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Q9Y6H3 (ATP23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial inner membrane protease ATP23 homolog

EC=3.4.24.-
Alternative name(s):
Ku70-binding protein 3
XRCC6-binding protein 1
Gene names
Name:XRCC6BP1
Synonyms:KUB3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with XRCC6. Ref.1

Sequence similarities

Belongs to the peptidase M76 family.

Sequence caution

The sequence AAD31085.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Mitochondrial inner membrane protease ATP23 homolog
PRO_0000330344

Sites

Active site1261 By similarity
Metal binding1251Divalent metal cation; catalytic By similarity
Metal binding1291Divalent metal cation; catalytic By similarity

Natural variations

Natural variant481S → C. Ref.1
Corresponds to variant rs3751325 [ dbSNP | Ensembl ].
VAR_054489

Sequences

Sequence LengthMass (Da)Tools
Q9Y6H3 [UniParc].

Last modified March 3, 2009. Version 3.
Checksum: A9541CBEA299A35F

FASTA24628,081
        10         20         30         40         50         60 
MAGAPDERRR GPAAGEQLQQ QHVSCQVFPE RLAQGNPQQG FFSSFFTSNQ KCQLRLLKTL 

        70         80         90        100        110        120 
ETNPYVKLLL DAMKHSGCAV NKDRHFSCED CNGNVSGGFD ASTSQIVLCQ NNIHNQAHMN 

       130        140        150        160        170        180 
RVVTHELIHA FDHCRAHVDW FTNIRHLACS EVRAANLSGD CSLVNEIFRL HFGLKQHHQT 

       190        200        210        220        230        240 
CVRDRATLSI LAVRNISKEV AKKAVDEVFE SCFNDHEPFG RIPHNKTYAR YAHRDFENRD 


RYYSNI 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of Ku70-binding proteins (KUBs)."
Yang C.-R., Yeh S.-Y., Leskov K., Odegaard E., Hsu H.L., Chang C., Kinsella T.J., Chen D.J., Boothman D.A.
Nucleic Acids Res. 27:2165-2174(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT CYS-48, INTERACTION WITH XRCC6.
Tissue: Liver.
[2]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF078164 mRNA. Translation: AAD31085.1. Different initiation.
AC084033 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97091.1.
BC012776 mRNA. Translation: AAH12776.3.
BC115381 mRNA. Translation: AAI15382.1.
BC115382 mRNA. Translation: AAI15383.1.
RefSeqNP_150592.1. NM_033276.2.
UniGeneHs.61188.

3D structure databases

ProteinModelPortalQ9Y6H3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124830. 1 interaction.
STRING9606.ENSP00000300145.

Protein family/group databases

MEROPSM76.001.

PTM databases

PhosphoSiteQ9Y6H3.

Polymorphism databases

DMDM224471894.

Proteomic databases

PaxDbQ9Y6H3.
PRIDEQ9Y6H3.

Protocols and materials databases

DNASU91419.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000300145; ENSP00000300145; ENSG00000166896.
ENST00000571490; ENSP00000460944; ENSG00000262145.
GeneID91419.
KEGGhsa:91419.
UCSCuc001sqp.3. human.

Organism-specific databases

CTD91419.
GeneCardsGC12P058335.
H-InvDBHIX0010758.
HGNCHGNC:29452. XRCC6BP1.
HPAHPA035804.
neXtProtNX_Q9Y6H3.
PharmGKBPA142670557.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG285435.
HOGENOMHOG000244058.
HOVERGENHBG055037.
InParanoidQ9Y6H3.
OMAVDWFTNI.
PhylomeDBQ9Y6H3.
TreeFamTF327014.

Gene expression databases

BgeeQ9Y6H3.
CleanExHS_XRCC6BP1.
GenevestigatorQ9Y6H3.

Family and domain databases

InterProIPR019165. Peptidase_M76_ATP23.
[Graphical view]
PfamPF09768. Peptidase_M76. 1 hit.
[Graphical view]
PROSITEPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi91419.
NextBio77237.
PROQ9Y6H3.

Entry information

Entry nameATP23_HUMAN
AccessionPrimary (citable) accession number: Q9Y6H3
Secondary accession number(s): Q1RLM4, Q96E81
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 3, 2009
Last modified: April 16, 2014
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM