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Protein

Solute carrier organic anion transporter family member 1B1

Gene

SLCO1B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-159418. Recycling of bile acids and salts.
R-HSA-879518. Transport of organic anions.

Protein family/group databases

TCDBi2.A.60.1.5. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1B1
Alternative name(s):
Liver-specific organic anion transporter 1
Short name:
LST-1
OATP-C
Sodium-independent organic anion-transporting polypeptide 2
Short name:
OATP-2
Solute carrier family 21 member 6
Gene namesi
Name:SLCO1B1
Synonyms:LST1, OATP1B1, OATP2, OATPC, SLC21A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000134538.2.
HGNCiHGNC:10959. SLCO1B1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicSequence analysisAdd BLAST28
Transmembranei29 – 48Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini49 – 67ExtracellularSequence analysisAdd BLAST19
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 94CytoplasmicSequence analysis6
Transmembranei95 – 119Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini120 – 168ExtracellularSequence analysisAdd BLAST49
Transmembranei169 – 197Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini198 – 216CytoplasmicSequence analysisAdd BLAST19
Transmembranei217 – 237Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini238 – 255ExtracellularSequence analysisAdd BLAST18
Transmembranei256 – 280Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini281 – 331CytoplasmicSequence analysisAdd BLAST51
Transmembranei332 – 353Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini354 – 373ExtracellularSequence analysisAdd BLAST20
Transmembranei374 – 397Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini398 – 401CytoplasmicSequence analysis4
Transmembranei402 – 425Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini426 – 537ExtracellularSequence analysisAdd BLAST112
Transmembranei538 – 560Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini561 – 569CytoplasmicSequence analysis9
Transmembranei570 – 595Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini596 – 629ExtracellularSequence analysisAdd BLAST34
Transmembranei630 – 647Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini648 – 691CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Hyperbilirubinemia, Rotor type (HBLRR)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal.
See also OMIM:237450

Organism-specific databases

DisGeNETi10599.
GeneReviewsiSLCO1B1.
MalaCardsiSLCO1B1.
MIMi237450. phenotype.
OpenTargetsiENSG00000134538.
Orphaneti3111. Rotor syndrome.
413696. Statin toxicity.
PharmGKBiPA134865839.

Chemistry databases

ChEMBLiCHEMBL1697668.
DrugBankiDB06151. Acetylcysteine.
DB06403. Ambrisentan.
DB00345. Aminohippuric acid.
DB01076. Atorvastatin.
DB06626. Axitinib.
DB01053. Benzylpenicillin.
DB01393. Bezafibrate.
DB06772. Cabazitaxel.
DB00520. Caspofungin.
DB00439. Cerivastatin.
DB02659. Cholic Acid.
DB01211. Clarithromycin.
DB05239. Cobimetinib.
DB00286. Conjugated Equine Estrogens.
DB00091. Cyclosporine.
DB08912. Dabrafenib.
DB09102. Daclatasvir.
DB05804. dehydroepiandrosterone sulfate.
DB00509. Dextrothyroxine.
DB00390. Digoxin.
DB00917. Dinoprostone.
DB04881. Elacridar.
DB06210. Eltrombopag.
DB09272. Eluxadoline.
DB00783. Estradiol.
DB00655. Estrone.
DB00973. Ezetimibe.
DB00950. Fexofenadine.
DB01095. Fluvastatin.
DB08884. Gadoxetic acid.
DB01241. Gemfibrozil.
DB11575. Grazoprevir.
DB01892. Hyperforin.
DB09054. Idelalisib.
DB00224. Indinavir.
DB00762. Irinotecan.
DB00583. L-Carnitine.
DB13153. Levomenol.
DB13139. Levosalbutamol.
DB00451. Levothyroxine.
DB00279. Liothyronine.
DB01583. Liotrix.
DB00227. Lovastatin.
DB00563. Methotrexate.
DB00688. Mycophenolate mofetil.
DB02691. N-Cholylglycine.
DB00220. Nelfinavir.
DB00275. Olmesartan.
DB01092. Ouabain.
DB00213. Pantoprazole.
DB13154. Parachlorophenol.
DB06589. Pazopanib.
DB00859. Penicillamine.
DB01132. Pioglitazone.
DB08860. Pitavastatin.
DB00175. Pravastatin.
DB00908. Quinidine.
DB00912. Repaglinide.
DB01045. Rifampicin.
DB08864. Rilpivirine.
DB00503. Ritonavir.
DB00412. Rosiglitazone.
DB01098. Rosuvastatin.
DB09292. Sacubitril.
DB01232. Saquinavir.
DB11362. Selexipag.
DB06290. Simeprevir.
DB00641. Simvastatin.
DB00877. Sirolimus.
DB00669. Sumatriptan.
DB04348. Taurocholic Acid.
DB09137. Technetium Tc 99m Mebrofenin.
DB00197. Troglitazone.
DB00177. Valsartan.
DB00661. Verapamil.
GuidetoPHARMACOLOGYi1220.

