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Q9Y6M5

- ZNT1_HUMAN

UniProt

Q9Y6M5 - ZNT1_HUMAN

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Protein

Zinc transporter 1

Gene

SLC30A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in zinc transport out of the cell.

GO - Molecular functioni

  1. calcium channel inhibitor activity Source: BHF-UCL
  2. zinc ion transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. cadmium ion transmembrane transport Source: BHF-UCL
  2. calcium ion import Source: Ensembl
  3. cellular calcium ion homeostasis Source: BHF-UCL
  4. cellular zinc ion homeostasis Source: BHF-UCL
  5. detoxification of cadmium ion Source: Ensembl
  6. in utero embryonic development Source: Ensembl
  7. negative regulation of calcium ion import Source: BHF-UCL
  8. negative regulation of neurotransmitter secretion Source: BHF-UCL
  9. negative regulation of zinc ion transmembrane import Source: BHF-UCL
  10. transmembrane transport Source: Reactome
  11. zinc ion transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_20582. Zinc efflux and compartmentalization by the SLC30 family.

Protein family/group databases

TCDBi2.A.4.2.6. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 1
Short name:
ZnT-1
Alternative name(s):
Solute carrier family 30 member 1
Gene namesi
Name:SLC30A1
Synonyms:ZNT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:11012. SLC30A1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProt
  2. endoplasmic reticulum Source: UniProt
  3. Golgi apparatus Source: UniProt
  4. integral component of membrane Source: UniProtKB-KW
  5. nuclear membrane Source: UniProt
  6. plasma membrane Source: BHF-UCL
  7. T-tubule Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35882.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Zinc transporter 1PRO_0000206090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
Modified residuei506 – 5061Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9Y6M5.
PaxDbiQ9Y6M5.
PRIDEiQ9Y6M5.

PTM databases

PhosphoSiteiQ9Y6M5.

Expressioni

Gene expression databases

BgeeiQ9Y6M5.
CleanExiHS_SLC30A1.
ExpressionAtlasiQ9Y6M5. baseline and differential.
GenevestigatoriQ9Y6M5.

Organism-specific databases

HPAiHPA015275.

Interactioni

Subunit structurei

Multimer.Curated

Protein-protein interaction databases

BioGridi113560. 10 interactions.
STRINGi9606.ENSP00000355968.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6M5.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Topological domaini32 – 354ExtracellularSequence Analysis
Topological domaini57 – 7822CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini100 – 11314ExtracellularSequence AnalysisAdd
BLAST
Topological domaini135 – 248114CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini270 – 30839ExtracellularSequence AnalysisAdd
BLAST
Topological domaini330 – 507178CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Transmembranei36 – 5621HelicalSequence AnalysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Transmembranei249 – 26921HelicalSequence AnalysisAdd
BLAST
Transmembranei309 – 32921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni146 – 158136 X 2 AA approximate repeats of H-GAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1230.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000166089.
HOVERGENiHBG000588.
InParanoidiQ9Y6M5.
KOiK14688.
OMAiRACLLEC.
OrthoDBiEOG7034GQ.
PhylomeDBiQ9Y6M5.
TreeFamiTF313924.

Family and domain databases

Gene3Di1.20.1510.10. 3 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y6M5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGCWGRNRGR LLCMLALTFM FMVLEVVVSR VTSSLAMLSD SFHMLSDVLA
60 70 80 90 100
LVVALVAERF ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA
110 120 130 140 150
IERFIEPHEM QQPLVVLGVG VAGLLVNVLG LCLFHHHSGF SQDSGHGHSH
160 170 180 190 200
GGHGHGHGLP KGPRVKSTRP GSSDINVAPG EQGPDQEETN TLVANTSNSN
210 220 230 240 250
GLKLDPADPE NPRSGDTVEV QVNGNLVREP DHMELEEDRA GQLNMRGVFL
260 270 280 290 300
HVLGDALGSV IVVVNALVFY FSWKGCSEGD FCVNPCFPDP CKAFVEIINS
310 320 330 340 350
THASVYEAGP CWVLYLDPTL CVVMVCILLY TTYPLLKESA LILLQTVPKQ
360 370 380 390 400
IDIRNLIKEL RNVEGVEEVH ELHVWQLAGS RIIATAHIKC EDPTSYMEVA
410 420 430 440 450
KTIKDVFHNH GIHATTIQPE FASVGSKSSV VPCELACRTQ CALKQCCGTL
460 470 480 490 500
PQAPSGKDAE KTPAVSISCL ELSNNLEKKP RRTKAENIPA VVIEIKNMPN

