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Q9Y6M4

- KC1G3_HUMAN

UniProt

Q9Y6M4 - KC1G3_HUMAN

Protein

Casein kinase I isoform gamma-3

Gene

CSNK1G3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 2 (10 May 2004)
      Previous versions | rss
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    Functioni

    Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Inhibited by triazolodiamine 1, 5-amino-3-{[4-(aminosulfonyl)phenyl]amino}-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide, (S)-propane-1,2-diol, 2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-ol, N2-[(1R,2S)-2-aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine and [4-amino-2-(3-chloroanilino)-1,3-thiazol-5-yl](4-fluorophenyl)methanone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei72 – 721ATPPROSITE-ProRule annotation
    Active sitei162 – 1621Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi49 – 579ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein kinase activity Source: ProtInc
    3. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cellular protein modification process Source: ProtInc
    2. signal transduction Source: ProtInc
    3. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Biological processi

    Wnt signaling pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.11.1. 2681.
    SignaLinkiQ9Y6M4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Casein kinase I isoform gamma-3 (EC:2.7.11.1)
    Short name:
    CKI-gamma 3
    Gene namesi
    Name:CSNK1G3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:2456. CSNK1G3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26956.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 447447Casein kinase I isoform gamma-3PRO_0000192846Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei413 – 4131Phosphoserine1 Publication

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y6M4.
    PaxDbiQ9Y6M4.
    PRIDEiQ9Y6M4.

    PTM databases

    PhosphoSiteiQ9Y6M4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y6M4.
    BgeeiQ9Y6M4.
    CleanExiHS_CSNK1G3.
    GenevestigatoriQ9Y6M4.

    Organism-specific databases

    HPAiHPA027010.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    BioGridi107840. 5 interactions.
    STRINGi9606.ENSP00000353904.

    Structurei

    Secondary structure

    1
    447
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni40 – 423
    Beta strandi43 – 486
    Beta strandi50 – 523
    Beta strandi56 – 627
    Turni63 – 664
    Beta strandi67 – 759
    Helixi83 – 9311
    Beta strandi102 – 1087
    Beta strandi111 – 1177
    Helixi123 – 1297
    Turni130 – 1323
    Helixi136 – 15520
    Helixi165 – 1673
    Beta strandi168 – 1703
    Helixi173 – 1753
    Turni176 – 1794
    Beta strandi180 – 1834
    Beta strandi190 – 1934
    Turni195 – 1973
    Beta strandi198 – 2003
    Turni213 – 2153
    Helixi218 – 2214
    Helixi228 – 24417
    Turni248 – 2514
    Helixi257 – 27014
    Helixi273 – 2764
    Turni277 – 2793
    Helixi281 – 29212
    Helixi301 – 31414
    Turni324 – 3274

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CHLX-ray1.95A35-362[»]
    2IZRX-ray1.30A35-362[»]
    2IZSX-ray1.95A35-362[»]
    2IZTX-ray2.00A35-362[»]
    2IZUX-ray1.85A35-362[»]
    4G16X-ray2.30A34-362[»]
    4G17X-ray2.10A34-362[»]
    4HGLX-ray2.40A34-362[»]
    4HGSX-ray2.40A34-362[»]
    ProteinModelPortaliQ9Y6M4.
    SMRiQ9Y6M4. Positions 36-333.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y6M4.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 313271Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni117 – 1259Inhibitors binding

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000182054.
    HOVERGENiHBG000176.
    KOiK08958.
    OMAiNREAHPH.
    OrthoDBiEOG7G1V66.
    PhylomeDBiQ9Y6M4.
    TreeFamiTF313349.

    Family and domain databases

    InterProiIPR022247. Casein_kinase-1_gamma_C.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF12605. CK1gamma_C. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y6M4-1) [UniParc]FASTAAdd to Basket

