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Q9Y6F9

- WNT6_HUMAN

UniProt

Q9Y6F9 - WNT6_HUMAN

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Protein

Protein Wnt-6

Gene
WNT6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway.1 Publication

GO - Molecular functioni

  1. frizzled binding Source: RefGenome

GO - Biological processi

  1. axis specification Source: Ensembl
  2. branching involved in ureteric bud morphogenesis Source: Ensembl
  3. cell fate commitment Source: RefGenome
  4. cellular response to retinoic acid Source: UniProtKB
  5. cornea development in camera-type eye Source: BHF-UCL
  6. epithelial-mesenchymal cell signaling Source: Ensembl
  7. nephron tubule formation Source: Ensembl
  8. neuron differentiation Source: UniProtKB
  9. odontogenesis of dentin-containing tooth Source: BHF-UCL
  10. positive regulation of gene expression Source: BHF-UCL
  11. positive regulation of tooth mineralization Source: BHF-UCL
  12. positive regulation of transcription, DNA-templated Source: Ensembl
  13. Wnt signaling pathway Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Wnt-6
Gene namesi
Name:WNT6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:12785. WNT6.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. endoplasmic reticulum lumen Source: Reactome
  3. extracellular region Source: Reactome
  4. extracellular space Source: RefGenome
  5. Golgi lumen Source: Reactome
  6. plasma membrane Source: Reactome
  7. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37386.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 365341Protein Wnt-6PRO_0000041440Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi76 ↔ 87 By similarity
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi124 ↔ 132 By similarity
Disulfide bondi134 ↔ 172 By similarity
Disulfide bondi222 ↔ 236 By similarity
Disulfide bondi224 ↔ 231 By similarity
Lipidationi228 – 2281O-palmitoyl serine; by PORCN By similarity
Disulfide bondi310 ↔ 325 By similarity
Glycosylationi311 – 3111N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi340 ↔ 355 By similarity
Disulfide bondi342 ↔ 352 By similarity
Disulfide bondi347 ↔ 348 By similarity

Post-translational modificationi

Palmitoylation at Ser-228 is required for efficient binding to frizzled receptors. Palmitoylation is necessary for proper trafficking to cell surface By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9Y6F9.
PRIDEiQ9Y6F9.

Expressioni

Tissue specificityi

Expressed in gastric cancer cell lines and gastric cancer tissues (at protein level). Detected in the apical gland region of the gastric foveolar epithelium (at protein level).1 Publication

Gene expression databases

ArrayExpressiQ9Y6F9.
BgeeiQ9Y6F9.
CleanExiHS_WNT6.
GenevestigatoriQ9Y6F9.

Organism-specific databases

HPAiHPA052031.

Interactioni

Subunit structurei

Interacts with PORCN By similarity.

Protein-protein interaction databases

STRINGi9606.ENSP00000233948.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6F9.
SMRiQ9Y6F9. Positions 63-356.

Family & Domainsi

Sequence similaritiesi

Belongs to the Wnt family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG246444.
HOGENOMiHOG000039528.
HOVERGENiHBG001595.
InParanoidiQ9Y6F9.
KOiK00445.
OMAiRTLKPPG.
OrthoDBiEOG7C8GJ8.
PhylomeDBiQ9Y6F9.
TreeFamiTF105310.

Family and domain databases

InterProiIPR005817. Wnt.
IPR009143. Wnt6.
IPR018161. Wnt_CS.
[Graphical view]
PANTHERiPTHR12027. PTHR12027. 1 hit.
PfamiPF00110. wnt. 1 hit.
[Graphical view]
PRINTSiPR01845. WNT6PROTEIN.
PR01349. WNTPROTEIN.
SMARTiSM00097. WNT1. 1 hit.
[Graphical view]
PROSITEiPS00246. WNT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6F9-1 [UniParc]FASTAAdd to Basket

« Hide

MLPPLPSRLG LLLLLLLCPA HVGGLWWAVG SPLVMDPTSI CRKARRLAGR    50
QAELCQAEPE VVAELARGAR LGVRECQFQF RFRRWNCSSH SKAFGRILQQ 100
DIRETAFVFA ITAAGASHAV TQACSMGELL QCGCQAPRGR APPRPSGLPG 150
TPGPPGPAGS PEGSAAWEWG GCGDDVDFGD EKSRLFMDAR HKRGRGDIRA 200
LVQLHNNEAG RLAVRSHTRT ECKCHGLSGS CALRTCWQKL PPFREVGARL 250
LERFHGASRV MGTNDGKALL PAVRTLKPPG RADLLYAADS PDFCAPNRRT 300
GSPGTRGRAC NSSAPDLSGC DLLCCGRGHR QESVQLEENC LCRFHWCCVV 350
QCHRCRVRKE LSLCL 365
Length:365
Mass (Da):39,721
Last modified:June 20, 2001 - v2
Checksum:i928DE396C58E295B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY009401 mRNA. Translation: AAG38661.1.
AB059570 mRNA. Translation: BAB55603.1.
BT007456 mRNA. Translation: AAP36124.1.
BC004329 mRNA. Translation: AAH04329.1.
AF315943 Genomic DNA. Translation: AAG45154.1.
AF079522 Genomic DNA. Translation: AAD41674.1.
CCDSiCCDS2425.1.
PIRiJC7694.
RefSeqiNP_006513.1. NM_006522.3.
UniGeneiHs.29764.

