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Q9Y6M5

- ZNT1_HUMAN

UniProt

Q9Y6M5 - ZNT1_HUMAN

Protein

Zinc transporter 1

Gene

SLC30A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 3 (07 Jul 2009)
      Previous versions | rss
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    Functioni

    May be involved in zinc transport out of the cell.

    GO - Molecular functioni

    1. calcium channel inhibitor activity Source: BHF-UCL
    2. protein binding Source: UniProt
    3. zinc ion transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. cadmium ion transmembrane transport Source: BHF-UCL
    2. calcium ion import Source: Ensembl
    3. cellular calcium ion homeostasis Source: BHF-UCL
    4. cellular zinc ion homeostasis Source: BHF-UCL
    5. detoxification of cadmium ion Source: Ensembl
    6. in utero embryonic development Source: Ensembl
    7. negative regulation of calcium ion import Source: BHF-UCL
    8. negative regulation of neurotransmitter secretion Source: BHF-UCL
    9. negative regulation of zinc ion transmembrane import Source: BHF-UCL
    10. transmembrane transport Source: Reactome
    11. zinc ion transport Source: BHF-UCL

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Enzyme and pathway databases

    ReactomeiREACT_20582. Zinc efflux and compartmentalization by the SLC30 family.

    Protein family/group databases

    TCDBi2.A.4.2.6. the cation diffusion facilitator (cdf) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter 1
    Short name:
    ZnT-1
    Alternative name(s):
    Solute carrier family 30 member 1
    Gene namesi
    Name:SLC30A1
    Synonyms:ZNT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11012. SLC30A1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProt
    2. endoplasmic reticulum Source: UniProt
    3. Golgi apparatus Source: UniProt
    4. integral component of membrane Source: UniProtKB-KW
    5. nuclear membrane Source: UniProt
    6. plasma membrane Source: BHF-UCL
    7. T-tubule Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35882.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507Zinc transporter 1PRO_0000206090Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
    Modified residuei506 – 5061Phosphoserine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y6M5.
    PaxDbiQ9Y6M5.
    PRIDEiQ9Y6M5.

    PTM databases

    PhosphoSiteiQ9Y6M5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y6M5.
    BgeeiQ9Y6M5.
    CleanExiHS_SLC30A1.
    GenevestigatoriQ9Y6M5.

    Organism-specific databases

    HPAiHPA015275.

    Interactioni

    Subunit structurei

    Multimer.Curated

    Protein-protein interaction databases

    BioGridi113560. 4 interactions.
    STRINGi9606.ENSP00000355968.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y6M5.
    SMRiQ9Y6M5. Positions 28-106.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 354ExtracellularSequence Analysis
    Topological domaini57 – 7822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini100 – 11314ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini135 – 248114CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini270 – 30839ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini330 – 507178CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei249 – 26921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei309 – 32921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni146 – 158136 X 2 AA approximate repeats of H-GAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1230.
    HOGENOMiHOG000166089.
    HOVERGENiHBG000588.
    InParanoidiQ9Y6M5.
    KOiK14688.
    OMAiRACLLEC.
    OrthoDBiEOG7034GQ.
    PhylomeDBiQ9Y6M5.
    TreeFamiTF313924.

    Family and domain databases

    Gene3Di1.20.1510.10. 3 hits.
    InterProiIPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view]
    PANTHERiPTHR11562. PTHR11562. 1 hit.
    PfamiPF01545. Cation_efflux. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01297. CDF. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Y6M5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCWGRNRGR LLCMLALTFM FMVLEVVVSR VTSSLAMLSD SFHMLSDVLA    50
    LVVALVAERF ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA 100
    IERFIEPHEM QQPLVVLGVG VAGLLVNVLG LCLFHHHSGF SQDSGHGHSH 150
    GGHGHGHGLP KGPRVKSTRP GSSDINVAPG EQGPDQEETN TLVANTSNSN 200
    GLKLDPADPE NPRSGDTVEV QVNGNLVREP DHMELEEDRA GQLNMRGVFL 250
    HVLGDALGSV IVVVNALVFY FSWKGCSEGD FCVNPCFPDP CKAFVEIINS 300
    THASVYEAGP CWVLYLDPTL CVVMVCILLY TTYPLLKESA LILLQTVPKQ 350
    IDIRNLIKEL RNVEGVEEVH ELHVWQLAGS RIIATAHIKC EDPTSYMEVA 400
    KTIKDVFHNH GIHATTIQPE FASVGSKSSV VPCELACRTQ CALKQCCGTL 450
    PQAPSGKDAE KTPAVSISCL ELSNNLEKKP RRTKAENIPA VVIEIKNMPN 500
    KQPESSL 507
    Length:507
    Mass (Da):55,300
    Last modified:July 7, 2009 - v3
    Checksum:i2FC5B67F033AE457
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti386 – 3861A → V in AAG53405. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF323590 Genomic DNA. Translation: AAG53405.1.
    AB451467 mRNA. Translation: BAG70281.1.
    CH471100 Genomic DNA. Translation: EAW93412.1.
    BC121015 mRNA. Translation: AAI21016.1.
    BC121016 mRNA. Translation: AAI21017.1.
    AF048701 Genomic DNA. Translation: AAD29840.1.
    CCDSiCCDS1499.1.
    RefSeqiNP_067017.2. NM_021194.2.
    UniGeneiHs.519469.