    Also known as: 3

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MENKKKDKDK SDDRMARPSG RSGHNTRGTG SSSSGVLMVG PNFRVGKKIG    50
    CGNFGELRLG KNLYTNEYVA IKLEPMKSRA PQLHLEYRFY KQLGSGDGIP 100
    QVYYFGPCGK YNAMVLELLG PSLEDLFDLC DRTFSLKTVL MIAIQLISRM 150
    EYVHSKNLIY RDVKPENFLI GRPGNKTQQV IHIIDFGLAK EYIDPETKKH 200
    IPYREHKSLT GTARYMSINT HLGKEQSRRD DLEALGHMFM YFLRGSLPWQ 250
    GLKADTLKER YQKIGDTKRA TPIEVLCENF PEMATYLRYV RRLDFFEKPD 300
    YDYLRKLFTD LFDRKGYMFD YEYDWIGKQL PTPVGAVQQD PALSSNREAH 350
    QHRDKMQQSK NQSADHRAAW DSQQANPHHL RAHLAADRHG GSVQVVSSTN 400
    GELNTDDPTA GRSNAPITAP TEVEVMDETK CCCFFKRRKR KTIQRHK 447
    Length:447
    Mass (Da):51,389
    Last modified:May 10, 2004 - v2
    Checksum:i6FAEDD605579ED3A
    GO
    Isoform 2 (identifier: Q9Y6M4-2) [UniParc]FASTAAdd to Basket

    Also known as: 3L, CSNK1G3L

    The sequence of this isoform differs from the canonical sequence as follows:
         430-430: K → NCQKVLNMW

    Show »
    Length:455
    Mass (Da):52,378
    Checksum:i23C1F32F3559120F
    GO
    Isoform 3 (identifier: Q9Y6M4-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         363-394: Missing.
         430-430: K → NCQKVLNMW

    Note: Contains a phosphoserine at position 366.

    Show »
    Length:423
    Mass (Da):48,898
    Checksum:i786AA3787897A4C5
    GO
    Isoform 4 (identifier: Q9Y6M4-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         282-282: E → EE
         363-394: Missing.
         430-430: K → NCQKVLNMW

    Note: Contains a phosphoserine at position 367.

    Show »
    Length:424
    Mass (Da):49,027
    Checksum:i0D2C64F25039E090
    GO
    Isoform 5 (identifier: Q9Y6M4-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-75: Missing.
         363-394: Missing.
         430-430: K → NCQKVLNMW

    Note: Contains a phosphoserine at position 291.

    Show »
    Length:348
    Mass (Da):40,729
    Checksum:i5AEB20AED88A1240
    GO
    Isoform 6 (identifier: Q9Y6M4-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-113: Missing.
         282-282: E → EE
         363-394: Missing.
         430-430: K → NCQKVLNMW

    Note: Contains a phosphoserine at position 254.

    Show »
    Length:311
    Mass (Da):36,492
    Checksum:i9A87163AF2FC9AFF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 911K → E in AAH47567. (PubMed:15489334)Curated
    Sequence conflicti174 – 1741G → R in AAD26525. (PubMed:9925945)Curated
    Sequence conflicti174 – 1741G → R in AAD26526. (PubMed:9925945)Curated
    Sequence conflicti241 – 2411Y → C in BAH14390. (PubMed:14702039)Curated
    Sequence conflicti302 – 3021D → E in AAD26525. (PubMed:9925945)Curated
    Sequence conflicti302 – 3021D → E in AAD26526. (PubMed:9925945)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 113113Missing in isoform 6. 1 PublicationVSP_047053Add
    BLAST
    Alternative sequencei1 – 7575Missing in isoform 5. 1 PublicationVSP_047054Add
    BLAST
    Alternative sequencei282 – 2821E → EE in isoform 4 and isoform 6. 1 PublicationVSP_047055
    Alternative sequencei363 – 39432Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 2 PublicationsVSP_010256Add
    BLAST
    Alternative sequencei430 – 4301K → NCQKVLNMW in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 3 PublicationsVSP_004749

