Q9Y6M7A6NIA8B2CI53B5M449B5M451B5M452B5M453B6DY52B6DY53C9JST9D3K174D3K175O60350Q6AHZ9Q9HC88Q9UIB9S4A7_HUMANSodium bicarbonate cotransporter 3Electroneutral Na/HCO(3) cotransporterSodium bicarbonate cotransporter 2Sodium bicarbonate cotransporter 2bBicarbonate transporterSolute carrier family 4 member 7SLC4A7BTNBC2NBC2BNBC3NBCn1SBC2SLC4A6Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoMolecular cloning of a new sodium bicarbonate cotransporter cDNA from human retina.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)TISSUE SPECIFICITYCloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)FUNCTIONBIOPHYSICOCHEMICAL PROPERTIESACTIVITY REGULATIONVARIANT LYS-326TRANSPORTER ACTIVITYTISSUE SPECIFICITYCloning of a HCO3 transporter, NT2-NBC, from human brain, similar to both the Anion exchangers (AEs) and the Na/Bicarbonate Cotransporters (NBCs).NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)Cloning and identification of novel human NBCn1 splice variants.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6; 7; 8; 9; 10; 11 AND 12)ALTERNATIVE SPLICINGVARIANT LYS-326Cloning and identification of two novel human NBCn1 splice variants.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 13 AND 14)The full-ORF clone resource of the German cDNA consortium.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)The DNA sequence, annotation and analysis of human chromosome 3.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3-cotransport isoform 3.FUNCTIONINTERACTION WITH CFTR AND NHERF1DOMAINTRANSPORTER ACTIVITYThe COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction.INTERACTION WITH ATP6V1B1 AND NHERF1MUTAGENESIS OF LEU-1214Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA.INTERACTION WITH CA2ACTIVITY REGULATIONMUTAGENESIS OF 1135-ASP-ASP-1136 AND 1163-ASP--ASP-1165FUNCTIONTRANSPORTER ACTIVITYRobust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Scaffold protein harmonin (USH1C) provides molecular links between Usher syndrome type 1 and type 2.INTERACTION WITH USH1CGlobal, in vivo, and site-specific phosphorylation dynamics in signaling networks.IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Structural and functional characterization of the human NBC3 sodium/bicarbonate co-transporter carboxyl-terminal cytoplasmic domain.FUNCTIONTRANSPORTER ACTIVITYMUTAGENESIS OF 1127-THR--LEU-1214REGIONSUBCELLULAR LOCATIONCombining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1167 AND SER-1176IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]A quantitative atlas of mitotic phosphorylation.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-403 AND SER-1213PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263 (ISOFORMS 11; 6 AND 9)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1109 AND SER-1115 (ISOFORM 13)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267 (ISOFORMS 13 AND 14)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258 (ISOFORM 2)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1010 AND SER-1016 (ISOFORM 3)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168 (ISOFORMS 3 AND 4)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-774 AND SER-780 (ISOFORM 5)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1105 AND SER-1111 (ISOFORM 6)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1233 AND SER-1239 (ISOFORM 7)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1220 AND SER-1226 (ISOFORM 8)IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Modular structure of sodium-coupled bicarbonate transporters.REVIEWALTERNATIVE SPLICINGMass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-776; ASN-786 AND ASN-791Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1167 AND SER-1176PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263 (ISOFORMS 11; 6 AND 9)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1077 (ISOFORM 13)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267 (ISOFORMS 13 AND 14)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258 (ISOFORM 2)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168 (ISOFORMS 3 AND 4)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-742 (ISOFORM 5)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1073 (ISOFORM 6)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1201 (ISOFORM 7)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1188 (ISOFORM 8)IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1176PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-260 AND SER-263 (ISOFORMS 11; 6 AND 9)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1106 AND SER-1109 (ISOFORM 13)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-264 AND SER-267 (ISOFORMS 13 AND 14)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-255 AND SER-258 (ISOFORM 2)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1007 AND SER-1010 (ISOFORM 3)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165 AND SER-168 (ISOFORMS 3 AND 4)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-771 AND SER-774 (ISOFORM 5)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1102 AND SER-1105 (ISOFORM 6)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1230 AND SER-1233 (ISOFORM 7)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1217 