Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y6F9

- WNT6_HUMAN

UniProt

Q9Y6F9 - WNT6_HUMAN

Protein

Protein Wnt-6

Gene

WNT6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (20 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.1 Publication

    GO - Molecular functioni

    1. frizzled binding Source: RefGenome

    GO - Biological processi

    1. axis specification Source: Ensembl
    2. branching involved in ureteric bud morphogenesis Source: Ensembl
    3. cell fate commitment Source: RefGenome
    4. cellular response to retinoic acid Source: UniProtKB
    5. cornea development in camera-type eye Source: BHF-UCL
    6. epithelial-mesenchymal cell signaling Source: Ensembl
    7. nephron tubule formation Source: Ensembl
    8. neuron differentiation Source: UniProtKB
    9. odontogenesis of dentin-containing tooth Source: BHF-UCL
    10. positive regulation of gene expression Source: BHF-UCL
    11. positive regulation of tooth mineralization Source: BHF-UCL
    12. positive regulation of transcription, DNA-templated Source: Ensembl
    13. Wnt signaling pathway Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Wnt-6
    Gene namesi
    Name:WNT6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:12785. WNT6.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. endoplasmic reticulum lumen Source: Reactome
    3. extracellular region Source: Reactome
    4. extracellular space Source: RefGenome
    5. Golgi lumen Source: Reactome
    6. plasma membrane Source: Reactome
    7. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37386.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 365341Protein Wnt-6PRO_0000041440Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi76 ↔ 87By similarity
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi124 ↔ 132By similarity
    Disulfide bondi134 ↔ 172By similarity
    Disulfide bondi222 ↔ 236By similarity
    Disulfide bondi224 ↔ 231By similarity
    Lipidationi228 – 2281O-palmitoyl serine; by PORCNBy similarity
    Disulfide bondi310 ↔ 325By similarity
    Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi340 ↔ 355By similarity
    Disulfide bondi342 ↔ 352By similarity
    Disulfide bondi347 ↔ 348By similarity

    Post-translational modificationi

    Palmitoylation at Ser-228 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ9Y6F9.
    PRIDEiQ9Y6F9.

    Expressioni

    Tissue specificityi

    Expressed in gastric cancer cell lines and gastric cancer tissues (at protein level). Detected in the apical gland region of the gastric foveolar epithelium (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ9Y6F9.
    BgeeiQ9Y6F9.
    CleanExiHS_WNT6.
    GenevestigatoriQ9Y6F9.

    Organism-specific databases

    HPAiHPA052031.

    Interactioni

    Subunit structurei

    Interacts with PORCN.By similarity

    Protein-protein interaction databases

    STRINGi9606.ENSP00000233948.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y6F9.
    SMRiQ9Y6F9. Positions 63-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Wnt family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG246444.
    HOGENOMiHOG000039528.
    HOVERGENiHBG001595.
    InParanoidiQ9Y6F9.
    KOiK00445.
    OMAiRTLKPPG.
    OrthoDBiEOG7C8GJ8.
    PhylomeDBiQ9Y6F9.
    TreeFamiTF105310.

    Family and domain databases

    InterProiIPR005817. Wnt.
    IPR009143. Wnt6.
    IPR018161. Wnt_CS.
    [Graphical view]
    PANTHERiPTHR12027. PTHR12027. 1 hit.
    PfamiPF00110. wnt. 1 hit.
    [Graphical view]
    PRINTSiPR01845. WNT6PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTiSM00097. WNT1. 1 hit.
    [Graphical view]
    PROSITEiPS00246. WNT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y6F9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLPPLPSRLG LLLLLLLCPA HVGGLWWAVG SPLVMDPTSI CRKARRLAGR    50
    QAELCQAEPE VVAELARGAR LGVRECQFQF RFRRWNCSSH SKAFGRILQQ 100
    DIRETAFVFA ITAAGASHAV TQACSMGELL QCGCQAPRGR APPRPSGLPG 150
    TPGPPGPAGS PEGSAAWEWG GCGDDVDFGD EKSRLFMDAR HKRGRGDIRA 200
    LVQLHNNEAG RLAVRSHTRT ECKCHGLSGS CALRTCWQKL PPFREVGARL 250
    LERFHGASRV MGTNDGKALL PAVRTLKPPG RADLLYAADS PDFCAPNRRT 300
    GSPGTRGRAC NSSAPDLSGC DLLCCGRGHR QESVQLEENC LCRFHWCCVV 350
    QCHRCRVRKE LSLCL 365
    Length:365
    Mass (Da):39,721
    Last modified:June 20, 2001 - v2
    Checksum:i928DE396C58E295B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY009401 mRNA. Translation: AAG38661.1.
    AB059570 mRNA. Translation: BAB55603.1.
    BT007456 mRNA. Translation: AAP36124.1.
    BC004329 mRNA. Translation: AAH04329.1.
    AF315943 Genomic DNA. Translation: AAG45154.1.
    AF079522 Genomic DNA. Translation: AAD41674.1.
    CCDSiCCDS2425.1.
    PIRiJC7694.
    RefSeqiNP_006513.1. NM_006522.3.
    UniGeneiHs.29764.

