Q9Y6M5 (ZNT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc transporter 1
Short name=ZnT-1

Alternative name(s):
Solute carrier family 30 member 1

Gene names

Name:	SLC30A1
Synonyms:	ZNT1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	507 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in zinc transport out of the cell.
Subunit structure	Multimer Probable.
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. [View classification]

Ontologies

Keywords
Biological process	Ion transport Transport Zinc transport
Cellular component	Cell membrane Membrane
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Zinc
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cadmium ion transmembrane transport Inferred from sequence or structural similarity. Source: BHF-UCL calcium ion import Inferred from electronic annotation. Source: Compara cellular calcium ion homeostasis Inferred from sequence or structural similarity. Source: BHF-UCL cellular zinc ion homeostasis Inferred from sequence or structural similarity. Source: BHF-UCL detoxification of cadmium ion Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara negative regulation of calcium ion import Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of neurotransmitter secretion Inferred from sequence or structural similarity. Source: BHF-UCL negative regulation of zinc ion transmembrane import Inferred from sequence or structural similarity. Source: BHF-UCL zinc ion transport Inferred from sequence or structural similarity. Source: BHF-UCL
Cellular_component	T-tubule Inferred from sequence or structural similarity. Source: BHF-UCL integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	calcium channel inhibitor activity Inferred from sequence or structural similarity. Source: BHF-UCL zinc ion transmembrane transporter activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 507	507	Zinc transporter 1		PRO_0000206090
Regions
	Topological domain	1 – 10	10	Cytoplasmic Potential
	Transmembrane	11 – 31	21	Helical; Potential
	Topological domain	32 – 35	4	Extracellular Potential
	Transmembrane	36 – 56	21	Helical; Potential
	Topological domain	57 – 78	22	Cytoplasmic Potential
	Transmembrane	79 – 99	21	Helical; Potential
	Topological domain	100 – 113	14	Extracellular Potential
	Transmembrane	114 – 134	21	Helical; Potential
	Topological domain	135 – 248	114	Cytoplasmic Potential
	Transmembrane	249 – 269	21	Helical; Potential
	Topological domain	270 – 308	39	Extracellular Potential
	Transmembrane	309 – 329	21	Helical; Potential
	Topological domain	330 – 507	178	Cytoplasmic Potential
	Region	146 – 158	13	6 X 2 AA approximate repeats of H-G
Amino acid modifications
	Modified residue	506	1	Phosphoserine Ref.7
	Glycosylation	299	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	386	1	A → V in AAG53405. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9Y6M5 [UniParc]. Last modified July 7, 2009. Version 3. Checksum: 2FC5B67F033AE457	FASTA	507	55,300
	10 20 30 40 50 60 MGCWGRNRGR LLCMLALTFM FMVLEVVVSR VTSSLAMLSD SFHMLSDVLA LVVALVAERF 70 80 90 100 110 120 ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA IERFIEPHEM QQPLVVLGVG 130 140 150 160 170 180 VAGLLVNVLG LCLFHHHSGF SQDSGHGHSH GGHGHGHGLP KGPRVKSTRP GSSDINVAPG 190 200 210 220 230 240 EQGPDQEETN TLVANTSNSN GLKLDPADPE NPRSGDTVEV QVNGNLVREP DHMELEEDRA 250 260 270 280 290 300 GQLNMRGVFL HVLGDALGSV IVVVNALVFY FSWKGCSEGD FCVNPCFPDP CKAFVEIINS 310 320 330 340 350 360 THASVYEAGP CWVLYLDPTL CVVMVCILLY TTYPLLKESA LILLQTVPKQ IDIRNLIKEL 370 380 390 400 410 420 RNVEGVEEVH ELHVWQLAGS RIIATAHIKC EDPTSYMEVA KTIKDVFHNH GIHATTIQPE 430 440 450 460 470 480 FASVGSKSSV VPCELACRTQ CALKQCCGTL PQAPSGKDAE KTPAVSISCL ELSNNLEKKP 490 500 RRTKAENIPA VVIEIKNMPN KQPESSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of human zinc transporter 1 (ZNT1)." Nanji M.S., Coronado V.A., Cox D.W. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Human Protein Factory: an infrastructure to convert the human transcriptome into the in vitro-expressed human proteome of versatile utility." Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B. , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N. Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Assignment of the human zinc transporter gene 1 (ZnT1) to chromosomes 1." Inoue H., Oka Y. Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 411-507.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-506, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF323590 Genomic DNA. Translation: AAG53405.1. AB451467 mRNA. Translation: BAG70281.1. CH471100 Genomic DNA. Translation: EAW93412.1. BC121015 mRNA. Translation: AAI21016.1. BC121016 mRNA. Translation: AAI21017.1. AF048701 Genomic DNA. Translation: AAD29840.1.
IPI	IPI00002483.
RefSeq	NP_067017.2. NM_021194.2.
UniGene	Hs.741489.
3D structure databases
ProteinModelPortal	Q9Y6M5.
SMR	Q9Y6M5. Positions 15-106.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000355968.
PTM databases
PhosphoSite	Q9Y6M5.
Polymorphism databases
DMDM	251757423.
Proteomic databases
PaxDb	Q9Y6M5.
PRIDE	Q9Y6M5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367001; ENSP00000355968; ENSG00000170385.
GeneID	7779.
KEGG	hsa:7779.
UCSC	uc001hio.1. human.
Organism-specific databases
CTD	7779.
GeneCards	GC01M211744.
HGNC	HGNC:11012. SLC30A1.
HPA	HPA015275.
MIM	609521. gene.
neXtProt	NX_Q9Y6M5.
PharmGKB	PA35882.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1230.
HOGENOM	HOG000166089.
HOVERGEN	HBG000588.
InParanoid	Q9Y6M5.
KO	K14688.
OMA	FMFMVLE.
OrthoDB	EOG4GF3F3.
PhylomeDB	Q9Y6M5.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q9Y6M5.
Bgee	Q9Y6M5.
CleanEx	HS_SLC30A1.
Genevestigator	Q9Y6M5.
GermOnline	ENSG00000170385. Homo sapiens.
Family and domain databases
InterPro	IPR002524. Cation_efflux. [Graphical view]
PANTHER	PTHR11562. PTHR11562. 1 hit.
Pfam	PF01545. Cation_efflux. 1 hit. [Graphical view]
TIGRFAMs	TIGR01297. CDF. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	7779.
NextBio	30115.
SOURCE	Search...

Entry information

Entry name

ZNT1_HUMAN

Accession

Primary (citable) accession number: Q9Y6M5
Secondary accession number(s): Q0VAK9, Q9BZF6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	July 7, 2009
Last modified:	May 1, 2013
This is version 103 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.