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Q9Y6M4

- KC1G3_HUMAN

UniProt

Q9Y6M4 - KC1G3_HUMAN

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Protein

Casein kinase I isoform gamma-3

Gene

CSNK1G3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Inhibited by triazolodiamine 1, 5-amino-3-{[4-(aminosulfonyl)phenyl]amino}-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide, (S)-propane-1,2-diol, 2-({6-[(3-chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)-3-methylbutan-1-ol, N2-[(1R,2S)-2-aminocyclohexyl]-N6-(3-chlorophenyl)-9-ethyl-9H-purine-2,6-diamine and [4-amino-2-(3-chloroanilino)-1,3-thiazol-5-yl](4-fluorophenyl)methanone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721ATPPROSITE-ProRule annotation
Active sitei162 – 1621Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi49 – 579ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein kinase activity Source: ProtInc
  3. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular protein modification process Source: ProtInc
  2. signal transduction Source: ProtInc
  3. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Wnt signaling pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1. 2681.
SignaLinkiQ9Y6M4.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I isoform gamma-3 (EC:2.7.11.1)
Short name:
CKI-gamma 3
Gene namesi
Name:CSNK1G3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:2456. CSNK1G3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26956.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Casein kinase I isoform gamma-3PRO_0000192846Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei413 – 4131Phosphoserine1 Publication

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9Y6M4.
PaxDbiQ9Y6M4.
PRIDEiQ9Y6M4.

PTM databases

PhosphoSiteiQ9Y6M4.

Expressioni

Gene expression databases

BgeeiQ9Y6M4.
CleanExiHS_CSNK1G3.
GenevestigatoriQ9Y6M4.

Organism-specific databases

HPAiHPA027010.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi107840. 8 interactions.
STRINGi9606.ENSP00000353904.

Structurei

Secondary structure

1
447
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni40 – 423Combined sources
Beta strandi43 – 486Combined sources
Beta strandi50 – 523Combined sources
Beta strandi56 – 627Combined sources
Turni63 – 664Combined sources
Beta strandi67 – 759Combined sources
Helixi83 – 9311Combined sources
Beta strandi102 – 1087Combined sources
Beta strandi111 – 1177Combined sources
Helixi123 – 1297Combined sources
Turni130 – 1323Combined sources
Helixi136 – 15520Combined sources
Helixi165 – 1673Combined sources
Beta strandi168 – 1703Combined sources
Helixi173 – 1753Combined sources
Turni176 – 1794Combined sources
Beta strandi180 – 1834Combined sources
Beta strandi190 – 1934Combined sources
Turni195 – 1973Combined sources
Beta strandi198 – 2003Combined sources
Turni213 – 2153Combined sources
Helixi218 – 2214Combined sources
Helixi228 – 24417Combined sources
Turni248 – 2514Combined sources
Helixi257 – 27014Combined sources
Helixi273 – 2764Combined sources
Turni277 – 2793Combined sources
Helixi281 – 29212Combined sources
Helixi301 – 31414Combined sources
Turni324 – 3274Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CHLX-ray1.95A35-362[»]
2IZRX-ray1.30A35-362[»]
2IZSX-ray1.95A35-362[»]
2IZTX-ray2.00A35-362[»]
2IZUX-ray1.85A35-362[»]
4G16X-ray2.30A34-362[»]
4G17X-ray2.10A34-362[»]
4HGLX-ray2.40A34-362[»]
4HGSX-ray2.40A34-362[»]
ProteinModelPortaliQ9Y6M4.
SMRiQ9Y6M4. Positions 36-333.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y6M4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 313271Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni117 – 1259Inhibitors binding

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119040.
HOGENOMiHOG000182054.
HOVERGENiHBG000176.
InParanoidiQ9Y6M4.
KOiK08958.
OMAiNREAHPH.
OrthoDBiEOG7G1V66.
PhylomeDBiQ9Y6M4.
TreeFamiTF313349.