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF049089 mRNA. Translation: AAD26525.1.
    AF049090 mRNA. Translation: AAD26526.1.
    AK289405 mRNA. Translation: BAF82094.1.
    AK299739 mRNA. Translation: BAG61634.1.
    AK316019 mRNA. Translation: BAH14390.1.
    AC008541 Genomic DNA. No translation available.
    AC026422 Genomic DNA. No translation available.
    CH471086 Genomic DNA. Translation: EAW48872.1.
    BC047567 mRNA. Translation: AAH47567.1.
    CCDSiCCDS34218.1. [Q9Y6M4-3]
    CCDS4135.1. [Q9Y6M4-1]
    CCDS43355.1. [Q9Y6M4-2]
    CCDS59491.1. [Q9Y6M4-4]
    CCDS59492.1. [Q9Y6M4-5]
    CCDS59493.1. [Q9Y6M4-6]
    RefSeqiNP_001026982.1. NM_001031812.3. [Q9Y6M4-3]
    NP_001038188.1. NM_001044723.2. [Q9Y6M4-2]
    NP_001257501.1. NM_001270572.1. [Q9Y6M4-4]
    NP_001257502.1. NM_001270573.1. [Q9Y6M4-5]
    NP_001257503.1. NM_001270574.1. [Q9Y6M4-6]
    NP_004375.2. NM_004384.4. [Q9Y6M4-1]
    XP_005271949.1. XM_005271892.2. [Q9Y6M4-2]
    XP_005271951.1. XM_005271894.2. [Q9Y6M4-1]
    XP_005271952.1. XM_005271895.1. [Q9Y6M4-4]
    UniGeneiHs.129206.
    Hs.741716.

    Genome annotation databases

    EnsembliENST00000345990; ENSP00000334735; ENSG00000151292. [Q9Y6M4-3]
    ENST00000360683; ENSP00000353904; ENSG00000151292. [Q9Y6M4-2]
    ENST00000361991; ENSP00000354942; ENSG00000151292. [Q9Y6M4-1]
    ENST00000510842; ENSP00000423838; ENSG00000151292. [Q9Y6M4-4]
    ENST00000511130; ENSP00000421385; ENSG00000151292. [Q9Y6M4-6]
    ENST00000512718; ENSP00000421998; ENSG00000151292. [Q9Y6M4-5]
    ENST00000521364; ENSP00000429412; ENSG00000151292. [Q9Y6M4-3]
    GeneIDi1456.
    KEGGihsa:1456.
    UCSCiuc003ktn.4. human. [Q9Y6M4-3]
    uc010jda.4. human.
    uc031skv.1. human. [Q9Y6M4-2]
    uc031skw.1. human. [Q9Y6M4-1]

    Polymorphism databases

    DMDMi47117932.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF049089 mRNA. Translation: AAD26525.1 .
    AF049090 mRNA. Translation: AAD26526.1 .
    AK289405 mRNA. Translation: BAF82094.1 .
    AK299739 mRNA. Translation: BAG61634.1 .
    AK316019 mRNA. Translation: BAH14390.1 .
    AC008541 Genomic DNA. No translation available.
    AC026422 Genomic DNA. No translation available.
    CH471086 Genomic DNA. Translation: EAW48872.1 .
    BC047567 mRNA. Translation: AAH47567.1 .
    CCDSi CCDS34218.1. [Q9Y6M4-3 ]
    CCDS4135.1. [Q9Y6M4-1 ]
    CCDS43355.1. [Q9Y6M4-2 ]
    CCDS59491.1. [Q9Y6M4-4 ]
    CCDS59492.1. [Q9Y6M4-5 ]
    CCDS59493.1. [Q9Y6M4-6 ]
    RefSeqi NP_001026982.1. NM_001031812.3. [Q9Y6M4-3 ]
    NP_001038188.1. NM_001044723.2. [Q9Y6M4-2 ]
    NP_001257501.1. NM_001270572.1. [Q9Y6M4-4 ]
    NP_001257502.1. NM_001270573.1. [Q9Y6M4-5 ]
    NP_001257503.1. NM_001270574.1. [Q9Y6M4-6 ]
    NP_004375.2. NM_004384.4. [Q9Y6M4-1 ]
    XP_005271949.1. XM_005271892.2. [Q9Y6M4-2 ]
    XP_005271951.1. XM_005271894.2. [Q9Y6M4-1 ]
    XP_005271952.1. XM_005271895.1. [Q9Y6M4-4 ]
    UniGenei Hs.129206.
    Hs.741716.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CHL X-ray 1.95 A 35-362 [» ]
    2IZR X-ray 1.30 A 35-362 [» ]
    2IZS X-ray 1.95 A 35-362 [» ]
    2IZT X-ray 2.00 A 35-362 [» ]
    2IZU X-ray 1.85 A 35-362 [» ]
    4G16 X-ray 2.30 A 34-362 [» ]
    4G17 X-ray 2.10 A 34-362 [» ]
    4HGL X-ray 2.40 A 34-362 [» ]
    4HGS X-ray 2.40 A 34-362 [» ]
    ProteinModelPortali Q9Y6M4.
    SMRi Q9Y6M4. Positions 36-333.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107840. 5 interactions.
    STRINGi 9606.ENSP00000353904.

    Chemistry

    BindingDBi Q9Y6M4.
    ChEMBLi CHEMBL5084.
    GuidetoPHARMACOLOGYi 2001.

    PTM databases

    PhosphoSitei Q9Y6M4.

    Polymorphism databases

    DMDMi 47117932.

    Proteomic databases

    MaxQBi Q9Y6M4.
    PaxDbi Q9Y6M4.
    PRIDEi Q9Y6M4.

    Protocols and materials databases

    DNASUi 1456.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000345990 ; ENSP00000334735 ; ENSG00000151292 . [Q9Y6M4-3 ]
    ENST00000360683 ; ENSP00000353904 ; ENSG00000151292 . [Q9Y6M4-2 ]
    ENST00000361991 ; ENSP00000354942 ; ENSG00000151292 . [Q9Y6M4-1 ]
    ENST00000510842 ; ENSP00000423838 ; ENSG00000151292 . [Q9Y6M4-4 ]
    ENST00000511130 ; ENSP00000421385 ; ENSG00000151292 . [Q9Y6M4-6 ]
    ENST00000512718 ; ENSP00000421998 ; ENSG00000151292 . [Q9Y6M4-5 ]
    ENST00000521364 ; ENSP00000429412 ; ENSG00000151292 . [Q9Y6M4-3 ]
    GeneIDi 1456.
    KEGGi hsa:1456.
    UCSCi uc003ktn.4. human. [Q9Y6M4-3 ]
    uc010jda.4. human.
    uc031skv.1. human. [Q9Y6M4-2 ]
    uc031skw.1. human. [Q9Y6M4-1 ]

    Organism-specific databases

    CTDi 1456.
    GeneCardsi GC05P122909.
    HGNCi HGNC:2456. CSNK1G3.
    HPAi HPA027010.
    MIMi 604253. gene.
    neXtProti NX_Q9Y6M4.
    PharmGKBi PA26956.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000182054.
    HOVERGENi HBG000176.
    KOi K08958.
    OMAi NREAHPH.
    OrthoDBi EOG7G1V66.
    PhylomeDBi Q9Y6M4.
    TreeFami TF313349.

    Enzyme and pathway databases

    BRENDAi 2.7.11.1. 2681.
    SignaLinki Q9Y6M4.

    Miscellaneous databases

    ChiTaRSi CSNK1G3. human.
    EvolutionaryTracei Q9Y6M4.
    GenomeRNAii 1456.
    NextBioi 35463704.
    PROi Q9Y6M4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y6M4.
    Bgeei Q9Y6M4.
    CleanExi HS_CSNK1G3.
    Genevestigatori Q9Y6M4.

    Family and domain databases

    InterProi IPR022247. Casein_kinase-1_gamma_C.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF12605. CK1gamma_C. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and chromosome mapping of the human casein kinase I gamma3 gene (CSNK1G3)."
      Kusuda J., Hirai M., Toyoda A., Tanuma R., Hashimoto K.
      Cytogenet. Cell Genet. 83:101-103(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6).
      Tissue: Astrocyte, Brain and Embryonic brain.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366 (ISOFORM 3), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-367 (ISOFORM 4), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-291 (ISOFORM 5), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254 (ISOFORM 6), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Structure of casein kinase 1 gamma 3."
      Bunkoczi G., Salah E., Rellos P., Das S., Fedorov O., Savitsky P., Gileadi O., Sundstrom M., Edwards A., Arrowsmith C., Ugochukwu E., Weigelt J., Von Delft F., Knapp S.
      Submitted (MAR-2006) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 35-362 IN COMPLEX WITH INHIBITORS.
    13. "Inhibitor binding by casein kinases."
      Bunkoczi G., Salah E., Rellos P., Das S., Fedorov O., Savitsky P., Debreczeni J.E., Gileadi O., Sundstrom M., Edwards A., Arrowsmith C., Weigelt J., Von Delft F., Knapp S.
      Submitted (FEB-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) OF 35-362 IN COMPLEX WITH INHIBITORS.

    Entry informationi

    Entry nameiKC1G3_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y6M4
    Secondary accession number(s): A8K040
    , B4DSH2, B7Z9Q4, E7EVD0, Q86WZ7, Q9Y6M3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3