Q9Y6N7 (ROBO1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Roundabout homolog 1

Alternative name(s):
Deleted in U twenty twenty
H-Robo-1

Gene names

Name:	ROBO1
Synonyms:	DUTT1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1651 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for SLIT1 and SLIT2 which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. May be required for lung development. Ref.6
Subunit structure	Interacts with SLIT1 and SLIT2. Ref.6 Ref.10
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Widely expressed, with exception of kidney. Ref.7
Post-translational modification	Ubiquitinated. May be deubiquitinated by USP33 By similarity.
Miscellaneous	Maps within a region of overlapping homozygous deletions characterized in both small cell lung cancer cell lines (SCLC) and in a breast cancer cell line. The promoter region of ROBO1 shows complete hypermethylation of CpG sites in the BT-20 breast tumor cell lines, some primary invasive breast carcinomasa and some primary clear cell renal cell carcinomas (CC-RCC).
Sequence similarities	Belongs to the immunoglobulin superfamily. ROBO family. Contains 3 fibronectin type-III domains. Contains 5 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Biological process	Chemotaxis Differentiation Neurogenesis
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Developmental protein Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Roundabout signaling pathway Inferred from mutant phenotype PubMed 18829537. Source: BHF-UCL activation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from mutant phenotype PubMed 18566128. Source: UniProtKB axon midline choice point recognition Inferred from sequence or structural similarity. Source: UniProtKB cell migration involved in sprouting angiogenesis Inferred from mutant phenotype PubMed 19351956. Source: BHF-UCL chemorepulsion involved in postnatal olfactory bulb interneuron migration Inferred from direct assay PubMed 15207848. Source: UniProtKB homophilic cell adhesion Inferred from direct assay PubMed 12504588. Source: UniProtKB mammary duct terminal end bud growth Inferred from electronic annotation. Source: Compara negative regulation of chemokine-mediated signaling pathway Inferred from mutant phenotype PubMed 18829537. Source: BHF-UCL negative regulation of mammary gland epithelial cell proliferation Inferred from mutant phenotype PubMed 18829537. Source: BHF-UCL negative regulation of negative chemotaxis Inferred from direct assay PubMed 11748139. Source: UniProtKB positive regulation of axonogenesis Inferred from direct assay PubMed 12504588. Source: UniProtKB
Cellular_component	axolemma Inferred from electronic annotation. Source: Compara cell surface Inferred from direct assay PubMed 12504588. Source: UniProtKB cytoplasm Inferred from direct assay PubMed 18566128. Source: UniProtKB integral to plasma membrane Traceable author statement Ref.7. Source: ProtInc
Molecular_function	axon guidance receptor activity Traceable author statement Ref.1. Source: ProtInc identical protein binding Inferred from direct assay PubMed 12504588. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y6N7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y6N7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     543-543: Q → QGKVN

Note: Incomplete.

Isoform 3 (identifier: Q9Y6N7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     40-57: HGTPIPTSDNDDNSLGYT → MIAEPAHFYLFGLICLCS
     348-348: Q → QVGS

Isoform 4 (identifier: Q9Y6N7-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.
     40-57: HGTPIPTSDNDDNSLGYT → MIAEPAHFYLFGLICLCS

Isoform 5 (identifier: Q9Y6N7-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: MKWKHVPFLVMISLLSLSPNHLFLAQLIPDPEDVERGNDHGTPIPTSDNDDNSLGYT → MIAEPAHFYLFGLICLCS
     348-348: Q → QVGS
     938-946: Missing.

Note: No experimental confirmation available.

Isoform 6 (identifier: Q9Y6N7-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: MKWKHVPFLVMISLLSLSPNHLFLAQLIPDPEDVERGNDHGTPIPTSDNDDNSLGYT → MIAEPAHFYLFGLICLCS
     348-348: Q → QVGS
     938-946: Missing.
     1013-1067: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 25

25

Potential

Chain

26 – 1651

1626

Roundabout homolog 1

PRO_0000031033

Regions

Topological domain

26 – 897

872

Extracellular Potential

Transmembrane

898 – 918

21

Helical; Potential

Topological domain

919 – 1651

733

Cytoplasmic Potential

Domain

68 – 164

97

Ig-like C2-type 1

Domain

170 – 257

88

Ig-like C2-type 2

Domain

262 – 346

85

Ig-like C2-type 3

Domain

351 – 446

96

Ig-like C2-type 4

Domain

455 – 541

87

Ig-like C2-type 5

Domain

561 – 646

86

Fibronectin type-III 1

Domain

673 – 763

91

Fibronectin type-III 2

Domain

775 – 864

90

Fibronectin type-III 3

Amino acid modifications

Modified residue

940

1

Phosphoserine Ref.13 Ref.14

Modified residue

1038

1

Phosphotyrosine; by ABL; in vitro Ref.9

Modified residue

1055

1

Phosphoserine Ref.13

Modified residue

1073

1

Phosphotyrosine; by ABL; in vitro Ref.9

Modified residue

1114

1

Phosphotyrosine; by ABL; in vitro Ref.9

Modified residue

1240

1

Phosphothreonine Ref.13

Modified residue

1297

1

Phosphoserine Ref.13

Glycosylation

160

1

N-linked (GlcNAc...) Potential

Glycosylation

463

1

N-linked (GlcNAc...) Potential

Glycosylation

790

1

N-linked (GlcNAc...) Potential

Glycosylation

820

1

N-linked (GlcNAc...) Potential

Glycosylation

827

1

N-linked (GlcNAc...) Potential

Disulfide bond

89 ↔ 147

Ref.16

Disulfide bond

191 ↔ 240

Potential

Disulfide bond

283 ↔ 330

Potential

Disulfide bond

372 ↔ 428

Potential

Disulfide bond

476 ↔ 525

Potential

Natural variations

Alternative sequence

1 – 57

57

MKWKH…SLGYT → MIAEPAHFYLFGLICLCS in isoform 5 and isoform 6.

VSP_043881

Alternative sequence

1 – 39

39

Missing in isoform 3 and isoform 4.

VSP_010643

Alternative sequence

40 – 57

18

HGTPI…SLGYT → MIAEPAHFYLFGLICLCS in isoform 3 and isoform 4.

VSP_010644

Alternative sequence

348

1

Q → QVGS in isoform 3, isoform 5 and isoform 6.

VSP_010645

Alternative sequence

543

1

Q → QGKVN in isoform 2.

VSP_010646

Alternative sequence

938 – 946

9

Missing in isoform 5 and isoform 6.

VSP_043882

Alternative sequence

1013 – 1067

55

Missing in isoform 6.

VSP_046084

Natural variant

336

1

V → A.
Corresponds to variant rs9647397 [ dbSNP | Ensembl ].

VAR_053640

Natural variant

1055

1

S → N in a breast cancer sample. Ref.11

VAR_019071

Natural variant

1091

1

S → N.
Corresponds to variant rs35456279 [ dbSNP | Ensembl ].

VAR_053641

Natural variant

1533

1

E → D in a breast cancer sample. Ref.11
Corresponds to variant rs36055689 [ dbSNP | Ensembl ].

VAR_019072

Experimental info

Sequence conflict

182

1

A → V in AAI15023. Ref.4

Sequence conflict

835

1

F → L in AAI15023. Ref.4

Sequence conflict

1095

1

G → S in CAD98093. Ref.5

Sequence conflict

1223

1

M → T in Z95705. Ref.2

Sequence conflict

1443

1

P → L in CAD98093. Ref.5

Sequence conflict

1536

1

D → G in Z95705. Ref.2

Secondary structure

1

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1651

Helix Strand Turn

Details...