    Genome annotation databases

    EnsembliENST00000367001; ENSP00000355968; ENSG00000170385.
    GeneIDi7779.
    KEGGihsa:7779.
    UCSCiuc001hio.1. human.

    Polymorphism databases

    DMDMi251757423.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF323590 Genomic DNA. Translation: AAG53405.1 .
    AB451467 mRNA. Translation: BAG70281.1 .
    CH471100 Genomic DNA. Translation: EAW93412.1 .
    BC121015 mRNA. Translation: AAI21016.1 .
    BC121016 mRNA. Translation: AAI21017.1 .
    AF048701 Genomic DNA. Translation: AAD29840.1 .
    CCDSi CCDS1499.1.
    RefSeqi NP_067017.2. NM_021194.2.
    UniGenei Hs.519469.

    3D structure databases

    ProteinModelPortali Q9Y6M5.
    SMRi Q9Y6M5. Positions 28-106.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113560. 4 interactions.
    STRINGi 9606.ENSP00000355968.

    Protein family/group databases

    TCDBi 2.A.4.2.6. the cation diffusion facilitator (cdf) family.

    PTM databases

    PhosphoSitei Q9Y6M5.

    Polymorphism databases

    DMDMi 251757423.

    Proteomic databases

    MaxQBi Q9Y6M5.
    PaxDbi Q9Y6M5.
    PRIDEi Q9Y6M5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367001 ; ENSP00000355968 ; ENSG00000170385 .
    GeneIDi 7779.
    KEGGi hsa:7779.
    UCSCi uc001hio.1. human.

    Organism-specific databases

    CTDi 7779.
    GeneCardsi GC01M211744.
    HGNCi HGNC:11012. SLC30A1.
    HPAi HPA015275.
    MIMi 609521. gene.
    neXtProti NX_Q9Y6M5.
    PharmGKBi PA35882.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1230.
    HOGENOMi HOG000166089.
    HOVERGENi HBG000588.
    InParanoidi Q9Y6M5.
    KOi K14688.
    OMAi RACLLEC.
    OrthoDBi EOG7034GQ.
    PhylomeDBi Q9Y6M5.
    TreeFami TF313924.

    Enzyme and pathway databases

    Reactomei REACT_20582. Zinc efflux and compartmentalization by the SLC30 family.

    Miscellaneous databases

    GeneWikii SLC30A1.
    GenomeRNAii 7779.
    NextBioi 30115.
    PROi Q9Y6M5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y6M5.
    Bgeei Q9Y6M5.
    CleanExi HS_SLC30A1.
    Genevestigatori Q9Y6M5.

    Family and domain databases

    Gene3Di 1.20.1510.10. 3 hits.
    InterProi IPR002524. Cation_efflux.
    IPR027469. Cation_efflux_TMD.
    [Graphical view ]
    PANTHERi PTHR11562. PTHR11562. 1 hit.
    Pfami PF01545. Cation_efflux. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01297. CDF. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of human zinc transporter 1 (ZNT1)."
      Nanji M.S., Coronado V.A., Cox D.W.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Human Protein Factory: an infrastructure to convert the human transcriptome into the in vitro-expressed human proteome of versatile utility."
      Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
      , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
      Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Assignment of the human zinc transporter gene 1 (ZnT1) to chromosomes 1."
      Inoue H., Oka Y.
      Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 411-507.
    6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-506, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiZNT1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y6M5
    Secondary accession number(s): Q0VAK9, Q9BZF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 117 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3