNPKET TRVAVFVRIL DVNDNAPQFA VFYDTFVCEN
510 520 530 540 550
ARPGQLIQTI SAVDKDDPLG GQKFFFSLAA VNPNFTVQDN EDNTARILTR
560 570 580 590 600
KNGFNRHEIS TYLLPVVISD NDYPIQSSTG TLTIRVCACD SQGNMQSCSA
610 620 630 640 650
EALLLPAGLS TGALIAILLC IIILLVIVVL FAALKRQRKK EPLILSKEDI
660 670 680 690 700
RDNIVSYNDE GGGEEDTQAF DIGTLRNPAA IEEKKLRRDI IPETLFIPRR
710 720 730 740 750
TPTAPDNTDV RDFINERLKE HDLDPTAPPY DSLATYAYEG NDSIAESLSS
760 770 780
LESGTTEGDQ NYDYLREWGP RFNKLAEMYG GGESDKDS
Length:788
Mass (Da):88,451
Last modified:October 17, 2006 - v2
Checksum:iE92908F9C19270B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34Q → R in AAD44017 (PubMed:10386616).Curated1
Sequence conflicti482V → A in AAD44017 (PubMed:10386616).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036102371V → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_028751413S → F.Corresponds to variant rs1395027dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039747 mRNA. Translation: AAD44017.1.
AB035303 mRNA. Translation: BAA87417.1.
CCDSiCCDS3892.1.
RefSeqiNP_006718.2. NM_006727.4.
XP_011512225.1. XM_011513923.2.
UniGeneiHs.92489.

Genome annotation databases

EnsembliENST00000264463; ENSP00000264463; ENSG00000040731.
GeneIDi1008.
KEGGihsa:1008.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039747 mRNA. Translation: AAD44017.1.
AB035303 mRNA. Translation: BAA87417.1.
CCDSiCCDS3892.1.
RefSeqiNP_006718.2. NM_006727.4.
XP_011512225.1. XM_011513923.2.
UniGeneiHs.92489.

3D structure databases

ProteinModelPortaliQ9Y6N8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107443. 6 interactors.
IntActiQ9Y6N8. 4 interactors.
MINTiMINT-1386628.
STRINGi9606.ENSP00000264463.

PTM databases

iPTMnetiQ9Y6N8.
PhosphoSitePlusiQ9Y6N8.

Polymorphism and mutation databases

BioMutaiCDH10.
DMDMi116241276.

Proteomic databases

PaxDbiQ9Y6N8.
PeptideAtlasiQ9Y6N8.
PRIDEiQ9Y6N8.

Protocols and materials databases

DNASUi1008.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264463; ENSP00000264463; ENSG00000040731.
GeneIDi1008.
KEGGihsa:1008.

Organism-specific databases

CTDi1008.
DisGeNETi1008.
GeneCardsiCDH10.
HGNCiHGNC:1749. CDH10.
HPAiHPA010651.
MIMi604555. gene.
neXtProtiNX_Q9Y6N8.
OpenTargetsiENSG00000040731.
PharmGKBiPA26283.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118954.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9Y6N8.
KOiK06802.
OMAiLLWVCLP.
OrthoDBiEOG091G0298.
PhylomeDBiQ9Y6N8.
TreeFamiTF329887.

Enzyme and pathway databases

ReactomeiR-HSA-418990. Adherens junctions interactions.

Miscellaneous databases

ChiTaRSiCDH10. human.
GeneWikiiCDH10.
GenomeRNAii1008.
PROiQ9Y6N8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000040731.
CleanExiHS_CDH10.
ExpressionAtlasiQ9Y6N8. baseline and differential.
GenevisibleiQ9Y6N8. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD10_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6N8
Secondary accession number(s): Q9ULB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.