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Q9Y6N3

- CLCA3_HUMAN

UniProt

Q9Y6N3 - CLCA3_HUMAN

Protein

Calcium-activated chloride channel regulator family member 3

Gene

CLCA3P

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium channel activity Source: UniProtKB-KW
    2. chloride channel activity Source: UniProtKB-KW
    3. transporter activity Source: ProtInc
    4. voltage-gated ion channel activity Source: UniProtKB-KW

    GO - Biological processi

    1. transport Source: ProtInc

    Keywords - Molecular functioni

    Calcium channel, Chloride channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium, Chloride

    Protein family/group databases

    TCDBi1.A.13.1.4. the epithelial chloride channel (e-clc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-activated chloride channel regulator family member 3
    Short name:
    Calcium-activated chloride channel family member 3
    Short name:
    hCLCA3
    Gene namesi
    Name:CLCA3P
    Synonyms:CLCA3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:2017. CLCA3P.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. chloride channel complex Source: UniProtKB-KW
    2. extracellular space Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 262242Calcium-activated chloride channel regulator family member 3PRO_0000306400Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9Y6N3.

    PTM databases

    PhosphoSiteiQ9Y6N3.

    Expressioni

    Tissue specificityi

    Expressed in the lung, trachea, spleen, thymus and mammary gland.1 Publication

    Gene expression databases

    GenevestigatoriQ9Y6N3.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CLCR family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG052848.
    InParanoidiQ9Y6N3.
    PhylomeDBiQ9Y6N3.

    Family and domain databases

    InterProiIPR013642. Cl_channel_Ca.
    [Graphical view]
    PfamiPF08434. CLCA_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y6N3-1 [UniParc]FASTAAdd to Basket

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    MVFSLKVILF LSLLLSPVLK SSLVTLNNNG YDGIVIAINP SVPEDEKLIQ    50
    NIKEMVTEAS THLFHATKQR AYFRNVSILI PMTYKSKSEY LIPKQETYDQ 100
    ADVIVADLYL KYGDDPYTLQ YGQCGDKGQY IHFTPNFLLT NNLATYGPRG 150
    KVFVHGWAHL RWGVFDEYNV DQPFYISRRN TTEATRCSTR ITVYMVLNEC 200
    KGASCIARPF RRDSQTGLYE AKCTFIPKRS QTAKESIVFM QNLDSVTEFC 250
    TEKTHNKEAP NL 262
    Length:262
    Mass (Da):29,971
    Last modified:November 1, 1999 - v1
    Checksum:iD6C0E9F21300E33A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti84 – 841Y → T Requires 2 nucleotide substitutions.
    Corresponds to variant rs2292830 [ dbSNP | Ensembl ].
    VAR_035296
    Natural varianti104 – 1041I → T.
    Corresponds to variant rs2292829 [ dbSNP | Ensembl ].
    VAR_035297

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043976 mRNA. Translation: AAD23734.1.
    UniGeneiHs.673847.

    Polymorphism databases

    DMDMi74721541.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF043976 mRNA. Translation: AAD23734.1 .
    UniGenei Hs.673847.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2364708.

    Protein family/group databases

    TCDBi 1.A.13.1.4. the epithelial chloride channel (e-clc) family.

    PTM databases

    PhosphoSitei Q9Y6N3.

    Polymorphism databases

    DMDMi 74721541.

    Proteomic databases

    PRIDEi Q9Y6N3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC01P087099.
    H-InvDB HIX0028523.
    HGNCi HGNC:2017. CLCA3P.
    MIMi 604337. gene.
    neXtProti NX_Q9Y6N3.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG052848.
    InParanoidi Q9Y6N3.
    PhylomeDBi Q9Y6N3.

    Miscellaneous databases

    PROi Q9Y6N3.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9Y6N3.

    Family and domain databases

    InterProi IPR013642. Cl_channel_Ca.
    [Graphical view ]
    Pfami PF08434. CLCA_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl- channels."
      Gruber A.D., Pauli B.U.
      Biochim. Biophys. Acta 1444:418-423(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, GLYCOSYLATION, TISSUE SPECIFICITY.
      Tissue: Spleen.

    Entry informationi

    Entry nameiCLCA3_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y6N3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    In contrast to other members of the family, this protein is much shorter and lacks the VWFA domain. Defined as a pseudogene by HGNC. PubMed:10095065 reports that it is expressed and glycosylated in mammalian cells.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3