Beta strand

66 – 72

7

Beta strand

77 – 79

3

Beta strand

85 – 87

3

Beta strand

90 – 95

6

Beta strand

98 – 103

6

Turn

111 – 113

3

Beta strand

118 – 121

4

Beta strand

127 – 131

5

Beta strand

143 – 151

9

Beta strand

154 – 157

4

Beta strand

161 – 165

5

Beta strand

179 – 182

4

Beta strand

187 – 190

4

Beta strand

196 – 198

3

Beta strand

201 – 206

6

Beta strand

209 – 211

3

Beta strand

213 – 215

3

Beta strand

218 – 221

4

Beta strand

224 – 229

6

Helix

232 – 234

3

Beta strand

236 – 244

9

Beta strand

247 – 250

4

Beta strand

254 – 259

6

Helix

261 – 266

6

Beta strand

464 – 467

4

Beta strand

471 – 475

5

Beta strand

485 – 494

10

Beta strand

502 – 506

5

Beta strand

509 – 514

6

Helix

517 – 519

3

Beta strand

523 – 528

6

Beta strand

533 – 537

5

Beta strand

540 – 543

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 9D98CD7CAB73074D	FASTA	1,651	180,930
	10 20 30 40 50 60 MKWKHVPFLV MISLLSLSPN HLFLAQLIPD PEDVERGNDH GTPIPTSDND DNSLGYTGSR 70 80 90 100 110 120 LRQEDFPPRI VEHPSDLIVS KGEPATLNCK AEGRPTPTIE WYKGGERVET DKDDPRSHRM 130 140 150 160 170 180 LLPSGSLFFL RIVHGRKSRP DEGVYVCVAR NYLGEAVSHN ASLEVAILRD DFRQNPSDVM 190 200 210 220 230 240 VAVGEPAVME CQPPRGHPEP TISWKKDGSP LDDKDERITI RGGKLMITYT RKSDAGKYVC 250 260 270 280 290 300 VGTNMVGERE SEVAELTVLE RPSFVKRPSN LAVTVDDSAE FKCEARGDPV PTVRWRKDDG 310 320 330 340 350 360 ELPKSRYEIR DDHTLKIRKV TAGDMGSYTC VAENMVGKAE ASATLTVQEP PHFVVKPRDQ 370 380 390 400 410 420 VVALGRTVTF QCEATGNPQP AIFWRREGSQ NLLFSYQPPQ SSSRFSVSQT GDLTITNVQR 430 440 450 460 470 480 SDVGYYICQT LNVAGSIITK AYLEVTDVIA DRPPPVIRQG PVNQTVAVDG TFVLSCVATG 490 500 510 520 530 540 SPVPTILWRK DGVLVSTQDS RIKQLENGVL QIRYAKLGDT GRYTCIASTP SGEATWSAYI 550 560 570 580 590 600 EVQEFGVPVQ PPRPTDPNLI PSAPSKPEVT DVSRNTVTLS WQPNLNSGAT PTSYIIEAFS 610 620 630 640 650 660 HASGSSWQTV AENVKTETSA IKGLKPNAIY LFLVRAANAY GISDPSQISD PVKTQDVLPT 670 680 690 700 710 720 SQGVDHKQVQ RELGNAVLHL HNPTVLSSSS IEVHWTVDQQ SQYIQGYKIL YRPSGANHGE 730 740 750 760 770 780 SDWLVFEVRT PAKNSVVIPD LRKGVNYEIK ARPFFNEFQG ADSEIKFAKT LEEAPSAPPQ 790 800 810 820 830 840 GVTVSKNDGN GTAILVSWQP PPEDTQNGMV QEYKVWCLGN ETRYHINKTV DGSTFSVVIP 850 860 870 880 890 900 FLVPGIRYSV EVAASTGAGS GVKSEPQFIQ LDAHGNPVSP EDQVSLAQQI SDVVKQPAFI 910 920 930 940 950 960 AGIGAACWII LMVFSIWLYR HRKKRNGLTS TYAGIRKVPS FTFTPTVTYQ RGGEAVSSGG 970 980 990 1000 1010 1020 RPGLLNISEP AAQPWLADTW PNTGNNHNDC SISCCTAGNG NSDSNLTTYS RPADCIANYN 1030 1040 1050 1060 1070 1080 NQLDNKQTNL MLPESTVYGD VDLSNKINEM KTFNSPNLKD GRFVNPSGQP TPYATTQLIQ 1090 1100 1110 1120 1130 1140 SNLSNNMNNG SGDSGEKHWK PLGQQKQEVA PVQYNIVEQN KLNKDYRAND TVPPTIPYNQ 1150 1160 1170 1180 1190 1200 SYDQNTGGSY NSSDRGSSTS GSQGHKKGAR TPKVPKQGGM NWADLLPPPP AHPPPHSNSE 1210 1220 1230 1240 1250 1260 EYNISVDESY DQEMPCPVPP ARMYLQQDEL EEEEDERGPT PPVRGAASSP AAVSYSHQST 1270 1280 1290 1300 1310 1320 ATLTPSPQEE LQPMLQDCPE ETGHMQHQPD RRRQPVSPPP PPRPISPPHT YGYISGPLVS 1330 1340 1350 1360 1370 1380 DMDTDAPEEE EDEADMEVAK MQTRRLLLRG LEQTPASSVG DLESSVTGSM INGWGSASEE 1390 1400 1410 1420 1430 1440 DNISSGRSSV SSSDGSFFTD ADFAQAVAAA AEYAGLKVAR RQMQDAAGRR HFHASQCPRP 1450 1460 1470 1480 1490 1500 TSPVSTDSNM SAAVMQKTRP AKKLKHQPGH LRRETYTDDL PPPPVPPPAI KSPTAQSKTQ 1510 1520 1530 1540 1550 1560 LEVRPVVVPK LPSMDARTDR SSDRKGSSYK GREVLDGRQV VDMRTNPGDP REAQEQQNDG 1570 1580 1590 1600 1610 1620 KGRGNKAAKR DLPPAKTHLI QEDILPYCRP TFPTSNNPRD PSSSSSMSSR GSGSRQREQA 1630 1640 1650 NVGRRNIAEM QVLGGYERGE DNNEELEETE S
	Isoform 2 [UniParc]. Checksum: EB2C3DFF6013A30F	FASTA	1,655	181,328
