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Protein

COMM domain-containing protein 10

Gene

COMMD10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).1 Publication1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 10
Gene namesi
Name:COMMD10
ORF Names:HSPC305, PTD002
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30201. COMMD10.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51397.
OpenTargetsiENSG00000145781.
PharmGKBiPA134862606.

Polymorphism and mutation databases

BioMutaiCOMMD10.
DMDMi51316122.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000774052 – 202COMM domain-containing protein 10Add BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei155PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y6G5.
MaxQBiQ9Y6G5.
PaxDbiQ9Y6G5.
PeptideAtlasiQ9Y6G5.
PRIDEiQ9Y6G5.

PTM databases

iPTMnetiQ9Y6G5.
PhosphoSitePlusiQ9Y6G5.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000145781.
CleanExiHS_COMMD10.
ExpressionAtlasiQ9Y6G5. baseline and differential.
GenevisibleiQ9Y6G5. HS.

Organism-specific databases

HPAiHPA045441.

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with CCDC22, CCDC93, SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL7.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC22O608268EBI-1550310,EBI-3943153

Protein-protein interaction databases

BioGridi119521. 27 interactors.
IntActiQ9Y6G5. 11 interactors.
STRINGi9606.ENSP00000274458.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6G5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 202COMMPROSITE-ProRule annotationAdd BLAST70

Sequence similaritiesi

Contains 1 COMM domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IWIY. Eukaryota.
ENOG4111JX3. LUCA.
GeneTreeiENSGT00390000001500.
HOGENOMiHOG000253918.
HOVERGENiHBG051075.
InParanoidiQ9Y6G5.
OMAiVNTWSSM.
OrthoDBiEOG091G0K3O.
PhylomeDBiQ9Y6G5.
TreeFamiTF352584.

Family and domain databases

InterProiIPR017920. COMM.
[Graphical view]
PfamiPF07258. COMM_domain. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVPAALILR ESPSMKKAVS LINAIDTGRF PRLLTRILQK LHLKAESSFS
60 70 80 90 100
EEEEEKLQAA FSLEKQDLHL VLETISFILE QAVYHNVKPA ALQQQLENIH
110 120 130 140 150
LRQDKAEAFV NTWSSMGQET VEKFRQRILA PCKLETVGWQ LNLQMAHSAQ
160 170 180 190 200
AKLKSPQAVL QLGVNNEDSK SLEKVLVEFS HKELFDFYNK LETIQAQLDS

LT
Length:202
Mass (Da):22,966
Last modified:November 1, 1999 - v1
Checksum:i4D3C014FE59188CB
GO

Sequence cautioni

The sequence AAF28983 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061122128I → S.Corresponds to variant rs1129495dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542165 mRNA. Translation: AAS22247.1.
AF078857 mRNA. Translation: AAD44489.1.
AF161423 mRNA. Translation: AAF28983.1. Different initiation.
AK002147 mRNA. Translation: BAA92108.1.
CH471086 Genomic DNA. Translation: EAW48941.1.
CH471086 Genomic DNA. Translation: EAW48942.1.
BC005179 mRNA. Translation: AAH05179.1.
CCDSiCCDS34215.1.
RefSeqiNP_001295009.1. NM_001308080.1.
NP_057228.1. NM_016144.3.
UniGeneiHs.483136.

Genome annotation databases

EnsembliENST00000274458; ENSP00000274458; ENSG00000145781.
GeneIDi51397.
KEGGihsa:51397.
UCSCiuc003krt.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542165 mRNA. Translation: AAS22247.1.
AF078857 mRNA. Translation: AAD44489.1.
AF161423 mRNA. Translation: AAF28983.1. Different initiation.
AK002147 mRNA. Translation: BAA92108.1.
CH471086 Genomic DNA. Translation: EAW48941.1.
CH471086 Genomic DNA. Translation: EAW48942.1.
BC005179 mRNA. Translation: AAH05179.1.
CCDSiCCDS34215.1.
RefSeqiNP_001295009.1. NM_001308080.1.
NP_057228.1. NM_016144.3.
UniGeneiHs.483136.

3D structure databases

ProteinModelPortaliQ9Y6G5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119521. 27 interactors.
IntActiQ9Y6G5. 11 interactors.
STRINGi9606.ENSP00000274458.

PTM databases

iPTMnetiQ9Y6G5.
PhosphoSitePlusiQ9Y6G5.

Polymorphism and mutation databases

BioMutaiCOMMD10.
DMDMi51316122.

Proteomic databases

EPDiQ9Y6G5.
MaxQBiQ9Y6G5.
PaxDbiQ9Y6G5.
PeptideAtlasiQ9Y6G5.
PRIDEiQ9Y6G5.

Protocols and materials databases

DNASUi51397.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274458; ENSP00000274458; ENSG00000145781.
GeneIDi51397.
KEGGihsa:51397.
UCSCiuc003krt.2. human.

Organism-specific databases

CTDi51397.
DisGeNETi51397.
GeneCardsiCOMMD10.
HGNCiHGNC:30201. COMMD10.
HPAiHPA045441.
MIMi616704. gene.
neXtProtiNX_Q9Y6G5.
OpenTargetsiENSG00000145781.
PharmGKBiPA134862606.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWIY. Eukaryota.
ENOG4111JX3. LUCA.
GeneTreeiENSGT00390000001500.
HOGENOMiHOG000253918.
HOVERGENiHBG051075.
InParanoidiQ9Y6G5.
OMAiVNTWSSM.
OrthoDBiEOG091G0K3O.
PhylomeDBiQ9Y6G5.
TreeFamiTF352584.

Miscellaneous databases

GenomeRNAii51397.
PROiQ9Y6G5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145781.
CleanExiHS_COMMD10.
ExpressionAtlasiQ9Y6G5. baseline and differential.
GenevisibleiQ9Y6G5. HS.

Family and domain databases

InterProiIPR017920. COMM.
[Graphical view]
PfamiPF07258. COMM_domain. 1 hit.
[Graphical view]
PROSITEiPS51269. COMM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOMDA_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6G5
Secondary accession number(s): D3DT07, Q9P077
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.