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Protein

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

Gene

NDUFB9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: UniProtKB

GO - Biological processi

  • mitochondrial electron transport, NADH to ubiquinone Source: UniProtKB
  • mitochondrial respiratory chain complex I assembly Source: Reactome
  • mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
  • sensory perception of sound Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
Alternative name(s):
Complex I-B22
Short name:
CI-B22
LYR motif-containing protein 3
NADH-ubiquinone oxidoreductase B22 subunit
Gene namesi
Name:NDUFB9
Synonyms:LYRM3, UQOR22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:7704. NDUFB9.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • mitochondrial inner membrane Source: Reactome
  • mitochondrial respiratory chain complex I Source: UniProtKB
  • mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

MalaCardsiNDUFB9.
Orphaneti2609. Isolated NADH-CoQ reductase deficiency.
PharmGKBiPA31515.

Chemistry

ChEMBLiCHEMBL2363065.

Polymorphism and mutation databases

BioMutaiNDUFB9.
DMDMi8134589.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources1 Publication
Chaini2 – 179178NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9PRO_0000174306Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources1 Publication
Modified residuei85 – 851PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y6M9.
MaxQBiQ9Y6M9.
PaxDbiQ9Y6M9.
PeptideAtlasiQ9Y6M9.
PRIDEiQ9Y6M9.
TopDownProteomicsiQ9Y6M9.

PTM databases

iPTMnetiQ9Y6M9.
PhosphoSiteiQ9Y6M9.
SwissPalmiQ9Y6M9.

Expressioni

Gene expression databases

BgeeiENSG00000147684.
CleanExiHS_NDUFB9.
ExpressionAtlasiQ9Y6M9. baseline and differential.
GenevisibleiQ9Y6M9. HS.

Organism-specific databases

HPAiHPA042768.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MAGEA11P43364-23EBI-713654,EBI-10178634

Protein-protein interaction databases

BioGridi110795. 62 interactions.
IntActiQ9Y6M9. 16 interactions.
MINTiMINT-1394411.
STRINGi9606.ENSP00000276689.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6M9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I LYR family.Curated

Phylogenomic databases

eggNOGiKOG3466. Eukaryota.
ENOG4111PES. LUCA.
GeneTreeiENSGT00390000005809.
HOGENOMiHOG000021684.
HOVERGENiHBG000418.
InParanoidiQ9Y6M9.
KOiK03965.
OMAiDYWHPSE.
PhylomeDBiQ9Y6M9.
TreeFamiTF315148.

Family and domain databases

InterProiIPR008011. Complex1_LYR.
IPR033034. NDUFB9.
[Graphical view]
PANTHERiPTHR12868:SF0. PTHR12868:SF0. 1 hit.
PfamiPF05347. Complex1_LYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLASGPYL THQQKVLRLY KRALRHLESW CVQRDKYRYF ACLMRARFEE
60 70 80 90 100
HKNEKDMAKA TQLLKEAEEE FWYRQHPQPY IFPDSPGGTS YERYDCYKVP
110 120 130 140 150
EWCLDDWHPS EKAMYPDYFA KREQWKKLRR ESWEREVKQL QEETPPGGPL
160 170
TEALPPARKE GDLPPLWWYI VTRPRERPM
Length:179
Mass (Da):21,831
Last modified:January 23, 2007 - v3
Checksum:i2287AE8757F85E68
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti146 – 1461P → S.1 Publication
Corresponds to variant rs10195 [ dbSNP | Ensembl ].
VAR_014484

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044956 mRNA. Translation: AAD42057.1.
AF261090 mRNA. Translation: AAF99683.1.
AF067168 mRNA. Translation: AAD32452.1.
AK313432 mRNA. Translation: BAG36223.1.
CH471060 Genomic DNA. Translation: EAW92068.1.
BC007672 mRNA. Translation: AAH07672.1.
CCDSiCCDS6352.1.
RefSeqiNP_001298097.1. NM_001311168.1.
NP_004996.1. NM_005005.2.
UniGeneiHs.15977.

Genome annotation databases

EnsembliENST00000276689; ENSP00000276689; ENSG00000147684.
GeneIDi4715.
KEGGihsa:4715.
UCSCiuc003yrg.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044956 mRNA. Translation: AAD42057.1.
AF261090 mRNA. Translation: AAF99683.1.
AF067168 mRNA. Translation: AAD32452.1.
AK313432 mRNA. Translation: BAG36223.1.
CH471060 Genomic DNA. Translation: EAW92068.1.
BC007672 mRNA. Translation: AAH07672.1.
CCDSiCCDS6352.1.
RefSeqiNP_001298097.1. NM_001311168.1.
NP_004996.1. NM_005005.2.
UniGeneiHs.15977.

3D structure databases

ProteinModelPortaliQ9Y6M9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110795. 62 interactions.
IntActiQ9Y6M9. 16 interactions.
MINTiMINT-1394411.
STRINGi9606.ENSP00000276689.

Chemistry

ChEMBLiCHEMBL2363065.

PTM databases

iPTMnetiQ9Y6M9.
PhosphoSiteiQ9Y6M9.
SwissPalmiQ9Y6M9.

Polymorphism and mutation databases

BioMutaiNDUFB9.
DMDMi8134589.

Proteomic databases

EPDiQ9Y6M9.
MaxQBiQ9Y6M9.
PaxDbiQ9Y6M9.
PeptideAtlasiQ9Y6M9.
PRIDEiQ9Y6M9.
TopDownProteomicsiQ9Y6M9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276689; ENSP00000276689; ENSG00000147684.
GeneIDi4715.
KEGGihsa:4715.
UCSCiuc003yrg.5. human.

Organism-specific databases

CTDi4715.
GeneCardsiNDUFB9.
HGNCiHGNC:7704. NDUFB9.
HPAiHPA042768.
MalaCardsiNDUFB9.
MIMi601445. gene.
neXtProtiNX_Q9Y6M9.
Orphaneti2609. Isolated NADH-CoQ reductase deficiency.
PharmGKBiPA31515.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3466. Eukaryota.
ENOG4111PES. LUCA.
GeneTreeiENSGT00390000005809.
HOGENOMiHOG000021684.
HOVERGENiHBG000418.
InParanoidiQ9Y6M9.
KOiK03965.
OMAiDYWHPSE.
PhylomeDBiQ9Y6M9.
TreeFamiTF315148.

Enzyme and pathway databases

ReactomeiR-HSA-611105. Respiratory electron transport.
R-HSA-6799198. Complex I biogenesis.

Miscellaneous databases

ChiTaRSiNDUFB9. human.
GeneWikiiNDUFB9.
GenomeRNAii4715.
PROiQ9Y6M9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147684.
CleanExiHS_NDUFB9.
ExpressionAtlasiQ9Y6M9. baseline and differential.
GenevisibleiQ9Y6M9. HS.

Family and domain databases

InterProiIPR008011. Complex1_LYR.
IPR033034. NDUFB9.
[Graphical view]
PANTHERiPTHR12868:SF0. PTHR12868:SF0. 1 hit.
PfamiPF05347. Complex1_LYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUB9_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6M9
Secondary accession number(s): B2R8M6, Q9UQE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.