AND SER-1220 (ISOFORM 8)IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242 AND SER-403PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-263 (ISOFORMS 11; 6 AND 9)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1106 (ISOFORM 13)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-267 (ISOFORMS 13 AND 14)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-258 (ISOFORM 2)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1007 (ISOFORM 3)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168 (ISOFORMS 3 AND 4)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-771 (ISOFORM 5)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1102 (ISOFORM 6)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1230 (ISOFORM 7)PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1217 (ISOFORM 8)IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Toward a comprehensive characterization of a human cancer cell phosphoproteome.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55; SER-242; SER-403; SER-407; SER-556 AND THR-557IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]N-terminome analysis of the human mitochondrial proteome.IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]The Bicarbonate Transporter SLC4A7 Plays a Key Role in Macrophage Phagosome Acidification.FUNCTIONTRANSPORTER ACTIVITYINDUCTIONMUTAGENESIS OF THR-549; ASP-811 AND 1008-THR--LEU-1131 (ISOFORM 6)SUBCELLULAR LOCATIONREGION (ISOFORM 6)The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis.FUNCTIONTRANSPORTER ACTIVITYINDUCTIONElectroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry (PubMed:10347222, PubMed:12403779, PubMed:14736710, PubMed:14578046). Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells (By similarity). Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis (PubMed:29779931). Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells (PubMed:35772404).Isoform 6Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis.hydrogencarbonate(in) + Na(+)(in) = hydrogencarbonate(out) + Na(+)(out)Isoform 6hydrogencarbonate(in) + Na(+)(in) = hydrogencarbonate(out) + Na(+)(out)Transporter activity is regulated by CA2/carbonic anhydrase 2, cAMP and PKA. Insensitive to stilbene derivatives. Inhibited by 5-(N-ethyl-N-isopropyl)-amiloride (EIPA).24 mM for external sodiumInteracts with CFTR through NHERF1/EBP50. Interacts with USH1C. Forms a complex with ATP6V1B1 and NHERF1/EBP50. Interacts in a pH dependent-manner with CA2/carbonic anhydrase 2.Q9Y6M7O76071false3Q9Y6M7Q9BYR2false3Basolateral cell membraneMulti-pass membrane proteinApical cell membraneMulti-pass membrane proteinCell projectionStereociliumCell membraneMulti-pass membrane proteinLocalizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells (By similarity).Isoform 6Cell membraneMulti-pass membrane proteinQ9Y6M7-11mNBC3NBCn1-AQ9Y6M7-22NBCn1-FQ9Y6M7-33Q9Y6M7-44Q9Y6M7-55Q9Y6M7-66NBCn1-GQ9Y6M7-77NBCn1-DQ9Y6M7-88NBCn1-CQ9Y6M7-99NBCn1-EQ9Y6M7-1010Q9Y6M7-1111Q9Y6M7-1212NBCn1-HQ9Y6M7-1313Q9Y6M7-1414Highly expressed in testis and spleen. Also expressed in retina, colon, small intestine, ovary, thymus, prostate, muscle, heart and kidney.Isoform 1Expressed in skeletal muscle and heart muscle.In response to growth factor stimuli, mTORC1 activation, through the RPS6KA1-dependent EIF4B phosphorylation, stimulates SLC4A7 mRNA translation (at protein level) (PubMed:35772404). Strongly induced upon macrophage differentiation (PubMed:29779931).The PDZ-binding motif mediates interaction with the CFTR, NHERF1/EBP50 complex and probably with USH1C.Belongs to the anion exchanger (TC 2.A.31) family.Alternative splicingCell membraneCell projectionDisulfide bondGlycoproteinIon transportMembranePhosphoproteinReference proteomeSodiumSodium transportSymportTransmembraneTransmembrane helixTransportMERFRLEKKLPMEADGAGEQMRPLLTRMERFRLEKKLPMEADGAGEQMRPLLTRVTSRSQRVQFILGTEDDDEEHIPHDLFTEMDEMAVTQFIHFREEIMGNMFFIIIFSTKDKPAVLLTGLTEVPVPTMEVVEAEKIVLLTSALFVQSSVDPSIVNISDEMAKTAQWKALSMNTENAKVTRSNMSPDKPVSVKISFEDEPRKKYVDAETSLGDPSIGNISDEMAKTAQWKALSMNTENAKVTRSNMSPDKPVSVKEKDDNNDDDNNNLGTIDAMERFRLEKKLPGPDEEAVVDLGKTSSTVNTKFEKEELESHRAVYIGVHVPFSKESRRRHRHRGHKHHHRRRKDKESDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDESIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLGHLLPSSRAGTPAGSRCTTPVPTPQNSPPSSPSISRLTSRSSQESQRQAPELLVSPASDDIPTVVIHPPEEDLEAALKGEEQKNEENVDLTPGILASPQSAPGNLDNSKSGEIKGNGSGGSRENSTVDFSKVDMNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLTGLTEVPVPTRFLFLLLGPAGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIPVFHNGSTPTLGETPKEAAHHAGPELQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILYKFCRDYQLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFDLGETYAFNMHNNLDKLTSYSCVCTEPPNPSNETLAQWKKDNITAHNISWRNLTVSECKKLRGVFLGSACGHHGPYIPDVLFWCVILFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVTIDYLVGVPSPKLHVPEKFEPTHPERGWIISPLGDNPWWTLLIAAIPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVGVMLGVCSVMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQLFDRIKLFGMPAKHQPDLIYLRYVPLWKVHIFTVIQLTCLVLLWVIKVSAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPESKKKKEDDKKKKEKEEAERMLQDDDDTVHLPFEGGSLLQIPVKALKYSPDKPVSVKISFEDEPRKKYVDAETSL
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