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Protein

Serine/threonine/tyrosine-interacting-like protein 1

Gene

STYXL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable pseudophosphatase. Contains a Ser residue instead of a conserved Cys residue in the dsPTPase catalytic loop which probably renders it catalytically inactive as a phosphatase. The binding pocket may be however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases.

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine/tyrosine-interacting-like protein 1
Alternative name(s):
Dual specificity phosphatase inhibitor MK-STYX
Dual specificity protein phosphatase 24
Map kinase phosphatase-like protein MK-STYX
Gene namesi
Name:STYXL1
Synonyms:DUSP24, MKSTYX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18165. STYXL1.

Subcellular locationi

GO - Cellular componenti

  • intracellular Source: GOC
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134942462.

Polymorphism and mutation databases

BioMutaiSTYXL1.
DMDMi29840801.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Serine/threonine/tyrosine-interacting-like protein 1PRO_0000094837Add
BLAST

Proteomic databases

MaxQBiQ9Y6J8.
PaxDbiQ9Y6J8.
PRIDEiQ9Y6J8.

PTM databases

DEPODiQ9Y6J8.
iPTMnetiQ9Y6J8.
PhosphoSiteiQ9Y6J8.

Expressioni

Gene expression databases

BgeeiQ9Y6J8.
CleanExiHS_STYXL1.
ExpressionAtlasiQ9Y6J8. baseline and differential.
GenevisibleiQ9Y6J8. HS.

Organism-specific databases

HPAiHPA050261.

Interactioni

Protein-protein interaction databases

BioGridi119663. 6 interactions.
STRINGi9606.ENSP00000248600.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6J8.
SMRiQ9Y6J8. Positions 130-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 140124RhodaneseAdd
BLAST
Domaini160 – 301142Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Contains 1 rhodanese domain.Curated

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00390000010113.
HOGENOMiHOG000004828.
HOVERGENiHBG052516.
InParanoidiQ9Y6J8.
KOiK18047.
OMAiLECVRYC.
PhylomeDBiQ9Y6J8.
TreeFamiTF352452.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q9Y6J8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGLLLCEPT ELYNILNQAT KLSRLTDPNY LCLLDVRSKW EYDESHVITA
60 70 80 90 100
LRVKKKNNEY LLPESVDLEC VKYCVVYDNN SSTLEILLKD DDDDSDSDGD
110 120 130 140 150
GKDLVPQAAI EYGRILTRLT HHPVYILKGG YERFSGTYHF LRTQKIIWMP
160 170 180 190 200
QELDAFQPYP IEIVPGKVFV GNFSQACDPK IQKDLKIKAH VNVSMDTGPF
210 220 230 240 250
FAGDADKLLH IRIEDSPEAQ ILPFLRHMCH FIEIHHHLGS VILIFSTQGI
260 270 280 290 300
SRSCAAIIAY LMHSNEQTLQ RSWAYVKKCK NNMCPNRGLV SQLLEWEKTI
310
LGDSITNIMD PLY
Length:313
Mass (Da):35,818
Last modified:November 1, 1999 - v1
Checksum:i5EDB25AB4EB60419
GO
Isoform 2 (identifier: Q9Y6J8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-287: EIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNR → GYQPQLCRHHSLPHA
     288-313: Missing.

Show »
Length:247
Mass (Da):28,330
Checksum:iBE7BE323BED2552D
GO
Isoform 3 (identifier: Q9Y6J8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-313: IHHHLGSVIL...SITNIMDPLY → VLGLCQEVQK...RRRPLLPESL

Show »
Length:318
Mass (Da):36,110
Checksum:i1C1DEC7DF8E9B493
GO
Isoform 4 (identifier: Q9Y6J8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-151: Missing.

Show »
Length:217
Mass (Da):24,752
Checksum:iDC1D778045C40929
GO
Isoform 5 (identifier: Q9Y6J8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     103-138: DLVPQAAIEYGRILTRLTHHPVYILKGGYERFSGTY → GTGCISAIP
     139-313: Missing.

Show »
Length:111
Mass (Da):12,475
Checksum:i42E0DCD053A70068
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei56 – 15196Missing in isoform 4. CuratedVSP_005175Add
BLAST
Alternative sequencei103 – 13836DLVPQ…FSGTY → GTGCISAIP in isoform 5. CuratedVSP_005176Add
BLAST
Alternative sequencei139 – 313175Missing in isoform 5. CuratedVSP_005177Add
BLAST
Alternative sequencei233 – 28755EIHHH…MCPNR → GYQPQLCRHHSLPHA in isoform 2. CuratedVSP_005178Add
BLAST
Alternative sequencei234 – 31380IHHHL…MDPLY → VLGLCQEVQKQHVSKSGIGE PAAGMGEDYPWRFHHKHHGS ALLIFSEAHRRVLKSLTWGH FVGGGPECVYPGLSGRRRPL LPESL in isoform 3. CuratedVSP_005180Add
BLAST
Alternative sequencei288 – 31326Missing in isoform 2. CuratedVSP_005179Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069762 mRNA. Translation: AAD36983.1.
AC006330 Genomic DNA. Translation: AAS07535.1.
BC024035 mRNA. Translation: AAH24035.1.
AF188201 mRNA. Translation: AAF04111.1.
AF188202 mRNA. Translation: AAF04112.1.
AF188203 mRNA. Translation: AAF04113.1.
AF188204 mRNA. Translation: AAF04114.1.
AF169647 mRNA. Translation: AAD53723.1.
AF169648 mRNA. Translation: AAD53724.1.
CCDSiCCDS5580.1. [Q9Y6J8-1]
RefSeqiNP_001304714.1. NM_001317785.1. [Q9Y6J8-1]
NP_001304715.1. NM_001317786.1. [Q9Y6J8-1]
NP_001304716.1. NM_001317787.1. [Q9Y6J8-4]
NP_001304717.1. NM_001317788.1.
NP_001304718.1. NM_001317789.1.
NP_057170.1. NM_016086.2. [Q9Y6J8-1]
XP_011514595.1. XM_011516293.1. [Q9Y6J8-1]
XP_011514598.1. XM_011516296.1. [Q9Y6J8-2]
UniGeneiHs.11615.

