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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

Gene

NDUFB9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.1 Publication

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: ProtInc

GO - Biological processi

  • mitochondrial electron transport, NADH to ubiquinone Source: ProtInc
  • mitochondrial respiratory chain complex I assembly Source: UniProtKB
  • sensory perception of sound Source: ProtInc

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105 Respiratory electron transport
R-HSA-6799198 Complex I biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
Alternative name(s):
Complex I-B22
Short name:
CI-B22
LYR motif-containing protein 3
NADH-ubiquinone oxidoreductase B22 subunit
Gene namesi
Name:NDUFB9
Synonyms:LYRM3, UQOR22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147684.7
HGNCiHGNC:7704 NDUFB9
MIMi601445 gene
neXtProtiNX_Q9Y6M9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4715
MalaCardsiNDUFB9
OpenTargetsiENSG00000147684
Orphaneti2609 Isolated NADH-CoQ reductase deficiency
PharmGKBiPA31515

Chemistry databases

ChEMBLiCHEMBL2363065
DrugBankiDB00157 NADH

Polymorphism and mutation databases

BioMutaiNDUFB9
DMDMi8134589

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001743062 – 179NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9Add BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei85PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y6M9
MaxQBiQ9Y6M9
PaxDbiQ9Y6M9
PeptideAtlasiQ9Y6M9
PRIDEiQ9Y6M9
TopDownProteomicsiQ9Y6M9

PTM databases

iPTMnetiQ9Y6M9
PhosphoSitePlusiQ9Y6M9
SwissPalmiQ9Y6M9

Expressioni

Gene expression databases

BgeeiENSG00000147684
CleanExiHS_NDUFB9
ExpressionAtlasiQ9Y6M9 baseline and differential
GenevisibleiQ9Y6M9 HS

Organism-specific databases

HPAiHPA042768

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi110795, 74 interactors
CORUMiQ9Y6M9
IntActiQ9Y6M9, 17 interactors
MINTiQ9Y6M9
STRINGi9606.ENSP00000276689

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XTCelectron microscopy3.70p8-179[»]
5XTDelectron microscopy3.70p8-179[»]
5XTHelectron microscopy3.90p8-179[»]
5XTIelectron microscopy17.40Bp/p8-179[»]
ProteinModelPortaliQ9Y6M9
SMRiQ9Y6M9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I LYR family.Curated

Phylogenomic databases

eggNOGiKOG3466 Eukaryota
ENOG4111PES LUCA
GeneTreeiENSGT00390000005809
HOGENOMiHOG000021684
HOVERGENiHBG000418
InParanoidiQ9Y6M9
KOiK03965
OMAiECYKVPE
PhylomeDBiQ9Y6M9
TreeFamiTF315148

Family and domain databases

InterProiView protein in InterPro
IPR008011 Complex1_LYR
IPR033034 NDUFB9
PANTHERiPTHR12868 PTHR12868, 1 hit
PfamiView protein in Pfam
PF05347 Complex1_LYR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLASGPYL THQQKVLRLY KRALRHLESW CVQRDKYRYF ACLMRARFEE
60 70 80 90 100
HKNEKDMAKA TQLLKEAEEE FWYRQHPQPY IFPDSPGGTS YERYDCYKVP
110 120 130 140 150
EWCLDDWHPS EKAMYPDYFA KREQWKKLRR ESWEREVKQL QEETPPGGPL
160 170
TEALPPARKE GDLPPLWWYI VTRPRERPM
Length:179
Mass (Da):21,831
Last modified:January 23, 2007 - v3
Checksum:i2287AE8757F85E68
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014484146P → S1 PublicationCorresponds to variant dbSNP:rs10195EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044956 mRNA Translation: AAD42057.1
AF261090 mRNA Translation: AAF99683.1
AF067168 mRNA Translation: AAD32452.1
AK313432 mRNA Translation: BAG36223.1
CH471060 Genomic DNA Translation: EAW92068.1
BC007672 mRNA Translation: AAH07672.1
CCDSiCCDS6352.1
RefSeqiNP_001298097.1, NM_001311168.1
NP_004996.1, NM_005005.2
UniGeneiHs.15977

Genome annotation databases

EnsembliENST00000276689; ENSP00000276689; ENSG00000147684
GeneIDi4715
KEGGihsa:4715
UCSCiuc003yrg.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNDUB9_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6M9
Secondary accession number(s): B2R8M6, Q9UQE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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