Reviewed, UniProtKB/Swiss-Prot Q9Y6G5 (COMDA_HUMAN)

Names and origin

Protein names

Recommended name:
    COMM domain-containing protein 10

Gene names

Name:	COMMD10
ORF Names:	HSPC305, PTD002

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 1 COMM domain.

Ontologies

Keywords
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Ref.1 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
COMMD1	Q8N668	1	EBI-1550310,EBI-1550112

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 202	202	COMM domain-containing protein 10		PRO_0000077405
Regions
	Domain	133 – 202	70	COMM

Sequences

	Sequence		Length	Mass (Da)
	Q9Y6G5-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 4D3C014FE59188CB	FASTA	202	22,966
	10 20 30 40 50 60 MAVPAALILR ESPSMKKAVS LINAIDTGRF PRLLTRILQK LHLKAESSFS EEEEEKLQAA 70 80 90 100 110 120 FSLEKQDLHL VLETISFILE QAVYHNVKPA ALQQQLENIH LRQDKAEAFV NTWSSMGQET 130 140 150 160 170 180 VEKFRQRILA PCKLETVGWQ LNLQMAHSAQ AKLKSPQAVL QLGVNNEDSK SLEKVLVEFS 190 200 HKELFDFYNK LETIQAQLDS LT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"COMMD proteins, a novel family of structural and functional homologs of MURR1." Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S. J. Biol. Chem. 280:22222-22232(2005) [PubMed: 15799966] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Fu G., Huang Q., Song H., Peng J., Zhang Q., Mao M., Dai M., Mao Y., Zhou J., Chen Z., Chen J. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary tumor.
[3]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Urinary bladder.
[6]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY542165 mRNA. Translation: AAS22247.1. AF078857 mRNA. Translation: AAD44489.1. AF161423 mRNA. Translation: AAF28983.1. Different initiation. AK002147 mRNA. Translation: BAA92108.1. BC005179 mRNA. Translation: AAH05179.1.
IPI	IPI00412811.
RefSeq	NP_057228.1.
UniGene	Hs.483136
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y6G5. 5 interactions.
STRING	Q9Y6G5.
Proteomic databases
PRIDE	Q9Y6G5.
Genome annotation databases
Ensembl	ENST00000274458; ENSP00000274458; ENSG00000145781; Homo sapiens. [Genome view]
GeneID	51397.
KEGG	hsa:51397.
UCSC	uc003krt.1. human.
Organism-specific databases
CTD	51397.
GeneCards	GC05P115448.
H-InvDB	HIX0005109.
HGNC	HGNC:30201. COMMD10.
PharmGKB	PA134862606.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9Y6G5.
HOVERGEN	Q9Y6G5.
OMA	SSMGQET
OrthoDB	EOG9Q87HQ
Gene expression databases
ArrayExpress	Q9Y6G5.
Bgee	Q9Y6G5.
CleanEx	HS_COMMD10.
Genevestigator	Q9Y6G5.
GermOnline	ENSG00000145781. Homo sapiens.
Family and domain databases
InterPro	IPR017920. COMM. IPR009886. HCaRG. [Graphical view]
Pfam	PF07258. HCaRG. 1 hit. [Graphical view]
PROSITE	PS51269. COMM. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	54929.

Entry information

Entry name

COMDA_HUMAN

Accession

Primary (citable) accession number: Q9Y6G5
Secondary accession number(s): Q9P077

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	November 1, 1999
Last modified:	November 24, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.