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Protein

TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

Gene

TAF6L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • protein heterodimerization activity Source: InterPro
  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

  • chromatin remodeling Source: ProtInc
  • DNA-templated transcription, initiation Source: InterPro
  • histone H3 acetylation Source: UniProtKB
  • regulation of DNA binding transcription factor activity Source: InterPro
  • regulation of transcription by RNA polymerase II Source: ProtInc

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
Alternative name(s):
PCAF-associated factor 65-alpha
Short name:
PAF65-alpha
Gene namesi
Name:TAF6L
Synonyms:PAF65A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000162227.7
HGNCiHGNC:17305 TAF6L
MIMi602946 gene
neXtProtiNX_Q9Y6J9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162227
PharmGKBiPA38224

Polymorphism and mutation databases

BioMutaiTAF6L
DMDMi46577572

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188791 – 622TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6LAdd BLAST622

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei495PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1
Modified residuei555Asymmetric dimethylarginineCombined sources1
Modified residuei561Asymmetric dimethylarginineCombined sources1
Modified residuei593Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9Y6J9
MaxQBiQ9Y6J9
PaxDbiQ9Y6J9
PeptideAtlasiQ9Y6J9
PRIDEiQ9Y6J9

PTM databases

iPTMnetiQ9Y6J9
PhosphoSitePlusiQ9Y6J9

Expressioni

Gene expression databases

BgeeiENSG00000162227
CleanExiHS_TAF6L
ExpressionAtlasiQ9Y6J9 baseline and differential
GenevisibleiQ9Y6J9 HS

Organism-specific databases

HPAiHPA067239

Interactioni

Subunit structurei

The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115873, 38 interactors
CORUMiQ9Y6J9
IntActiQ9Y6J9, 14 interactors
MINTiQ9Y6J9
STRINGi9606.ENSP00000294168

Structurei

3D structure databases

ProteinModelPortaliQ9Y6J9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TAF6 family.Curated

Phylogenomic databases

eggNOGiKOG2549 Eukaryota
COG5095 LUCA
GeneTreeiENSGT00640000091486
HOGENOMiHOG000059613
HOVERGENiHBG061566
InParanoidiQ9Y6J9
KOiK03131
OMAiMPQLTAN
OrthoDBiEOG091G05S9
PhylomeDBiQ9Y6J9
TreeFamiTF328731

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR037796 TAF6
IPR011442 TAF6_C
IPR004823 TAF_TATA-bd
PANTHERiPTHR10221 PTHR10221, 1 hit
PfamiView protein in Pfam
PF02969 TAF, 1 hit
PF07571 TAF6_C, 1 hit
SMARTiView protein in SMART
SM00803 TAF, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y6J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEREERRFV EIPRESVRLM AESTGLELSD EVAALLAEDV CYRLREATQN
60 70 80 90 100
SSQFMKHTKR RKLTVEDFNR ALRWSSVEAV CGYGSQEALP MRPAREGELY
110 120 130 140 150
FPEDREVNLV ELALATNIPK GCAETAVRVH VSYLDGKGNL APQGSVPSAV
160 170 180 190 200
SSLTDDLLKY YHQVTRAVLG DDPQLMKVAL QDLQTNSKIG ALLPYFVYVV
210 220 230 240 250
SGVKSVSHDL EQLHRLLQVA RSLFRNPHLC LGPYVRCLVG SVLYCVLEPL
260 270 280 290 300
AASINPLNDH WTLRDGAALL LSHIFWTHGD LVSGLYQHIL LSLQKILADP
310 320 330 340 350
VRPLCCHYGA VVGLHALGWK AVERVLYPHL STYWTNLQAV LDDYSVSNAQ
360 370 380 390 400
VKADGHKVYG AILVAVERLL KMKAQAAEPN RGGPGGRGCR RLDDLPWDSL
410 420 430 440 450
LFQESSSGGG AEPSFGSGLP LPPGGAGPED PSLSVTLADI YRELYAFFGD
460 470 480 490 500
SLATRFGTGQ PAPTAPRPPG DKKEPAAAPD SVRKMPQLTA SAIVSPHGDE
510 520 530 540 550
SPRGSGGGGP ASASGPAASE SRPLPRVHRA RGAPRQQGPG TGTRDVFQKS
560 570 580 590 600
RFAPRGAPHF RFIIAGRQAG RRCRGRLFQT AFPAPYGPSP ASRYVQKLPM
610 620
IGRTSRPARR WALSDYSLYL PL
Length:622
Mass (Da):67,814
Last modified:November 1, 1999 - v1
Checksum:iF294E71AF7D4C8C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069735 mRNA Translation: AAC39905.1
AK314330 mRNA Translation: BAG36977.1
CH471076 Genomic DNA Translation: EAW74093.1
CCDSiCCDS8035.1
RefSeqiNP_006464.1, NM_006473.3
UniGeneiHs.714400

Genome annotation databases

EnsembliENST00000294168; ENSP00000294168; ENSG00000162227
GeneIDi10629
KEGGihsa:10629
UCSCiuc001nvc.4 human

Similar proteinsi

Entry informationi

Entry nameiTAF6L_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6J9
Secondary accession number(s): B2RAT0, Q96HA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health