KQPESSL
Length:507
Mass (Da):55,300
Last modified:July 7, 2009 - v3
Checksum:i2FC5B67F033AE457
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti386 – 3861A → V in AAG53405. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF323590 Genomic DNA. Translation: AAG53405.1.
AB451467 mRNA. Translation: BAG70281.1.
CH471100 Genomic DNA. Translation: EAW93412.1.
BC121015 mRNA. Translation: AAI21016.1.
BC121016 mRNA. Translation: AAI21017.1.
AF048701 Genomic DNA. Translation: AAD29840.1.
CCDSiCCDS1499.1.
RefSeqiNP_067017.2. NM_021194.2.
UniGeneiHs.519469.

Genome annotation databases

EnsembliENST00000367001; ENSP00000355968; ENSG00000170385.
GeneIDi7779.
KEGGihsa:7779.
UCSCiuc001hio.1. human.

Polymorphism databases

DMDMi251757423.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF323590 Genomic DNA. Translation: AAG53405.1 .
AB451467 mRNA. Translation: BAG70281.1 .
CH471100 Genomic DNA. Translation: EAW93412.1 .
BC121015 mRNA. Translation: AAI21016.1 .
BC121016 mRNA. Translation: AAI21017.1 .
AF048701 Genomic DNA. Translation: AAD29840.1 .
CCDSi CCDS1499.1.
RefSeqi NP_067017.2. NM_021194.2.
UniGenei Hs.519469.

3D structure databases

ProteinModelPortali Q9Y6M5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113560. 10 interactions.
STRINGi 9606.ENSP00000355968.

Protein family/group databases

TCDBi 2.A.4.2.6. the cation diffusion facilitator (cdf) family.

PTM databases

PhosphoSitei Q9Y6M5.

Polymorphism databases

DMDMi 251757423.

Proteomic databases

MaxQBi Q9Y6M5.
PaxDbi Q9Y6M5.
PRIDEi Q9Y6M5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000367001 ; ENSP00000355968 ; ENSG00000170385 .
GeneIDi 7779.
KEGGi hsa:7779.
UCSCi uc001hio.1. human.

Organism-specific databases

CTDi 7779.
GeneCardsi GC01M211744.
HGNCi HGNC:11012. SLC30A1.
HPAi HPA015275.
MIMi 609521. gene.
neXtProti NX_Q9Y6M5.
PharmGKBi PA35882.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1230.
GeneTreei ENSGT00550000074381.
HOGENOMi HOG000166089.
HOVERGENi HBG000588.
InParanoidi Q9Y6M5.
KOi K14688.
OMAi RACLLEC.
OrthoDBi EOG7034GQ.
PhylomeDBi Q9Y6M5.
TreeFami TF313924.

Enzyme and pathway databases

Reactomei REACT_20582. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

GeneWikii SLC30A1.
GenomeRNAii 7779.
NextBioi 30115.
PROi Q9Y6M5.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y6M5.
CleanExi HS_SLC30A1.
ExpressionAtlasi Q9Y6M5. baseline and differential.
Genevestigatori Q9Y6M5.

Family and domain databases

Gene3Di 1.20.1510.10. 3 hits.
InterProi IPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view ]
PANTHERi PTHR11562. PTHR11562. 1 hit.
Pfami PF01545. Cation_efflux. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01297. CDF. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of human zinc transporter 1 (ZNT1)."
    Nanji M.S., Coronado V.A., Cox D.W.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Human Protein Factory: an infrastructure to convert the human transcriptome into the in vitro-expressed human proteome of versatile utility."
    Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B.
    , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N.
    Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Assignment of the human zinc transporter gene 1 (ZnT1) to chromosomes 1."
    Inoue H., Oka Y.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 411-507.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-506, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZNT1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6M5
Secondary accession number(s): Q0VAK9, Q9BZF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 7, 2009
Last modified: October 29, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3