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Q9Y6G5

- COMDA_HUMAN

UniProt

Q9Y6G5 - COMDA_HUMAN

Protein

COMM domain-containing protein 10

Gene

COMMD10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    COMM domain-containing protein 10
    Gene namesi
    Name:COMMD10
    ORF Names:HSPC305, PTD002
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:30201. COMMD10.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134862606.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 202201COMM domain-containing protein 10PRO_0000077405Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei155 – 1551Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y6G5.
    PaxDbiQ9Y6G5.
    PRIDEiQ9Y6G5.

    PTM databases

    PhosphoSiteiQ9Y6G5.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y6G5.
    BgeeiQ9Y6G5.
    CleanExiHS_COMMD10.
    GenevestigatoriQ9Y6G5.

    Organism-specific databases

    HPAiHPA045441.

    Interactioni

    Subunit structurei

    Interacts (via COMM domain) with COMMD1 (via COMM domain).1 Publication

    Protein-protein interaction databases

    BioGridi119521. 9 interactions.
    IntActiQ9Y6G5. 5 interactions.
    STRINGi9606.ENSP00000274458.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y6G5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini133 – 20270COMMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 COMM domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG78491.
    HOGENOMiHOG000253918.
    HOVERGENiHBG051075.
    InParanoidiQ9Y6G5.
    OMAiVNTWSSM.
    OrthoDBiEOG7DRJ48.
    PhylomeDBiQ9Y6G5.
    TreeFamiTF352584.

    Family and domain databases

    InterProiIPR017920. COMM.
    IPR009886. HCaRG.
    [Graphical view]
    PfamiPF07258. HCaRG. 1 hit.
    [Graphical view]
    PROSITEiPS51269. COMM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y6G5-1 [UniParc]FASTAAdd to Basket

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    MAVPAALILR ESPSMKKAVS LINAIDTGRF PRLLTRILQK LHLKAESSFS    50
    EEEEEKLQAA FSLEKQDLHL VLETISFILE QAVYHNVKPA ALQQQLENIH 100
    LRQDKAEAFV NTWSSMGQET VEKFRQRILA PCKLETVGWQ LNLQMAHSAQ 150
    AKLKSPQAVL QLGVNNEDSK SLEKVLVEFS HKELFDFYNK LETIQAQLDS 200
    LT 202
    Length:202
    Mass (Da):22,966
    Last modified:November 1, 1999 - v1
    Checksum:i4D3C014FE59188CB
    GO

    Sequence cautioni

    The sequence AAF28983.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti128 – 1281I → S.
    Corresponds to variant rs1129495 [ dbSNP | Ensembl ].
    VAR_061122

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY542165 mRNA. Translation: AAS22247.1.
    AF078857 mRNA. Translation: AAD44489.1.
    AF161423 mRNA. Translation: AAF28983.1. Different initiation.
    AK002147 mRNA. Translation: BAA92108.1.
    CH471086 Genomic DNA. Translation: EAW48941.1.
    CH471086 Genomic DNA. Translation: EAW48942.1.
    BC005179 mRNA. Translation: AAH05179.1.
    CCDSiCCDS34215.1.
    RefSeqiNP_057228.1. NM_016144.2.
    UniGeneiHs.483136.

    Genome annotation databases

    EnsembliENST00000274458; ENSP00000274458; ENSG00000145781.
    GeneIDi51397.
    KEGGihsa:51397.
    UCSCiuc003krt.1. human.

    Polymorphism databases

    DMDMi51316122.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY542165 mRNA. Translation: AAS22247.1 .
    AF078857 mRNA. Translation: AAD44489.1 .
    AF161423 mRNA. Translation: AAF28983.1 . Different initiation.
    AK002147 mRNA. Translation: BAA92108.1 .
    CH471086 Genomic DNA. Translation: EAW48941.1 .
    CH471086 Genomic DNA. Translation: EAW48942.1 .
    BC005179 mRNA. Translation: AAH05179.1 .
    CCDSi CCDS34215.1.
    RefSeqi NP_057228.1. NM_016144.2.
    UniGenei Hs.483136.

    3D structure databases

    ProteinModelPortali Q9Y6G5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119521. 9 interactions.
    IntActi Q9Y6G5. 5 interactions.
    STRINGi 9606.ENSP00000274458.

    PTM databases

    PhosphoSitei Q9Y6G5.

    Polymorphism databases

    DMDMi 51316122.

    Proteomic databases

    MaxQBi Q9Y6G5.
    PaxDbi Q9Y6G5.
    PRIDEi Q9Y6G5.

    Protocols and materials databases

    DNASUi 51397.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274458 ; ENSP00000274458 ; ENSG00000145781 .
    GeneIDi 51397.
    KEGGi hsa:51397.
    UCSCi uc003krt.1. human.

    Organism-specific databases

    CTDi 51397.
    GeneCardsi GC05P115448.
    HGNCi HGNC:30201. COMMD10.
    HPAi HPA045441.
    neXtProti NX_Q9Y6G5.
    PharmGKBi PA134862606.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG78491.
    HOGENOMi HOG000253918.
    HOVERGENi HBG051075.
    InParanoidi Q9Y6G5.
    OMAi VNTWSSM.
    OrthoDBi EOG7DRJ48.
    PhylomeDBi Q9Y6G5.
    TreeFami TF352584.

    Miscellaneous databases

    GenomeRNAii 51397.
    NextBioi 54929.
    PROi Q9Y6G5.

    Gene expression databases

    ArrayExpressi Q9Y6G5.
    Bgeei Q9Y6G5.
    CleanExi HS_COMMD10.
    Genevestigatori Q9Y6G5.

    Family and domain databases

    InterProi IPR017920. COMM.
    IPR009886. HCaRG.
    [Graphical view ]
    Pfami PF07258. HCaRG. 1 hit.
    [Graphical view ]
    PROSITEi PS51269. COMM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH COMMD1, TISSUE SPECIFICITY.
    2. Fu G., Huang Q., Song H., Peng J., Zhang Q., Mao M., Dai M., Mao Y., Zhou J., Chen Z., Chen J.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary tumor.
    3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Urinary bladder.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-155, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCOMDA_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y6G5
    Secondary accession number(s): D3DT07, Q9P077
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3