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Protein

39S ribosomal protein L42, mitochondrial

Gene

MRPL42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L42, mitochondrial1 Publication
Short name:
L42mt
Short name:
MRP-L42
Alternative name(s):
39S ribosomal protein L31, mitochondrialBy similarity
Short name:
L31mt
Short name:
MRP-L31
Mitochondrial large ribosomal subunit protein mL421 Publication
Gene namesi
Name:MRPL42
Synonyms:MRPL31, MRPS32, RPML31
ORF Names:HSPC204, PTD007
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:14493. MRPL42.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial large ribosomal subunit Source: UniProtKB
  • mitochondrial small ribosomal subunit Source: UniProtKB
  • mitochondrion Source: HPA
  • plasma membrane Source: HPA

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198015.
PharmGKBiPA30974.

Polymorphism and mutation databases

BioMutaiMRPL42.
DMDMi24212391.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 32MitochondrionBy similarityAdd BLAST32
ChainiPRO_000008772433 – 14239S ribosomal protein L42, mitochondrialAdd BLAST110

Proteomic databases

EPDiQ9Y6G3.
MaxQBiQ9Y6G3.
PaxDbiQ9Y6G3.
PeptideAtlasiQ9Y6G3.
PRIDEiQ9Y6G3.
TopDownProteomicsiQ9Y6G3.

PTM databases

iPTMnetiQ9Y6G3.
PhosphoSitePlusiQ9Y6G3.

Expressioni

Gene expression databases

BgeeiENSG00000198015.
CleanExiHS_MRPL42.
ExpressionAtlasiQ9Y6G3. baseline and differential.
GenevisibleiQ9Y6G3. HS.

Organism-specific databases

HPAiHPA039398.

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Protein-protein interaction databases

BioGridi118800. 72 interactors.
IntActiQ9Y6G3. 3 interactors.
MINTiMINT-1389592.
STRINGi9606.ENSP00000447547.

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi105 – 116Combined sources12
Helixi120 – 122Combined sources3
Helixi128 – 133Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40a1-142[»]
3J9Melectron microscopy3.50a1-142[»]
ProteinModelPortaliQ9Y6G3.
SMRiQ9Y6G3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4106. Eukaryota.
ENOG4111TTH. LUCA.
GeneTreeiENSGT00390000010491.
HOGENOMiHOG000293154.
HOVERGENiHBG023706.
InParanoidiQ9Y6G3.
KOiK17423.
OMAiMQLTHTT.
PhylomeDBiQ9Y6G3.
TreeFamiTF324368.

Family and domain databases

InterProiView protein in InterPro
IPR019346. Ribosomal-S32_mit.
PfamiView protein in Pfam
PF10210. MRP-S32. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVAAVKWVM SKRTILKHLF PVQNGALYCV CHKSTYSPLP DDYNCNVELA
60 70 80 90 100
LTSDGRTIVC YHPSVDIPYE HTKPIPRPDP VHNNEETHDQ VLKTRLEEKV
110 120 130 140
EHLEEGPMIE QLSKMFFTTK HRWYPHGRYH RCRKNLNPPK DR
Length:142
Mass (Da):16,661
Last modified:November 1, 1999 - v1
Checksum:iAED9ECFA653F870A
GO

Sequence cautioni

The sequence AAF36124 differs from that shown. Reason: Frameshift at several positions.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078860 mRNA. Translation: AAD44492.1.
AF135160 mRNA. Translation: AAF43784.1.
AF151038 mRNA. Translation: AAF36124.1. Frameshift.
AL136659 mRNA. Translation: CAB66594.1.
AK000285 mRNA. Translation: BAA91054.1.
CR533495 mRNA. Translation: CAG38526.1.
CH471054 Genomic DNA. Translation: EAW97484.1.
BC040240 mRNA. Translation: AAH40240.1.
AB051626 Genomic DNA. Translation: BAB54953.1.
CCDSiCCDS9045.1.
RefSeqiNP_054769.1. NM_014050.3.
NP_751917.1. NM_172177.3.
UniGeneiHs.199579.

Genome annotation databases

EnsembliENST00000549561; ENSP00000449392; ENSG00000198015.
ENST00000549982; ENSP00000449884; ENSG00000198015.
ENST00000552217; ENSP00000447547; ENSG00000198015.
GeneIDi28977.
KEGGihsa:28977.
UCSCiuc001tcr.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRM42_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6G3
Secondary accession number(s): Q6FID1, Q96Q48, Q9P0S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: June 7, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Has also been found in a preparation of mitochondrial small ribosomal subunits. Was erroneously (PubMed:11279123, PubMed:11551941) assigned to be MRP-S32.2 Publications

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families