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Q9Y6L6

- SO1B1_HUMAN

UniProt

Q9Y6L6 - SO1B1_HUMAN

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Protein

Solute carrier organic anion transporter family member 1B1

Gene
SLCO1B1, LST1, OATP1B1, OATP2, OATPC, SLC21A6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.4 Publications

GO - Molecular functioni

  1. sodium-independent organic anion transmembrane transporter activity Source: ProtInc

GO - Biological processi

  1. bile acid and bile salt transport Source: Reactome
  2. bile acid metabolic process Source: Reactome
  3. organic anion transport Source: ProtInc
  4. small molecule metabolic process Source: Reactome
  5. sodium-independent organic anion transport Source: Reactome
  6. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_11042. Recycling of bile acids and salts.
REACT_23988. Transport of organic anions.

Protein family/group databases

TCDBi2.A.60.1.5. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1B1
Alternative name(s):
Liver-specific organic anion transporter 1
Short name:
LST-1
OATP-C
Sodium-independent organic anion-transporting polypeptide 2
Short name:
OATP-2
Solute carrier family 21 member 6
Gene namesi
Name:SLCO1B1
Synonyms:LST1, OATP1B1, OATP2, OATPC, SLC21A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:10959. SLCO1B1.

Subcellular locationi

Basolateral cell membrane; Multi-pass membrane protein
Note: Detected in basolateral membranes of hepatocytes.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei29 – 4820Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini49 – 6719Extracellular Reviewed predictionAdd
BLAST
Transmembranei68 – 8821Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini89 – 946Cytoplasmic Reviewed prediction
Transmembranei95 – 11925Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini120 – 16849Extracellular Reviewed predictionAdd
BLAST
Transmembranei169 – 19729Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini198 – 21619Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei217 – 23721Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini238 – 25518Extracellular Reviewed predictionAdd
BLAST
Transmembranei256 – 28025Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini281 – 33151Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei332 – 35322Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini354 – 37320Extracellular Reviewed predictionAdd
BLAST
Transmembranei374 – 39724Helical; Name=8; Reviewed predictionAdd
BLAST
Topological domaini398 – 4014Cytoplasmic Reviewed prediction
Transmembranei402 – 42524Helical; Name=9; Reviewed predictionAdd
BLAST
Topological domaini426 – 537112Extracellular Reviewed predictionAdd
BLAST
Transmembranei538 – 56023Helical; Name=10; Reviewed predictionAdd
BLAST
Topological domaini561 – 5699Cytoplasmic Reviewed prediction
Transmembranei570 – 59526Helical; Name=11; Reviewed predictionAdd
BLAST
Topological domaini596 – 62934Extracellular Reviewed predictionAdd
BLAST
Transmembranei630 – 64718Helical; Name=12; Reviewed predictionAdd
BLAST
Topological domaini648 – 69144Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: ProtInc
  3. membrane Source: ProtInc
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Organism-specific databases

MIMi237450. phenotype.
Orphaneti240851. Atorvastatin toxicity.
240903. Pravastatin toxicity.
240909. Rosuvastatin toxicity.
3111. Rotor syndrome.
240913. Simvastatin toxicity.
240961. Susceptibility to adverse reaction due to atorvastatin treatment.
240981. Susceptibility to adverse reaction due to pravastatin treatment.
240983. Susceptibility to adverse reaction due to rosuvastatin treatment.
240985. Susceptibility to adverse reaction due to simvastatin treatment.
306566. Susceptibility to myopathies due to statin treatment.
PharmGKBiPA134865839.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 691691Solute carrier organic anion transporter family member 1B1PRO_0000191050Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction
Glycosylationi134 – 1341N-linked (GlcNAc...)1 Publication
Glycosylationi432 – 4321N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi459 ↔ 485 By similarity
Disulfide bondi463 ↔ 474 By similarity
Disulfide bondi465 ↔ 489 By similarity
Glycosylationi503 – 5031N-linked (GlcNAc...)1 Publication
Glycosylationi516 – 5161N-linked (GlcNAc...)1 Publication
Glycosylationi617 – 6171N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y6L6.
PRIDEiQ9Y6L6.

PTM databases

PhosphoSiteiQ9Y6L6.

