Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y6H3

- ATP23_HUMAN

UniProt

Q9Y6H3 - ATP23_HUMAN

Protein

Mitochondrial inner membrane protease ATP23 homolog

Gene

XRCC6BP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 3 (03 Mar 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi125 – 1251Divalent metal cation; catalyticBy similarity
    Active sitei126 – 1261PROSITE-ProRule annotation
    Metal bindingi129 – 1291Divalent metal cation; catalyticBy similarity

    GO - Molecular functioni

    1. DNA-dependent protein kinase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. metalloendopeptidase activity Source: InterPro

    GO - Biological processi

    1. double-strand break repair via nonhomologous end joining Source: UniProtKB
    2. protein phosphorylation Source: GOC

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding

    Protein family/group databases

    MEROPSiM76.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial inner membrane protease ATP23 homolog (EC:3.4.24.-)
    Alternative name(s):
    Ku70-binding protein 3
    XRCC6-binding protein 1
    Gene namesi
    Name:XRCC6BP1
    Synonyms:KUB3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:29452. XRCC6BP1.

    Subcellular locationi

    GO - Cellular componenti

    1. DNA-dependent protein kinase-DNA ligase 4 complex Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670557.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Mitochondrial inner membrane protease ATP23 homologPRO_0000330344Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y6H3.
    PaxDbiQ9Y6H3.
    PRIDEiQ9Y6H3.

    PTM databases

    PhosphoSiteiQ9Y6H3.

    Expressioni

    Gene expression databases

    BgeeiQ9Y6H3.
    CleanExiHS_XRCC6BP1.
    GenevestigatoriQ9Y6H3.

    Organism-specific databases

    HPAiHPA035804.

    Interactioni

    Subunit structurei

    Interacts with XRCC6.1 Publication

    Protein-protein interaction databases

    BioGridi124830. 1 interaction.
    STRINGi9606.ENSP00000300145.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y6H3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M76 family.Curated

    Phylogenomic databases

    eggNOGiNOG285435.
    HOGENOMiHOG000244058.
    HOVERGENiHBG055037.
    InParanoidiQ9Y6H3.
    KOiK18156.
    OMAiRTPMVKF.
    PhylomeDBiQ9Y6H3.
    TreeFamiTF327014.

    Family and domain databases

    InterProiIPR019165. Peptidase_M76_ATP23.
    [Graphical view]
    PfamiPF09768. Peptidase_M76. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y6H3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGAPDERRR GPAAGEQLQQ QHVSCQVFPE RLAQGNPQQG FFSSFFTSNQ    50
    KCQLRLLKTL ETNPYVKLLL DAMKHSGCAV NKDRHFSCED CNGNVSGGFD 100
    ASTSQIVLCQ NNIHNQAHMN RVVTHELIHA FDHCRAHVDW FTNIRHLACS 150
    EVRAANLSGD CSLVNEIFRL HFGLKQHHQT CVRDRATLSI LAVRNISKEV 200
    AKKAVDEVFE SCFNDHEPFG RIPHNKTYAR YAHRDFENRD RYYSNI 246
    Length:246
    Mass (Da):28,081
    Last modified:March 3, 2009 - v3
    Checksum:iA9541CBEA299A35F
    GO

    Sequence cautioni

    The sequence AAD31085.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti48 – 481S → C.1 Publication
    Corresponds to variant rs3751325 [ dbSNP | Ensembl ].
    VAR_054489

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF078164 mRNA. Translation: AAD31085.1. Different initiation.
    AC084033 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW97091.1.
    BC012776 mRNA. Translation: AAH12776.3.
    BC115381 mRNA. Translation: AAI15382.1.
    BC115382 mRNA. Translation: AAI15383.1.
    CCDSiCCDS41802.1.
    RefSeqiNP_150592.1. NM_033276.2.
    UniGeneiHs.61188.

    Genome annotation databases

    EnsembliENST00000300145; ENSP00000300145; ENSG00000166896.
    ENST00000571490; ENSP00000460944; ENSG00000262145.
    GeneIDi91419.
    KEGGihsa:91419.
    UCSCiuc001sqp.3. human.

    Polymorphism databases

    DMDMi224471894.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF078164 mRNA. Translation: AAD31085.1 . Different initiation.
    AC084033 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW97091.1 .
    BC012776 mRNA. Translation: AAH12776.3 .
    BC115381 mRNA. Translation: AAI15382.1 .
    BC115382 mRNA. Translation: AAI15383.1 .
    CCDSi CCDS41802.1.
    RefSeqi NP_150592.1. NM_033276.2.
    UniGenei Hs.61188.

    3D structure databases

    ProteinModelPortali Q9Y6H3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124830. 1 interaction.
    STRINGi 9606.ENSP00000300145.

    Protein family/group databases

    MEROPSi M76.001.

    PTM databases

    PhosphoSitei Q9Y6H3.

    Polymorphism databases

    DMDMi 224471894.

    Proteomic databases

    MaxQBi Q9Y6H3.
    PaxDbi Q9Y6H3.
    PRIDEi Q9Y6H3.

    Protocols and materials databases

    DNASUi 91419.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300145 ; ENSP00000300145 ; ENSG00000166896 .
    ENST00000571490 ; ENSP00000460944 ; ENSG00000262145 .
    GeneIDi 91419.
    KEGGi hsa:91419.
    UCSCi uc001sqp.3. human.

    Organism-specific databases

    CTDi 91419.
    GeneCardsi GC12P058335.
    H-InvDB HIX0010758.
    HGNCi HGNC:29452. XRCC6BP1.
    HPAi HPA035804.
    neXtProti NX_Q9Y6H3.
    PharmGKBi PA142670557.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG285435.
    HOGENOMi HOG000244058.
    HOVERGENi HBG055037.
    InParanoidi Q9Y6H3.
    KOi K18156.
    OMAi RTPMVKF.
    PhylomeDBi Q9Y6H3.
    TreeFami TF327014.

    Miscellaneous databases

    GenomeRNAii 91419.
    NextBioi 77237.
    PROi Q9Y6H3.

    Gene expression databases

    Bgeei Q9Y6H3.
    CleanExi HS_XRCC6BP1.
    Genevestigatori Q9Y6H3.

    Family and domain databases

    InterProi IPR019165. Peptidase_M76_ATP23.
    [Graphical view ]
    Pfami PF09768. Peptidase_M76. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT CYS-48, INTERACTION WITH XRCC6.
      Tissue: Liver.
    2. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiATP23_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y6H3
    Secondary accession number(s): Q1RLM4, Q96E81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 84 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3