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Q9Y6M5 (ZNT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc transporter 1

Short name=ZnT-1
Alternative name(s):
Solute carrier family 30 member 1
Gene names
Name:SLC30A1
Synonyms:ZNT1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in zinc transport out of the cell.

Subunit structure

Multimer Probable.

Subcellular location

Cell membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. [View classification]

Ontologies

Keywords
   Biological processIon transport
Transport
Zinc transport
   Cellular componentCell membrane
Membrane
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandZinc
   PTMGlycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcadmium ion transmembrane transport

Inferred from sequence or structural similarity. Source: BHF-UCL

calcium ion import

Inferred from electronic annotation. Source: Ensembl

cellular calcium ion homeostasis

Inferred from sequence or structural similarity. Source: BHF-UCL

cellular zinc ion homeostasis

Inferred from sequence or structural similarity. Source: BHF-UCL

detoxification of cadmium ion

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

negative regulation of calcium ion import

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of neurotransmitter secretion

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of zinc ion transmembrane import

Inferred from sequence or structural similarity. Source: BHF-UCL

transmembrane transport

Traceable author statement. Source: Reactome

zinc ion transport

Inferred from sequence or structural similarity. Source: BHF-UCL

   Cellular_componentGolgi apparatus

Inferred from direct assay PubMed 18158319. Source: UniProt

T-tubule

Inferred from sequence or structural similarity. Source: BHF-UCL

cytoplasm

Inferred from direct assay PubMed 18158319. Source: UniProt

endoplasmic reticulum

Inferred from direct assay PubMed 18158319. Source: UniProt

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

nuclear membrane

Inferred from direct assay PubMed 18158319. Source: UniProt

plasma membrane

Inferred from direct assay PubMed 17349999. Source: BHF-UCL

   Molecular_functioncalcium channel inhibitor activity

Inferred from sequence or structural similarity. Source: BHF-UCL

protein binding

Inferred from physical interaction PubMed 18158319. Source: UniProt

zinc ion transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507Zinc transporter 1
PRO_0000206090

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121Helical; Potential
Topological domain32 – 354Extracellular Potential
Transmembrane36 – 5621Helical; Potential
Topological domain57 – 7822Cytoplasmic Potential
Transmembrane79 – 9921Helical; Potential
Topological domain100 – 11314Extracellular Potential
Transmembrane114 – 13421Helical; Potential
Topological domain135 – 248114Cytoplasmic Potential
Transmembrane249 – 26921Helical; Potential
Topological domain270 – 30839Extracellular Potential
Transmembrane309 – 32921Helical; Potential
Topological domain330 – 507178Cytoplasmic Potential
Region146 – 158136 X 2 AA approximate repeats of H-G

Amino acid modifications

Modified residue5061Phosphoserine Ref.7
Glycosylation2991N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict3861A → V in AAG53405. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9Y6M5 [UniParc].

Last modified July 7, 2009. Version 3.
Checksum: 2FC5B67F033AE457

FASTA50755,300
        10         20         30         40         50         60 
MGCWGRNRGR LLCMLALTFM FMVLEVVVSR VTSSLAMLSD SFHMLSDVLA LVVALVAERF 

        70         80         90        100        110        120 
ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA IERFIEPHEM QQPLVVLGVG 

       130        140        150        160        170        180 
VAGLLVNVLG LCLFHHHSGF SQDSGHGHSH GGHGHGHGLP KGPRVKSTRP GSSDINVAPG 

       190        200        210        220        230        240 
EQGPDQEETN TLVANTSNSN GLKLDPADPE NPRSGDTVEV QVNGNLVREP DHMELEEDRA 

       250        260        270        280        290        300 
GQLNMRGVFL HVLGDALGSV IVVVNALVFY FSWKGCSEGD FCVNPCFPDP CKAFVEIINS 

       310        320        330        340        350        360 
THASVYEAGP CWVLYLDPTL CVVMVCILLY TTYPLLKESA LILLQTVPKQ IDIRNLIKEL 

       370        380        390        400        410        420 
RNVEGVEEVH ELHVWQLAGS RIIATAHIKC EDPTSYMEVA KTIKDVFHNH GIHATTIQPE 

       430        440        450        460        470        480 
FASVGSKSSV VPCELACRTQ CALKQCCGTL PQAPSGKDAE KTPAVSISCL ELSNNLEKKP 

       490        500 
RRTKAENIPA VVIEIKNMPN KQPESSL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of human zinc transporter 1 (ZNT1)."
Nanji M.S., Coronado V.A., Cox D.W.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human Protein Factory: an infrastructure to convert the human transcriptome into the in vitro-expressed human proteome of versatile utility."
Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B. expand/collapse author list , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Assignment of the human zinc transporter gene 1 (ZnT1) to chromosomes 1."
Inoue H., Oka Y.
Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 411-507.
[6]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-506, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[8]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF323590 Genomic DNA. Translation: AAG53405.1.
AB451467 mRNA. Translation: BAG70281.1.
CH471100 Genomic DNA. Translation: EAW93412.1.
BC121015 mRNA. Translation: AAI21016.1.
BC121016 mRNA. Translation: AAI21017.1.
AF048701 Genomic DNA. Translation: AAD29840.1.
CCDSCCDS1499.1.
RefSeqNP_067017.2. NM_021194.2.
UniGeneHs.519469.

3D structure databases

ProteinModelPortalQ9Y6M5.
SMRQ9Y6M5. Positions 28-106.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid113560. 4 interactions.
STRING9606.ENSP00000355968.

Protein family/group databases

TCDB2.A.4.2.6. the cation diffusion facilitator (cdf) family.

PTM databases

PhosphoSiteQ9Y6M5.

Polymorphism databases

DMDM251757423.

Proteomic databases

MaxQBQ9Y6M5.
PaxDbQ9Y6M5.
PRIDEQ9Y6M5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367001; ENSP00000355968; ENSG00000170385.
GeneID7779.
KEGGhsa:7779.
UCSCuc001hio.1. human.

Organism-specific databases

CTD7779.
GeneCardsGC01M211744.
HGNCHGNC:11012. SLC30A1.
HPAHPA015275.
MIM609521. gene.
neXtProtNX_Q9Y6M5.
PharmGKBPA35882.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1230.
HOGENOMHOG000166089.
HOVERGENHBG000588.
InParanoidQ9Y6M5.
KOK14688.
OMARACLLEC.
OrthoDBEOG7034GQ.
PhylomeDBQ9Y6M5.
TreeFamTF313924.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ9Y6M5.
BgeeQ9Y6M5.
CleanExHS_SLC30A1.
GenevestigatorQ9Y6M5.

Family and domain databases

Gene3D1.20.1510.10. 3 hits.
InterProIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERPTHR11562. PTHR11562. 1 hit.
PfamPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsTIGR01297. CDF. 1 hit.
ProtoNetSearch...

Other

GeneWikiSLC30A1.
GenomeRNAi7779.
NextBio30115.
PROQ9Y6M5.
SOURCESearch...

Entry information

Entry nameZNT1_HUMAN
AccessionPrimary (citable) accession number: Q9Y6M5
Secondary accession number(s): Q0VAK9, Q9BZF6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 7, 2009
Last modified: July 9, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM