Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y6L6

- SO1B1_HUMAN

UniProt

Q9Y6L6 - SO1B1_HUMAN

Protein

Solute carrier organic anion transporter family member 1B1

Gene

SLCO1B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Mediates the Na+-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.4 Publications

    GO - Molecular functioni

    1. sodium-independent organic anion transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    1. bile acid and bile salt transport Source: Reactome
    2. bile acid metabolic process Source: Reactome
    3. organic anion transport Source: ProtInc
    4. small molecule metabolic process Source: Reactome
    5. sodium-independent organic anion transport Source: Reactome
    6. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_11042. Recycling of bile acids and salts.
    REACT_23988. Transport of organic anions.

    Protein family/group databases

    TCDBi2.A.60.1.5. the organo anion transporter (oat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 1B1
    Alternative name(s):
    Liver-specific organic anion transporter 1
    Short name:
    LST-1
    OATP-C
    Sodium-independent organic anion-transporting polypeptide 2
    Short name:
    OATP-2
    Solute carrier family 21 member 6
    Gene namesi
    Name:SLCO1B1
    Synonyms:LST1, OATP1B1, OATP2, OATPC, SLC21A6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:10959. SLCO1B1.

    Subcellular locationi

    Basolateral cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Detected in basolateral membranes of hepatocytes.

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: ProtInc
    3. membrane Source: ProtInc
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi237450. phenotype.
    Orphaneti240851. Atorvastatin toxicity.
    240903. Pravastatin toxicity.
    240909. Rosuvastatin toxicity.
    3111. Rotor syndrome.
    240913. Simvastatin toxicity.
    240961. Susceptibility to adverse reaction due to atorvastatin treatment.
    240981. Susceptibility to adverse reaction due to pravastatin treatment.
    240983. Susceptibility to adverse reaction due to rosuvastatin treatment.
    240985. Susceptibility to adverse reaction due to simvastatin treatment.
    306566. Susceptibility to myopathies due to statin treatment.
    PharmGKBiPA134865839.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 691691Solute carrier organic anion transporter family member 1B1PRO_0000191050Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi134 – 1341N-linked (GlcNAc...)1 Publication
    Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi459 ↔ 485PROSITE-ProRule annotation
    Disulfide bondi463 ↔ 474PROSITE-ProRule annotation
    Disulfide bondi465 ↔ 489PROSITE-ProRule annotation
    Glycosylationi503 – 5031N-linked (GlcNAc...)1 Publication
    Glycosylationi516 – 5161N-linked (GlcNAc...)1 Publication
    Glycosylationi617 – 6171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9Y6L6.
    PRIDEiQ9Y6L6.

    PTM databases

    PhosphoSiteiQ9Y6L6.

    Expressioni

    Tissue specificityi

    Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte.3 Publications

    Gene expression databases

    ArrayExpressiQ9Y6L6.
    BgeeiQ9Y6L6.
    CleanExiHS_LST1.
    HS_SLCO1B1.
    GenevestigatoriQ9Y6L6.