	10 20 30 40 50 60 MKWKHVPFLV MISLLSLSPN HLFLAQLIPD PEDVERGNDH GTPIPTSDND DNSLGYTGSR 70 80 90 100 110 120 LRQEDFPPRI VEHPSDLIVS KGEPATLNCK AEGRPTPTIE WYKGGERVET DKDDPRSHRM 130 140 150 160 170 180 LLPSGSLFFL RIVHGRKSRP DEGVYVCVAR NYLGEAVSHN ASLEVAILRD DFRQNPSDVM 190 200 210 220 230 240 VAVGEPAVME CQPPRGHPEP TISWKKDGSP LDDKDERITI RGGKLMITYT RKSDAGKYVC 250 260 270 280 290 300 VGTNMVGERE SEVAELTVLE RPSFVKRPSN LAVTVDDSAE FKCEARGDPV PTVRWRKDDG 310 320 330 340 350 360 ELPKSRYEIR DDHTLKIRKV TAGDMGSYTC VAENMVGKAE ASATLTVQEP PHFVVKPRDQ 370 380 390 400 410 420 VVALGRTVTF QCEATGNPQP AIFWRREGSQ NLLFSYQPPQ SSSRFSVSQT GDLTITNVQR 430 440 450 460 470 480 SDVGYYICQT LNVAGSIITK AYLEVTDVIA DRPPPVIRQG PVNQTVAVDG TFVLSCVATG 490 500 510 520 530 540 SPVPTILWRK DGVLVSTQDS RIKQLENGVL QIRYAKLGDT GRYTCIASTP SGEATWSAYI 550 560 570 580 590 600 EVQGKVNEFG VPVQPPRPTD PNLIPSAPSK PEVTDVSRNT VTLSWQPNLN SGATPTSYII 610 620 630 640 650 660 EAFSHASGSS WQTVAENVKT ETSAIKGLKP NAIYLFLVRA ANAYGISDPS QISDPVKTQD 670 680 690 700 710 720 VLPTSQGVDH KQVQRELGNA VLHLHNPTVL SSSSIEVHWT VDQQSQYIQG YKILYRPSGA 730 740 750 760 770 780 NHGESDWLVF EVRTPAKNSV VIPDLRKGVN YEIKARPFFN EFQGADSEIK FAKTLEEAPS 790 800 810 820 830 840 APPQGVTVSK NDGNGTAILV SWQPPPEDTQ NGMVQEYKVW CLGNETRYHI NKTVDGSTFS 850 860 870 880 890 900 VVIPFLVPGI RYSVEVAAST GAGSGVKSEP QFIQLDAHGN PVSPEDQVSL AQQISDVVKQ 910 920 930 940 950 960 PAFIAGIGAA CWIILMVFSI WLYRHRKKRN GLTSTYAGIR KVPSFTFTPT VTYQRGGEAV 970 980 990 1000 1010 1020 SSGGRPGLLN ISEPAAQPWL ADTWPNTGNN HNDCSISCCT AGNGNSDSNL TTYSRPADCI 1030 1040 1050 1060 1070 1080 ANYNNQLDNK QTNLMLPEST VYGDVDLSNK INEMKTFNSP NLKDGRFVNP SGQPTPYATT 1090 1100 1110 1120 1130 1140 QLIQSNLSNN MNNGSGDSGE KHWKPLGQQK QEVAPVQYNI VEQNKLNKDY RANDTVPPTI 1150 1160 1170 1180 1190 1200 PYNQSYDQNT GGSYNSSDRG SSTSGSQGHK KGARTPKVPK QGGMNWADLL PPPPAHPPPH 1210 1220 1230 1240 1250 1260 SNSEEYNISV DESYDQEMPC PVPPARMYLQ QDELEEEEDE RGPTPPVRGA ASSPAAVSYS 1270 1280 1290 1300 1310 1320 HQSTATLTPS PQEELQPMLQ DCPEETGHMQ HQPDRRRQPV SPPPPPRPIS PPHTYGYISG 1330 1340 1350 1360 1370 1380 PLVSDMDTDA PEEEEDEADM EVAKMQTRRL LLRGLEQTPA SSVGDLESSV TGSMINGWGS 1390 1400 1410 1420 1430 1440 ASEEDNISSG RSSVSSSDGS FFTDADFAQA VAAAAEYAGL KVARRQMQDA AGRRHFHASQ 1450 1460 1470 1480 1490 1500 CPRPTSPVST DSNMSAAVMQ KTRPAKKLKH QPGHLRRETY TDDLPPPPVP PPAIKSPTAQ 1510 1520 1530 1540 1550 1560 SKTQLEVRPV VVPKLPSMDA RTDRSSDRKG SSYKGREVLD GRQVVDMRTN PGDPREAQEQ 1570 1580 1590 1600 1610 1620 QNDGKGRGNK AAKRDLPPAK THLIQEDILP YCRPTFPTSN NPRDPSSSSS MSSRGSGSRQ 1630 1640 1650 REQANVGRRN IAEMQVLGGY ERGEDNNEEL EETES
	Isoform 3 [UniParc]. Checksum: 66D6413527161E25	FASTA	1,615	176,814
	10 20 30 40 50 60 MIAEPAHFYL FGLICLCSGS RLRQEDFPPR IVEHPSDLIV SKGEPATLNC KAEGRPTPTI 70 80 90 100 110 120 EWYKGGERVE TDKDDPRSHR MLLPSGSLFF LRIVHGRKSR PDEGVYVCVA RNYLGEAVSH 130 140 150 160 170 180 NASLEVAILR DDFRQNPSDV MVAVGEPAVM ECQPPRGHPE PTISWKKDGS PLDDKDERIT 190 200 210 220 230 240 IRGGKLMITY TRKSDAGKYV CVGTNMVGER ESEVAELTVL ERPSFVKRPS NLAVTVDDSA 250 260 270 280 290 300 EFKCEARGDP VPTVRWRKDD GELPKSRYEI RDDHTLKIRK VTAGDMGSYT CVAENMVGKA 310 320 330 340 350 360 EASATLTVQV GSEPPHFVVK PRDQVVALGR TVTFQCEATG NPQPAIFWRR EGSQNLLFSY 370 380 390 400 410 420 QPPQSSSRFS VSQTGDLTIT NVQRSDVGYY ICQTLNVAGS IITKAYLEVT DVIADRPPPV 430 440 450 460 470 480 IRQGPVNQTV AVDGTFVLSC VATGSPVPTI LWRKDGVLVS TQDSRIKQLE NGVLQIRYAK 490 500 510 520 530 540 LGDTGRYTCI ASTPSGEATW SAYIEVQEFG VPVQPPRPTD PNLIPSAPSK PEVTDVSRNT 550 560 570 580 590 600 VTLSWQPNLN SGATPTSYII EAFSHASGSS WQTVAENVKT ETSAIKGLKP NAIYLFLVRA 610 620 630 640 650 660 ANAYGISDPS QISDPVKTQD VLPTSQGVDH KQVQRELGNA VLHLHNPTVL SSSSIEVHWT 670 680 690 700 710 720 VDQQSQYIQG YKILYRPSGA NHGESDWLVF EVRTPAKNSV VIPDLRKGVN YEIKARPFFN 730 740 750 760 770 780 EFQGADSEIK FAKTLEEAPS APPQGVTVSK NDGNGTAILV SWQPPPEDTQ NGMVQEYKVW 790 800 810 820 830 840 CLGNETRYHI NKTVDGSTFS VVIPFLVPGI RYSVEVAAST GAGSGVKSEP QFIQLDAHGN 850 860 870 880 890 900 PVSPEDQVSL AQQISDVVKQ PAFIAGIGAA CWIILMVFSI WLYRHRKKRN GLTSTYAGIR 910 920 930 940 950 960 KVPSFTFTPT VTYQRGGEAV SSGGRPGLLN ISEPAAQPWL ADTWPNTGNN HNDCSISCCT 970 980 990 1000 1010 1020 AGNGNSDSNL TTYSRPADCI ANYNNQLDNK QTNLMLPEST VYGDVDLSNK INEMKTFNSP 1030 1040 1050 1060 1070 1080 NLKDGRFVNP SGQPTPYATT QLIQSNLSNN MNNGSGDSGE KHWKPLGQQK QEVAPVQYNI 1090 1100 1110 1120 1130 1140 VEQNKLNKDY RANDTVPPTI PYNQSYDQNT GGSYNSSDRG SSTSGSQGHK KGARTPKVPK 1150 1160 1170 1180 1190 1200 QGGMNWADLL PPPPAHPPPH SNSEEYNISV DESYDQEMPC PVPPARMYLQ QDELEEEEDE 1210 1220 1230 1240 1250 1260 RGPTPPVRGA ASSPAAVSYS HQSTATLTPS PQEELQPMLQ DCPEETGHMQ HQPDRRRQPV 1270 1280 1290 1300 1310 1320 SPPPPPRPIS PPHTYGYISG PLVSDMDTDA PEEEEDEADM EVAKMQTRRL LLRGLEQTPA 1330 1340 1350 1360 1370 1380 SSVGDLESSV TGSMINGWGS ASEEDNISSG RSSVSSSDGS FFTDADFAQA VAAAAEYAGL 1390 1400 1410 1420 1430 1440 KVARRQMQDA AGRRHFHASQ CPRPTSPVST DSNMSAAVMQ KTRPAKKLKH QPGHLRRETY 1450 1460 1470 1480 1490 1500 TDDLPPPPVP PPAIKSPTAQ SKTQLEVRPV VVPKLPSMDA RTDRSSDRKG SSYKGREVLD 1510 1520 1530 1540 1550 1560 GRQVVDMRTN PGDPREAQEQ QNDGKGRGNK AAKRDLPPAK THLIQEDILP YCRPTFPTSN 1570 1580 1590 1600 1610 NPRDPSSSSS MSSRGSGSRQ REQANVGRRN IAEMQVLGGY ERGEDNNEEL EETES