Genome annotation databases

EnsembliENST00000248600; ENSP00000248600; ENSG00000127952. [Q9Y6J8-1]
ENST00000340062; ENSP00000343383; ENSG00000127952. [Q9Y6J8-4]
ENST00000359697; ENSP00000352726; ENSG00000127952. [Q9Y6J8-1]
ENST00000360591; ENSP00000353798; ENSG00000127952. [Q9Y6J8-4]
ENST00000431581; ENSP00000392221; ENSG00000127952. [Q9Y6J8-1]
GeneIDi51657.
KEGGihsa:51657.
UCSCiuc003uek.5. human. [Q9Y6J8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069762 mRNA. Translation: AAD36983.1.
AC006330 Genomic DNA. Translation: AAS07535.1.
BC024035 mRNA. Translation: AAH24035.1.
AF188201 mRNA. Translation: AAF04111.1.
AF188202 mRNA. Translation: AAF04112.1.
AF188203 mRNA. Translation: AAF04113.1.
AF188204 mRNA. Translation: AAF04114.1.
AF169647 mRNA. Translation: AAD53723.1.
AF169648 mRNA. Translation: AAD53724.1.
CCDSiCCDS5580.1. [Q9Y6J8-1]
RefSeqiNP_001304714.1. NM_001317785.1. [Q9Y6J8-1]
NP_001304715.1. NM_001317786.1. [Q9Y6J8-1]
NP_001304716.1. NM_001317787.1. [Q9Y6J8-4]
NP_001304717.1. NM_001317788.1.
NP_001304718.1. NM_001317789.1.
NP_057170.1. NM_016086.2. [Q9Y6J8-1]
XP_011514595.1. XM_011516293.1. [Q9Y6J8-1]
XP_011514598.1. XM_011516296.1. [Q9Y6J8-2]
UniGeneiHs.11615.

3D structure databases

ProteinModelPortaliQ9Y6J8.
SMRiQ9Y6J8. Positions 130-301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119663. 6 interactions.
STRINGi9606.ENSP00000248600.

PTM databases

DEPODiQ9Y6J8.
iPTMnetiQ9Y6J8.
PhosphoSiteiQ9Y6J8.

Polymorphism and mutation databases

BioMutaiSTYXL1.
DMDMi29840801.

Proteomic databases

MaxQBiQ9Y6J8.
PaxDbiQ9Y6J8.
PRIDEiQ9Y6J8.

Protocols and materials databases

DNASUi51657.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248600; ENSP00000248600; ENSG00000127952. [Q9Y6J8-1]
ENST00000340062; ENSP00000343383; ENSG00000127952. [Q9Y6J8-4]
ENST00000359697; ENSP00000352726; ENSG00000127952. [Q9Y6J8-1]
ENST00000360591; ENSP00000353798; ENSG00000127952. [Q9Y6J8-4]
ENST00000431581; ENSP00000392221; ENSG00000127952. [Q9Y6J8-1]
GeneIDi51657.
KEGGihsa:51657.
UCSCiuc003uek.5. human. [Q9Y6J8-1]

Organism-specific databases

CTDi51657.
GeneCardsiSTYXL1.
HGNCiHGNC:18165. STYXL1.
HPAiHPA050261.
neXtProtiNX_Q9Y6J8.
PharmGKBiPA134942462.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00390000010113.
HOGENOMiHOG000004828.
HOVERGENiHBG052516.
InParanoidiQ9Y6J8.
KOiK18047.
OMAiLECVRYC.
PhylomeDBiQ9Y6J8.
TreeFamiTF352452.

Miscellaneous databases

ChiTaRSiSTYXL1. human.
GeneWikiiSTYXL1.
GenomeRNAii51657.
PROiQ9Y6J8.

Gene expression databases

BgeeiQ9Y6J8.
CleanExiHS_STYXL1.
ExpressionAtlasiQ9Y6J8. baseline and differential.
GenevisibleiQ9Y6J8. HS.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains."
    Wishart M.J., Dixon J.E.
    Trends Biochem. Sci. 23:301-306(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  4. Walker L.C., Morris C.M.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 46-313 (ISOFORMS 3; 4 AND 5).
  5. "Differential expression of PTPase RNAs resulting from K562 differentiation induced by PMA."
    Dayton M.A., Blanchard K.L.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 149-313 (ISOFORMS 2 AND 3).

Entry informationi

Entry nameiSTYL1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6J8
Secondary accession number(s): Q9UBP1
, Q9UK06, Q9UK07, Q9UKG2, Q9UKG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.