Adenylate kinase isoenzyme 5 - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot Q9Y6K8 (KAD5_HUMAN)

Last modified June 16, 2009. Version 80. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Adenylate kinase isoenzyme 5
      Short name=AK 5
    EC=2.7.4.3
Alternative name(s):
    ATP-AMP transphosphorylase 5

Gene names

Name:

AK5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm.
Tissue specificity	Brain specific.
Sequence similarities	Belongs to the adenylate kinase family.

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Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	3D-structure
Gene Ontology (GO)
Biological process	ADP biosynthetic process Ref.1 Traceable author statement. Source: ProtInc ATP metabolic process Inferred from electronic annotation. Source: InterPro dADP biosynthetic process Ref.1 Traceable author statement. Source: ProtInc pyrimidine ribonucleotide biosynthetic process Ref.1 Traceable author statement. Source: ProtInc
Cellular component	cytosol Ref.1 Inferred from Experiment. Source: Reactome
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Ref.1 Traceable author statement. Source: ProtInc nucleoside kinase activity Ref.1 Inferred from Experiment. Source: Reactome
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 198

198

Adenylate kinase isoenzyme 5

PRO_0000158930

Regions

Nucleotide binding

18 – 26

ATP By similarity

Nucleotide binding

97 – 104

AMP By similarity

Sites

Binding site

AMP By similarity

Experimental info

Sequence conflict

197

Missing in AAH12467. Ref.3

Secondary structure

198

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9Y6K8-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 8E8FA514CB7C3B58
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FASTA

198

22,087

        10         20         30         40         50         60 
MGGFMEDLRK CKIIFIIGGP GSGKGTQCEK LVEKYGFTHL STGELLREEL ASESERSKLI 

        70         80         90        100        110        120 
RDIMERGDLV PSGIVLELLK EAMVASLGDT RGFLIDGYPR EVKQGEEFGR RIGDPQLVIC 

       130        140        150        160        170        180 
MDCSADTMTN RLLQRSRSSL PVDDTTKTIA KRLEAYYRAS IPVIAYYETK TQLHKINAEG 

       190 
TPEDVFLQLC TAIDSIIF

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein." Van Rompay A.R., Johansson M., Karlsson A. Eur. J. Biochem. 261:509-517(1999) [PubMed: 10215863] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[4]	"Crystal structure of adenylate kinase 5." Structural genomics consortium (SGC) Submitted (JUL-2005) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEX WITH AMP.

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Cross-references

Sequence databases

AF062595 mRNA. Translation: AAD27956.1.
CR541890 mRNA. Translation: CAG46688.1.
BC012467 mRNA. Translation: AAH12467.2. Different initiation.

IPI

IPI00844054.

RefSeq

NP_036225.2.

UniGene

Hs.559718

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2BWJ	X-ray	2.30	A/B/C/D/E/F	1-196	[»]

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9Y6K8. 7 interactions.

Genome annotation databases

Ensembl

ENSG00000154027. Homo sapiens. [Contig view]

GeneID

26289.

KEGG

hsa:26289.

Organism-specific databases

GeneCards

GC01P077459.

H-InvDB

HIX0020812.

HGNC

HGNC:365. AK5.

MIM

608009. gene.

PharmGKB

PA24659.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q9Y6K8.

Enzyme and pathway databases

BRENDA

2.7.4.3. 247.

Reactome

REACT_1698. Nucleotide metabolism.

Gene expression databases

ArrayExpress

Q9Y6K8.

Bgee

Q9Y6K8.

CleanEx

HS_AK5.

GermOnline

ENSG00000154027. Homo sapiens.

Family and domain databases

InterPro

IPR000850. Adenylate_kin.
IPR006267. Adenylate_kin1.
[Graphical view]

PANTHER

PTHR23359. Adenylate_kin. 1 hit.

Pfam

PF00406. ADK. 1 hit.
[Graphical view]

PRINTS

PR00094. ADENYLTKNASE.

ProDom

PD000657. Adenylate_kin. 1 hit.
[Graphical view] [Entries sharing at least one domain]

TIGRFAMs

TIGR01360. aden_kin_iso1. 1 hit.

PROSITE

PS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

48625.

SOURCE

Search...

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Entry information

Entry name

KAD5_HUMAN

Accession

Primary (citable) accession number: Q9Y6K8
Secondary accession number(s): Q6FH66, Q96EC9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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