Expressioni

Tissue specificityi

Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.3 Publications

Gene expression databases

ArrayExpressiQ9Y6L6.
BgeeiQ9Y6L6.
CleanExiHS_LST1.
HS_SLCO1B1.
GenevestigatoriQ9Y6L6.

Organism-specific databases

HPAiHPA050892.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000256958.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6L6.
SMRiQ9Y6L6. Positions 463-489.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini453 – 50856Kazal-likeAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG322696.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9Y6L6.
KOiK05043.
OMAiHIERRFE.
OrthoDBiEOG7GFB4C.
PhylomeDBiQ9Y6L6.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y6L6-1 [UniParc]FASTAAdd to Basket

« Hide

MDQNQHLNKT AEAQPSENKK TRYCNGLKMF LAALSLSFIA KTLGAIIMKS    50
SIIHIERRFE ISSSLVGFID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG 100
CFIMGIGGVL TALPHFFMGY YRYSKETNIN SSENSTSTLS TCLINQILSL 150
NRASPEIVGK GCLKESGSYM WIYVFMGNML RGIGETPIVP LGLSYIDDFA 200
KEGHSSLYLG ILNAIAMIGP IIGFTLGSLF SKMYVDIGYV DLSTIRITPT 250
DSRWVGAWWL NFLVSGLFSI ISSIPFFFLP QTPNKPQKER KASLSLHVLE 300
TNDEKDQTAN LTNQGKNITK NVTGFFQSFK SILTNPLYVM FVLLTLLQVS 350
SYIGAFTYVF KYVEQQYGQP SSKANILLGV ITIPIFASGM FLGGYIIKKF 400
KLNTVGIAKF SCFTAVMSLS FYLLYFFILC ENKSVAGLTM TYDGNNPVTS 450
HRDVPLSYCN SDCNCDESQW EPVCGNNGIT YISPCLAGCK SSSGNKKPIV 500
FYNCSCLEVT GLQNRNYSAH LGECPRDDAC TRKFYFFVAI QVLNLFFSAL 550
GGTSHVMLIV KIVQPELKSL ALGFHSMVIR ALGGILAPIY FGALIDTTCI 600
KWSTNNCGTR GSCRTYNSTS FSRVYLGLSS MLRVSSLVLY IILIYAMKKK 650
YQEKDINASE NGSVMDEANL ESLNKNKHFV PSAGADSETH C 691
Length:691
Mass (Da):76,449
Last modified:December 1, 2000 - v2
Checksum:iD13D5130189383A3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti73 – 731F → L.1 Publication
Corresponds to variant rs56101265 [ dbSNP | Ensembl ].
VAR_015070
Natural varianti82 – 821V → A.1 Publication
Corresponds to variant rs56061388 [ dbSNP | Ensembl ].
VAR_015071
Natural varianti130 – 1301N → D.6 Publications
Corresponds to variant rs2306283 [ dbSNP | Ensembl ].
VAR_015072
Natural varianti151 – 1511N → S.
Corresponds to variant rs2306282 [ dbSNP | Ensembl ].
VAR_057724
Natural varianti152 – 1521R → K.3 Publications
VAR_015073
Natural varianti155 – 1551P → T Decreased transport activity. 3 Publications
Corresponds to variant rs11045819 [ dbSNP | Ensembl ].
VAR_015074
Natural varianti156 – 1561E → G Decreased transport activity. 1 Publication
VAR_015075
Natural varianti174 – 1741V → A Decreased transport activity. 2 Publications
Corresponds to variant rs4149056 [ dbSNP | Ensembl ].
VAR_015076
Natural varianti193 – 1931L → R Strongly decreases expression at the plasma membrane; abolishes transport activity. 1 Publication
VAR_015077
Natural varianti241 – 2411D → N.3 Publications
VAR_015078
Natural varianti245 – 2451I → V.
Corresponds to variant rs11045852 [ dbSNP | Ensembl ].
VAR_060108
Natural varianti353 – 3531I → T.1 Publication
Corresponds to variant rs55901008 [ dbSNP | Ensembl ].
VAR_015079
Natural varianti432 – 4321N → D.1 Publication
Corresponds to variant rs56387224 [ dbSNP | Ensembl ].
VAR_015080
Natural varianti462 – 4621D → G.1 Publication
VAR_015081
Natural varianti488 – 4881G → A.1 Publication
Corresponds to variant rs59502379 [ dbSNP | Ensembl ].
VAR_015082
Natural varianti643 – 6431L → F.
Corresponds to variant rs34671512 [ dbSNP | Ensembl ].
VAR_057725
Natural varianti655 – 6551D → G.1 Publication
Corresponds to variant rs56199088 [ dbSNP | Ensembl ].
VAR_015083
Natural varianti667 – 6671E → G.1 Publication
Corresponds to variant rs55737008 [ dbSNP | Ensembl ].
VAR_015084