Family and domain databases

InterProiIPR022247. Casein_kinase-1_gamma_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF12605. CK1gamma_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y6M4-1) [UniParc]FASTAAdd to Basket

Also known as: 3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENKKKDKDK SDDRMARPSG RSGHNTRGTG SSSSGVLMVG PNFRVGKKIG
60 70 80 90 100
CGNFGELRLG KNLYTNEYVA IKLEPMKSRA PQLHLEYRFY KQLGSGDGIP
110 120 130 140 150
QVYYFGPCGK YNAMVLELLG PSLEDLFDLC DRTFSLKTVL MIAIQLISRM
160 170 180 190 200
EYVHSKNLIY RDVKPENFLI GRPGNKTQQV IHIIDFGLAK EYIDPETKKH
210 220 230 240 250
IPYREHKSLT GTARYMSINT HLGKEQSRRD DLEALGHMFM YFLRGSLPWQ
260 270 280 290 300
GLKADTLKER YQKIGDTKRA TPIEVLCENF PEMATYLRYV RRLDFFEKPD
310 320 330 340 350
YDYLRKLFTD LFDRKGYMFD YEYDWIGKQL PTPVGAVQQD PALSSNREAH
360 370 380 390 400
QHRDKMQQSK NQSADHRAAW DSQQANPHHL RAHLAADRHG GSVQVVSSTN
410 420 430 440
GELNTDDPTA GRSNAPITAP TEVEVMDETK CCCFFKRRKR KTIQRHK
Length:447
Mass (Da):51,389
Last modified:May 10, 2004 - v2
Checksum:i6FAEDD605579ED3A
GO
Isoform 2 (identifier: Q9Y6M4-2) [UniParc]FASTAAdd to Basket

Also known as: 3L, CSNK1G3L

The sequence of this isoform differs from the canonical sequence as follows:
     430-430: K → NCQKVLNMW

Show »
Length:455
Mass (Da):52,378
Checksum:i23C1F32F3559120F
GO
Isoform 3 (identifier: Q9Y6M4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     363-394: Missing.
     430-430: K → NCQKVLNMW

Note: Contains a phosphoserine at position 366.

Show »
Length:423
Mass (Da):48,898
Checksum:i786AA3787897A4C5
GO
Isoform 4 (identifier: Q9Y6M4-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     282-282: E → EE
     363-394: Missing.
     430-430: K → NCQKVLNMW

Note: Contains a phosphoserine at position 367.

Show »
Length:424
Mass (Da):49,027
Checksum:i0D2C64F25039E090
GO
Isoform 5 (identifier: Q9Y6M4-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     363-394: Missing.
     430-430: K → NCQKVLNMW

Note: Contains a phosphoserine at position 291.

Show »
Length:348
Mass (Da):40,729
Checksum:i5AEB20AED88A1240
GO
Isoform 6 (identifier: Q9Y6M4-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-113: Missing.
     282-282: E → EE
     363-394: Missing.
     430-430: K → NCQKVLNMW

Note: Contains a phosphoserine at position 254.

Show »
Length:311
Mass (Da):36,492
Checksum:i9A87163AF2FC9AFF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911K → E in AAH47567. (PubMed:15489334)Curated
Sequence conflicti174 – 1741G → R in AAD26525. (PubMed:9925945)Curated
Sequence conflicti174 – 1741G → R in AAD26526. (PubMed:9925945)Curated
Sequence conflicti241 – 2411Y → C in BAH14390. (PubMed:14702039)Curated
Sequence conflicti302 – 3021D → E in AAD26525. (PubMed:9925945)Curated
Sequence conflicti302 – 3021D → E in AAD26526. (PubMed:9925945)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 113113Missing in isoform 6. 1 PublicationVSP_047053Add
BLAST
Alternative sequencei1 – 7575Missing in isoform 5. 1 PublicationVSP_047054Add
BLAST
Alternative sequencei282 – 2821E → EE in isoform 4 and isoform 6. 1 PublicationVSP_047055
Alternative sequencei363 – 39432Missing in isoform 3, isoform 4, isoform 5 and isoform 6. 2 PublicationsVSP_010256Add
BLAST
Alternative sequencei430 – 4301K → NCQKVLNMW in isoform 2, isoform 3, isoform 4, isoform 5 and isoform 6. 3 PublicationsVSP_004749