    Genome annotation databases

    EnsembliENST00000233948; ENSP00000233948; ENSG00000115596.
    GeneIDi7475.
    KEGGihsa:7475.
    UCSCiuc002vjc.1. human.

    Polymorphism databases

    DMDMi14424016.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY009401 mRNA. Translation: AAG38661.1 .
    AB059570 mRNA. Translation: BAB55603.1 .
    BT007456 mRNA. Translation: AAP36124.1 .
    BC004329 mRNA. Translation: AAH04329.1 .
    AF315943 Genomic DNA. Translation: AAG45154.1 .
    AF079522 Genomic DNA. Translation: AAD41674.1 .
    CCDSi CCDS2425.1.
    PIRi JC7694.
    RefSeqi NP_006513.1. NM_006522.3.
    UniGenei Hs.29764.

    3D structure databases

    ProteinModelPortali Q9Y6F9.
    SMRi Q9Y6F9. Positions 63-356.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000233948.

    Polymorphism databases

    DMDMi 14424016.

    Proteomic databases

    PaxDbi Q9Y6F9.
    PRIDEi Q9Y6F9.

    Protocols and materials databases

    DNASUi 7475.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000233948 ; ENSP00000233948 ; ENSG00000115596 .
    GeneIDi 7475.
    KEGGi hsa:7475.
    UCSCi uc002vjc.1. human.

    Organism-specific databases

    CTDi 7475.
    GeneCardsi GC02P219724.
    HGNCi HGNC:12785. WNT6.
    HPAi HPA052031.
    MIMi 604663. gene.
    neXtProti NX_Q9Y6F9.
    PharmGKBi PA37386.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG246444.
    HOGENOMi HOG000039528.
    HOVERGENi HBG001595.
    InParanoidi Q9Y6F9.
    KOi K00445.
    OMAi RTLKPPG.
    OrthoDBi EOG7C8GJ8.
    PhylomeDBi Q9Y6F9.
    TreeFami TF105310.

    Enzyme and pathway databases

    Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
    REACT_18372. Class B/2 (Secretin family receptors).

    Miscellaneous databases

    GenomeRNAii 7475.
    NextBioi 29280.
    PROi Q9Y6F9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y6F9.
    Bgeei Q9Y6F9.
    CleanExi HS_WNT6.
    Genevestigatori Q9Y6F9.

    Family and domain databases

    InterProi IPR005817. Wnt.
    IPR009143. Wnt6.
    IPR018161. Wnt_CS.
    [Graphical view ]
    PANTHERi PTHR12027. PTHR12027. 1 hit.
    Pfami PF00110. wnt. 1 hit.
    [Graphical view ]
    PRINTSi PR01845. WNT6PROTEIN.
    PR01349. WNTPROTEIN.
    SMARTi SM00097. WNT1. 1 hit.
    [Graphical view ]
    PROSITEi PS00246. WNT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of six novel human WNT genes."
      Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., Reith A.D., Barnes M.R.
      Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly co-expressed in SW480 cells."
      Kirikoshi H., Sekihara H., Katoh M.
      Biochem. Biophys. Res. Commun. 283:798-805(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    5. "Genomic sequence of the Wnt6 gene and the Wnt10a gene from human 2q35."
      Rump A., Hayes C., Brown S.D.M., Rosenthal A.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-365.
    6. "Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization."
      Rankin J., Strachan T., Lako M., Lindsay S.
      Cytogenet. Cell Genet. 84:50-52(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 295-337.
    7. "WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells."
      Yuan G., Regel I., Lian F., Friedrich T., Hitkova I., Hofheinz R.D., Stroebel P., Langer R., Keller G., Roecken C., Zimmermann W., Schmid R.M., Ebert M.P.A., Burgermeister E.
      Oncogene 32:375-387(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiWNT6_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y6F9
    Secondary accession number(s): Q9H1J6, Q9H238
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: June 20, 2001
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3