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Protein

Sulfide:quinone oxidoreductase, mitochondrial

Gene

SQRDL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro).1 Publication

Cofactori

FAD1 PublicationNote: Binds 1 FAD per subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei201 – 2011Cysteine persulfide intermediate1 Publication
Active sitei379 – 3791Cysteine persulfide intermediate1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi50 – 545FADBy similarity

GO - Molecular functioni

  • quinone binding Source: UniProtKB-KW
  • sulfide:quinone oxidoreductase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.8.5.4. 2681.
ReactomeiR-HSA-1614517. Sulfide oxidation to sulfate.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfide:quinone oxidoreductase, mitochondrial (EC:1.8.5.-1 Publication)
Short name:
SQOR
Gene namesi
Name:SQRDL
ORF Names:CGI-44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:20390. SQRDL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134894920.

Polymorphism and mutation databases

DMDMi27151704.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 450Sulfide:quinone oxidoreductase, mitochondrialPRO_0000022408
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei173 – 1731N6-acetyllysineBy similarity
Modified residuei343 – 3431PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Quinone

Proteomic databases

EPDiQ9Y6N5.
MaxQBiQ9Y6N5.
PaxDbiQ9Y6N5.
PeptideAtlasiQ9Y6N5.
PRIDEiQ9Y6N5.

PTM databases

iPTMnetiQ9Y6N5.
PhosphoSiteiQ9Y6N5.
SwissPalmiQ9Y6N5.

Expressioni

Gene expression databases

BgeeiQ9Y6N5.
CleanExiHS_SQRDL.
ExpressionAtlasiQ9Y6N5. baseline and differential.
GenevisibleiQ9Y6N5. HS.

Organism-specific databases

HPAiHPA017079.
HPA041589.

Interactioni

Protein-protein interaction databases

BioGridi121806. 26 interactions.
IntActiQ9Y6N5. 19 interactions.
MINTiMINT-4657978.
STRINGi9606.ENSP00000260324.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6N5.
SMRiQ9Y6N5. Positions 41-398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SQRD family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3851. Eukaryota.
COG0446. LUCA.
GeneTreeiENSGT00390000019406.
HOGENOMiHOG000249874.
HOVERGENiHBG029110.
InParanoidiQ9Y6N5.
KOiK17218.
OMAiYSMLHVT.
PhylomeDBiQ9Y6N5.
TreeFamiTF314384.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPLVAVVSG PRAQLFACLL RLGTQQVGPL QLHTGASHAA RNHYEVLVLG
60 70 80 90 100
GGSGGITMAA RMKRKVGAEN VAIVEPSERH FYQPIWTLVG AGAKQLSSSG
110 120 130 140 150
RPTASVIPSG VEWIKARVTE LNPDKNCIHT DDDEKISYRY LIIALGIQLD
160 170 180 190 200
YEKIKGLPEG FAHPKIGSNY SVKTVEKTWK ALQDFKEGNA IFTFPNTPVK
210 220 230 240 250
CAGAPQKIMY LSEAYFRKTG KRSKANIIFN TSLGAIFGVK KYADALQEII
260 270 280 290 300
QERNLTVNYK KNLIEVRADK QEAVFENLDK PGETQVISYE MLHVTPPMSP
310 320 330 340 350
PDVLKTSPVA DAAGWVDVDK ETLQHRRYPN VFGIGDCTNL PTSKTAAAVA
360 370 380 390 400
AQSGILDRTI SVIMKNQTPT KKYDGYTSCP LVTGYNRVIL AEFDYKAEPL
410 420 430 440 450
ETFPFDQSKE RLSMYLMKAD LMPFLYWNMM LRGYWGGPAF LRKLFHLGMS
Length:450
Mass (Da):49,961
Last modified:November 1, 1999 - v1
Checksum:i943ABD4049E3634D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti264 – 2641I → T.1 Publication
Corresponds to variant rs1044032 [ dbSNP | Ensembl ].
VAR_014959

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042284 mRNA. Translation: AAD41160.1.
AF151802 mRNA. Translation: AAD34039.1.
BC016836 mRNA. Translation: AAH16836.1.
CCDSiCCDS10127.1.
RefSeqiNP_001258142.1. NM_001271213.1.
NP_067022.1. NM_021199.3.
UniGeneiHs.511251.
Hs.743355.

Genome annotation databases

EnsembliENST00000260324; ENSP00000260324; ENSG00000137767.
ENST00000568606; ENSP00000456019; ENSG00000137767.
GeneIDi58472.
KEGGihsa:58472.
UCSCiuc001zvv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF042284 mRNA. Translation: AAD41160.1.
AF151802 mRNA. Translation: AAD34039.1.
BC016836 mRNA. Translation: AAH16836.1.
CCDSiCCDS10127.1.
RefSeqiNP_001258142.1. NM_001271213.1.
NP_067022.1. NM_021199.3.
UniGeneiHs.511251.
Hs.743355.

3D structure databases

ProteinModelPortaliQ9Y6N5.
SMRiQ9Y6N5. Positions 41-398.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121806. 26 interactions.
IntActiQ9Y6N5. 19 interactions.
MINTiMINT-4657978.
STRINGi9606.ENSP00000260324.

PTM databases

iPTMnetiQ9Y6N5.
PhosphoSiteiQ9Y6N5.
SwissPalmiQ9Y6N5.

Polymorphism and mutation databases

DMDMi27151704.

Proteomic databases

EPDiQ9Y6N5.
MaxQBiQ9Y6N5.
PaxDbiQ9Y6N5.
PeptideAtlasiQ9Y6N5.
PRIDEiQ9Y6N5.

Protocols and materials databases

DNASUi58472.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260324; ENSP00000260324; ENSG00000137767.
ENST00000568606; ENSP00000456019; ENSG00000137767.
GeneIDi58472.
KEGGihsa:58472.
UCSCiuc001zvv.4. human.

Organism-specific databases

CTDi58472.
GeneCardsiSQRDL.
HGNCiHGNC:20390. SQRDL.
HPAiHPA017079.
HPA041589.
neXtProtiNX_Q9Y6N5.
PharmGKBiPA134894920.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3851. Eukaryota.
COG0446. LUCA.
GeneTreeiENSGT00390000019406.
HOGENOMiHOG000249874.
HOVERGENiHBG029110.
InParanoidiQ9Y6N5.
KOiK17218.
OMAiYSMLHVT.
PhylomeDBiQ9Y6N5.
TreeFamiTF314384.

Enzyme and pathway databases

BRENDAi1.8.5.4. 2681.
ReactomeiR-HSA-1614517. Sulfide oxidation to sulfate.

Miscellaneous databases

ChiTaRSiSQRDL. human.
GenomeRNAii58472.
NextBioi64896.
PROiQ9Y6N5.

Gene expression databases

BgeeiQ9Y6N5.
CleanExiHS_SQRDL.
ExpressionAtlasiQ9Y6N5. baseline and differential.
GenevisibleiQ9Y6N5. HS.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A fission yeast gene for mitochondrial sulfide oxidation."
    Vande Weghe J.G., Ow D.W.
    J. Biol. Chem. 274:13250-13257(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-264.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Human sulfide:quinone oxidoreductase catalyzes the first step in hydrogen sulfide metabolism and produces a sulfane sulfur metabolite."
    Jackson M.R., Melideo S.L., Jorns M.S.
    Biochemistry 51:6804-6815(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, COFACTOR, ACTIVE SITE.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSQRD_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6N5
Secondary accession number(s): Q9UQM8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: November 1, 1999
Last modified: April 13, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.