Polymorphism and mutation databases

BioMutaiSLCO1B1.
DMDMi12643959.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910501 – 691Solute carrier organic anion transporter family member 1B1Add BLAST691

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei293PhosphoserineCombined sources1
Modified residuei295PhosphoserineCombined sources1
Glycosylationi432N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi459 ↔ 485PROSITE-ProRule annotation
Disulfide bondi463 ↔ 474PROSITE-ProRule annotation
Disulfide bondi465 ↔ 489PROSITE-ProRule annotation
Glycosylationi503N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi516N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi617N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei672PhosphoserineCombined sources1
Modified residuei682PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9Y6L6.
PaxDbiQ9Y6L6.
PeptideAtlasiQ9Y6L6.
PRIDEiQ9Y6L6.

PTM databases

iPTMnetiQ9Y6L6.
PhosphoSitePlusiQ9Y6L6.

Expressioni

Tissue specificityi

Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.3 Publications

Gene expression databases

BgeeiENSG00000134538.
CleanExiHS_LST1.
HS_SLCO1B1.
ExpressionAtlasiQ9Y6L6. baseline and differential.
GenevisibleiQ9Y6L6. HS.

Organism-specific databases

HPAiHPA050892.

Interactioni

Protein-protein interaction databases

BioGridi115847. 11 interactors.
STRINGi9606.ENSP00000256958.

