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Q9Y6G1

- TM14A_HUMAN

UniProt

Q9Y6G1 - TM14A_HUMAN

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Protein

Transmembrane protein 14A

Gene

TMEM14A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 14A
Gene namesi
Name:TMEM14A
Synonyms:C6orf73
ORF Names:PTD011
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21076. TMEM14A.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134974524.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9999Transmembrane protein 14APRO_0000221169Add
BLAST

Proteomic databases

PaxDbiQ9Y6G1.
PRIDEiQ9Y6G1.

PTM databases

PhosphoSiteiQ9Y6G1.

Expressioni

Gene expression databases

BgeeiQ9Y6G1.
CleanExiHS_TMEM14A.
GenevestigatoriQ9Y6G1.

Interactioni

Protein-protein interaction databases

BioGridi118801. 3 interactions.
IntActiQ9Y6G1. 4 interactions.

Structurei

Secondary structure

1
99
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1914
Helixi29 – 4618
Beta strandi47 – 493
Helixi54 – 6714
Beta strandi73 – 808
Helixi81 – 9414

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LOONMR-A1-99[»]
2LOPNMR-A1-99[»]
ProteinModelPortaliQ9Y6G1.
SMRiQ9Y6G1. Positions 1-87.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence AnalysisAdd
BLAST
Transmembranei24 – 4421HelicalSequence AnalysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0136 (TMEM14) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311488.
GeneTreeiENSGT00390000013475.
HOGENOMiHOG000211932.
HOVERGENiHBG054211.
InParanoidiQ9Y6G1.
OMAiMGMRFKR.
OrthoDBiEOG7NKKP0.
PhylomeDBiQ9Y6G1.
TreeFamiTF323345.

Family and domain databases

InterProiIPR005349. UPF0136_TM.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y6G1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLIGFGYAA LVTFGSIFGY KRRGGVPSLI AGLFVGCLAG YGAYRVSNDK
60 70 80 90
RDVKVSLFTA FFLATIMGVR FKRSKKIMPA GLVAGLSLMM ILRLVLLLL
Length:99
Mass (Da):10,712
Last modified:November 1, 1999 - v1
Checksum:iD41CBB95241969B3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371C → R.
Corresponds to variant rs11543266 [ dbSNP | Ensembl ].
VAR_052497

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF078864 mRNA. Translation: AAD44496.1.
AF239771 mRNA. Translation: AAF59948.1.
AK312063 mRNA. Translation: BAG34999.1.
AL109918 Genomic DNA. Translation: CAB92769.1.
CH471081 Genomic DNA. Translation: EAX04380.1.
BC015097 mRNA. Translation: AAH15097.1.
BC019328 mRNA. Translation: AAH19328.1.
CCDSiCCDS4943.1.
RefSeqiNP_054770.1. NM_014051.3.
UniGeneiHs.94896.

Genome annotation databases

EnsembliENST00000211314; ENSP00000211314; ENSG00000096092.
GeneIDi28978.
KEGGihsa:28978.
UCSCiuc003pax.3. human.

Polymorphism databases

DMDMi9910842.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF078864 mRNA. Translation: AAD44496.1 .
AF239771 mRNA. Translation: AAF59948.1 .
AK312063 mRNA. Translation: BAG34999.1 .
AL109918 Genomic DNA. Translation: CAB92769.1 .
CH471081 Genomic DNA. Translation: EAX04380.1 .
BC015097 mRNA. Translation: AAH15097.1 .
BC019328 mRNA. Translation: AAH19328.1 .
CCDSi CCDS4943.1.
RefSeqi NP_054770.1. NM_014051.3.
UniGenei Hs.94896.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LOO NMR - A 1-99 [» ]
2LOP NMR - A 1-99 [» ]
ProteinModelPortali Q9Y6G1.
SMRi Q9Y6G1. Positions 1-87.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118801. 3 interactions.
IntActi Q9Y6G1. 4 interactions.

PTM databases

PhosphoSitei Q9Y6G1.

Polymorphism databases

DMDMi 9910842.

Proteomic databases

PaxDbi Q9Y6G1.
PRIDEi Q9Y6G1.

Protocols and materials databases

DNASUi 28978.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000211314 ; ENSP00000211314 ; ENSG00000096092 .
GeneIDi 28978.
KEGGi hsa:28978.
UCSCi uc003pax.3. human.

Organism-specific databases

CTDi 28978.
GeneCardsi GC06P052535.
HGNCi HGNC:21076. TMEM14A.
neXtProti NX_Q9Y6G1.
PharmGKBi PA134974524.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG311488.
GeneTreei ENSGT00390000013475.
HOGENOMi HOG000211932.
HOVERGENi HBG054211.
InParanoidi Q9Y6G1.
OMAi MGMRFKR.
OrthoDBi EOG7NKKP0.
PhylomeDBi Q9Y6G1.
TreeFami TF323345.

Miscellaneous databases

GenomeRNAii 28978.
NextBioi 51863.
PROi Q9Y6G1.

Gene expression databases

Bgeei Q9Y6G1.
CleanExi HS_TMEM14A.
Genevestigatori Q9Y6G1.

Family and domain databases

InterProi IPR005349. UPF0136_TM.
[Graphical view ]
PANTHERi PTHR12668. PTHR12668. 1 hit.
Pfami PF03647. Tmemb_14. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Zhou J., Huang Q., Song H., Peng J., Zhang Q., Fu G., Dai M., Mao Y., Mao M., Chen Z., Chen J.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary tumor.
  2. Tong X., Liu B., Sun Z.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Urinary bladder.
  7. Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiTM14A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6G1
Secondary accession number(s): B2R552
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3