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Protein

TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

Gene

TAF6L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

  • chromatin remodeling Source: ProtInc
  • DNA-templated transcription, initiation Source: InterPro
  • histone H3 acetylation Source: UniProtKB
  • regulation of sequence-specific DNA binding transcription factor activity Source: InterPro
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
Alternative name(s):
PCAF-associated factor 65-alpha
Short name:
PAF65-alpha
Gene namesi
Name:TAF6L
Synonyms:PAF65A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17305. TAF6L.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • histone deacetylase complex Source: ProtInc
  • STAGA complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38224.

Polymorphism and mutation databases

BioMutaiTAF6L.
DMDMi46577572.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 622622TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6LPRO_0000118879Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei495 – 4951PhosphoserineCombined sources
Modified residuei501 – 5011PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y6J9.
MaxQBiQ9Y6J9.
PaxDbiQ9Y6J9.
PeptideAtlasiQ9Y6J9.
PRIDEiQ9Y6J9.

PTM databases

iPTMnetiQ9Y6J9.
PhosphoSiteiQ9Y6J9.

Expressioni

Gene expression databases

BgeeiENSG00000162227.
CleanExiHS_TAF6L.
ExpressionAtlasiQ9Y6J9. baseline and differential.
GenevisibleiQ9Y6J9. HS.

Organism-specific databases

HPAiHPA067239.

Interactioni

Subunit structurei

The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TAF9Q165946EBI-743984,EBI-712521
TAF9BQ9HBM63EBI-743984,EBI-751601

Protein-protein interaction databases

BioGridi115873. 31 interactions.
IntActiQ9Y6J9. 9 interactions.
MINTiMINT-1456123.
STRINGi9606.ENSP00000294168.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6J9.
SMRiQ9Y6J9. Positions 12-73, 153-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TAF6 family.Curated

Phylogenomic databases

eggNOGiKOG2549. Eukaryota.
COG5095. LUCA.
GeneTreeiENSGT00640000091486.
HOGENOMiHOG000059613.
HOVERGENiHBG061566.
InParanoidiQ9Y6J9.
KOiK03131.
OMAiMPQLTAN.
OrthoDBiEOG091G05S9.
PhylomeDBiQ9Y6J9.
TreeFamiTF328731.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR011442. TAF6_C.
IPR004823. TAF_TATA-bd.
[Graphical view]
PfamiPF02969. TAF. 1 hit.
PF07571. TAF6_C. 1 hit.
[Graphical view]
SMARTiSM00803. TAF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y6J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEREERRFV EIPRESVRLM AESTGLELSD EVAALLAEDV CYRLREATQN
60 70 80 90 100
SSQFMKHTKR RKLTVEDFNR ALRWSSVEAV CGYGSQEALP MRPAREGELY
110 120 130 140 150
FPEDREVNLV ELALATNIPK GCAETAVRVH VSYLDGKGNL APQGSVPSAV
160 170 180 190 200
SSLTDDLLKY YHQVTRAVLG DDPQLMKVAL QDLQTNSKIG ALLPYFVYVV
210 220 230 240 250
SGVKSVSHDL EQLHRLLQVA RSLFRNPHLC LGPYVRCLVG SVLYCVLEPL
260 270 280 290 300
AASINPLNDH WTLRDGAALL LSHIFWTHGD LVSGLYQHIL LSLQKILADP
310 320 330 340 350
VRPLCCHYGA VVGLHALGWK AVERVLYPHL STYWTNLQAV LDDYSVSNAQ
360 370 380 390 400
VKADGHKVYG AILVAVERLL KMKAQAAEPN RGGPGGRGCR RLDDLPWDSL
410 420 430 440 450
LFQESSSGGG AEPSFGSGLP LPPGGAGPED PSLSVTLADI YRELYAFFGD
460 470 480 490 500
SLATRFGTGQ PAPTAPRPPG DKKEPAAAPD SVRKMPQLTA SAIVSPHGDE
510 520 530 540 550
SPRGSGGGGP ASASGPAASE SRPLPRVHRA RGAPRQQGPG TGTRDVFQKS
560 570 580 590 600
RFAPRGAPHF RFIIAGRQAG RRCRGRLFQT AFPAPYGPSP ASRYVQKLPM
610 620
IGRTSRPARR WALSDYSLYL PL
Length:622
Mass (Da):67,814
Last modified:November 1, 1999 - v1
Checksum:iF294E71AF7D4C8C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069735 mRNA. Translation: AAC39905.1.
AK314330 mRNA. Translation: BAG36977.1.
CH471076 Genomic DNA. Translation: EAW74093.1.
CCDSiCCDS8035.1.
RefSeqiNP_006464.1. NM_006473.3.
UniGeneiHs.714400.

Genome annotation databases

EnsembliENST00000294168; ENSP00000294168; ENSG00000162227.
GeneIDi10629.
KEGGihsa:10629.
UCSCiuc001nvc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069735 mRNA. Translation: AAC39905.1.
AK314330 mRNA. Translation: BAG36977.1.
CH471076 Genomic DNA. Translation: EAW74093.1.
CCDSiCCDS8035.1.
RefSeqiNP_006464.1. NM_006473.3.
UniGeneiHs.714400.

3D structure databases

ProteinModelPortaliQ9Y6J9.
SMRiQ9Y6J9. Positions 12-73, 153-333.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115873. 31 interactions.
IntActiQ9Y6J9. 9 interactions.
MINTiMINT-1456123.
STRINGi9606.ENSP00000294168.

PTM databases

iPTMnetiQ9Y6J9.
PhosphoSiteiQ9Y6J9.

Polymorphism and mutation databases

BioMutaiTAF6L.
DMDMi46577572.

Proteomic databases

EPDiQ9Y6J9.
MaxQBiQ9Y6J9.
PaxDbiQ9Y6J9.
PeptideAtlasiQ9Y6J9.
PRIDEiQ9Y6J9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294168; ENSP00000294168; ENSG00000162227.
GeneIDi10629.
KEGGihsa:10629.
UCSCiuc001nvc.4. human.

Organism-specific databases

CTDi10629.
GeneCardsiTAF6L.
HGNCiHGNC:17305. TAF6L.
HPAiHPA067239.
MIMi602946. gene.
neXtProtiNX_Q9Y6J9.
PharmGKBiPA38224.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2549. Eukaryota.
COG5095. LUCA.
GeneTreeiENSGT00640000091486.
HOGENOMiHOG000059613.
HOVERGENiHBG061566.
InParanoidiQ9Y6J9.
KOiK03131.
OMAiMPQLTAN.
OrthoDBiEOG091G05S9.
PhylomeDBiQ9Y6J9.
TreeFamiTF328731.

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.

Miscellaneous databases

ChiTaRSiTAF6L. human.
GeneWikiiTAF6L.
GenomeRNAii10629.
PROiQ9Y6J9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162227.
CleanExiHS_TAF6L.
ExpressionAtlasiQ9Y6J9. baseline and differential.
GenevisibleiQ9Y6J9. HS.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR011442. TAF6_C.
IPR004823. TAF_TATA-bd.
[Graphical view]
PfamiPF02969. TAF. 1 hit.
PF07571. TAF6_C. 1 hit.
[Graphical view]
SMARTiSM00803. TAF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTAF6L_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6J9
Secondary accession number(s): B2RAT0, Q96HA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.