Chemistry databases

BindingDBiQ9Y6L6.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6L6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini453 – 508Kazal-likePROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ9Y6L6.
KOiK05043.
OMAiIDRACMK.
OrthoDBiEOG091G08QD.
PhylomeDBiQ9Y6L6.
TreeFamiTF317540.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiView protein in Pfam
PF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
SUPFAMiSSF100895. SSF100895. 1 hit.
SSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiView protein in PROSITE
PS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y6L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQNQHLNKT AEAQPSENKK TRYCNGLKMF LAALSLSFIA KTLGAIIMKS
60 70 80 90 100
SIIHIERRFE ISSSLVGFID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG
110 120 130 140 150
CFIMGIGGVL TALPHFFMGY YRYSKETNIN SSENSTSTLS TCLINQILSL
160 170 180 190 200
NRASPEIVGK GCLKESGSYM WIYVFMGNML RGIGETPIVP LGLSYIDDFA
210 220 230 240 250
KEGHSSLYLG ILNAIAMIGP IIGFTLGSLF SKMYVDIGYV DLSTIRITPT
260 270 280 290 300
DSRWVGAWWL NFLVSGLFSI ISSIPFFFLP QTPNKPQKER KASLSLHVLE
310 320 330 340 350
TNDEKDQTAN LTNQGKNITK NVTGFFQSFK SILTNPLYVM FVLLTLLQVS
360 370 380 390 400
SYIGAFTYVF KYVEQQYGQP SSKANILLGV ITIPIFASGM FLGGYIIKKF
410 420 430 440 450
KLNTVGIAKF SCFTAVMSLS FYLLYFFILC ENKSVAGLTM TYDGNNPVTS
460 470 480 490 500
HRDVPLSYCN SDCNCDESQW EPVCGNNGIT YISPCLAGCK SSSGNKKPIV
510 520 530 540 550
FYNCSCLEVT GLQNRNYSAH LGECPRDDAC TRKFYFFVAI QVLNLFFSAL
560 570 580 590 600
GGTSHVMLIV KIVQPELKSL ALGFHSMVIR ALGGILAPIY FGALIDTTCI
610 620 630 640 650
KWSTNNCGTR GSCRTYNSTS FSRVYLGLSS MLRVSSLVLY IILIYAMKKK
660 670 680 690
YQEKDINASE NGSVMDEANL ESLNKNKHFV PSAGADSETH C
Length:691
Mass (Da):76,449
Last modified:December 1, 2000 - v2
Checksum:iD13D5130189383A3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01507073F → L1 PublicationCorresponds to variant dbSNP:rs56101265Ensembl.1
Natural variantiVAR_01507182V → A1 PublicationCorresponds to variant dbSNP:rs56061388Ensembl.1
Natural variantiVAR_015072130N → D6 PublicationsCorresponds to variant dbSNP:rs2306283Ensembl.1
Natural variantiVAR_057724151N → S. Corresponds to variant dbSNP:rs2306282Ensembl.1
Natural variantiVAR_015073152R → K3 Publications1
Natural variantiVAR_015074155P → T Decreased transport activity. 3 PublicationsCorresponds to variant dbSNP:rs11045819Ensembl.1
Natural variantiVAR_015075156E → G Decreased transport activity. 1 PublicationCorresponds to variant dbSNP:rs72559745Ensembl.1
Natural variantiVAR_015076174V → A Decreased transport activity. 2 PublicationsCorresponds to variant dbSNP:rs4149056Ensembl.1
Natural variantiVAR_015077193L → R Strongly decreases expression at the plasma membrane; abolishes transport activity. 1 PublicationCorresponds to variant dbSNP:rs72559746Ensembl.1
Natural variantiVAR_015078241D → N3 Publications1
Natural variantiVAR_060108245I → V. Corresponds to variant dbSNP:rs11045852Ensembl.1
Natural variantiVAR_015079353I → T1 PublicationCorresponds to variant dbSNP:rs55901008Ensembl.1
Natural variantiVAR_015080432N → D1 PublicationCorresponds to variant dbSNP:rs56387224Ensembl.1
Natural variantiVAR_015081462D → G1 PublicationCorresponds to variant dbSNP:rs72559748Ensembl.1
Natural variantiVAR_015082488G → A1 PublicationCorresponds to variant dbSNP:rs59502379Ensembl.1
Natural variantiVAR_057725643L → F. Corresponds to variant dbSNP:rs34671512Ensembl.1
Natural variantiVAR_015083655D → G1 PublicationCorresponds to variant dbSNP:rs56199088Ensembl.1
Natural variantiVAR_015084667E → G1 PublicationCorresponds to variant dbSNP:rs55737008Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060500 mRNA. Translation: AAD38323.1.
AF205071 mRNA. Translation: AAF20212.1.
AJ132573 mRNA. Translation: CAB62577.1.
AB026257 mRNA. Translation: BAA78639.1.
AJ400749
, AJ400750, AJ400751, AJ400752, AJ400753, AJ400754, AJ400755, AJ400756, AJ400757, AJ400758, AJ400759, AJ400760, AJ400761, AJ400762 Genomic DNA. Translation: CAB97007.1.
AY945934 Genomic DNA. Translation: AAX20114.1.
AK312970 mRNA. Translation: BAG35809.1.
CH471094 Genomic DNA. Translation: EAW96420.1.
BC114376 mRNA. Translation: AAI14377.1.
CCDSiCCDS8685.1.
RefSeqiNP_006437.3. NM_006446.4.
UniGeneiHs.449738.

Genome annotation databases

EnsembliENST00000256958; ENSP00000256958; ENSG00000134538.
GeneIDi10599.
KEGGihsa:10599.
UCSCiuc001req.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSO1B1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6L6
Secondary accession number(s): B2R7G2
, Q29R64, Q9NQ37, Q9UBF3, Q9UH89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: September 27, 2017
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families