	Isoform 4 [UniParc]. Checksum: 4625E96485E88C34	FASTA	1,612	176,571
	10 20 30 40 50 60 MIAEPAHFYL FGLICLCSGS RLRQEDFPPR IVEHPSDLIV SKGEPATLNC KAEGRPTPTI 70 80 90 100 110 120 EWYKGGERVE TDKDDPRSHR MLLPSGSLFF LRIVHGRKSR PDEGVYVCVA RNYLGEAVSH 130 140 150 160 170 180 NASLEVAILR DDFRQNPSDV MVAVGEPAVM ECQPPRGHPE PTISWKKDGS PLDDKDERIT 190 200 210 220 230 240 IRGGKLMITY TRKSDAGKYV CVGTNMVGER ESEVAELTVL ERPSFVKRPS NLAVTVDDSA 250 260 270 280 290 300 EFKCEARGDP VPTVRWRKDD GELPKSRYEI RDDHTLKIRK VTAGDMGSYT CVAENMVGKA 310 320 330 340 350 360 EASATLTVQE PPHFVVKPRD QVVALGRTVT FQCEATGNPQ PAIFWRREGS QNLLFSYQPP 370 380 390 400 410 420 QSSSRFSVSQ TGDLTITNVQ RSDVGYYICQ TLNVAGSIIT KAYLEVTDVI ADRPPPVIRQ 430 440 450 460 470 480 GPVNQTVAVD GTFVLSCVAT GSPVPTILWR KDGVLVSTQD SRIKQLENGV LQIRYAKLGD 490 500 510 520 530 540 TGRYTCIAST PSGEATWSAY IEVQEFGVPV QPPRPTDPNL IPSAPSKPEV TDVSRNTVTL 550 560 570 580 590 600 SWQPNLNSGA TPTSYIIEAF SHASGSSWQT VAENVKTETS AIKGLKPNAI YLFLVRAANA 610 620 630 640 650 660 YGISDPSQIS DPVKTQDVLP TSQGVDHKQV QRELGNAVLH LHNPTVLSSS SIEVHWTVDQ 670 680 690 700 710 720 QSQYIQGYKI LYRPSGANHG ESDWLVFEVR TPAKNSVVIP DLRKGVNYEI KARPFFNEFQ 730 740 750 760 770 780 GADSEIKFAK TLEEAPSAPP QGVTVSKNDG NGTAILVSWQ PPPEDTQNGM VQEYKVWCLG 790 800 810 820 830 840 NETRYHINKT VDGSTFSVVI PFLVPGIRYS VEVAASTGAG SGVKSEPQFI QLDAHGNPVS 850 860 870 880 890 900 PEDQVSLAQQ ISDVVKQPAF IAGIGAACWI ILMVFSIWLY RHRKKRNGLT STYAGIRKVP 910 920 930 940 950 960 SFTFTPTVTY QRGGEAVSSG GRPGLLNISE PAAQPWLADT WPNTGNNHND CSISCCTAGN 970 980 990 1000 1010 1020 GNSDSNLTTY SRPADCIANY NNQLDNKQTN LMLPESTVYG DVDLSNKINE MKTFNSPNLK 1030 1040 1050 1060 1070 1080 DGRFVNPSGQ PTPYATTQLI QSNLSNNMNN GSGDSGEKHW KPLGQQKQEV APVQYNIVEQ 1090 1100 1110 1120 1130 1140 NKLNKDYRAN DTVPPTIPYN QSYDQNTGGS YNSSDRGSST SGSQGHKKGA RTPKVPKQGG 1150 1160 1170 1180 1190 1200 MNWADLLPPP PAHPPPHSNS EEYNISVDES YDQEMPCPVP PARMYLQQDE LEEEEDERGP 1210 1220 1230 1240 1250 1260 TPPVRGAASS PAAVSYSHQS TATLTPSPQE ELQPMLQDCP EETGHMQHQP DRRRQPVSPP 1270 1280 1290 1300 1310 1320 PPPRPISPPH TYGYISGPLV SDMDTDAPEE EEDEADMEVA KMQTRRLLLR GLEQTPASSV 1330 1340 1350 1360 1370 1380 GDLESSVTGS MINGWGSASE EDNISSGRSS VSSSDGSFFT DADFAQAVAA AAEYAGLKVA 1390 1400 1410 1420 1430 1440 RRQMQDAAGR RHFHASQCPR PTSPVSTDSN MSAAVMQKTR PAKKLKHQPG HLRRETYTDD 1450 1460 1470 1480 1490 1500 LPPPPVPPPA IKSPTAQSKT QLEVRPVVVP KLPSMDARTD RSSDRKGSSY KGREVLDGRQ 1510 1520 1530 1540 1550 1560 VVDMRTNPGD PREAQEQQND GKGRGNKAAK RDLPPAKTHL IQEDILPYCR PTFPTSNNPR 1570 1580 1590 1600 1610 DPSSSSSMSS RGSGSRQREQ ANVGRRNIAE MQVLGGYERG EDNNEELEET ES
	Isoform 5 [UniParc]. Checksum: 79FA0AA96275B1A2	FASTA	1,606	175,836
	10 20 30 40 50 60 MIAEPAHFYL FGLICLCSGS RLRQEDFPPR IVEHPSDLIV SKGEPATLNC KAEGRPTPTI 70 80 90 100 110 120 EWYKGGERVE TDKDDPRSHR MLLPSGSLFF LRIVHGRKSR PDEGVYVCVA RNYLGEAVSH 130 140 150 160 170 180 NASLEVAILR DDFRQNPSDV MVAVGEPAVM ECQPPRGHPE PTISWKKDGS PLDDKDERIT 190 200 210 220 230 240 IRGGKLMITY TRKSDAGKYV CVGTNMVGER ESEVAELTVL ERPSFVKRPS NLAVTVDDSA 250 260 270 280 290 300 EFKCEARGDP VPTVRWRKDD GELPKSRYEI RDDHTLKIRK VTAGDMGSYT CVAENMVGKA 310 320 330 340 350 360 EASATLTVQV GSEPPHFVVK PRDQVVALGR TVTFQCEATG NPQPAIFWRR EGSQNLLFSY 370 380 390 400 410 420 QPPQSSSRFS VSQTGDLTIT NVQRSDVGYY ICQTLNVAGS IITKAYLEVT DVIADRPPPV 430 440 450 460 470 480 IRQGPVNQTV AVDGTFVLSC VATGSPVPTI LWRKDGVLVS TQDSRIKQLE NGVLQIRYAK 490 500 510 520 530 540 LGDTGRYTCI ASTPSGEATW SAYIEVQEFG VPVQPPRPTD PNLIPSAPSK PEVTDVSRNT 550 560 570 