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Q9Y6L6 (SO1B1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier organic anion transporter family member 1B1
Alternative name(s):
Liver-specific organic anion transporter 1
Short name=LST-1
OATP-C
Sodium-independent organic anion-transporting polypeptide 2
Short name=OATP-2
Solute carrier family 21 member 6
Gene names
Name:SLCO1B1
Synonyms:LST1, OATP1B1, OATP2, OATPC, SLC21A6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length691 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates the Na+-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. Ref.1 Ref.2 Ref.10 Ref.13

Subcellular location

Basolateral cell membrane; Multi-pass membrane protein. Note: Detected in basolateral membranes of hepatocytes. Ref.13

Tissue specificity

Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte. Ref.1 Ref.2 Ref.10

Involvement in disease

Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10

Sequence similarities

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]

Contains 1 Kazal-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 691691Solute carrier organic anion transporter family member 1B1
PRO_0000191050

Regions

Topological domain1 – 2828Cytoplasmic Potential
Transmembrane29 – 4820Helical; Name=1; Potential
Topological domain49 – 6719Extracellular Potential
Transmembrane68 – 8821Helical; Name=2; Potential
Topological domain89 – 946Cytoplasmic Potential
Transmembrane95 – 11925Helical; Name=3; Potential
Topological domain120 – 16849Extracellular Potential
Transmembrane169 – 19729Helical; Name=4; Potential
Topological domain198 – 21619Cytoplasmic Potential
Transmembrane217 – 23721Helical; Name=5; Potential
Topological domain238 – 25518Extracellular Potential
Transmembrane256 – 28025Helical; Name=6; Potential
Topological domain281 – 33151Cytoplasmic Potential
Transmembrane332 – 35322Helical; Name=7; Potential
Topological domain354 – 37320Extracellular Potential
Transmembrane374 – 39724Helical; Name=8; Potential
Topological domain398 – 4014Cytoplasmic Potential
Transmembrane402 – 42524Helical; Name=9; Potential
Topological domain426 – 537112Extracellular Potential
Transmembrane538 – 56023Helical; Name=10; Potential
Topological domain561 – 5699Cytoplasmic Potential
Transmembrane570 – 59526Helical; Name=11; Potential
Topological domain596 – 62934Extracellular Potential
Transmembrane630 – 64718Helical; Name=12; Potential
Topological domain648 – 69144Cytoplasmic Potential
Domain453 – 50856Kazal-like

Amino acid modifications

Glycosylation1301N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Ref.11
Glycosylation4321N-linked (GlcNAc...) Potential
Glycosylation5031N-linked (GlcNAc...) Ref.11
Glycosylation5161N-linked (GlcNAc...) Ref.11
Glycosylation6171N-linked (GlcNAc...) Potential
Disulfide bond459 ↔ 485 By similarity
Disulfide bond463 ↔ 474 By similarity
Disulfide bond465 ↔ 489 By similarity

Natural variations

Natural variant731F → L. Ref.12
Corresponds to variant rs56101265 [ dbSNP | Ensembl ].
VAR_015070
Natural variant821V → A. Ref.12
Corresponds to variant rs56061388 [ dbSNP | Ensembl ].
VAR_015071
Natural variant1301N → D. Ref.2 Ref.6 Ref.9 Ref.12 Ref.13 Ref.14
Corresponds to variant rs2306283 [ dbSNP | Ensembl ].
VAR_015072
Natural variant1511N → S.
Corresponds to variant rs2306282 [ dbSNP | Ensembl ].
VAR_057724
Natural variant1521R → K. Ref.1 Ref.12 Ref.14
VAR_015073
Natural variant1551P → T Decreased transport activity. Ref.9 Ref.12 Ref.13
Corresponds to variant rs11045819 [ dbSNP | Ensembl ].
VAR_015074
Natural variant1561E → G Decreased transport activity. Ref.12
VAR_015075
Natural variant1741V → A Decreased transport activity. Ref.12 Ref.14
Corresponds to variant rs4149056 [ dbSNP | Ensembl ].
VAR_015076
Natural variant1931L → R Strongly decreases expression at the plasma membrane; abolishes transport activity. Ref.13
VAR_015077
Natural variant2411D → N. Ref.1 Ref.12 Ref.14
VAR_015078
Natural variant2451I → V.
Corresponds to variant rs11045852 [ dbSNP | Ensembl ].
VAR_060108
Natural variant3531I → T. Ref.12
Corresponds to variant rs55901008 [ dbSNP | Ensembl ].
VAR_015079
Natural variant4321N → D. Ref.12
Corresponds to variant rs56387224 [ dbSNP | Ensembl ].
VAR_015080
Natural variant4621D → G. Ref.12
VAR_015081
Natural variant4881G → A. Ref.12
Corresponds to variant rs59502379 [ dbSNP | Ensembl ].
VAR_015082
Natural variant6431L → F.
Corresponds to variant rs34671512 [ dbSNP | Ensembl ].
VAR_057725
Natural variant6551D → G. Ref.12
Corresponds to variant rs56199088 [ dbSNP | Ensembl ].
VAR_015083
Natural variant6671E → G. Ref.12
Corresponds to variant rs55737008 [ dbSNP | Ensembl ].
VAR_015084