    Organism-specific databases

    HPAiHPA050892.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000256958.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y6L6.
    SMRiQ9Y6L6. Positions 463-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini49 – 6719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini89 – 946CytoplasmicSequence Analysis
    Topological domaini120 – 16849ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini198 – 21619CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini238 – 25518ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini281 – 33151CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini354 – 37320ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini398 – 4014CytoplasmicSequence Analysis
    Topological domaini426 – 537112ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini561 – 5699CytoplasmicSequence Analysis
    Topological domaini596 – 62934ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini648 – 69144CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4820Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei68 – 8821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei95 – 11925Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei169 – 19729Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei256 – 28025Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei332 – 35322Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei374 – 39724Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei402 – 42524Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei538 – 56023Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei570 – 59526Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei630 – 64718Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini453 – 50856Kazal-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG322696.
    HOGENOMiHOG000231269.
    HOVERGENiHBG063896.
    InParanoidiQ9Y6L6.
    KOiK05043.
    OMAiHIERRFE.
    OrthoDBiEOG7GFB4C.
    PhylomeDBiQ9Y6L6.
    TreeFamiTF317540.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view]
    SMARTiSM00280. KAZAL. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 3 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y6L6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQNQHLNKT AEAQPSENKK TRYCNGLKMF LAALSLSFIA KTLGAIIMKS    50
    SIIHIERRFE ISSSLVGFID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG 100
    CFIMGIGGVL TALPHFFMGY YRYSKETNIN SSENSTSTLS TCLINQILSL 150
    NRASPEIVGK GCLKESGSYM WIYVFMGNML RGIGETPIVP LGLSYIDDFA 200
    KEGHSSLYLG ILNAIAMIGP IIGFTLGSLF SKMYVDIGYV DLSTIRITPT 250
    DSRWVGAWWL NFLVSGLFSI ISSIPFFFLP QTPNKPQKER KASLSLHVLE 300
    TNDEKDQTAN LTNQGKNITK NVTGFFQSFK SILTNPLYVM FVLLTLLQVS 350
    SYIGAFTYVF KYVEQQYGQP SSKANILLGV ITIPIFASGM FLGGYIIKKF 400
    KLNTVGIAKF SCFTAVMSLS FYLLYFFILC ENKSVAGLTM TYDGNNPVTS 450
    HRDVPLSYCN SDCNCDESQW EPVCGNNGIT YISPCLAGCK SSSGNKKPIV 500
    FYNCSCLEVT GLQNRNYSAH LGECPRDDAC TRKFYFFVAI QVLNLFFSAL 550
    GGTSHVMLIV KIVQPELKSL ALGFHSMVIR ALGGILAPIY FGALIDTTCI 600
    KWSTNNCGTR GSCRTYNSTS FSRVYLGLSS MLRVSSLVLY IILIYAMKKK 650
    YQEKDINASE NGSVMDEANL ESLNKNKHFV PSAGADSETH C 691
    Length:691
    Mass (Da):76,449
    Last modified:December 1, 2000 - v2
    Checksum:iD13D5130189383A3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti73 – 731F → L.1 Publication
    Corresponds to variant rs56101265 [ dbSNP | Ensembl ].
    VAR_015070
    Natural varianti82 – 821V → A.1 Publication
    Corresponds to variant rs56061388 [ dbSNP | Ensembl ].
    VAR_015071
    Natural varianti130 – 1301N → D.5 Publications
    Corresponds to variant rs2306283 [ dbSNP | Ensembl ].
    VAR_015072
    Natural varianti151 – 1511N → S.
    Corresponds to variant rs2306282 [ dbSNP | Ensembl ].
    VAR_057724
    Natural varianti152 – 1521R → K.3 Publications
    VAR_015073
    Natural varianti155 – 1551P → T Decreased transport activity. 2 Publications
    Corresponds to variant rs11045819 [ dbSNP | Ensembl ].
    VAR_015074
    Natural varianti156 – 1561E → G Decreased transport activity. 1 Publication
    VAR_015075
    Natural varianti174 – 1741V → A Decreased transport activity. 2 Publications
    Corresponds to variant rs4149056 [ dbSNP | Ensembl ].
    VAR_015076
    Natural varianti193 – 1931L → R Strongly decreases expression at the plasma membrane; abolishes transport activity.
    VAR_015077
    Natural varianti241 – 2411D → N.3 Publications
    VAR_015078
    Natural varianti245 – 2451I → V.
    Corresponds to variant rs11045852 [ dbSNP | Ensembl ].
    VAR_060108
    Natural varianti353 – 3531I → T.1 Publication
    Corresponds to variant rs55901008 [ dbSNP | Ensembl ].
    VAR_015079
    Natural varianti432 – 4321N → D.1 Publication
    Corresponds to variant rs56387224 [ dbSNP | Ensembl ].
    VAR_015080
    Natural varianti462 – 4621D → G.1 Publication
    VAR_015081
    Natural varianti488 – 4881G → A.1 Publication
    Corresponds to variant rs59502379 [ dbSNP | Ensembl ].
    VAR_015082
    Natural varianti643 – 6431L → F.
    Corresponds to variant rs34671512 [ dbSNP | Ensembl ].
    VAR_057725
    Natural varianti655 – 6551D → G.1 Publication
    Corresponds to variant rs56199088 [ dbSNP | Ensembl ].
    VAR_015083
    Natural varianti667 – 6671E → G.1 Publication
    Corresponds to variant rs55737008 [ dbSNP | Ensembl ].
    VAR_015084