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049089 mRNA. Translation: AAD26525.1.
AF049090 mRNA. Translation: AAD26526.1.
AK289405 mRNA. Translation: BAF82094.1.
AK299739 mRNA. Translation: BAG61634.1.
AK316019 mRNA. Translation: BAH14390.1.
AC008541 Genomic DNA. No translation available.
AC026422 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW48872.1.
BC047567 mRNA. Translation: AAH47567.1.
CCDSiCCDS34218.1. [Q9Y6M4-3]
CCDS4135.1. [Q9Y6M4-1]
CCDS43355.1. [Q9Y6M4-2]
CCDS59491.1. [Q9Y6M4-4]
CCDS59492.1. [Q9Y6M4-5]
CCDS59493.1. [Q9Y6M4-6]
RefSeqiNP_001026982.1. NM_001031812.3. [Q9Y6M4-3]
NP_001038188.1. NM_001044723.2. [Q9Y6M4-2]
NP_001257501.1. NM_001270572.1. [Q9Y6M4-4]
NP_001257502.1. NM_001270573.1. [Q9Y6M4-5]
NP_001257503.1. NM_001270574.1. [Q9Y6M4-6]
NP_004375.2. NM_004384.4. [Q9Y6M4-1]
XP_005271949.1. XM_005271892.2. [Q9Y6M4-2]
XP_005271951.1. XM_005271894.2. [Q9Y6M4-1]
XP_005271952.1. XM_005271895.1. [Q9Y6M4-4]
UniGeneiHs.129206.
Hs.741716.

Genome annotation databases

EnsembliENST00000345990; ENSP00000334735; ENSG00000151292. [Q9Y6M4-3]
ENST00000360683; ENSP00000353904; ENSG00000151292. [Q9Y6M4-2]
ENST00000361991; ENSP00000354942; ENSG00000151292. [Q9Y6M4-1]
ENST00000510842; ENSP00000423838; ENSG00000151292. [Q9Y6M4-4]
ENST00000511130; ENSP00000421385; ENSG00000151292. [Q9Y6M4-6]
ENST00000512718; ENSP00000421998; ENSG00000151292. [Q9Y6M4-5]
ENST00000521364; ENSP00000429412; ENSG00000151292. [Q9Y6M4-3]
GeneIDi1456.
KEGGihsa:1456.
UCSCiuc003ktn.4. human. [Q9Y6M4-3]
uc010jda.4. human.
uc031skv.1. human. [Q9Y6M4-2]
uc031skw.1. human. [Q9Y6M4-1]

Polymorphism databases

DMDMi47117932.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049089 mRNA. Translation: AAD26525.1 .
AF049090 mRNA. Translation: AAD26526.1 .
AK289405 mRNA. Translation: BAF82094.1 .
AK299739 mRNA. Translation: BAG61634.1 .
AK316019 mRNA. Translation: BAH14390.1 .
AC008541 Genomic DNA. No translation available.
AC026422 Genomic DNA. No translation available.
CH471086 Genomic DNA. Translation: EAW48872.1 .
BC047567 mRNA. Translation: AAH47567.1 .
CCDSi CCDS34218.1. [Q9Y6M4-3 ]
CCDS4135.1. [Q9Y6M4-1 ]
CCDS43355.1. [Q9Y6M4-2 ]
CCDS59491.1. [Q9Y6M4-4 ]
CCDS59492.1. [Q9Y6M4-5 ]
CCDS59493.1. [Q9Y6M4-6 ]
RefSeqi NP_001026982.1. NM_001031812.3. [Q9Y6M4-3 ]
NP_001038188.1. NM_001044723.2. [Q9Y6M4-2 ]
NP_001257501.1. NM_001270572.1. [Q9Y6M4-4 ]
NP_001257502.1. NM_001270573.1. [Q9Y6M4-5 ]
NP_001257503.1. NM_001270574.1. [Q9Y6M4-6 ]
NP_004375.2. NM_004384.4. [Q9Y6M4-1 ]
XP_005271949.1. XM_005271892.2. [Q9Y6M4-2 ]
XP_005271951.1. XM_005271894.2. [Q9Y6M4-1 ]
XP_005271952.1. XM_005271895.1. [Q9Y6M4-4 ]
UniGenei Hs.129206.
Hs.741716.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CHL X-ray 1.95 A 35-362 [» ]
2IZR X-ray 1.30 A 35-362 [» ]
2IZS X-ray 1.95 A 35-362 [» ]
2IZT X-ray 2.00 A 35-362 [» ]
2IZU X-ray 1.85 A 35-362 [» ]
4G16 X-ray 2.30 A 34-362 [» ]
4G17 X-ray 2.10 A 34-362 [» ]
4HGL X-ray 2.40 A 34-362 [» ]
4HGS X-ray 2.40 A 34-362 [» ]
ProteinModelPortali Q9Y6M4.
SMRi Q9Y6M4. Positions 36-333.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107840. 8 interactions.
STRINGi 9606.ENSP00000353904.

