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Q9Y6N3 (CLCA3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcium-activated chloride channel regulator family member 3

Short name=Calcium-activated chloride channel family member 3
Short name=hCLCA3
Gene names
Name:CLCA3P
Synonyms:CLCA3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted Ref.1.

Tissue specificity

Expressed in the lung, trachea, spleen, thymus and mammary gland. Ref.1

Post-translational modification

N-glycosylated. Ref.1

Sequence similarities

Belongs to the CLCR family.

Caution

In contrast to other members of the family, this protein is much shorter and lacks the VWFA domain. Defined as a pseudogene by HGNC. Ref.1 reports that it is expressed and glycosylated in mammalian cells.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 262242Calcium-activated chloride channel regulator family member 3
PRO_0000306400

Amino acid modifications

Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation1801N-linked (GlcNAc...) Potential

Natural variations

Natural variant841Y → T Requires 2 nucleotide substitutions.
Corresponds to variant rs2292830 [ dbSNP | Ensembl ].
VAR_035296
Natural variant1041I → T.
Corresponds to variant rs2292829 [ dbSNP | Ensembl ].
VAR_035297

Sequences

Sequence LengthMass (Da)Tools
Q9Y6N3 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: D6C0E9F21300E33A

FASTA26229,971
        10         20         30         40         50         60 
MVFSLKVILF LSLLLSPVLK SSLVTLNNNG YDGIVIAINP SVPEDEKLIQ NIKEMVTEAS 

        70         80         90        100        110        120 
THLFHATKQR AYFRNVSILI PMTYKSKSEY LIPKQETYDQ ADVIVADLYL KYGDDPYTLQ 

       130        140        150        160        170        180 
YGQCGDKGQY IHFTPNFLLT NNLATYGPRG KVFVHGWAHL RWGVFDEYNV DQPFYISRRN 

       190        200        210        220        230        240 
TTEATRCSTR ITVYMVLNEC KGASCIARPF RRDSQTGLYE AKCTFIPKRS QTAKESIVFM 

       250        260 
QNLDSVTEFC TEKTHNKEAP NL 

« Hide

References

[1]"Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl- channels."
Gruber A.D., Pauli B.U.
Biochim. Biophys. Acta 1444:418-423(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, GLYCOSYLATION, TISSUE SPECIFICITY.
Tissue: Spleen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF043976 mRNA. Translation: AAD23734.1.
UniGeneHs.673847.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL2364708.

Protein family/group databases

TCDB1.A.13.1.4. the epithelial chloride channel (e-clc) family.

PTM databases

PhosphoSiteQ9Y6N3.

Polymorphism databases

DMDM74721541.

Proteomic databases

PRIDEQ9Y6N3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC01P087099.
H-InvDBHIX0028523.
HGNCHGNC:2017. CLCA3P.
MIM604337. gene.
neXtProtNX_Q9Y6N3.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG052848.
InParanoidQ9Y6N3.
PhylomeDBQ9Y6N3.

Gene expression databases

GenevestigatorQ9Y6N3.

Family and domain databases

InterProIPR013642. Cl_channel_Ca.
[Graphical view]
PfamPF08434. CLCA_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9Y6N3.
SOURCESearch...

Entry information

Entry nameCLCA3_HUMAN
AccessionPrimary (citable) accession number: Q9Y6N3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM