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Protein

Cadherin-10

Gene

CDH10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-418990. Adherens junctions interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-10
Alternative name(s):
T2-cadherin
Gene namesi
Name:CDH10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:1749. CDH10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini55 – 613559ExtracellularSequence analysisAdd
BLAST
Transmembranei614 – 63421HelicalSequence analysisAdd
BLAST
Topological domaini635 – 788154CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26283.

Polymorphism and mutation databases

BioMutaiCDH10.
DMDMi116241276.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 5432Sequence analysisPRO_0000003781Add
BLAST
Chaini55 – 788734Cadherin-10PRO_0000003782Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence analysis
Glycosylationi438 – 4381N-linked (GlcNAc...)Sequence analysis
Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence analysis
Glycosylationi534 – 5341N-linked (GlcNAc...)Sequence analysis
Modified residuei784 – 7841PhosphoserineCombined sources
Modified residuei788 – 7881PhosphoserineBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9Y6N8.
PeptideAtlasiQ9Y6N8.
PRIDEiQ9Y6N8.

PTM databases

iPTMnetiQ9Y6N8.
PhosphoSiteiQ9Y6N8.

Expressioni

Tissue specificityi

Predominantly expressed in brain. Also found in adult and fetal kidney. Very low levels detected in prostate and fetal lung.1 Publication

Gene expression databases

BgeeiQ9Y6N8.
CleanExiHS_CDH10.
ExpressionAtlasiQ9Y6N8. baseline and differential.
GenevisibleiQ9Y6N8. HS.

Organism-specific databases

HPAiHPA010651.

Interactioni

Protein-protein interaction databases

BioGridi107443. 6 interactions.
IntActiQ9Y6N8. 4 interactions.
MINTiMINT-1386628.
STRINGi9606.ENSP00000264463.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6N8.
SMRiQ9Y6N8. Positions 56-587, 687-782.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 160106Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini161 – 269109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini270 – 384115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini385 – 487103Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini488 – 606119Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9Y6N8.
KOiK06802.
OMAiLLWVCLP.
OrthoDBiEOG7GBFW7.
PhylomeDBiQ9Y6N8.
TreeFamiTF329887.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIHQFLLLF LFWVCLPHFC SPEIMFRRTP VPQQRILSSR VPRSDGKILH
60 70 80 90 100
RQKRGWMWNQ FFLLEEYTGS DYQYVGKLHS DQDKGDGSLK YILSGDGAGT
110 120 130 140 150
LFIIDEKTGD IHATRRIDRE EKAFYTLRAQ AINRRTLRPV EPESEFVIKI
160 170 180 190 200
HDINDNEPTF PEEIYTASVP EMSVVGTSVV QVTATDADDP SYGNSARVIY
210 220 230 240 250
SILQGQPYFS VEPETGIIRT ALPNMNRENR EQYQVVIQAK DMGGQMGGLS
260 270 280 290 300
GTTTVNITLT DVNDNPPRFP QNTIHLRVLE SSPVGTAIGS VKATDADTGK
310 320 330 340 350
NAEVEYRIID GDGTDMFDIV TEKDTQEGII TVKKPLDYES RRLYTLKVEA
360 370 380 390 400
ENTHVDPRFY YLGPFKDTTI VKISIEDVDE PPVFSRSSYL FEVHEDIEVG
410 420 430 440 450
TIIGTVMARD PDSISSPIRF SLDRHTDLDR IFNIHSGNGS LYTSKPLDRE
460 470 480 490 500
LSQWHNLTVI AAEINNPKET TRVAVFVRIL DVNDNAPQFA VFYDTFVCEN
510 520 530 540 550
ARPGQLIQTI SAVDKDDPLG GQKFFFSLAA VNPNFTVQDN EDNTARILTR
560 570 580 590 600
KNGFNRHEIS TYLLPVVISD NDYPIQSSTG TLTIRVCACD SQGNMQSCSA
610 620 630 640 650
EALLLPAGLS TGALIAILLC IIILLVIVVL FAALKRQRKK EPLILSKEDI
660 670 680 690 700
RDNIVSYNDE GGGEEDTQAF DIGTLRNPAA IEEKKLRRDI IPETLFIPRR
710 720 730 740 750
TPTAPDNTDV RDFINERLKE HDLDPTAPPY DSLATYAYEG NDSIAESLSS
760 770 780
LESGTTEGDQ NYDYLREWGP RFNKLAEMYG GGESDKDS
Length:788
Mass (Da):88,451
Last modified:October 17, 2006 - v2
Checksum:iE92908F9C19270B2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341Q → R in AAD44017 (PubMed:10386616).Curated
Sequence conflicti482 – 4821V → A in AAD44017 (PubMed:10386616).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti371 – 3711V → L in a breast cancer sample; somatic mutation. 1 Publication
VAR_036102
Natural varianti413 – 4131S → F.
Corresponds to variant rs1395027 [ dbSNP | Ensembl ].
VAR_028751

