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Protein

Zinc transporter 1

Gene

SLC30A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in zinc transport out of the cell.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170385-MONOMER.
ReactomeiR-HSA-435368. Zinc efflux and compartmentalization by the SLC30 family.

Protein family/group databases

TCDBi2.A.4.2.6. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 1
Short name:
ZnT-1
Alternative name(s):
Solute carrier family 30 member 1
Gene namesi
Name:SLC30A1
Synonyms:ZNT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11012. SLC30A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 35ExtracellularSequence analysis4
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 78CytoplasmicSequence analysisAdd BLAST22
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 113ExtracellularSequence analysisAdd BLAST14
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 248CytoplasmicSequence analysisAdd BLAST114
Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 308ExtracellularSequence analysisAdd BLAST39
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Topological domaini330 – 507CytoplasmicSequence analysisAdd BLAST178

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB
  • Golgi apparatus Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • nuclear membrane Source: UniProtKB
  • plasma membrane Source: BHF-UCL
  • T-tubule Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7779.
OpenTargetsiENSG00000170385.
PharmGKBiPA35882.

Polymorphism and mutation databases

BioMutaiSLC30A1.
DMDMi251757423.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002060901 – 507Zinc transporter 1Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1
Modified residuei506PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9Y6M5.
MaxQBiQ9Y6M5.
PaxDbiQ9Y6M5.
PeptideAtlasiQ9Y6M5.
PRIDEiQ9Y6M5.

PTM databases

iPTMnetiQ9Y6M5.
PhosphoSitePlusiQ9Y6M5.
SwissPalmiQ9Y6M5.

Expressioni

Gene expression databases

BgeeiENSG00000170385.
CleanExiHS_SLC30A1.
GenevisibleiQ9Y6M5. HS.

Organism-specific databases

HPAiHPA015275.
HPA049000.

Interactioni

Subunit structurei

Multimer.Curated

Protein-protein interaction databases

BioGridi113560. 20 interactors.
IntActiQ9Y6M5. 4 interactors.
STRINGi9606.ENSP00000355968.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6M5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni146 – 1586 X 2 AA approximate repeats of H-GAdd BLAST13

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1483. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000166089.
HOVERGENiHBG000588.
InParanoidiQ9Y6M5.
KOiK14688.
OMAiHHHSGFS.
OrthoDBiEOG091G08R5.
PhylomeDBiQ9Y6M5.
TreeFamiTF313924.

Family and domain databases

Gene3Di1.20.1510.10. 3 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 3 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y6M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCWGRNRGR LLCMLALTFM FMVLEVVVSR VTSSLAMLSD SFHMLSDVLA
60 70 80 90 100
LVVALVAERF ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA
110 120 130 140 150
IERFIEPHEM QQPLVVLGVG VAGLLVNVLG LCLFHHHSGF SQDSGHGHSH
160 170 180 190 200
GGHGHGHGLP KGPRVKSTRP GSSDINVAPG EQGPDQEETN TLVANTSNSN
210 220 230 240 250
GLKLDPADPE NPRSGDTVEV QVNGNLVREP DHMELEEDRA GQLNMRGVFL
260 270 280 290 300
HVLGDALGSV IVVVNALVFY FSWKGCSEGD FCVNPCFPDP CKAFVEIINS
310 320 330 340 350
THASVYEAGP CWVLYLDPTL CVVMVCILLY TTYPLLKESA LILLQTVPKQ
360 370 380 390 400
IDIRNLIKEL RNVEGVEEVH ELHVWQLAGS RIIATAHIKC EDPTSYMEVA
410 420 430 440 450
KTIKDVFHNH GIHATTIQPE FASVGSKSSV VPCELACRTQ CALKQCCGTL
460 470 480 490 500
PQAPSGKDAE KTPAVSISCL ELSNNLEKKP RRTKAENIPA VVIEIKNMPN

KQPESSL
Length:507
Mass (Da):55,300
Last modified:July 7, 2009 - v3
Checksum:i2FC5B67F033AE457
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti386A → V in AAG53405 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323590 Genomic DNA. Translation: AAG53405.1.
AB451467 mRNA. Translation: BAG70281.1.
CH471100 Genomic DNA. Translation: EAW93412.1.
BC121015 mRNA. Translation: AAI21016.1.
BC121016 mRNA. Translation: AAI21017.1.
AF048701 Genomic DNA. Translation: AAD29840.1.
CCDSiCCDS1499.1.
RefSeqiNP_067017.2. NM_021194.2.
UniGeneiHs.519469.

Genome annotation databases

EnsembliENST00000367001; ENSP00000355968; ENSG00000170385.
GeneIDi7779.
KEGGihsa:7779.
UCSCiuc001hio.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323590 Genomic DNA. Translation: AAG53405.1.
AB451467 mRNA. Translation: BAG70281.1.
CH471100 Genomic DNA. Translation: EAW93412.1.
BC121015 mRNA. Translation: AAI21016.1.
BC121016 mRNA. Translation: AAI21017.1.
AF048701 Genomic DNA. Translation: AAD29840.1.
CCDSiCCDS1499.1.
RefSeqiNP_067017.2. NM_021194.2.
UniGeneiHs.519469.

3D structure databases

ProteinModelPortaliQ9Y6M5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113560. 20 interactors.
IntActiQ9Y6M5. 4 interactors.
STRINGi9606.ENSP00000355968.

Protein family/group databases

TCDBi2.A.4.2.6. the cation diffusion facilitator (cdf) family.

PTM databases

iPTMnetiQ9Y6M5.
PhosphoSitePlusiQ9Y6M5.
SwissPalmiQ9Y6M5.

Polymorphism and mutation databases

BioMutaiSLC30A1.
DMDMi251757423.

Proteomic databases

EPDiQ9Y6M5.
MaxQBiQ9Y6M5.
PaxDbiQ9Y6M5.
PeptideAtlasiQ9Y6M5.
PRIDEiQ9Y6M5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367001; ENSP00000355968; ENSG00000170385.
GeneIDi7779.
KEGGihsa:7779.
UCSCiuc001hio.2. human.

Organism-specific databases

CTDi7779.
DisGeNETi7779.
GeneCardsiSLC30A1.
HGNCiHGNC:11012. SLC30A1.
HPAiHPA015275.
HPA049000.
MIMi609521. gene.
neXtProtiNX_Q9Y6M5.
OpenTargetsiENSG00000170385.
PharmGKBiPA35882.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1483. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000166089.
HOVERGENiHBG000588.
InParanoidiQ9Y6M5.
KOiK14688.
OMAiHHHSGFS.
OrthoDBiEOG091G08R5.
PhylomeDBiQ9Y6M5.
TreeFamiTF313924.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170385-MONOMER.
ReactomeiR-HSA-435368. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

GeneWikiiSLC30A1.
GenomeRNAii7779.
PROiQ9Y6M5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170385.
CleanExiHS_SLC30A1.
GenevisibleiQ9Y6M5. HS.

Family and domain databases

Gene3Di1.20.1510.10. 3 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 3 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZNT1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6M5
Secondary accession number(s): Q0VAK9, Q9BZF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 7, 2009
Last modified: November 2, 2016
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.