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Q9Y6G1

- TM14A_HUMAN

UniProt

Q9Y6G1 - TM14A_HUMAN

Protein

Transmembrane protein 14A

Gene

TMEM14A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 14A
    Gene namesi
    Name:TMEM14A
    Synonyms:C6orf73
    ORF Names:PTD011
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21076. TMEM14A.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134974524.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9999Transmembrane protein 14APRO_0000221169Add
    BLAST

    Proteomic databases

    PaxDbiQ9Y6G1.
    PRIDEiQ9Y6G1.

    PTM databases

    PhosphoSiteiQ9Y6G1.

    Expressioni

    Gene expression databases

    BgeeiQ9Y6G1.
    CleanExiHS_TMEM14A.
    GenevestigatoriQ9Y6G1.

    Interactioni

    Protein-protein interaction databases

    BioGridi118801. 3 interactions.
    IntActiQ9Y6G1. 4 interactions.

    Structurei

    Secondary structure

    1
    99
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi6 – 1914
    Helixi29 – 4618
    Beta strandi47 – 493
    Helixi54 – 6714
    Beta strandi73 – 808
    Helixi81 – 9414

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LOONMR-A1-99[»]
    2LOPNMR-A1-99[»]
    ProteinModelPortaliQ9Y6G1.
    SMRiQ9Y6G1. Positions 1-87.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei24 – 4421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPF0136 (TMEM14) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG311488.
    HOGENOMiHOG000211932.
    HOVERGENiHBG054211.
    InParanoidiQ9Y6G1.
    OMAiMGMRFKR.
    OrthoDBiEOG7NKKP0.
    PhylomeDBiQ9Y6G1.
    TreeFamiTF323345.

    Family and domain databases

    InterProiIPR005349. UPF0136_TM.
    [Graphical view]
    PANTHERiPTHR12668. PTHR12668. 1 hit.
    PfamiPF03647. Tmemb_14. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y6G1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLIGFGYAA LVTFGSIFGY KRRGGVPSLI AGLFVGCLAG YGAYRVSNDK   50
    RDVKVSLFTA FFLATIMGVR FKRSKKIMPA GLVAGLSLMM ILRLVLLLL 99
    Length:99
    Mass (Da):10,712
    Last modified:November 1, 1999 - v1
    Checksum:iD41CBB95241969B3
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti37 – 371C → R.
    Corresponds to variant rs11543266 [ dbSNP | Ensembl ].
    VAR_052497

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF078864 mRNA. Translation: AAD44496.1.
    AF239771 mRNA. Translation: AAF59948.1.
    AK312063 mRNA. Translation: BAG34999.1.
    AL109918 Genomic DNA. Translation: CAB92769.1.
    CH471081 Genomic DNA. Translation: EAX04380.1.
    BC015097 mRNA. Translation: AAH15097.1.
    BC019328 mRNA. Translation: AAH19328.1.
    CCDSiCCDS4943.1.
    RefSeqiNP_054770.1. NM_014051.3.
    UniGeneiHs.94896.

    Genome annotation databases

    EnsembliENST00000211314; ENSP00000211314; ENSG00000096092.
    GeneIDi28978.
    KEGGihsa:28978.
    UCSCiuc003pax.3. human.

    Polymorphism databases

    DMDMi9910842.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF078864 mRNA. Translation: AAD44496.1 .
    AF239771 mRNA. Translation: AAF59948.1 .
    AK312063 mRNA. Translation: BAG34999.1 .
    AL109918 Genomic DNA. Translation: CAB92769.1 .
    CH471081 Genomic DNA. Translation: EAX04380.1 .
    BC015097 mRNA. Translation: AAH15097.1 .
    BC019328 mRNA. Translation: AAH19328.1 .
    CCDSi CCDS4943.1.
    RefSeqi NP_054770.1. NM_014051.3.
    UniGenei Hs.94896.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LOO NMR - A 1-99 [» ]
    2LOP NMR - A 1-99 [» ]
    ProteinModelPortali Q9Y6G1.
    SMRi Q9Y6G1. Positions 1-87.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118801. 3 interactions.
    IntActi Q9Y6G1. 4 interactions.

    PTM databases

    PhosphoSitei Q9Y6G1.

    Polymorphism databases

    DMDMi 9910842.

    Proteomic databases

    PaxDbi Q9Y6G1.
    PRIDEi Q9Y6G1.

    Protocols and materials databases

    DNASUi 28978.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000211314 ; ENSP00000211314 ; ENSG00000096092 .
    GeneIDi 28978.
    KEGGi hsa:28978.
    UCSCi uc003pax.3. human.

    Organism-specific databases

    CTDi 28978.
    GeneCardsi GC06P052535.
    HGNCi HGNC:21076. TMEM14A.
    neXtProti NX_Q9Y6G1.
    PharmGKBi PA134974524.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG311488.
    HOGENOMi HOG000211932.
    HOVERGENi HBG054211.
    InParanoidi Q9Y6G1.
    OMAi MGMRFKR.
    OrthoDBi EOG7NKKP0.
    PhylomeDBi Q9Y6G1.
    TreeFami TF323345.

    Miscellaneous databases

    GenomeRNAii 28978.
    NextBioi 51863.
    PROi Q9Y6G1.

    Gene expression databases

    Bgeei Q9Y6G1.
    CleanExi HS_TMEM14A.
    Genevestigatori Q9Y6G1.

    Family and domain databases

    InterProi IPR005349. UPF0136_TM.
    [Graphical view ]
    PANTHERi PTHR12668. PTHR12668. 1 hit.
    Pfami PF03647. Tmemb_14. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Zhou J., Huang Q., Song H., Peng J., Zhang Q., Fu G., Dai M., Mao Y., Mao M., Chen Z., Chen J.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pituitary tumor.
    2. Tong X., Liu B., Sun Z.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Urinary bladder.
    7. Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiTM14A_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y6G1
    Secondary accession number(s): B2R552
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families
    6. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3