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Protein

COMM domain-containing protein 10

Gene

COMMD10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966).1 Publication1 Publication

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 10
Gene namesi
Name:COMMD10
ORF Names:HSPC305, PTD002
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145781.8
HGNCiHGNC:30201 COMMD10
MIMi616704 gene
neXtProtiNX_Q9Y6G5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51397
OpenTargetsiENSG00000145781
PharmGKBiPA134862606

Polymorphism and mutation databases

BioMutaiCOMMD10
DMDMi51316122

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000774052 – 202COMM domain-containing protein 10Add BLAST201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei155PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y6G5
MaxQBiQ9Y6G5
PaxDbiQ9Y6G5
PeptideAtlasiQ9Y6G5
PRIDEiQ9Y6G5

PTM databases

iPTMnetiQ9Y6G5
PhosphoSitePlusiQ9Y6G5

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000145781
CleanExiHS_COMMD10
ExpressionAtlasiQ9Y6G5 baseline and differential
GenevisibleiQ9Y6G5 HS

Organism-specific databases

HPAiHPA045441
HPA075641

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with RELA, RELB, NFKB1/p105, NFKB2/p100. Interacts with CCDC22, CCDC93, SCNN1B, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL7.5 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119521, 27 interactors
CORUMiQ9Y6G5
IntActiQ9Y6G5, 11 interactors
STRINGi9606.ENSP00000274458

Structurei

3D structure databases

ProteinModelPortaliQ9Y6G5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 202COMMPROSITE-ProRule annotationAdd BLAST70

Phylogenomic databases

eggNOGiENOG410IWIY Eukaryota
ENOG4111JX3 LUCA
GeneTreeiENSGT00390000001500
HOGENOMiHOG000253918
HOVERGENiHBG051075
InParanoidiQ9Y6G5
OMAiVNTWSSM
OrthoDBiEOG091G0K3O
PhylomeDBiQ9Y6G5
TreeFamiTF352584

Family and domain databases

CDDicd04758 Commd10, 1 hit
InterProiView protein in InterPro
IPR017920 COMM
IPR037361 COMMD10
PANTHERiPTHR12333 PTHR12333, 1 hit
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6G5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVPAALILR ESPSMKKAVS LINAIDTGRF PRLLTRILQK LHLKAESSFS
60 70 80 90 100
EEEEEKLQAA FSLEKQDLHL VLETISFILE QAVYHNVKPA ALQQQLENIH
110 120 130 140 150
LRQDKAEAFV NTWSSMGQET VEKFRQRILA PCKLETVGWQ LNLQMAHSAQ
160 170 180 190 200
AKLKSPQAVL QLGVNNEDSK SLEKVLVEFS HKELFDFYNK LETIQAQLDS

LT
Length:202
Mass (Da):22,966
Last modified:November 1, 1999 - v1
Checksum:i4D3C014FE59188CB
GO

Sequence cautioni

The sequence AAF28983 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061122128I → S. Corresponds to variant dbSNP:rs1129495Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY542165 mRNA Translation: AAS22247.1
AF078857 mRNA Translation: AAD44489.1
AF161423 mRNA Translation: AAF28983.1 Different initiation.
AK002147 mRNA Translation: BAA92108.1
CH471086 Genomic DNA Translation: EAW48941.1
CH471086 Genomic DNA Translation: EAW48942.1
BC005179 mRNA Translation: AAH05179.1
CCDSiCCDS34215.1
RefSeqiNP_001295009.1, NM_001308080.1
NP_057228.1, NM_016144.3
UniGeneiHs.483136

Genome annotation databases

EnsembliENST00000274458; ENSP00000274458; ENSG00000145781
GeneIDi51397
KEGGihsa:51397
UCSCiuc003krt.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOMDA_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6G5
Secondary accession number(s): D3DT07, Q9P077
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health