580 590 600 VTLSWQPNLN SGATPTSYII EAFSHASGSS WQTVAENVKT ETSAIKGLKP NAIYLFLVRA 610 620 630 640 650 660 ANAYGISDPS QISDPVKTQD VLPTSQGVDH KQVQRELGNA VLHLHNPTVL SSSSIEVHWT 670 680 690 700 710 720 VDQQSQYIQG YKILYRPSGA NHGESDWLVF EVRTPAKNSV VIPDLRKGVN YEIKARPFFN 730 740 750 760 770 780 EFQGADSEIK FAKTLEEAPS APPQGVTVSK NDGNGTAILV SWQPPPEDTQ NGMVQEYKVW 790 800 810 820 830 840 CLGNETRYHI NKTVDGSTFS VVIPFLVPGI RYSVEVAAST GAGSGVKSEP QFIQLDAHGN 850 860 870 880 890 900 PVSPEDQVSL AQQISDVVKQ PAFIAGIGAA CWIILMVFSI WLYRHRKKRN GLTSTYAGIR 910 920 930 940 950 960 KVTYQRGGEA VSSGGRPGLL NISEPAAQPW LADTWPNTGN NHNDCSISCC TAGNGNSDSN 970 980 990 1000 1010 1020 LTTYSRPADC IANYNNQLDN KQTNLMLPES TVYGDVDLSN KINEMKTFNS PNLKDGRFVN 1030 1040 1050 1060 1070 1080 PSGQPTPYAT TQLIQSNLSN NMNNGSGDSG EKHWKPLGQQ KQEVAPVQYN IVEQNKLNKD 1090 1100 1110 1120 1130 1140 YRANDTVPPT IPYNQSYDQN TGGSYNSSDR GSSTSGSQGH KKGARTPKVP KQGGMNWADL 1150 1160 1170 1180 1190 1200 LPPPPAHPPP HSNSEEYNIS VDESYDQEMP CPVPPARMYL QQDELEEEED ERGPTPPVRG 1210 1220 1230 1240 1250 1260 AASSPAAVSY SHQSTATLTP SPQEELQPML QDCPEETGHM QHQPDRRRQP VSPPPPPRPI 1270 1280 1290 1300 1310 1320 SPPHTYGYIS GPLVSDMDTD APEEEEDEAD MEVAKMQTRR LLLRGLEQTP ASSVGDLESS 1330 1340 1350 1360 1370 1380 VTGSMINGWG SASEEDNISS GRSSVSSSDG SFFTDADFAQ AVAAAAEYAG LKVARRQMQD 1390 1400 1410 1420 1430 1440 AAGRRHFHAS QCPRPTSPVS TDSNMSAAVM QKTRPAKKLK HQPGHLRRET YTDDLPPPPV 1450 1460 1470 1480 1490 1500 PPPAIKSPTA QSKTQLEVRP VVVPKLPSMD ARTDRSSDRK GSSYKGREVL DGRQVVDMRT 1510 1520 1530 1540 1550 1560 NPGDPREAQE QQNDGKGRGN KAAKRDLPPA KTHLIQEDIL PYCRPTFPTS NNPRDPSSSS 1570 1580 1590 1600 SMSSRGSGSR QREQANVGRR NIAEMQVLGG YERGEDNNEE LEETES
	Isoform 6 [UniParc]. Checksum: 89F1C62C15B8C9A2	FASTA	1,551	169,661
	10 20 30 40 50 60 MIAEPAHFYL FGLICLCSGS RLRQEDFPPR IVEHPSDLIV SKGEPATLNC KAEGRPTPTI 70 80 90 100 110 120 EWYKGGERVE TDKDDPRSHR MLLPSGSLFF LRIVHGRKSR PDEGVYVCVA RNYLGEAVSH 130 140 150 160 170 180 NASLEVAILR DDFRQNPSDV MVAVGEPAVM ECQPPRGHPE PTISWKKDGS PLDDKDERIT 190 200 210 220 230 240 IRGGKLMITY TRKSDAGKYV CVGTNMVGER ESEVAELTVL ERPSFVKRPS NLAVTVDDSA 250 260 270 280 290 300 EFKCEARGDP VPTVRWRKDD GELPKSRYEI RDDHTLKIRK VTAGDMGSYT CVAENMVGKA 310 320 330 340 350 360 EASATLTVQV GSEPPHFVVK PRDQVVALGR TVTFQCEATG NPQPAIFWRR EGSQNLLFSY 370 380 390 400 410 420 QPPQSSSRFS VSQTGDLTIT NVQRSDVGYY ICQTLNVAGS IITKAYLEVT DVIADRPPPV 430 440 450 460 470 480 IRQGPVNQTV AVDGTFVLSC VATGSPVPTI LWRKDGVLVS TQDSRIKQLE NGVLQIRYAK 490 500 510 520 530 540 LGDTGRYTCI ASTPSGEATW SAYIEVQEFG VPVQPPRPTD PNLIPSAPSK PEVTDVSRNT 550 560 570 580 590 600 VTLSWQPNLN SGATPTSYII EAFSHASGSS WQTVAENVKT ETSAIKGLKP NAIYLFLVRA 610 620 630 640 650 660 ANAYGISDPS QISDPVKTQD VLPTSQGVDH KQVQRELGNA VLHLHNPTVL SSSSIEVHWT 670 680 690 700 710 720 VDQQSQYIQG YKILYRPSGA NHGESDWLVF EVRTPAKNSV VIPDLRKGVN YEIKARPFFN 730 740 750 760 770 780 EFQGADSEIK FAKTLEEAPS APPQGVTVSK NDGNGTAILV SWQPPPEDTQ NGMVQEYKVW 790 800 810 820 830 840 CLGNETRYHI NKTVDGSTFS VVIPFLVPGI RYSVEVAAST GAGSGVKSEP QFIQLDAHGN 850 860 870 880 890 900 PVSPEDQVSL AQQISDVVKQ PAFIAGIGAA CWIILMVFSI WLYRHRKKRN GLTSTYAGIR 910 920 930 940 950 960 KVTYQRGGEA VSSGGRPGLL NISEPAAQPW LADTWPNTGN NHNDCSISCC TAGNGNSDSN 970 980 990 1000 1010 1020 LTTYSRPGQP TPYATTQLIQ SNLSNNMNNG SGDSGEKHWK PLGQQKQEVA PVQYNIVEQN 1030 1040 1050 1060 1070 1080 KLNKDYRAND TVPPTIPYNQ SYDQNTGGSY NSSDRGSSTS GSQGHKKGAR TPKVPKQGGM 1090 1100 1110 1120 1130 1140 NWADLLPPPP AHPPPHSNSE EYNISVDESY DQEMPCPVPP ARMYLQQDEL EEEEDERGPT 1150 1160 1170 1180 1190 1200 PPVRGAASSP AAVSYSHQST ATLTPSPQEE LQPMLQDCPE ETGHMQHQPD RRRQPVSPPP 1210 1220 1230 1240 1250 1260 PPRPISPPHT YGYISGPLVS DMDTDAPEEE EDEADMEVAK MQTRRLLLRG LEQTPASSVG 1270 1280 1290 1300 1310 1320 DLESSVTGSM INGWGSASEE DNISSGRSSV SSSDGSFFTD ADFAQAVAAA AEYAGLKVAR 1330 1340 1350 1360 1370 1380 RQMQDAAGRR HFHASQCPRP TSPVSTDSNM SAAVMQKTRP AKKLKHQPGH LRRETYTDDL 1390 1400 1410 1420 1430 1440 PPPPVPPPAI KSPTAQSKTQ LEVRPVVVPK LPSMDARTDR SSDRKGSSYK GREVLDGRQV 1450 1460 1470 1480 1490 1500 VDMRTNPGDP REAQEQQNDG KGRGNKAAKR DLPPAKTHLI QEDILPYCRP TFPTSNNPRD 1510 1520 1530 1540 1550 PSSSSSMSSR GSGSRQREQA NVGRRNIAEM QVLGGYERGE DNNEELEETE S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors." Kidd T., Brose K., Mitchell K.J., Fetter R.D., Tessier-Lavigne M., Goodman C.S., Tear G. Cell 92:205-215(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1158-1651 (ISOFORMS 1/2/3/4). Tissue: Placenta.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 366-1651 (ISOFORM 2). Tissue: Uterine endothelium.