Sequences

Sequence LengthMass (Da)Tools
Q9Y6L6 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: D13D5130189383A3

FASTA69176,449
        10         20         30         40         50         60 
MDQNQHLNKT AEAQPSENKK TRYCNGLKMF LAALSLSFIA KTLGAIIMKS SIIHIERRFE 

        70         80         90        100        110        120 
ISSSLVGFID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG CFIMGIGGVL TALPHFFMGY 

       130        140        150        160        170        180 
YRYSKETNIN SSENSTSTLS TCLINQILSL NRASPEIVGK GCLKESGSYM WIYVFMGNML 

       190        200        210        220        230        240 
RGIGETPIVP LGLSYIDDFA KEGHSSLYLG ILNAIAMIGP IIGFTLGSLF SKMYVDIGYV 

       250        260        270        280        290        300 
DLSTIRITPT DSRWVGAWWL NFLVSGLFSI ISSIPFFFLP QTPNKPQKER KASLSLHVLE 

       310        320        330        340        350        360 
TNDEKDQTAN LTNQGKNITK NVTGFFQSFK SILTNPLYVM FVLLTLLQVS SYIGAFTYVF 

       370        380        390        400        410        420 
KYVEQQYGQP SSKANILLGV ITIPIFASGM FLGGYIIKKF KLNTVGIAKF SCFTAVMSLS 

       430        440        450        460        470        480 
FYLLYFFILC ENKSVAGLTM TYDGNNPVTS HRDVPLSYCN SDCNCDESQW EPVCGNNGIT 

       490        500        510        520        530        540 
YISPCLAGCK SSSGNKKPIV FYNCSCLEVT GLQNRNYSAH LGECPRDDAC TRKFYFFVAI 

       550        560        570        580        590        600 
QVLNLFFSAL GGTSHVMLIV KIVQPELKSL ALGFHSMVIR ALGGILAPIY FGALIDTTCI 

       610        620        630        640        650        660 
KWSTNNCGTR GSCRTYNSTS FSRVYLGLSS MLRVSSLVLY IILIYAMKKK YQEKDINASE 

       670        680        690 
NGSVMDEANL ESLNKNKHFV PSAGADSETH C 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1."
Abe T., Kakyo M., Tokui T., Nakagomi R., Nishio T., Nakai D., Nomura H., Unno M., Suzuki M., Naitoh T., Matsuno S., Yawo H.
J. Biol. Chem. 274:17159-17163(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANTS LYS-152 AND ASN-241.
Tissue: Liver.
[2]"A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters."
Hsiang B.H., Zhu Y., Wang Z., Wu Y., Sasseville V., Yang W.-P., Kirchgessner T.G.
J. Biol. Chem. 274:37161-37168(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANT ASP-130.
Tissue: Liver.
[3]"A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane."
Koenig J., Cui Y., Nies A.T., Keppler D.
Am. J. Physiol. 278:G156-G164(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[4]Nezu J.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[5]"Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide."
Koenig J., Cui Y., Nies A.T., Keppler D.
J. Biol. Chem. 275:23161-23168(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]SeattleSNPs variation discovery resource
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-130.
[7]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASP-130 AND THR-155.
[10]"Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver."
van de Steeg E., Stranecky V., Hartmannova H., Noskova L., Hrebicek M., Wagenaar E., van Esch A., de Waart D.R., Oude Elferink R.P., Kenworthy K.E., Sticova E., al-Edreesi M., Knisely A.S., Kmoch S., Jirsa M., Schinkel A.H.
J. Clin. Invest. 122:519-528(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, INVOLVEMENT IN HBLRR.
[11]"N-Glycosylation dictates proper processing of organic anion transporting polypeptide 1B1."
Yao J., Hong W., Huang J., Zhan K., Huang H., Hong M.
PLoS ONE 7:E52563-E52563(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-134; ASN-503 AND ASN-516.
[12]"Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans."
Tirona R.G., Leake B.F., Merino G., Kim R.B.
J. Biol. Chem. 276:35669-35675(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS LEU-73; ALA-82; ASP-130; LYS-152; THR-155; GLY-156; ALA-174; ASN-241; THR-353; ASP-432; GLY-462; ALA-488; GLY-655 AND GLY-667, CHARACTERIZATION.
[13]"A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter."
Michalski C., Cui Y., Nies A.T., Nuessler A.K., Neuhaus P., Zanger U.M., Klein K., Eichelbaum M., Keppler D., Koenig J.
J. Biol. Chem. 277:43058-43063(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF VARIANTS ASP-130; THR-155 AND ARG-193, FUNCTION, SUBCELLULAR LOCATION.
[14]"Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis."
Nozawa T., Nakajima M., Tamai I., Noda K., Nezu J., Sai Y., Tsuji A., Yokoi T.
J. Pharmacol. Exp. Ther. 302:804-813(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ASP-130; LYS-152; ALA-174 AND ASN-241.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF060500 mRNA. Translation: AAD38323.1.
AF205071 mRNA. Translation: AAF20212.1.
AJ132573 mRNA. Translation: CAB62577.1.
AB026257 mRNA. Translation: BAA78639.1.
AJ400749 expand/collapse EMBL AC list , AJ400750, AJ400751, AJ400752, AJ400753, AJ400754, AJ400755, AJ400756, AJ400757, AJ400758, AJ400759, AJ400760, AJ400761, AJ400762 Genomic DNA. Translation: CAB97007.1.
AY945934 Genomic DNA. Translation: AAX20114.1.
AK312970 mRNA. Translation: BAG35809.1.
CH471094 Genomic DNA. Translation: EAW96420.1.
BC114376 mRNA. Translation: AAI14377.1.
RefSeqNP_006437.3. NM_006446.4.
UniGeneHs.449738.

