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Protein

Testis-expressed sequence 264 protein

Gene

TEX264

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-expressed sequence 264 protein
Alternative name(s):
Putative secreted protein Zsig11
Gene namesi
Name:TEX264
Synonyms:ZSIG11
ORF Names:UNQ337/PRO536
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30247. TEX264.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134875244.

Polymorphism and mutation databases

BioMutaiTEX264.
DMDMi22002027.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence analysisAdd
BLAST
Chaini33 – 313281Testis-expressed sequence 264 proteinPRO_0000022601Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi45 – 451N-linked (GlcNAc...)Sequence analysis
Modified residuei239 – 2391PhosphoserineCombined sources
Modified residuei244 – 2441PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9Y6I9.
MaxQBiQ9Y6I9.
PaxDbiQ9Y6I9.
PRIDEiQ9Y6I9.
TopDownProteomicsiQ9Y6I9.

PTM databases

iPTMnetiQ9Y6I9.
PhosphoSiteiQ9Y6I9.
SwissPalmiQ9Y6I9.

Expressioni

Gene expression databases

BgeeiQ9Y6I9.
CleanExiHS_TEX264.
ExpressionAtlasiQ9Y6I9. baseline and differential.
GenevisibleiQ9Y6I9. HS.

Organism-specific databases

HPAiCAB005002.
HPA017739.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TMEM79Q9BSE23EBI-10329860,EBI-8649725

Protein-protein interaction databases

BioGridi119503. 43 interactions.
IntActiQ9Y6I9. 3 interactions.
STRINGi9606.ENSP00000340969.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6I9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJI6. Eukaryota.
ENOG4111NB9. LUCA.
GeneTreeiENSGT00390000016901.
HOGENOMiHOG000065678.
HOVERGENiHBG059535.
InParanoidiQ9Y6I9.
OMAiAYKFHVG.
PhylomeDBiQ9Y6I9.
TreeFamiTF328465.

Family and domain databases

Gene3Di3.20.80.10. 1 hit.
InterProiIPR011256. Reg_factor_effector_dom.
[Graphical view]
SUPFAMiSSF55136. SSF55136. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLLLLGLI GGLTLLLLLT LLAFAGYSGL LAGVEVSAGS PPIRNVTVAY
60 70 80 90 100
KFHMGLYGET GRLFTESCSI SPKLRSIAVY YDNPHMVPPD KCRCAVGSIL
110 120 130 140 150
SEGEESPSPE LIDLYQKFGF KVFSFPAPSH VVTATFPYTT ILSIWLATRR
160 170 180 190 200
VHPALDTYIK ERKLCAYPRL EIYQEDQIHF MCPLARQGDF YVPEMKETEW
210 220 230 240 250
KWRGLVEAID TQVDGTGADT MSDTSSVSLE VSPGSRETSA ATLSPGASSR
260 270 280 290 300
GWDDGDTRSE HSYSESGASG SSFEELDLEG EGPLGESRLD PGTEPLGTTK
310
WLWEPTAPEK GKE
Length:313
Mass (Da):34,189
Last modified:November 1, 1999 - v1
Checksum:i6159011A220F1C67
GO

Sequence cautioni

The sequence AAD52584.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti292 – 2921G → E.
Corresponds to variant rs11553574 [ dbSNP | Ensembl ].
VAR_061718

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072733 mRNA. Translation: AAD22397.1.
AY358972 mRNA. Translation: AAQ89331.1.
AK023997 mRNA. Translation: BAG51249.1.
CH471055 Genomic DNA. Translation: EAW65146.1.
BC008742 mRNA. Translation: AAH08742.1.
AF172327 mRNA. Translation: AAD52584.1. Different initiation.
CCDSiCCDS2833.1.
RefSeqiNP_001123356.1. NM_001129884.2.
NP_001230654.1. NM_001243725.1.
NP_001230655.1. NM_001243726.1.
NP_001230656.1. NM_001243727.2.
NP_001265124.1. NM_001278195.1.
NP_057010.1. NM_015926.5.
XP_006713258.1. XM_006713195.2.
XP_006713259.1. XM_006713196.2.
XP_006713260.1. XM_006713197.2.
XP_011532107.1. XM_011533805.1.
UniGeneiHs.517864.
Hs.733397.

