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Protein

Cytoplasmic dynein 1 light intermediate chain 1

Gene

DYNC1LI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 81ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • dynein heavy chain binding Source: FlyBase
  • GDP binding Source: FlyBase
  • microtubule motor activity Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Host-virus interaction, Mitosis, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144635-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic dynein 1 light intermediate chain 1
Short name:
LIC1
Alternative name(s):
Dynein light chain A
Short name:
DLC-A
Dynein light intermediate chain 1, cytosolic
Gene namesi
Name:DYNC1LI1
Synonyms:DNCLI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18745. DYNC1LI1.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • condensed chromosome kinetochore Source: UniProtKB-SubCell
  • cytoplasm Source: HPA
  • cytoplasmic dynein complex Source: UniProtKB
  • kinetochore Source: UniProtKB
  • membrane Source: UniProtKB
  • microtubule Source: UniProtKB-KW
  • nucleoplasm Source: HPA
  • plasma membrane Source: HPA
  • spindle pole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Dynein, Kinetochore, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi51143.
OpenTargetsiENSG00000144635.
PharmGKBiPA38670.

Polymorphism and mutation databases

BioMutaiDYNC1LI1.
DMDMi134047749.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001146661 – 523Cytoplasmic dynein 1 light intermediate chain 1Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei207PhosphoserineCombined sources1 Publication1
Modified residuei213PhosphothreonineCombined sources1
Modified residuei398PhosphoserineCombined sources1 Publication1
Modified residuei405PhosphoserineCombined sources1 Publication1
Modified residuei408PhosphothreonineCombined sources1 Publication1
Modified residuei412PhosphoserineCombined sources1
Modified residuei419PhosphoserineCombined sources1
Modified residuei421PhosphoserineCombined sources1
Modified residuei427PhosphoserineCombined sources1
Modified residuei487PhosphoserineCombined sources1
Modified residuei510PhosphoserineCombined sources1
Modified residuei512PhosphothreonineCombined sources1
Modified residuei513PhosphothreonineCombined sources1
Modified residuei515PhosphothreonineCombined sources1
Modified residuei516PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated during mitosis but not in interphase.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y6G9.
MaxQBiQ9Y6G9.
PaxDbiQ9Y6G9.
PeptideAtlasiQ9Y6G9.
PRIDEiQ9Y6G9.

PTM databases

iPTMnetiQ9Y6G9.
PhosphoSitePlusiQ9Y6G9.

Expressioni

Gene expression databases

BgeeiENSG00000144635.
CleanExiHS_DYNC1LI1.
ExpressionAtlasiQ9Y6G9. baseline and differential.
GenevisibleiQ9Y6G9. HS.

Organism-specific databases

HPAiHPA035013.

Interactioni

Subunit structurei

Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1. Interacts with PCNT (By similarity). Interacts with human adenovirus 5 hexon protein; this interaction probably allows virus intracellular transport.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RELQ048643EBI-2556107,EBI-307352

GO - Molecular functioni

  • dynein heavy chain binding Source: FlyBase

Protein-protein interaction databases

BioGridi119327. 51 interactors.
IntActiQ9Y6G9. 23 interactors.
STRINGi9606.ENSP00000273130.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3905. Eukaryota.
ENOG410XQS4. LUCA.
GeneTreeiENSGT00390000008295.
HOGENOMiHOG000236263.
HOVERGENiHBG005546.
InParanoidiQ9Y6G9.
KOiK10416.
OMAiKEIDMSQ.
OrthoDBiEOG091G0B3J.
PhylomeDBiQ9Y6G9.
TreeFamiTF352602.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR008467. Dynein1_light_intermed_chain.
IPR022780. Dynein_light_int_chain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR12688. PTHR12688. 1 hit.
PfamiPF05783. DLIC. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9Y6G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVGRVGSF GSSPPGLSST YTGGPLGNEI ASGNGGAAAG DDEDGQNLWS
60 70 80 90 100
CILSEVSTRS RSKLPAGKNV LLLGEDGAGK TSLIRKIQGI EEYKKGRGLE
110 120 130 140 150
YLYLNVHDED RDDQTRCNVW ILDGDLYHKG LLKFSLDAVS LKDTLVMLVV
160 170 180 190 200
DMSKPWTALD SLQKWASVVR EHVDKLKIPP EEMKQMEQKL IRDFQEYVEP
210 220 230 240 250
GEDFPASPQR RNTASQEDKD DSVVLPLGAD TLTHNLGIPV LVVCTKCDAI
260 270 280 290 300
SVLEKEHDYR DEHFDFIQSH IRKFCLQYGA ALIYTSVKEN KNIDLVYKYI
310 320 330 340 350
VQKLYGFPYK IPAVVVEKDA VFIPAGWDND KKIGILHENF QTLKAEDNFE
360 370 380 390 400
DIITKPPVRK FVHEKEIMAE DDQVFLMKLQ SLLAKQPPTA AGRPVDASPR
410 420 430 440 450
VPGGSPRTPN RSVSSNVASV SPIPAGSKKI DPNMKAGATS EGVLANFFNS
460 470 480 490 500
LLSKKTGSPG GPGVSGGSPA GGAGGGSSGL PPSTKKSGQK PVLDVHAELD
510 520
RITRKPVTVS PTTPTSPTEG EAS
Length:523
Mass (Da):56,579
Last modified:March 20, 2007 - v3
Checksum:i29159F560E382095
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186M → I in BAD96293 (Ref. 2) Curated1
Sequence conflicti210R → G in BAD96293 (Ref. 2) Curated1
Sequence conflicti225L → V in AAD44481 (Ref. 1) Curated1
Sequence conflicti267I → F in AAD44481 (Ref. 1) Curated1
Sequence conflicti351D → G in BAD96293 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061141147M → T.Corresponds to variant rs34181332dbSNPEnsembl.1
Natural variantiVAR_023325277Q → R.2 PublicationsCorresponds to variant rs2303857dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078849 mRNA. Translation: AAD44481.1.
AK222573 mRNA. Translation: BAD96293.1.
AK222653 mRNA. Translation: BAD96373.1.
CH471055 Genomic DNA. Translation: EAW64433.1.
BC131620 mRNA. Translation: AAI31621.1.
CCDSiCCDS2654.1.
RefSeqiNP_057225.2. NM_016141.3.
UniGeneiHs.529495.

Genome annotation databases

EnsembliENST00000273130; ENSP00000273130; ENSG00000144635.
GeneIDi51143.
KEGGihsa:51143.
UCSCiuc003cfb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078849 mRNA. Translation: AAD44481.1.
AK222573 mRNA. Translation: BAD96293.1.
AK222653 mRNA. Translation: BAD96373.1.
CH471055 Genomic DNA. Translation: EAW64433.1.
BC131620 mRNA. Translation: AAI31621.1.
CCDSiCCDS2654.1.
RefSeqiNP_057225.2. NM_016141.3.
UniGeneiHs.529495.

3D structure databases

ProteinModelPortaliQ9Y6G9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119327. 51 interactors.
IntActiQ9Y6G9. 23 interactors.
STRINGi9606.ENSP00000273130.

PTM databases

iPTMnetiQ9Y6G9.
PhosphoSitePlusiQ9Y6G9.

Polymorphism and mutation databases

BioMutaiDYNC1LI1.
DMDMi134047749.

Proteomic databases

EPDiQ9Y6G9.
MaxQBiQ9Y6G9.
PaxDbiQ9Y6G9.
PeptideAtlasiQ9Y6G9.
PRIDEiQ9Y6G9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273130; ENSP00000273130; ENSG00000144635.
GeneIDi51143.
KEGGihsa:51143.
UCSCiuc003cfb.4. human.

Organism-specific databases

CTDi51143.
DisGeNETi51143.
GeneCardsiDYNC1LI1.
HGNCiHGNC:18745. DYNC1LI1.
HPAiHPA035013.
MIMi615890. gene.
neXtProtiNX_Q9Y6G9.
OpenTargetsiENSG00000144635.
PharmGKBiPA38670.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3905. Eukaryota.
ENOG410XQS4. LUCA.
GeneTreeiENSGT00390000008295.
HOGENOMiHOG000236263.
HOVERGENiHBG005546.
InParanoidiQ9Y6G9.
KOiK10416.
OMAiKEIDMSQ.
OrthoDBiEOG091G0B3J.
PhylomeDBiQ9Y6G9.
TreeFamiTF352602.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144635-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiDYNC1LI1. human.
GeneWikiiDYNC1LI1.
GenomeRNAii51143.
PROiQ9Y6G9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144635.
CleanExiHS_DYNC1LI1.
ExpressionAtlasiQ9Y6G9. baseline and differential.
GenevisibleiQ9Y6G9. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR008467. Dynein1_light_intermed_chain.
IPR022780. Dynein_light_int_chain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR12688. PTHR12688. 1 hit.
PfamiPF05783. DLIC. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiDC1L1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6G9
Secondary accession number(s): A2RRG7, Q53HC8, Q53HK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 20, 2007
Last modified: November 30, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.