Chemistry

BindingDBi Q9Y6M4.
ChEMBLi CHEMBL5084.
GuidetoPHARMACOLOGYi 2001.

PTM databases

PhosphoSitei Q9Y6M4.

Polymorphism databases

DMDMi 47117932.

Proteomic databases

MaxQBi Q9Y6M4.
PaxDbi Q9Y6M4.
PRIDEi Q9Y6M4.

Protocols and materials databases

DNASUi 1456.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000345990 ; ENSP00000334735 ; ENSG00000151292 . [Q9Y6M4-3 ]
ENST00000360683 ; ENSP00000353904 ; ENSG00000151292 . [Q9Y6M4-2 ]
ENST00000361991 ; ENSP00000354942 ; ENSG00000151292 . [Q9Y6M4-1 ]
ENST00000510842 ; ENSP00000423838 ; ENSG00000151292 . [Q9Y6M4-4 ]
ENST00000511130 ; ENSP00000421385 ; ENSG00000151292 . [Q9Y6M4-6 ]
ENST00000512718 ; ENSP00000421998 ; ENSG00000151292 . [Q9Y6M4-5 ]
ENST00000521364 ; ENSP00000429412 ; ENSG00000151292 . [Q9Y6M4-3 ]
GeneIDi 1456.
KEGGi hsa:1456.
UCSCi uc003ktn.4. human. [Q9Y6M4-3 ]
uc010jda.4. human.
uc031skv.1. human. [Q9Y6M4-2 ]
uc031skw.1. human. [Q9Y6M4-1 ]

Organism-specific databases

CTDi 1456.
GeneCardsi GC05P122848.
HGNCi HGNC:2456. CSNK1G3.
HPAi HPA027010.
MIMi 604253. gene.
neXtProti NX_Q9Y6M4.
PharmGKBi PA26956.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119040.
HOGENOMi HOG000182054.
HOVERGENi HBG000176.
InParanoidi Q9Y6M4.
KOi K08958.
OMAi NREAHPH.
OrthoDBi EOG7G1V66.
PhylomeDBi Q9Y6M4.
TreeFami TF313349.

Enzyme and pathway databases

BRENDAi 2.7.11.1. 2681.
SignaLinki Q9Y6M4.

Miscellaneous databases

ChiTaRSi CSNK1G3. human.
EvolutionaryTracei Q9Y6M4.
GenomeRNAii 1456.
NextBioi 35463704.
PROi Q9Y6M4.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y6M4.
CleanExi HS_CSNK1G3.
Genevestigatori Q9Y6M4.

Family and domain databases

InterProi IPR022247. Casein_kinase-1_gamma_C.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF12605. CK1gamma_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and chromosome mapping of the human casein kinase I gamma3 gene (CSNK1G3)."
    Kusuda J., Hirai M., Toyoda A., Tanuma R., Hashimoto K.
    Cytogenet. Cell Genet. 83:101-103(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4; 5 AND 6).
    Tissue: Astrocyte, Brain and Embryonic brain.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-413, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-366 (ISOFORM 3), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-367 (ISOFORM 4), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-291 (ISOFORM 5), PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254 (ISOFORM 6), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Structure of casein kinase 1 gamma 3."
    Bunkoczi G., Salah E., Rellos P., Das S., Fedorov O., Savitsky P., Gileadi O., Sundstrom M., Edwards A., Arrowsmith C., Ugochukwu E., Weigelt J., Von Delft F., Knapp S.
    Submitted (MAR-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 35-362 IN COMPLEX WITH INHIBITORS.
  13. "Inhibitor binding by casein kinases."
    Bunkoczi G., Salah E., Rellos P., Das S., Fedorov O., Savitsky P., Debreczeni J.E., Gileadi O., Sundstrom M., Edwards A., Arrowsmith C., Weigelt J., Von Delft F., Knapp S.
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.30 ANGSTROMS) OF 35-362 IN COMPLEX WITH INHIBITORS.

Entry informationi

Entry nameiKC1G3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6M4
Secondary accession number(s): A8K040
, B4DSH2, B7Z9Q4, E7EVD0, Q86WZ7, Q9Y6M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 10, 2004
Last modified: November 26, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Triazolodiamine 1 is a commercial name for 5-amino-3-([4-(aminosulfonyl)phenyl]amino)-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3