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Q9Y6F9 (WNT6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein Wnt-6
Gene names
Name:WNT6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway. Ref.7

Subunit structure

Interacts with PORCN By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix.

Tissue specificity

Expressed in gastric cancer cell lines and gastric cancer tissues (at protein level). Detected in the apical gland region of the gastric foveolar epithelium (at protein level). Ref.7

Post-translational modification

Palmitoylation at Ser-228 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation at Cys-76. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Sequence similarities

Belongs to the Wnt family.

Ontologies

Keywords
   Biological processWnt signaling pathway
   Cellular componentExtracellular matrix
Secreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processWnt signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

axis specification

Inferred from electronic annotation. Source: Ensembl

branching involved in ureteric bud morphogenesis

Inferred from electronic annotation. Source: Ensembl

cell fate commitment

Inferred from Biological aspect of Ancestor. Source: RefGenome

cellular response to retinoic acid

Inferred from sequence or structural similarity. Source: UniProtKB

cornea development in camera-type eye

Inferred from sequence or structural similarity PubMed 16258938. Source: BHF-UCL

epithelial-mesenchymal cell signaling

Inferred from electronic annotation. Source: Ensembl

nephron tubule formation

Inferred from electronic annotation. Source: Ensembl

neuron differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

odontogenesis of dentin-containing tooth

Inferred from mutant phenotype PubMed 20113781. Source: BHF-UCL

positive regulation of gene expression

Inferred from mutant phenotype PubMed 20113781. Source: BHF-UCL

positive regulation of tooth mineralization

Inferred from mutant phenotype PubMed 20113781. Source: BHF-UCL

positive regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi lumen

Traceable author statement. Source: Reactome

cell surface

Inferred from electronic annotation. Source: Ensembl

endoplasmic reticulum lumen

Traceable author statement. Source: Reactome

extracellular region

Traceable author statement. Source: Reactome

extracellular space

Inferred from Biological aspect of Ancestor. Source: RefGenome

plasma membrane

Traceable author statement. Source: Reactome

proteinaceous extracellular matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionfrizzled binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 365341Protein Wnt-6
PRO_0000041440

Amino acid modifications

Lipidation761S-palmitoyl cysteine By similarity
Lipidation2281O-palmitoyl serine; by PORCN By similarity
Glycosylation861N-linked (GlcNAc...) Potential
Glycosylation3111N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9Y6F9 [UniParc].

Last modified June 20, 2001. Version 2.
Checksum: 928DE396C58E295B

FASTA36539,721
        10         20         30         40         50         60 
MLPPLPSRLG LLLLLLLCPA HVGGLWWAVG SPLVMDPTSI CRKARRLAGR QAELCQAEPE 

        70         80         90        100        110        120 
VVAELARGAR LGVRECQFQF RFRRWNCSSH SKAFGRILQQ DIRETAFVFA ITAAGASHAV 

       130        140        150        160        170        180 
TQACSMGELL QCGCQAPRGR APPRPSGLPG TPGPPGPAGS PEGSAAWEWG GCGDDVDFGD 

       190        200        210        220        230        240 
EKSRLFMDAR HKRGRGDIRA LVQLHNNEAG RLAVRSHTRT ECKCHGLSGS CALRTCWQKL 

       250        260        270        280        290        300 
PPFREVGARL LERFHGASRV MGTNDGKALL PAVRTLKPPG RADLLYAADS PDFCAPNRRT 

       310        320        330        340        350        360 
GSPGTRGRAC NSSAPDLSGC DLLCCGRGHR QESVQLEENC LCRFHWCCVV QCHRCRVRKE 


LSLCL 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of six novel human WNT genes."
Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., Reith A.D., Barnes M.R.
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly co-expressed in SW480 cells."
Kirikoshi H., Sekihara H., Katoh M.
Biochem. Biophys. Res. Commun. 283:798-805(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[5]"Genomic sequence of the Wnt6 gene and the Wnt10a gene from human 2q35."
Rump A., Hayes C., Brown S.D.M., Rosenthal A.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-365.
[6]"Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization."
Rankin J., Strachan T., Lako M., Lindsay S.
Cytogenet. Cell Genet. 84:50-52(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 295-337.
[7]"WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells."
Yuan G., Regel I., Lian F., Friedrich T., Hitkova I., Hofheinz R.D., Stroebel P., Langer R., Keller G., Roecken C., Zimmermann W., Schmid R.M., Ebert M.P.A., Burgermeister E.
Oncogene 32:375-387(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY009401 mRNA. Translation: AAG38661.1.
AB059570 mRNA. Translation: BAB55603.1.
BT007456 mRNA. Translation: AAP36124.1.
BC004329 mRNA. Translation: AAH04329.1.
AF315943 Genomic DNA. Translation: AAG45154.1.
AF079522 Genomic DNA. Translation: AAD41674.1.
CCDSCCDS2425.1.
PIRJC7694.
RefSeqNP_006513.1. NM_006522.3.
UniGeneHs.29764.

3D structure databases

ProteinModelPortalQ9Y6F9.
SMRQ9Y6F9. Positions 63-356.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000233948.

Polymorphism databases

DMDM14424016.

Proteomic databases

PaxDbQ9Y6F9.
PRIDEQ9Y6F9.

Protocols and materials databases

DNASU7475.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000233948; ENSP00000233948; ENSG00000115596.
GeneID7475.
KEGGhsa:7475.
UCSCuc002vjc.1. human.

Organism-specific databases

CTD7475.
GeneCardsGC02P219724.
HGNCHGNC:12785. WNT6.
HPAHPA052031.
MIM604663. gene.
neXtProtNX_Q9Y6F9.
PharmGKBPA37386.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG246444.
HOGENOMHOG000039528.
HOVERGENHBG001595.
InParanoidQ9Y6F9.
KOK00445.
OMARTLKPPG.
OrthoDBEOG7C8GJ8.
PhylomeDBQ9Y6F9.
TreeFamTF105310.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ9Y6F9.
BgeeQ9Y6F9.
CleanExHS_WNT6.
GenevestigatorQ9Y6F9.

Family and domain databases

InterProIPR005817. Wnt.
IPR009143. Wnt6.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERPTHR12027. PTHR12027. 1 hit.
PfamPF00110. wnt. 1 hit.
[Graphical view]
PRINTSPR01845. WNT6PROTEIN.
PR01349. WNTPROTEIN.
SMARTSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEPS00246. WNT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi7475.
NextBio29280.
PROQ9Y6F9.
SOURCESearch...

Entry information

Entry nameWNT6_HUMAN
AccessionPrimary (citable) accession number: Q9Y6F9
Secondary accession number(s): Q9H1J6, Q9H238
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 20, 2001
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM