Q9Y6G1 (TM14A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 14A

Gene names

Name:	TMEM14A
Synonyms:	C6orf73
ORF Names:	PTD011

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	99 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the UPF0136 (TMEM14) family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 99

99

Transmembrane protein 14A

PRO_0000221169

Regions

Transmembrane

1 – 21

21

Helical; Potential

Transmembrane

24 – 44

21

Helical; Potential

Transmembrane

79 – 99

21

Helical; Potential

Natural variations

Natural variant

37

1

C → R.
Corresponds to variant rs11543266 [ dbSNP | Ensembl ].

VAR_052497

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

99

Helix Strand Turn

Details...

Helix

6 – 19

14

Helix

29 – 46

18

Beta strand

47 – 49

3

Helix

54 – 67

14

Beta strand

73 – 80

8

Helix

81 – 94

14

Sequences

	Sequence		Length	Mass (Da)
	Q9Y6G1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: D41CBB95241969B3	FASTA	99	10,712
	10 20 30 40 50 60 MDLIGFGYAA LVTFGSIFGY KRRGGVPSLI AGLFVGCLAG YGAYRVSNDK RDVKVSLFTA 70 80 90 FFLATIMGVR FKRSKKIMPA GLVAGLSLMM ILRLVLLLL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Zhou J., Huang Q., Song H., Peng J., Zhang Q., Fu G., Dai M., Mao Y., Mao M., Chen Z., Chen J. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pituitary tumor.
[2]	Tong X., Liu B., Sun Z. Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum.
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung and Urinary bladder.
[7]	"Facile backbone structure determination of human membrane proteins by NMR spectroscopy." Klammt C., Maslennikov I., Bayrhuber M., Eichmann C., Vajpai N., Chiu E.J., Blain K.Y., Esquivies L., Kwon J.H., Balana B., Pieper U., Sali A., Slesinger P.A., Kwiatkowski W., Riek R., Choe S. Nat. Methods 9:834-839(2012) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF078864 mRNA. Translation: AAD44496.1.
AF239771 mRNA. Translation: AAF59948.1.
AK312063 mRNA. Translation: BAG34999.1.
AL109918 Genomic DNA. Translation: CAB92769.1.
CH471081 Genomic DNA. Translation: EAX04380.1.
BC015097 mRNA. Translation: AAH15097.1.
BC019328 mRNA. Translation: AAH19328.1.

IPI

IPI00002253.

RefSeq

NP_054770.1. NM_014051.3.

UniGene

Hs.94896.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2LOO	NMR	-	A	1-99	[»]
2LOP	NMR	-	A	1-99	[»]

ProteinModelPortal

Q9Y6G1.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9Y6G1. 1 interaction.

PTM databases

PhosphoSite

Q9Y6G1.

Polymorphism databases

DMDM

9910842.

Proteomic databases

PaxDb

Q9Y6G1.

PRIDE

Q9Y6G1.

Protocols and materials databases

DNASU

28978.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000211314; ENSP00000211314; ENSG00000096092.

GeneID

28978.

KEGG

hsa:28978.

UCSC

uc003pax.3. human.

Organism-specific databases

CTD

28978.

GeneCards

GC06P052535.

HGNC

HGNC:21076. TMEM14A.

neXtProt

NX_Q9Y6G1.

PharmGKB

PA134974524.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG311488.

HOGENOM

HOG000211932.

HOVERGEN

HBG054211.

InParanoid

Q9Y6G1.

OMA

MAIDWIG.

OrthoDB

EOG45X7XT.

PhylomeDB

Q9Y6G1.

Gene expression databases

Bgee

Q9Y6G1.

CleanEx

HS_TMEM14A.

Genevestigator

Q9Y6G1.

GermOnline

ENSG00000096092. Homo sapiens.

Family and domain databases

InterPro

IPR005349. UPF0136_TM.
[Graphical view]

PANTHER

PTHR12668. PTHR12668. 1 hit.

Pfam

PF03647. Tmemb_14. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

28978.

NextBio

51863.

Entry information

Entry name

TM14A_HUMAN

Accession

Primary (citable) accession number: Q9Y6G1
Secondary accession number(s): B2R552

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.