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF060500 mRNA. Translation: AAD38323.1.
    AF205071 mRNA. Translation: AAF20212.1.
    AJ132573 mRNA. Translation: CAB62577.1.
    AB026257 mRNA. Translation: BAA78639.1.
    AJ400749
    , AJ400750, AJ400751, AJ400752, AJ400753, AJ400754, AJ400755, AJ400756, AJ400757, AJ400758, AJ400759, AJ400760, AJ400761, AJ400762 Genomic DNA. Translation: CAB97007.1.
    AY945934 Genomic DNA. Translation: AAX20114.1.
    AK312970 mRNA. Translation: BAG35809.1.
    CH471094 Genomic DNA. Translation: EAW96420.1.
    BC114376 mRNA. Translation: AAI14377.1.
    CCDSiCCDS8685.1.
    RefSeqiNP_006437.3. NM_006446.4.
    UniGeneiHs.449738.

    Genome annotation databases

    EnsembliENST00000256958; ENSP00000256958; ENSG00000134538.
    GeneIDi10599.
    KEGGihsa:10599.
    UCSCiuc001req.4. human.

    Polymorphism databases

    DMDMi12643959.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF060500 mRNA. Translation: AAD38323.1 .
    AF205071 mRNA. Translation: AAF20212.1 .
    AJ132573 mRNA. Translation: CAB62577.1 .
    AB026257 mRNA. Translation: BAA78639.1 .
    AJ400749
    , AJ400750 , AJ400751 , AJ400752 , AJ400753 , AJ400754 , AJ400755 , AJ400756 , AJ400757 , AJ400758 , AJ400759 , AJ400760 , AJ400761 , AJ400762 Genomic DNA. Translation: CAB97007.1 .
    AY945934 Genomic DNA. Translation: AAX20114.1 .
    AK312970 mRNA. Translation: BAG35809.1 .
    CH471094 Genomic DNA. Translation: EAW96420.1 .
    BC114376 mRNA. Translation: AAI14377.1 .
    CCDSi CCDS8685.1.
    RefSeqi NP_006437.3. NM_006446.4.
    UniGenei Hs.449738.

    3D structure databases

    ProteinModelPortali Q9Y6L6.
    SMRi Q9Y6L6. Positions 463-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000256958.

    Chemistry

    BindingDBi Q9Y6L6.
    ChEMBLi CHEMBL1697668.
    DrugBanki DB00390. Digoxin.
    DB01241. Gemfibrozil.
    DB00175. Pravastatin.
    GuidetoPHARMACOLOGYi 1220.

    Protein family/group databases

    TCDBi 2.A.60.1.5. the organo anion transporter (oat) family.

    PTM databases

    PhosphoSitei Q9Y6L6.

    Polymorphism databases

    DMDMi 12643959.

    Proteomic databases

    PaxDbi Q9Y6L6.
    PRIDEi Q9Y6L6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256958 ; ENSP00000256958 ; ENSG00000134538 .
    GeneIDi 10599.
    KEGGi hsa:10599.
    UCSCi uc001req.4. human.

    Organism-specific databases

    CTDi 10599.
    GeneCardsi GC12P021284.
    GeneReviewsi SLCO1B1.
    HGNCi HGNC:10959. SLCO1B1.
    HPAi HPA050892.
    MIMi 237450. phenotype.
    604843. gene.
    neXtProti NX_Q9Y6L6.
    Orphaneti 240851. Atorvastatin toxicity.
    240903. Pravastatin toxicity.
    240909. Rosuvastatin toxicity.
    3111. Rotor syndrome.
    240913. Simvastatin toxicity.
    240961. Susceptibility to adverse reaction due to atorvastatin treatment.
    240981. Susceptibility to adverse reaction due to pravastatin treatment.
    240983. Susceptibility to adverse reaction due to rosuvastatin treatment.
    240985. Susceptibility to adverse reaction due to simvastatin treatment.
    306566. Susceptibility to myopathies due to statin treatment.
    PharmGKBi PA134865839.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322696.
    HOGENOMi HOG000231269.
    HOVERGENi HBG063896.
    InParanoidi Q9Y6L6.
    KOi K05043.
    OMAi HIERRFE.
    OrthoDBi EOG7GFB4C.
    PhylomeDBi Q9Y6L6.
    TreeFami TF317540.

