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Protein

Transmembrane protein 14A

Gene

TMEM14A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 14A
Gene namesi
Name:TMEM14A
Synonyms:C6orf73
ORF Names:PTD011
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21076. TMEM14A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence AnalysisAdd
BLAST
Transmembranei24 – 4421HelicalSequence AnalysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134974524.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9999Transmembrane protein 14APRO_0000221169Add
BLAST

Proteomic databases

PaxDbiQ9Y6G1.
PRIDEiQ9Y6G1.

PTM databases

PhosphoSiteiQ9Y6G1.

Expressioni

Gene expression databases

BgeeiQ9Y6G1.
CleanExiHS_TMEM14A.
GenevestigatoriQ9Y6G1.

Interactioni

Protein-protein interaction databases

BioGridi118801. 3 interactions.
IntActiQ9Y6G1. 4 interactions.

Structurei

Secondary structure

1
99
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1914Combined sources
Helixi29 – 4517Combined sources
Beta strandi47 – 493Combined sources
Helixi54 – 6714Combined sources
Beta strandi75 – 773Combined sources
Helixi78 – 9619Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LOONMR-A1-99[»]
2LOPNMR-A1-99[»]
ProteinModelPortaliQ9Y6G1.
SMRiQ9Y6G1. Positions 1-87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0136 (TMEM14) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311488.
GeneTreeiENSGT00390000013475.
HOGENOMiHOG000211932.
HOVERGENiHBG054211.
InParanoidiQ9Y6G1.
OMAiMTIDWIG.
OrthoDBiEOG7NKKP0.
PhylomeDBiQ9Y6G1.
TreeFamiTF323345.

Family and domain databases

InterProiIPR005349. UPF0136_TM.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y6G1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLIGFGYAA LVTFGSIFGY KRRGGVPSLI AGLFVGCLAG YGAYRVSNDK
60 70 80 90
RDVKVSLFTA FFLATIMGVR FKRSKKIMPA GLVAGLSLMM ILRLVLLLL
Length:99
Mass (Da):10,712
Last modified:November 1, 1999 - v1
Checksum:iD41CBB95241969B3
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371C → R.
Corresponds to variant rs11543266 [ dbSNP | Ensembl ].
VAR_052497

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078864 mRNA. Translation: AAD44496.1.
AF239771 mRNA. Translation: AAF59948.1.
AK312063 mRNA. Translation: BAG34999.1.
AL109918 Genomic DNA. Translation: CAB92769.1.
CH471081 Genomic DNA. Translation: EAX04380.1.
BC015097 mRNA. Translation: AAH15097.1.
BC019328 mRNA. Translation: AAH19328.1.
CCDSiCCDS4943.1.
RefSeqiNP_054770.1. NM_014051.3.
UniGeneiHs.94896.

Genome annotation databases

EnsembliENST00000211314; ENSP00000211314; ENSG00000096092.
GeneIDi28978.
KEGGihsa:28978.
UCSCiuc003pax.3. human.

Polymorphism databases

DMDMi9910842.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078864 mRNA. Translation: AAD44496.1.
AF239771 mRNA. Translation: AAF59948.1.
AK312063 mRNA. Translation: BAG34999.1.
AL109918 Genomic DNA. Translation: CAB92769.1.
CH471081 Genomic DNA. Translation: EAX04380.1.
BC015097 mRNA. Translation: AAH15097.1.
BC019328 mRNA. Translation: AAH19328.1.
CCDSiCCDS4943.1.
RefSeqiNP_054770.1. NM_014051.3.
UniGeneiHs.94896.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LOONMR-A1-99[»]
2LOPNMR-A1-99[»]
ProteinModelPortaliQ9Y6G1.
SMRiQ9Y6G1. Positions 1-87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118801. 3 interactions.
IntActiQ9Y6G1. 4 interactions.

PTM databases

PhosphoSiteiQ9Y6G1.

Polymorphism databases

DMDMi9910842.

Proteomic databases

PaxDbiQ9Y6G1.
PRIDEiQ9Y6G1.

Protocols and materials databases

DNASUi28978.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000211314; ENSP00000211314; ENSG00000096092.
GeneIDi28978.
KEGGihsa:28978.
UCSCiuc003pax.3. human.

Organism-specific databases

CTDi28978.
GeneCardsiGC06P052535.
HGNCiHGNC:21076. TMEM14A.
neXtProtiNX_Q9Y6G1.
PharmGKBiPA134974524.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG311488.
GeneTreeiENSGT00390000013475.
HOGENOMiHOG000211932.
HOVERGENiHBG054211.
InParanoidiQ9Y6G1.
OMAiMTIDWIG.
OrthoDBiEOG7NKKP0.
PhylomeDBiQ9Y6G1.
TreeFamiTF323345.

Miscellaneous databases

ChiTaRSiTMEM14A. human.
GenomeRNAii28978.
NextBioi51863.
PROiQ9Y6G1.

Gene expression databases

BgeeiQ9Y6G1.
CleanExiHS_TMEM14A.
GenevestigatoriQ9Y6G1.

Family and domain databases

InterProiIPR005349. UPF0136_TM.
[Graphical view]
PANTHERiPTHR12668. PTHR12668. 1 hit.
PfamiPF03647. Tmemb_14. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Zhou J., Huang Q., Song H., Peng J., Zhang Q., Fu G., Dai M., Mao Y., Mao M., Chen Z., Chen J.
    Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary tumor.
  2. Tong X., Liu B., Sun Z.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fetal brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Urinary bladder.
  7. Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiTM14A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6G1
Secondary accession number(s): B2R552
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: February 4, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.