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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

Gene

NDUFB9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: ProtInc

GO - Biological processi

  • mitochondrial electron transport, NADH to ubiquinone Source: Reactome
  • mitochondrial respiratory chain complex I assembly Source: UniProtKB
  • sensory perception of sound Source: ProtInc

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
Alternative name(s):
Complex I-B22
Short name:
CI-B22
LYR motif-containing protein 3
NADH-ubiquinone oxidoreductase B22 subunit
Gene namesi
Name:NDUFB9
Synonyms:LYRM3, UQOR22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147684.7.
HGNCiHGNC:7704. NDUFB9.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4715.
MalaCardsiNDUFB9.
OpenTargetsiENSG00000147684.
Orphaneti2609. Isolated NADH-CoQ reductase deficiency.
PharmGKBiPA31515.

Chemistry databases

ChEMBLiCHEMBL2363065.
DrugBankiDB00157. NADH.

Polymorphism and mutation databases

BioMutaiNDUFB9.
DMDMi8134589.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001743062 – 179NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9Add BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei85PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y6M9.
MaxQBiQ9Y6M9.
PaxDbiQ9Y6M9.
PeptideAtlasiQ9Y6M9.
PRIDEiQ9Y6M9.
TopDownProteomicsiQ9Y6M9.

PTM databases

iPTMnetiQ9Y6M9.
PhosphoSitePlusiQ9Y6M9.
SwissPalmiQ9Y6M9.

Expressioni

Gene expression databases

BgeeiENSG00000147684.
CleanExiHS_NDUFB9.
ExpressionAtlasiQ9Y6M9. baseline and differential.
GenevisibleiQ9Y6M9. HS.

Organism-specific databases

HPAiHPA042768.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110795. 72 interactors.
CORUMiQ9Y6M9.
IntActiQ9Y6M9. 17 interactors.
MINTiMINT-1394411.
STRINGi9606.ENSP00000276689.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6M9.
SMRiQ9Y6M9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I LYR family.Curated

Phylogenomic databases

eggNOGiKOG3466. Eukaryota.
ENOG4111PES. LUCA.
GeneTreeiENSGT00390000005809.
HOGENOMiHOG000021684.
HOVERGENiHBG000418.
InParanoidiQ9Y6M9.
KOiK03965.
OMAiECYKVPE.
PhylomeDBiQ9Y6M9.
TreeFamiTF315148.

Family and domain databases

InterProiView protein in InterPro
IPR008011. Complex1_LYR.
IPR033034. NDUFB9.
PANTHERiPTHR12868:SF1. PTHR12868:SF1. 1 hit.
PfamiView protein in Pfam
PF05347. Complex1_LYR. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLASGPYL THQQKVLRLY KRALRHLESW CVQRDKYRYF ACLMRARFEE
60 70 80 90 100
HKNEKDMAKA TQLLKEAEEE FWYRQHPQPY IFPDSPGGTS YERYDCYKVP
110 120 130 140 150
EWCLDDWHPS EKAMYPDYFA KREQWKKLRR ESWEREVKQL QEETPPGGPL
160 170
TEALPPARKE GDLPPLWWYI VTRPRERPM
Length:179
Mass (Da):21,831
Last modified:January 23, 2007 - v3
Checksum:i2287AE8757F85E68
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014484146P → S1 PublicationCorresponds to variant dbSNP:rs10195Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044956 mRNA. Translation: AAD42057.1.
AF261090 mRNA. Translation: AAF99683.1.
AF067168 mRNA. Translation: AAD32452.1.
AK313432 mRNA. Translation: BAG36223.1.
CH471060 Genomic DNA. Translation: EAW92068.1.
BC007672 mRNA. Translation: AAH07672.1.
CCDSiCCDS6352.1.
RefSeqiNP_001298097.1. NM_001311168.1.
NP_004996.1. NM_005005.2.
UniGeneiHs.15977.

Genome annotation databases

EnsembliENST00000276689; ENSP00000276689; ENSG00000147684.
GeneIDi4715.
KEGGihsa:4715.
UCSCiuc003yrg.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNDUB9_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6M9
Secondary accession number(s): B2R8M6, Q9UQE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families