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF060500 mRNA. Translation: AAD38323.1.
AF205071 mRNA. Translation: AAF20212.1.
AJ132573 mRNA. Translation: CAB62577.1.
AB026257 mRNA. Translation: BAA78639.1.
AJ400749
, AJ400750, AJ400751, AJ400752, AJ400753, AJ400754, AJ400755, AJ400756, AJ400757, AJ400758, AJ400759, AJ400760, AJ400761, AJ400762 Genomic DNA. Translation: CAB97007.1.
AY945934 Genomic DNA. Translation: AAX20114.1.
AK312970 mRNA. Translation: BAG35809.1.
CH471094 Genomic DNA. Translation: EAW96420.1.
BC114376 mRNA. Translation: AAI14377.1.
CCDSiCCDS8685.1.
RefSeqiNP_006437.3. NM_006446.4.
UniGeneiHs.449738.

Genome annotation databases

EnsembliENST00000256958; ENSP00000256958; ENSG00000134538.
GeneIDi10599.
KEGGihsa:10599.
UCSCiuc001req.4. human.

Polymorphism databases

DMDMi12643959.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF060500 mRNA. Translation: AAD38323.1 .
AF205071 mRNA. Translation: AAF20212.1 .
AJ132573 mRNA. Translation: CAB62577.1 .
AB026257 mRNA. Translation: BAA78639.1 .
AJ400749
, AJ400750 , AJ400751 , AJ400752 , AJ400753 , AJ400754 , AJ400755 , AJ400756 , AJ400757 , AJ400758 , AJ400759 , AJ400760 , AJ400761 , AJ400762 Genomic DNA. Translation: CAB97007.1 .
AY945934 Genomic DNA. Translation: AAX20114.1 .
AK312970 mRNA. Translation: BAG35809.1 .
CH471094 Genomic DNA. Translation: EAW96420.1 .
BC114376 mRNA. Translation: AAI14377.1 .
CCDSi CCDS8685.1.
RefSeqi NP_006437.3. NM_006446.4.
UniGenei Hs.449738.

3D structure databases

ProteinModelPortali Q9Y6L6.
SMRi Q9Y6L6. Positions 463-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000256958.

Chemistry

BindingDBi Q9Y6L6.
ChEMBLi CHEMBL1697668.
DrugBanki DB00390. Digoxin.
DB01241. Gemfibrozil.
DB00175. Pravastatin.
GuidetoPHARMACOLOGYi 1220.

Protein family/group databases

TCDBi 2.A.60.1.5. the organo anion transporter (oat) family.

PTM databases

PhosphoSitei Q9Y6L6.

Polymorphism databases

DMDMi 12643959.

Proteomic databases

PaxDbi Q9Y6L6.
PRIDEi Q9Y6L6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000256958 ; ENSP00000256958 ; ENSG00000134538 .
GeneIDi 10599.
KEGGi hsa:10599.
UCSCi uc001req.4. human.

Organism-specific databases

CTDi 10599.
GeneCardsi GC12P021284.
GeneReviewsi SLCO1B1.
HGNCi HGNC:10959. SLCO1B1.
HPAi HPA050892.
MIMi 237450. phenotype.
604843. gene.
neXtProti NX_Q9Y6L6.
Orphaneti 240851. Atorvastatin toxicity.
240903. Pravastatin toxicity.
240909. Rosuvastatin toxicity.
3111. Rotor syndrome.
240913. Simvastatin toxicity.
240961. Susceptibility to adverse reaction due to atorvastatin treatment.
240981. Susceptibility to adverse reaction due to pravastatin treatment.
240983. Susceptibility to adverse reaction due to rosuvastatin treatment.
240985. Susceptibility to adverse reaction due to simvastatin treatment.
306566. Susceptibility to myopathies due to statin treatment.
PharmGKBi PA134865839.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322696.
HOGENOMi HOG000231269.
HOVERGENi HBG063896.
InParanoidi Q9Y6L6.
KOi K05043.
OMAi HIERRFE.
OrthoDBi EOG7GFB4C.
PhylomeDBi Q9Y6L6.
TreeFami TF317540.