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039747 mRNA. Translation: AAD44017.1.
AB035303 mRNA. Translation: BAA87417.1.
CCDSiCCDS3892.1.
RefSeqiNP_006718.2. NM_006727.4.
XP_011512225.1. XM_011513923.1.
XP_011512226.1. XM_011513924.1.
UniGeneiHs.92489.

Genome annotation databases

EnsembliENST00000264463; ENSP00000264463; ENSG00000040731.
GeneIDi1008.
KEGGihsa:1008.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF039747 mRNA. Translation: AAD44017.1.
AB035303 mRNA. Translation: BAA87417.1.
CCDSiCCDS3892.1.
RefSeqiNP_006718.2. NM_006727.4.
XP_011512225.1. XM_011513923.1.
XP_011512226.1. XM_011513924.1.
UniGeneiHs.92489.

3D structure databases

ProteinModelPortaliQ9Y6N8.
SMRiQ9Y6N8. Positions 56-587, 687-782.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107443. 6 interactions.
IntActiQ9Y6N8. 4 interactions.
MINTiMINT-1386628.
STRINGi9606.ENSP00000264463.

PTM databases

iPTMnetiQ9Y6N8.
PhosphoSiteiQ9Y6N8.

Polymorphism and mutation databases

BioMutaiCDH10.
DMDMi116241276.

Proteomic databases

PaxDbiQ9Y6N8.
PeptideAtlasiQ9Y6N8.
PRIDEiQ9Y6N8.

Protocols and materials databases

DNASUi1008.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264463; ENSP00000264463; ENSG00000040731.
GeneIDi1008.
KEGGihsa:1008.

Organism-specific databases

CTDi1008.
GeneCardsiCDH10.
HGNCiHGNC:1749. CDH10.
HPAiHPA010651.
MIMi604555. gene.
neXtProtiNX_Q9Y6N8.
PharmGKBiPA26283.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiQ9Y6N8.
KOiK06802.
OMAiLLWVCLP.
OrthoDBiEOG7GBFW7.
PhylomeDBiQ9Y6N8.
TreeFamiTF329887.

Enzyme and pathway databases

ReactomeiR-HSA-418990. Adherens junctions interactions.

Miscellaneous databases

ChiTaRSiCDH10. human.
GeneWikiiCDH10.
GenomeRNAii1008.
PROiQ9Y6N8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y6N8.
CleanExiHS_CDH10.
ExpressionAtlasiQ9Y6N8. baseline and differential.
GenevisibleiQ9Y6N8. HS.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14."
    Kools P., Vanhalst K., van den Eynde E., van Roy F.
    FEBS Lett. 452:328-334(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadherins."
    Shimoyama Y., Tsujimoto G., Kitajima M., Natori M.
    Biochem. J. 349:159-167(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-784, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-784, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-371.

Entry informationi

Entry nameiCAD10_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6N8
Secondary accession number(s): Q9ULB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 17, 2006
Last modified: July 6, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.