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Protein

Peroxisomal membrane protein 4

Gene

PXMP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

Hypermethylation-mediated silencing of PXMP4 may be involved in prostate carcinogenesis. PXMP4 undergoes hypermethylation and silencing during the transition of prostate adenocarcinoma cells from androgen dependence to androgen independence.

Protein family/group databases

TCDBi1.B.69.1.1. the peroxysomal membrane porin 4 (pxmp4) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal membrane protein 4
Alternative name(s):
24 kDa peroxisomal intrinsic membrane protein
Gene namesi
Name:PXMP4
Synonyms:PMP24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15920. PXMP4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei153 – 173HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • peroxisomal membrane Source: UniProtKB
  • peroxisome Source: LIFEdb

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Organism-specific databases

DisGeNETi11264.
OpenTargetsiENSG00000101417.
PharmGKBiPA34061.

Polymorphism and mutation databases

BioMutaiPXMP4.
DMDMi29840804.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189321 – 212Peroxisomal membrane protein 4Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y6I8.
PaxDbiQ9Y6I8.
PeptideAtlasiQ9Y6I8.
PRIDEiQ9Y6I8.

PTM databases

iPTMnetiQ9Y6I8.
PhosphoSitePlusiQ9Y6I8.

Expressioni

Tissue specificityi

Expressed in normal prostate epithelial cells, and androgen-sensitive prostate adenocarcinoma cells. Not expressed in androgen-insensitive prostate adenocarcinoma cells.1 Publication

Gene expression databases

BgeeiENSG00000101417.
CleanExiHS_PXMP4.
ExpressionAtlasiQ9Y6I8. baseline and differential.
GenevisibleiQ9Y6I8. HS.

Organism-specific databases

HPAiHPA050077.

Interactioni

Subunit structurei

Interacts with PEX19.2 Publications

Protein-protein interaction databases

BioGridi116423. 1 interactor.
IntActiQ9Y6I8. 1 interactor.
MINTiMINT-2824156.
STRINGi9606.ENSP00000386385.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6I8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIYG. Eukaryota.
ENOG410ZE52. LUCA.
GeneTreeiENSGT00390000001562.
HOGENOMiHOG000230881.
HOVERGENiHBG053773.
InParanoidiQ9Y6I8.
KOiK13350.
OMAiYTHSRNL.
OrthoDBiEOG091G0K56.
PhylomeDBiQ9Y6I8.
TreeFamiTF105313.

Family and domain databases

InterProiView protein in InterPro
IPR019531. Pmp4.
IPR003397. Tim17/Tim22/Tim23/PMP24.
PfamiView protein in Pfam
PF02466. Tim17. 1 hit.
PIRSFiPIRSF013674. PXMP4. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y6I8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPPQLRAL LVVVNALLRK RRYHAALAVL KGFRNGAVYG AKIRAPHALV
60 70 80 90 100
MTFLFRNGSL QEKLWAILQA TYIHSWNLAR FVFTYKGLRA LQSYIQGKTY
110 120 130 140 150
PAHAFLAAFL GGILVFGENN NINSQINMYL LSRVLFALSR LAVEKGYIPE
160 170 180 190 200
PRWDPFPLLT AVVWGLVLWL FEYHRSTLQP SLQSSMTYLY EDSNVWHDIS
210
DFLVYNKSRP SN
Length:212
Mass (Da):24,264
Last modified:January 23, 2007 - v3
Checksum:iEE4DDA4B9BD16401
GO
Isoform 2 (identifier: Q9Y6I8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-71: SLQEKLWAILQAT → RSTCTCCHASCLP
     72-212: Missing.

Show »
Length:71
Mass (Da):7,763
Checksum:iB93B120C6EA15A9C
GO

Sequence cautioni

Isoform 2 : The sequence AK297018 differs from that shown. a conflict in position 70Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015426204V → I2 PublicationsCorresponds to variant dbSNP:rs910397Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04121759 – 71SLQEK…ILQAT → RSTCTCCHASCLP in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_04121872 – 212Missing in isoform 2. 1 PublicationAdd BLAST141

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072864 mRNA. Translation: AAD43195.1.
AL136648 mRNA. Translation: CAB66583.1.
AK297018 mRNA. No translation available.
AL050349 Genomic DNA. Translation: CAC14086.1.
AL050349 Genomic DNA. Translation: CAM28271.1.
BC001147 mRNA. Translation: AAH01147.1.
CCDSiCCDS13225.1. [Q9Y6I8-1]
CCDS13226.1. [Q9Y6I8-2]
RefSeqiNP_009169.3. NM_007238.4. [Q9Y6I8-1]
NP_899634.1. NM_183397.2. [Q9Y6I8-2]
UniGeneiHs.654857.

Genome annotation databases

EnsembliENST00000344022; ENSP00000343071; ENSG00000101417. [Q9Y6I8-2]
ENST00000409299; ENSP00000386385; ENSG00000101417. [Q9Y6I8-1]
GeneIDi11264.
KEGGihsa:11264.
UCSCiuc002wzv.4. human. [Q9Y6I8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPXMP4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6I8
Secondary accession number(s): A2A2I7, Q9H0T4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families