Genome annotation databases

EnsembliENST00000233948; ENSP00000233948; ENSG00000115596.
GeneIDi7475.
KEGGihsa:7475.
UCSCiuc002vjc.1. human.

Polymorphism databases

DMDMi14424016.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY009401 mRNA. Translation: AAG38661.1 .
AB059570 mRNA. Translation: BAB55603.1 .
BT007456 mRNA. Translation: AAP36124.1 .
BC004329 mRNA. Translation: AAH04329.1 .
AF315943 Genomic DNA. Translation: AAG45154.1 .
AF079522 Genomic DNA. Translation: AAD41674.1 .
CCDSi CCDS2425.1.
PIRi JC7694.
RefSeqi NP_006513.1. NM_006522.3.
UniGenei Hs.29764.

3D structure databases

ProteinModelPortali Q9Y6F9.
SMRi Q9Y6F9. Positions 63-356.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000233948.

Polymorphism databases

DMDMi 14424016.

Proteomic databases

PaxDbi Q9Y6F9.
PRIDEi Q9Y6F9.

Protocols and materials databases

DNASUi 7475.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000233948 ; ENSP00000233948 ; ENSG00000115596 .
GeneIDi 7475.
KEGGi hsa:7475.
UCSCi uc002vjc.1. human.

Organism-specific databases

CTDi 7475.
GeneCardsi GC02P219724.
HGNCi HGNC:12785. WNT6.
HPAi HPA052031.
MIMi 604663. gene.
neXtProti NX_Q9Y6F9.
PharmGKBi PA37386.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG246444.
HOGENOMi HOG000039528.
HOVERGENi HBG001595.
InParanoidi Q9Y6F9.
KOi K00445.
OMAi RTLKPPG.
OrthoDBi EOG7C8GJ8.
PhylomeDBi Q9Y6F9.
TreeFami TF105310.

Enzyme and pathway databases

Reactomei REACT_163710. WNT ligand biogenesis and trafficking.
REACT_18372. Class B/2 (Secretin family receptors).

Miscellaneous databases

GenomeRNAii 7475.
NextBioi 29280.
PROi Q9Y6F9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y6F9.
Bgeei Q9Y6F9.
CleanExi HS_WNT6.
Genevestigatori Q9Y6F9.

Family and domain databases

InterProi IPR005817. Wnt.
IPR009143. Wnt6.
IPR018161. Wnt_CS.
[Graphical view ]
PANTHERi PTHR12027. PTHR12027. 1 hit.
Pfami PF00110. wnt. 1 hit.
[Graphical view ]
PRINTSi PR01845. WNT6PROTEIN.
PR01349. WNTPROTEIN.
SMARTi SM00097. WNT1. 1 hit.
[Graphical view ]
PROSITEi PS00246. WNT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of six novel human WNT genes."
    Testa T.T., Mossakowska D.E., Carter P.S., Hu E., Zhu Y., Kelsell D.P., Murdock P.R., Herrity N.C., Lewis C.J., Cross D.A., Culbert A.A., Reith A.D., Barnes M.R.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly co-expressed in SW480 cells."
    Kirikoshi H., Sekihara H., Katoh M.
    Biochem. Biophys. Res. Commun. 283:798-805(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. "Genomic sequence of the Wnt6 gene and the Wnt10a gene from human 2q35."
    Rump A., Hayes C., Brown S.D.M., Rosenthal A.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 28-365.
  6. "Partial cloning and assignment of WNT6 to human chromosome band 2q35 by in situ hybridization."
    Rankin J., Strachan T., Lako M., Lindsay S.
    Cytogenet. Cell Genet. 84:50-52(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 295-337.
  7. "WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells."
    Yuan G., Regel I., Lian F., Friedrich T., Hitkova I., Hofheinz R.D., Stroebel P., Langer R., Keller G., Roecken C., Zimmermann W., Schmid R.M., Ebert M.P.A., Burgermeister E.
    Oncogene 32:375-387(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiWNT6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6F9
Secondary accession number(s): Q9H1J6, Q9H238
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: June 20, 2001
Last modified: September 3, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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