Enzyme and pathway databases

Reactomei REACT_11042. Recycling of bile acids and salts.
REACT_23988. Transport of organic anions.

Miscellaneous databases

ChiTaRSi SLCO1B1. human.
GeneWikii SLCO1B1.
GenomeRNAii 10599.
NextBioi 40250.
PROi Q9Y6L6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y6L6.
Bgeei Q9Y6L6.
CleanExi HS_LST1.
HS_SLCO1B1.
Genevestigatori Q9Y6L6.

Family and domain databases

InterProi IPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view ]
PANTHERi PTHR11388. PTHR11388. 1 hit.
Pfami PF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view ]
SMARTi SM00280. KAZAL. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
TIGRFAMsi TIGR00805. oat. 1 hit.
PROSITEi PS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1."
    Abe T., Kakyo M., Tokui T., Nakagomi R., Nishio T., Nakai D., Nomura H., Unno M., Suzuki M., Naitoh T., Matsuno S., Yawo H.
    J. Biol. Chem. 274:17159-17163(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANTS LYS-152 AND ASN-241.
    Tissue: Liver.
  2. "A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters."
    Hsiang B.H., Zhu Y., Wang Z., Wu Y., Sasseville V., Yang W.-P., Kirchgessner T.G.
    J. Biol. Chem. 274:37161-37168(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANT ASP-130.
    Tissue: Liver.
  3. "A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane."
    Koenig J., Cui Y., Nies A.T., Keppler D.
    Am. J. Physiol. 278:G156-G164(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  4. Nezu J.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  5. "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide."
    Koenig J., Cui Y., Nies A.T., Keppler D.
    J. Biol. Chem. 275:23161-23168(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. SeattleSNPs variation discovery resource
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-130.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASP-130 AND THR-155.
  10. "Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver."
    van de Steeg E., Stranecky V., Hartmannova H., Noskova L., Hrebicek M., Wagenaar E., van Esch A., de Waart D.R., Oude Elferink R.P., Kenworthy K.E., Sticova E., al-Edreesi M., Knisely A.S., Kmoch S., Jirsa M., Schinkel A.H.
    J. Clin. Invest. 122:519-528(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INVOLVEMENT IN HBLRR.
  11. "N-Glycosylation dictates proper processing of organic anion transporting polypeptide 1B1."
    Yao J., Hong W., Huang J., Zhan K., Huang H., Hong M.
    PLoS ONE 7:E52563-E52563(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT ASN-134; ASN-503 AND ASN-516.
  12. "Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans."
    Tirona R.G., Leake B.F., Merino G., Kim R.B.
    J. Biol. Chem. 276:35669-35675(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LEU-73; ALA-82; ASP-130; LYS-152; THR-155; GLY-156; ALA-174; ASN-241; THR-353; ASP-432; GLY-462; ALA-488; GLY-655 AND GLY-667, CHARACTERIZATION.
  13. "A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter."
    Michalski C., Cui Y., Nies A.T., Nuessler A.K., Neuhaus P., Zanger U.M., Klein K., Eichelbaum M., Keppler D., Koenig J.
    J. Biol. Chem. 277:43058-43063(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF VARIANTS ASP-130; THR-155 AND ARG-193, FUNCTION, SUBCELLULAR LOCATION.
  14. "Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis."
    Nozawa T., Nakajima M., Tamai I., Noda K., Nezu J., Sai Y., Tsuji A., Yokoi T.
    J. Pharmacol. Exp. Ther. 302:804-813(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ASP-130; LYS-152; ALA-174 AND ASN-241.

Entry informationi

Entry nameiSO1B1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6L6
Secondary accession number(s): B2R7G2
, Q29R64, Q9NQ37, Q9UBF3, Q9UH89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: September 3, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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