Q9Y6G5D3DT07Q9P077COMDA_HUMANCOMM domain-containing protein 10COMMD10HSPC305PTD002Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoCOMMD proteins, a novel family of structural and functional homologs of MURR1.NUCLEOTIDE SEQUENCE [MRNA]FUNCTIONINTERACTION WITH COMMD1; RELA; RELB; NFKB1 AND NFKB2TISSUE SPECIFICITYNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Complete sequencing and characterization of 21,243 full-length human cDNAs.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Initial characterization of the human central proteome.IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.FUNCTIONINTERACTION WITH CUL1; CUL2; CUL3; CUL4B AND CUL7SUBCELLULAR LOCATIONN-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel.INTERACTION WITH SCNN1BCCDC22 deficiency in humans blunts activation of proinflammatory NF-kappaB signaling.INTERACTION WITH CCDC22Toward a comprehensive characterization of a human cancer cell phosphoproteome.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.INTERACTION WITH CCDC93N-terminome analysis of the human mitochondrial proteome.ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with CCDC22, CCDC93, SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL7.Q9Y6G5O60826false11Q9Y6G5Q567U6false4Q9Y6G5Q8N668false4Q9Y6G5Q9GZQ3false11Q9Y6G5Q0VDC6false3Q9Y6G5P01100false3Q9Y6G5P50440false3Q9Y6G5P31930false3CytoplasmNucleusUbiquitous.3D-structureAcetylationCytoplasmNucleusPhosphoproteinReference proteomeTranscriptionTranscription regulationUbl conjugation pathwayISMAVPAALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRILAPCKLETVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSKSLEKVLVEFSHKELFDFYNKLETIQAQLDSLT
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