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Protein

39S ribosomal protein L42, mitochondrial

Gene

MRPL42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L42, mitochondrial
Short name:
L42mt
Short name:
MRP-L42
Alternative name(s):
28S ribosomal protein S32, mitochondrial
Short name:
MRP-S32
Short name:
S32mt
39S ribosomal protein L31, mitochondrial
Short name:
L31mt
Short name:
MRP-L31
Gene namesi
Name:MRPL42
Synonyms:MRPL31, MRPS32, RPML31
ORF Names:HSPC204, PTD007
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:14493. MRPL42.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30974.

Polymorphism and mutation databases

BioMutaiMRPL42.
DMDMi24212391.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3232MitochondrionBy similarityAdd
BLAST
Chaini33 – 14211039S ribosomal protein L42, mitochondrialPRO_0000087724Add
BLAST

Proteomic databases

EPDiQ9Y6G3.
MaxQBiQ9Y6G3.
PaxDbiQ9Y6G3.
PeptideAtlasiQ9Y6G3.
PRIDEiQ9Y6G3.
TopDownProteomicsiQ9Y6G3.

PTM databases

iPTMnetiQ9Y6G3.
PhosphoSiteiQ9Y6G3.

Expressioni

Gene expression databases

BgeeiQ9Y6G3.
CleanExiHS_MRPL42.
ExpressionAtlasiQ9Y6G3. baseline and differential.
GenevisibleiQ9Y6G3. HS.

Organism-specific databases

HPAiHPA039398.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.2 Publications

Protein-protein interaction databases

BioGridi118800. 72 interactions.
IntActiQ9Y6G3. 3 interactions.
MINTiMINT-1389592.
STRINGi9606.ENSP00000447547.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40a1-142[»]
3J9Melectron microscopy3.50a1-142[»]
ProteinModelPortaliQ9Y6G3.
SMRiQ9Y6G3. Positions 104-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4106. Eukaryota.
ENOG4111TTH. LUCA.
GeneTreeiENSGT00390000010491.
HOGENOMiHOG000293154.
HOVERGENiHBG023706.
InParanoidiQ9Y6G3.
KOiK17423.
OMAiEIPYEHT.
OrthoDBiEOG7BW0N0.
PhylomeDBiQ9Y6G3.
TreeFamiTF324368.

Family and domain databases

InterProiIPR019346. Ribosomal-S32_mit.
[Graphical view]
PfamiPF10210. MRP-S32. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6G3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVAAVKWVM SKRTILKHLF PVQNGALYCV CHKSTYSPLP DDYNCNVELA
60 70 80 90 100
LTSDGRTIVC YHPSVDIPYE HTKPIPRPDP VHNNEETHDQ VLKTRLEEKV
110 120 130 140
EHLEEGPMIE QLSKMFFTTK HRWYPHGRYH RCRKNLNPPK DR
Length:142
Mass (Da):16,661
Last modified:November 1, 1999 - v1
Checksum:iAED9ECFA653F870A
GO

Sequence cautioni

The sequence AAF36124.1 differs from that shown. Reason: Frameshift at several positions. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078860 mRNA. Translation: AAD44492.1.
AF135160 mRNA. Translation: AAF43784.1.
AF151038 mRNA. Translation: AAF36124.1. Frameshift.
AL136659 mRNA. Translation: CAB66594.1.
AK000285 mRNA. Translation: BAA91054.1.
CR533495 mRNA. Translation: CAG38526.1.
CH471054 Genomic DNA. Translation: EAW97484.1.
BC040240 mRNA. Translation: AAH40240.1.
AB051626 Genomic DNA. Translation: BAB54953.1.
CCDSiCCDS9045.1.
RefSeqiNP_054769.1. NM_014050.3.
NP_751917.1. NM_172177.3.
UniGeneiHs.199579.

Genome annotation databases

EnsembliENST00000549561; ENSP00000449392; ENSG00000198015.
ENST00000549982; ENSP00000449884; ENSG00000198015.
ENST00000552217; ENSP00000447547; ENSG00000198015.
GeneIDi28977.
KEGGihsa:28977.
UCSCiuc001tcr.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078860 mRNA. Translation: AAD44492.1.
AF135160 mRNA. Translation: AAF43784.1.
AF151038 mRNA. Translation: AAF36124.1. Frameshift.
AL136659 mRNA. Translation: CAB66594.1.
AK000285 mRNA. Translation: BAA91054.1.
CR533495 mRNA. Translation: CAG38526.1.
CH471054 Genomic DNA. Translation: EAW97484.1.
BC040240 mRNA. Translation: AAH40240.1.
AB051626 Genomic DNA. Translation: BAB54953.1.
CCDSiCCDS9045.1.
RefSeqiNP_054769.1. NM_014050.3.
NP_751917.1. NM_172177.3.
UniGeneiHs.199579.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40a1-142[»]
3J9Melectron microscopy3.50a1-142[»]
ProteinModelPortaliQ9Y6G3.
SMRiQ9Y6G3. Positions 104-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118800. 72 interactions.
IntActiQ9Y6G3. 3 interactions.
MINTiMINT-1389592.
STRINGi9606.ENSP00000447547.

PTM databases

iPTMnetiQ9Y6G3.
PhosphoSiteiQ9Y6G3.

Polymorphism and mutation databases

BioMutaiMRPL42.
DMDMi24212391.

Proteomic databases

EPDiQ9Y6G3.
MaxQBiQ9Y6G3.
PaxDbiQ9Y6G3.
PeptideAtlasiQ9Y6G3.
PRIDEiQ9Y6G3.
TopDownProteomicsiQ9Y6G3.

Protocols and materials databases

DNASUi28977.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000549561; ENSP00000449392; ENSG00000198015.
ENST00000549982; ENSP00000449884; ENSG00000198015.
ENST00000552217; ENSP00000447547; ENSG00000198015.
GeneIDi28977.
KEGGihsa:28977.
UCSCiuc001tcr.4. human.

Organism-specific databases

CTDi28977.
GeneCardsiMRPL42.
HGNCiHGNC:14493. MRPL42.
HPAiHPA039398.
MIMi611847. gene.
neXtProtiNX_Q9Y6G3.
PharmGKBiPA30974.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4106. Eukaryota.
ENOG4111TTH. LUCA.
GeneTreeiENSGT00390000010491.
HOGENOMiHOG000293154.
HOVERGENiHBG023706.
InParanoidiQ9Y6G3.
KOiK17423.
OMAiEIPYEHT.
OrthoDBiEOG7BW0N0.
PhylomeDBiQ9Y6G3.
TreeFamiTF324368.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPL42. human.
GeneWikiiMitochondrial_ribosomal_protein_L42.
GenomeRNAii28977.
PROiQ9Y6G3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y6G3.
CleanExiHS_MRPL42.
ExpressionAtlasiQ9Y6G3. baseline and differential.
GenevisibleiQ9Y6G3. HS.

Family and domain databases

InterProiIPR019346. Ribosomal-S32_mit.
[Graphical view]
PfamiPF10210. MRP-S32. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Mao Y.F., Peng Y., Dai M., Huang Q.H., Song H., Zhang Q.H., Mao M., Fu G., Luo M., Chen J.H., Hu R.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary tumor.
  2. "Isolating a new human cDNA."
    Chen J.H., Luo W.Q., Hu S.N., Li G.T., Jin J., Huang X.W., Zhou H.J., Yuan J.G., Qiang B.Q.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  9. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 78-128.
  10. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MITOCHONDRIAL RIBOSOME SMALL SUBUNIT, IDENTIFICATION BY MASS SPECTROMETRY.
  11. "The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moyer M.B., Schlatzer D.M., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:43958-43969(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MITOCHONDRIAL RIBOSOME LARGE SUBUNIT, IDENTIFICATION BY MASS SPECTROMETRY.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRM42_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6G3
Secondary accession number(s): Q6FID1, Q96Q48, Q9P0S1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Has been found in the mitochondrial ribosome large and small subunits. Was erronously (PubMed:11551941) assigned to be MRP-S31.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.