Genome annotation databases

EnsembliENST00000341333; ENSP00000340969; ENSG00000164081.
ENST00000395057; ENSP00000378497; ENSG00000164081.
ENST00000415259; ENSP00000396628; ENSG00000164081.
ENST00000416589; ENSP00000398802; ENSG00000164081.
ENST00000457573; ENSP00000408186; ENSG00000164081.
ENST00000611400; ENSP00000477946; ENSG00000164081.
GeneIDi51368.
KEGGihsa:51368.
UCSCiuc003dbk.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072733 mRNA. Translation: AAD22397.1.
AY358972 mRNA. Translation: AAQ89331.1.
AK023997 mRNA. Translation: BAG51249.1.
CH471055 Genomic DNA. Translation: EAW65146.1.
BC008742 mRNA. Translation: AAH08742.1.
AF172327 mRNA. Translation: AAD52584.1. Different initiation.
CCDSiCCDS2833.1.
RefSeqiNP_001123356.1. NM_001129884.2.
NP_001230654.1. NM_001243725.1.
NP_001230655.1. NM_001243726.1.
NP_001230656.1. NM_001243727.2.
NP_001265124.1. NM_001278195.1.
NP_057010.1. NM_015926.5.
XP_006713258.1. XM_006713195.2.
XP_006713259.1. XM_006713196.2.
XP_006713260.1. XM_006713197.2.
XP_011532107.1. XM_011533805.1.
UniGeneiHs.517864.
Hs.733397.

3D structure databases

ProteinModelPortaliQ9Y6I9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119503. 43 interactions.
IntActiQ9Y6I9. 3 interactions.
STRINGi9606.ENSP00000340969.

PTM databases

iPTMnetiQ9Y6I9.
PhosphoSiteiQ9Y6I9.
SwissPalmiQ9Y6I9.

Polymorphism and mutation databases

BioMutaiTEX264.
DMDMi22002027.

Proteomic databases

EPDiQ9Y6I9.
MaxQBiQ9Y6I9.
PaxDbiQ9Y6I9.
PRIDEiQ9Y6I9.
TopDownProteomicsiQ9Y6I9.

Protocols and materials databases

DNASUi51368.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341333; ENSP00000340969; ENSG00000164081.
ENST00000395057; ENSP00000378497; ENSG00000164081.
ENST00000415259; ENSP00000396628; ENSG00000164081.
ENST00000416589; ENSP00000398802; ENSG00000164081.
ENST00000457573; ENSP00000408186; ENSG00000164081.
ENST00000611400; ENSP00000477946; ENSG00000164081.
GeneIDi51368.
KEGGihsa:51368.
UCSCiuc003dbk.6. human.

Organism-specific databases

CTDi51368.
GeneCardsiTEX264.
HGNCiHGNC:30247. TEX264.
HPAiCAB005002.
HPA017739.
neXtProtiNX_Q9Y6I9.
PharmGKBiPA134875244.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJI6. Eukaryota.
ENOG4111NB9. LUCA.
GeneTreeiENSGT00390000016901.
HOGENOMiHOG000065678.
HOVERGENiHBG059535.
InParanoidiQ9Y6I9.
OMAiAYKFHVG.
PhylomeDBiQ9Y6I9.
TreeFamiTF328465.

Miscellaneous databases

ChiTaRSiTEX264. human.
GenomeRNAii51368.
PROiQ9Y6I9.

Gene expression databases

BgeeiQ9Y6I9.
CleanExiHS_TEX264.
ExpressionAtlasiQ9Y6I9. baseline and differential.
GenevisibleiQ9Y6I9. HS.

Family and domain databases

Gene3Di3.20.80.10. 1 hit.
InterProiIPR011256. Reg_factor_effector_dom.
[Graphical view]
SUPFAMiSSF55136. SSF55136. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Sheppard P., Sexson S., Jelinek L., Whitmore T., Grant F., O'Hara P.J.
    Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  6. "New sequences cloned from adult brain cDNA library."
    Deng Y.C., Yao L.B., Su C.Z., Lui X.P., Nie X.Y., Wang J.C., Zhang X.G., Yang M., Ji S.P., Li F.Y., Han J., Han Y.H., He P.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 212-313.
    Tissue: Brain.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-239 AND SER-244, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTX264_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6I9
Secondary accession number(s): B3KN87, Q9UKD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.