    Enzyme and pathway databases

    Reactomei REACT_11042. Recycling of bile acids and salts.
    REACT_23988. Transport of organic anions.

    Miscellaneous databases

    ChiTaRSi SLCO1B1. human.
    GeneWikii SLCO1B1.
    GenomeRNAii 10599.
    NextBioi 40250.
    PROi Q9Y6L6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y6L6.
    Bgeei Q9Y6L6.
    CleanExi HS_LST1.
    HS_SLCO1B1.
    Genevestigatori Q9Y6L6.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view ]
    PANTHERi PTHR11388. PTHR11388. 1 hit.
    Pfami PF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view ]
    SMARTi SM00280. KAZAL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 3 hits.
    TIGRFAMsi TIGR00805. oat. 1 hit.
    PROSITEi PS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1."
      Abe T., Kakyo M., Tokui T., Nakagomi R., Nishio T., Nakai D., Nomura H., Unno M., Suzuki M., Naitoh T., Matsuno S., Yawo H.
      J. Biol. Chem. 274:17159-17163(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANTS LYS-152 AND ASN-241.
      Tissue: Liver.
    2. "A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters."
      Hsiang B.H., Zhu Y., Wang Z., Wu Y., Sasseville V., Yang W.-P., Kirchgessner T.G.
      J. Biol. Chem. 274:37161-37168(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, VARIANT ASP-130.
      Tissue: Liver.
    3. "A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane."
      Koenig J., Cui Y., Nies A.T., Keppler D.
      Am. J. Physiol. 278:G156-G164(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    4. Nezu J.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    5. "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide."
      Koenig J., Cui Y., Nies A.T., Keppler D.
      J. Biol. Chem. 275:23161-23168(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. SeattleSNPs variation discovery resource
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-130.
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ASP-130 AND THR-155.
    10. "Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver."
      van de Steeg E., Stranecky V., Hartmannova H., Noskova L., Hrebicek M., Wagenaar E., van Esch A., de Waart D.R., Oude Elferink R.P., Kenworthy K.E., Sticova E., al-Edreesi M., Knisely A.S., Kmoch S., Jirsa M., Schinkel A.H.
      J. Clin. Invest. 122:519-528(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, INVOLVEMENT IN HBLRR.
    11. "N-Glycosylation dictates proper processing of organic anion transporting polypeptide 1B1."
      Yao J., Hong W., Huang J., Zhan K., Huang H., Hong M.
      PLoS ONE 7:E52563-E52563(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION AT ASN-134; ASN-503 AND ASN-516.
    12. "Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans."
      Tirona R.G., Leake B.F., Merino G., Kim R.B.
      J. Biol. Chem. 276:35669-35675(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LEU-73; ALA-82; ASP-130; LYS-152; THR-155; GLY-156; ALA-174; ASN-241; THR-353; ASP-432; GLY-462; ALA-488; GLY-655 AND GLY-667, CHARACTERIZATION.
    13. "A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter."
      Michalski C., Cui Y., Nies A.T., Nuessler A.K., Neuhaus P., Zanger U.M., Klein K., Eichelbaum M., Keppler D., Koenig J.
      J. Biol. Chem. 277:43058-43063(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF VARIANTS ASP-130; THR-155 AND ARG-193, FUNCTION, SUBCELLULAR LOCATION.
    14. "Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis."
      Nozawa T., Nakajima M., Tamai I., Noda K., Nezu J., Sai Y., Tsuji A., Yokoi T.
      J. Pharmacol. Exp. Ther. 302:804-813(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ASP-130; LYS-152; ALA-174 AND ASN-241.

    Entry informationi

    Entry nameiSO1B1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y6L6
    Secondary accession number(s): B2R7G2
    , Q29R64, Q9NQ37, Q9UBF3, Q9UH89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3