Q9Y6F9 (WNT6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Wnt-6

Gene names

Name:

WNT6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Subunit structure	Interacts with PORCN By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Post-translational modification	Palmitoylation at Ser-228 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-76. Palmitoylation is necessary for proper trafficking to cell surface By similarity.
Sequence similarities	Belongs to the Wnt family.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Extracellular matrix Secreted
Domain	Signal
Molecular function	Developmental protein
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from Biological aspect of Ancestor. Source: RefGenome axis specification Inferred from Biological aspect of Ancestor. Source: RefGenome branching involved in ureteric bud morphogenesis Inferred from electronic annotation. Source: Compara branching morphogenesis of an epithelial tube Inferred from Biological aspect of Ancestor. Source: RefGenome canonical Wnt receptor signaling pathway Inferred from Biological aspect of Ancestor. Source: RefGenome cell-cell signaling Non-traceable author statement. Source: UniProtKB cellular response to retinoic acid Inferred from sequence or structural similarity. Source: UniProtKB cornea development in camera-type eye Inferred from sequence or structural similarity PubMed 16258938. Source: BHF-UCL epithelial-mesenchymal cell signaling Inferred from electronic annotation. Source: Compara nephron tubule development Inferred from Biological aspect of Ancestor. Source: RefGenome nephron tubule formation Inferred from electronic annotation. Source: Compara neuron differentiation Inferred from sequence or structural similarity. Source: UniProtKB odontogenesis of dentin-containing tooth Inferred from mutant phenotype PubMed 20113781. Source: BHF-UCL positive regulation of gene expression Inferred from mutant phenotype PubMed 20113781. Source: BHF-UCL positive regulation of tooth mineralization Inferred from mutant phenotype PubMed 20113781. Source: BHF-UCL positive regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara
Cellular_component	cell surface Inferred from electronic annotation. Source: Compara extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor binding Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 365	341	Protein Wnt-6		PRO_0000041440
Amino acid modifications
	Lipidation	76	1	S-palmitoyl cysteine By similarity
	Lipidation	228	1	O-palmitoyl serine; by PORCN By similarity
	Glycosylation	86	1	N-linked (GlcNAc...) Potential
	Glycosylation	311	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9Y6F9 [UniParc]. Last modified June 20, 2001. Version 2. Checksum: 928DE396C58E295B	FASTA	365	39,721
	10 20 30 40 50 60 MLPPLPSRLG LLLLLLLCPA HVGGLWWAVG SPLVMDPTSI CRKARRLAGR QAELCQAEPE 70 80 90 100 110 120 VVAELARGAR LGVRECQFQF RFRRWNCSSH SKAFGRILQQ DIRETAFVFA ITAAGASHAV 130 140 150 160 170 180 TQACSMGELL QCGCQAPRGR APPRPSGLPG TPGPPGPAGS PEGSAAWEWG GCGDDVDFGD 190 200 210 220 230 240 EKSRLFMDAR HKRGRGDIRA LVQLHNNEAG RLAVRSHTRT ECKCHGLSGS CALRTCWQKL 250 260 270 280 290 300 PPFREVGARL LERFHGASRV MGTNDGKALL PAVRTLKPPG RADLLYAADS PDFCAPNRRT 310 320 330 340 350 360 GSPGTRGRAC NSSAPDLSGC DLLCCGRGHR QESVQLEENC LCRFHWCCVV QCHRCRVRKE LSLCL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of six novel human WNT genes." Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., Reith A.D., Barnes M.R. Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly co-expressed in SW480 cells." Kirikoshi H., Sekihara H., Katoh M. Biochem. Biophys. Res. Commun. 283:798-805(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[5]	"Genomic sequence of the Wnt6 gene and the Wnt10a gene from human 2q35." Rump A., Hayes C., Brown S.D.M., Rosenthal A. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-365.
[6]	"Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization." Rankin J., Strachan T., Lako M., Lindsay S. Cytogenet. Cell Genet. 84:50-52(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 295-337.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY009401 mRNA. Translation: AAG38661.1. AB059570 mRNA. Translation: BAB55603.1. BT007456 mRNA. Translation: AAP36124.1. BC004329 mRNA. Translation: AAH04329.1. AF315943 Genomic DNA. Translation: AAG45154.1. AF079522 Genomic DNA. Translation: AAD41674.1.
IPI	IPI00002239.
PIR	JC7694.
RefSeq	NP_006513.1. NM_006522.3.
UniGene	Hs.29764.
3D structure databases
ProteinModelPortal	Q9Y6F9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000233948.
Polymorphism databases
DMDM	14424016.
Proteomic databases
PaxDb	Q9Y6F9.
PRIDE	Q9Y6F9.
Protocols and materials databases
DNASU	7475.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000233948; ENSP00000233948; ENSG00000115596.
GeneID	7475.
KEGG	hsa:7475.
UCSC	uc002vjc.1. human.
Organism-specific databases
CTD	7475.
GeneCards	GC02P219724.
HGNC	HGNC:12785. WNT6.
HPA	HPA052031.
MIM	604663. gene.
neXtProt	NX_Q9Y6F9.
PharmGKB	PA37386.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG246444.
HOGENOM	HOG000039528.
HOVERGEN	HBG001595.
InParanoid	Q9Y6F9.
KO	K00445.
OMA	RTLKPPG.
OrthoDB	EOG4BZN2W.
PhylomeDB	Q9Y6F9.
Enzyme and pathway databases
Pathway_Interaction_DB	wnt_calcium_pathway. Noncanonical Wnt signaling pathway. wnt_signaling_pathway. Wnt signaling.
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q9Y6F9.
Bgee	Q9Y6F9.
CleanEx	HS_WNT6.
Genevestigator	Q9Y6F9.
GermOnline	ENSG00000115596. Homo sapiens.
Family and domain databases
InterPro	IPR005817. Wnt. IPR009143. Wnt6. IPR018161. Wnt_CS. [Graphical view]
PANTHER	PTHR12027. PTHR12027. 1 hit. PTHR12027:SF14. PTHR12027:SF14. 1 hit.
Pfam	PF00110. wnt. 1 hit. [Graphical view]
PRINTS	PR01845. WNT6PROTEIN. PR01349. WNTPROTEIN.
SMART	SM00097. WNT1. 1 hit. [Graphical view]
PROSITE	PS00246. WNT1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7475.
NextBio	29280.
SOURCE	Search...

Entry information

Entry name

WNT6_HUMAN

Accession

Primary (citable) accession number: Q9Y6F9
Secondary accession number(s): Q9H1J6, Q9H238

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	June 20, 2001
Last modified:	May 1, 2013
This is version 111 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.