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Protein

Calcium-activated chloride channel regulator family member 3

Gene

CLCA3P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • ion transmembrane transport Source: Reactome
  • transmembrane transport Source: Reactome
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Chloride channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Chloride

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.

Protein family/group databases

TCDBi1.A.13.1.4. the epithelial chloride channel (e-clc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-activated chloride channel regulator family member 3
Short name:
Calcium-activated chloride channel family member 3
Short name:
hCLCA3
Gene namesi
Name:CLCA3P
Synonyms:CLCA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:2017. CLCA3P.

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

  • chloride channel complex Source: UniProtKB-KW
  • extracellular region Source: Reactome
  • extracellular space Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74721541.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 262242Calcium-activated chloride channel regulator family member 3PRO_0000306400Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9Y6N3.

PTM databases

PhosphoSiteiQ9Y6N3.

Expressioni

Tissue specificityi

Expressed in the lung, trachea, spleen, thymus and mammary gland.1 Publication

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni45 – 199155Metalloprotease domain; probably inactiveBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the CLCR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG052848.
InParanoidiQ9Y6N3.
PhylomeDBiQ9Y6N3.

Family and domain databases

InterProiIPR013642. Cl_channel_Ca.
[Graphical view]
PfamiPF08434. CLCA_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6N3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVFSLKVILF LSLLLSPVLK SSLVTLNNNG YDGIVIAINP SVPEDEKLIQ
60 70 80 90 100
NIKEMVTEAS THLFHATKQR AYFRNVSILI PMTYKSKSEY LIPKQETYDQ
110 120 130 140 150
ADVIVADLYL KYGDDPYTLQ YGQCGDKGQY IHFTPNFLLT NNLATYGPRG
160 170 180 190 200
KVFVHGWAHL RWGVFDEYNV DQPFYISRRN TTEATRCSTR ITVYMVLNEC
210 220 230 240 250
KGASCIARPF RRDSQTGLYE AKCTFIPKRS QTAKESIVFM QNLDSVTEFC
260
TEKTHNKEAP NL
Length:262
Mass (Da):29,971
Last modified:November 1, 1999 - v1
Checksum:iD6C0E9F21300E33A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti84 – 841Y → T Requires 2 nucleotide substitutions.
Corresponds to variant rs2292830 [ dbSNP | Ensembl ].
VAR_035296
Natural varianti104 – 1041I → T.
Corresponds to variant rs2292829 [ dbSNP | Ensembl ].
VAR_035297

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043976 mRNA. Translation: AAD23734.1.
UniGeneiHs.673847.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043976 mRNA. Translation: AAD23734.1.
UniGeneiHs.673847.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL2364708.

Protein family/group databases

TCDBi1.A.13.1.4. the epithelial chloride channel (e-clc) family.

PTM databases

PhosphoSiteiQ9Y6N3.

Polymorphism and mutation databases

DMDMi74721541.

Proteomic databases

PRIDEiQ9Y6N3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiGC01P087099.
H-InvDBHIX0028523.
HGNCiHGNC:2017. CLCA3P.
MIMi604337. gene.
neXtProtiNX_Q9Y6N3.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG052848.
InParanoidiQ9Y6N3.
PhylomeDBiQ9Y6N3.

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.

Miscellaneous databases

PROiQ9Y6N3.
SOURCEiSearch...

Family and domain databases

InterProiIPR013642. Cl_channel_Ca.
[Graphical view]
PfamiPF08434. CLCA_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl- channels."
    Gruber A.D., Pauli B.U.
    Biochim. Biophys. Acta 1444:418-423(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, GLYCOSYLATION, TISSUE SPECIFICITY.
    Tissue: Spleen.

Entry informationi

Entry nameiCLCA3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 1, 1999
Last modified: June 24, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

In contrast to other members of the family, this protein is much shorter and lacks the VWFA domain. Defined as a pseudogene by HGNC. PubMed:10095065 reports that it is expressed and glycosylated in mammalian cells.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.