[6]	"Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance." Brose K., Bland K.S., Wang K.H., Arnott D., Henzel W., Goodman C.S., Tessier-Lavigne M., Kidd T. Cell 96:795-806(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH SLIT2. Tissue: Fetal brain.
[7]	"The DUTT1 gene, a novel NCAM family member is expressed in developing murine neural tissues and has an unusually broad pattern of expression." Sundaresan V., Roberts I., Bateman A., Bankier A., Sheppard M., Hobbs C., Xiong J., Minna J., Latif F., Lerman M., Rabbitts P. Mol. Cell. Neurosci. 11:29-35(1998) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[8]	"Homozygous deletions at 3p12 in breast and lung cancer." Sundaresan V., Chung G., Heppell-Parton A., Xiong J., Grundy C., Roberts I., James L., Cahn A., Bench A., Douglas J., Minna J., Sekido Y., Lerman M., Latif F., Bergh J., Li H., Lowe N., Ogilvie D., Rabbitts P. Oncogene 17:1723-1729(1998) [PubMed] [Europe PMC] [Abstract] Cited for: MAPPING, IDENTIFICATION (ISOFORM 3).
[9]	"Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor." Bashaw G.J., Kidd T., Murray D., Pawson T., Goodman C.S. Cell 101:703-715(2000) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT TYR-1038; TYR-1073 AND TYR-1114.
[10]	"Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance." Nguyen-Ba-Charvet K.T., Brose K., Ma L., Wang K.H., Marillat V., Sotelo C., Tessier-Lavigne M., Chedotal A. J. Neurosci. 21:4281-4289(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SLIT2.
[11]	"Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers." Dallol A., Forgacs E., Martinez A., Sekido Y., Walker R., Kishida T., Rabbitts P., Maher E.R., Minna J.D., Latif F. Oncogene 21:3020-3028(2002) [PubMed] [Europe PMC] [Abstract] Cited for: PROMOTER HYPERMETHYLATION, VARIANTS ASN-1055 AND ASP-1533.
[12]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-940; SER-1055; THR-1240 AND SER-1297, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-940, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]	"Structural insights into the Slit-Robo complex." Morlot C., Thielens N.M., Ravelli R.B., Hemrika W., Romijn R.A., Gros P., Cusack S., McCarthy A.A. Proc. Natl. Acad. Sci. U.S.A. 104:14923-14928(2007) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 61-166 IN COMPLEX WITH SLIT2, DISULFIDE BOND.
[17]	"Solution structure of the fifth Ig-like domain from human roundabout homolog 1." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2007) to the PDB data bank Cited for: STRUCTURE BY NMR OF 454-564.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF040990 mRNA. Translation: AAC39575.1.
Z95705 Genomic DNA. No translation available.
AC016946 Genomic DNA. No translation available.
AC055731 Genomic DNA. No translation available.
AC106718 Genomic DNA. No translation available.
AC106720 Genomic DNA. No translation available.
AC108719 Genomic DNA. No translation available.
AC117461 Genomic DNA. No translation available.
AC117479 Genomic DNA. No translation available.
AC119035 Genomic DNA. No translation available.
AC123565 Genomic DNA. No translation available.
AC125624 Genomic DNA. No translation available.
AC125766 Genomic DNA. No translation available.
AC125815 Genomic DNA. No translation available.
AC131008 Genomic DNA. No translation available.
CH471110 Genomic DNA. Translation: EAW68884.1.
CH471110 Genomic DNA. Translation: EAW68885.1.
BC001969 mRNA. Translation: AAH01969.1.
BC115022 mRNA. Translation: AAI15023.1.
BC157861 mRNA. Translation: AAI57862.1.
BC171855 mRNA. Translation: AAI71855.1.
BX538319 mRNA. Translation: CAD98093.1.

IPI

IPI00219798.
IPI00418121.
IPI00418122.
IPI00829739.
IPI00946477.
IPI00980964.

RefSeq

NP_001139317.1. NM_001145845.1.
NP_002932.1. NM_002941.3.
NP_598334.2. NM_133631.3.

UniGene

Hs.13640.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2EO9	NMR	-	A	454-564	[»]
2V9Q	X-ray	2.50	A	61-266	[»]
2V9R	X-ray	2.00	A	61-266	[»]
2V9T	X-ray	1.70	A	61-166	[»]

ProteinModelPortal

Q9Y6N7.

ModBase

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Protein-protein interaction databases

DIP

DIP-33034N.

IntAct

Q9Y6N7. 2 interactions.

MINT

MINT-1392694.

STRING

9606.ENSP00000381450.

PTM databases

PhosphoSite

Q9Y6N7.

Polymorphism databases

DMDM

49036500.

Proteomic databases

PaxDb

Q9Y6N7.

PRIDE

Q9Y6N7.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000436010; ENSP00000406043; ENSG00000169855.
ENST00000464233; ENSP00000420321; ENSG00000169855.
ENST00000467549; ENSP00000417992; ENSG00000169855.
ENST00000495273; ENSP00000420637; ENSG00000169855.

GeneID

6091.

KEGG

hsa:6091.

UCSC

uc003dqb.2. human.
uc003dqe.2. human.

Organism-specific databases

CTD

6091.

GeneCards

GC03M078729.

HGNC

HGNC:10249. ROBO1.

HPA

CAB013524.

MIM

602430. gene.

neXtProt

NX_Q9Y6N7.

PharmGKB

PA34620.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG238978.

HOGENOM

HOG000010267.

HOVERGEN

HBG073476.

InParanoid

Q9Y6N7.

KO

K06753.

OrthoDB

EOG44QT01.

Enzyme and pathway databases

Reactome

REACT_111045. Developmental Biology.

Gene expression databases

ArrayExpress

Q9Y6N7.

Bgee

Q9Y6N7.

CleanEx

HS_ROBO1.

Genevestigator

Q9Y6N7.

GermOnline

ENSG00000169855. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 9 hits.

InterPro

IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR003596. Ig_V-set_subgr.
[Graphical view]

Pfam

PF00041. fn3. 3 hits.
PF07679. I-set. 5 hits.
[Graphical view]

SMART

SM00060. FN3. 3 hits.
SM00408. IGc2. 4 hits.
SM00406. IGv. 1 hit.
[Graphical view]

SUPFAM

SSF49265. FN_III-like. 3 hits.

PROSITE

PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

ROBO1. human.

EvolutionaryTrace

Q9Y6N7.

GenomeRNAi

6091.

NextBio

23685.

SOURCE

Search...

Entry information

Entry name

ROBO1_HUMAN

Accession

Primary (citable) accession number: Q9Y6N7
Secondary accession number(s): B2RXI1 , D3DU36, E9PD49, Q1RMC7, Q7Z300, Q9BUS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2004
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.