3D structure databases

ProteinModelPortalQ9Y6L6.
SMRQ9Y6L6. Positions 179-234, 462-528, 556-598.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000256958.

Chemistry

BindingDBQ9Y6L6.
ChEMBLCHEMBL1697668.
DrugBankDB00390. Digoxin.
DB01241. Gemfibrozil.
DB00175. Pravastatin.
GuidetoPHARMACOLOGY1220.

Protein family/group databases

TCDB2.A.60.1.5. the organo anion transporter (oat) family.

PTM databases

PhosphoSiteQ9Y6L6.

Polymorphism databases

DMDM12643959.

Proteomic databases

PaxDbQ9Y6L6.
PRIDEQ9Y6L6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000256958; ENSP00000256958; ENSG00000134538.
GeneID10599.
KEGGhsa:10599.
UCSCuc001req.4. human.

Organism-specific databases

CTD10599.
GeneCardsGC12P021284.
HGNCHGNC:10959. SLCO1B1.
HPAHPA050892.
MIM237450. phenotype.
604843. gene.
neXtProtNX_Q9Y6L6.
Orphanet240851. Atorvastatin toxicity.
240903. Pravastatin toxicity.
240909. Rosuvastatin toxicity.
3111. Rotor syndrome.
240913. Simvastatin toxicity.
240961. Susceptibility to adverse reaction due to atorvastatin treatment.
240981. Susceptibility to adverse reaction due to pravastatin treatment.
240983. Susceptibility to adverse reaction due to rosuvastatin treatment.
240985. Susceptibility to adverse reaction due to simvastatin treatment.
306566. Susceptibility to myopathies due to statin treatment.
PharmGKBPA134865839.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG322696.
HOGENOMHOG000231269.
HOVERGENHBG063896.
InParanoidQ9Y6L6.
KOK05043.
OMAHIERRFE.
OrthoDBEOG7GFB4C.
PhylomeDBQ9Y6L6.
TreeFamTF317540.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
REACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ9Y6L6.
BgeeQ9Y6L6.
CleanExHS_LST1.
HS_SLCO1B1.
GenevestigatorQ9Y6L6.

Family and domain databases

InterProIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERPTHR11388. PTHR11388. 1 hit.
PfamPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 3 hits.
TIGRFAMsTIGR00805. oat. 1 hit.
PROSITEPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLCO1B1. human.
GeneWikiSLCO1B1.
GenomeRNAi10599.
NextBio40250.
PROQ9Y6L6.
SOURCESearch...

Entry information

Entry nameSO1B1_HUMAN
AccessionPrimary (citable) accession number: Q9Y6L6
Secondary accession number(s): B2R7G2 expand/collapse secondary AC list , Q29R64, Q9NQ37, Q9UBF3, Q9UH89
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: April 16, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM