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Protein

Peroxisomal membrane protein 4

Gene

PXMP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Hypermethylation-mediated silencing of PXMP4 may be involved in prostate carcinogenesis. PXMP4 undergoes hypermethylation and silencing during the transition of prostate adenocarcinoma cells from androgen dependence to androgen independence.

Protein family/group databases

TCDBi1.B.69.1.1 the peroxysomal membrane porin 4 (pxmp4) family

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein 4
Alternative name(s):
24 kDa peroxisomal intrinsic membrane protein
Gene namesi
Name:PXMP4
Synonyms:PMP24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000101417.11
HGNCiHGNC:15920 PXMP4
MIMi616397 gene
neXtProtiNX_Q9Y6I8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Organism-specific databases

DisGeNETi11264
OpenTargetsiENSG00000101417
PharmGKBiPA34061

Polymorphism and mutation databases

BioMutaiPXMP4
DMDMi29840804

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189321 – 212Peroxisomal membrane protein 4Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y6I8
PaxDbiQ9Y6I8
PeptideAtlasiQ9Y6I8
PRIDEiQ9Y6I8
ProteomicsDBi86696
86697 [Q9Y6I8-2]

PTM databases

iPTMnetiQ9Y6I8
PhosphoSitePlusiQ9Y6I8

Expressioni

Tissue specificityi

Expressed in normal prostate epithelial cells, and androgen-sensitive prostate adenocarcinoma cells. Not expressed in androgen-insensitive prostate adenocarcinoma cells.1 Publication

Gene expression databases

BgeeiENSG00000101417
CleanExiHS_PXMP4
ExpressionAtlasiQ9Y6I8 baseline and differential
GenevisibleiQ9Y6I8 HS

Organism-specific databases

HPAiHPA050077

Interactioni

Subunit structurei

Interacts with PEX19.2 Publications

Protein-protein interaction databases

BioGridi116423, 1 interactor
IntActiQ9Y6I8, 1 interactor
STRINGi9606.ENSP00000386385

Structurei

3D structure databases

ProteinModelPortaliQ9Y6I8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIYG Eukaryota
ENOG410ZE52 LUCA
GeneTreeiENSGT00390000001562
HOGENOMiHOG000230881
HOVERGENiHBG053773
InParanoidiQ9Y6I8
KOiK13350
OMAiYTHSRNL
OrthoDBiEOG091G0K56
PhylomeDBiQ9Y6I8
TreeFamiTF105313

Family and domain databases

InterProiView protein in InterPro
IPR019531 Pmp4
PANTHERiPTHR15460 PTHR15460, 1 hit
PIRSFiPIRSF013674 PXMP4, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y6I8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPPQLRAL LVVVNALLRK RRYHAALAVL KGFRNGAVYG AKIRAPHALV
60 70 80 90 100
MTFLFRNGSL QEKLWAILQA TYIHSWNLAR FVFTYKGLRA LQSYIQGKTY
110 120 130 140 150
PAHAFLAAFL GGILVFGENN NINSQINMYL LSRVLFALSR LAVEKGYIPE
160 170 180 190 200
PRWDPFPLLT AVVWGLVLWL FEYHRSTLQP SLQSSMTYLY EDSNVWHDIS
210
DFLVYNKSRP SN
Length:212
Mass (Da):24,264
Last modified:January 23, 2007 - v3
Checksum:iEE4DDA4B9BD16401
GO
Isoform 2 (identifier: Q9Y6I8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-71: SLQEKLWAILQAT → RSTCTCCHASCLP
     72-212: Missing.

Show »
Length:71
Mass (Da):7,763
Checksum:iB93B120C6EA15A9C
GO

Sequence cautioni

Isoform 2 : The sequence AK297018 differs from that shown. a conflict in position 70Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015426204V → I2 PublicationsCorresponds to variant dbSNP:rs910397Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04121759 – 71SLQEK…ILQAT → RSTCTCCHASCLP in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_04121872 – 212Missing in isoform 2. 1 PublicationAdd BLAST141

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072864 mRNA Translation: AAD43195.1
AL136648 mRNA Translation: CAB66583.1
AK297018 mRNA No translation available.
AL050349 Genomic DNA No translation available.
BC001147 mRNA Translation: AAH01147.1
CCDSiCCDS13225.1 [Q9Y6I8-1]
CCDS13226.1 [Q9Y6I8-2]
RefSeqiNP_009169.3, NM_007238.4 [Q9Y6I8-1]
NP_899634.1, NM_183397.2 [Q9Y6I8-2]
UniGeneiHs.654857

Genome annotation databases

EnsembliENST00000344022; ENSP00000343071; ENSG00000101417 [Q9Y6I8-2]
ENST00000409299; ENSP00000386385; ENSG00000101417 [Q9Y6I8-1]
GeneIDi11264
KEGGihsa:11264
UCSCiuc002wzv.4 human [Q9Y6I8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPXMP4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6I8
Secondary accession number(s): A2A2I7, Q9H0T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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