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Q9Y6F8

- CDY1_HUMAN

UniProt

Q9Y6F8 - CDY1_HUMAN

Protein

Testis-specific chromodomain protein Y 1

Gene

CDY1

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Has histone acetyltransferase activity, with a preference for histone H4.1 Publication

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC
    2. methylated histone binding Source: UniProtKB

    GO - Biological processi

    1. spermatogenesis Source: ProtInc

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Testis-specific chromodomain protein Y 1 (EC:2.3.1.48)
    Gene namesi
    Name:CDY1
    Synonyms:CDY1A
    AND
    Name:CDY1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome Y

    Organism-specific databases

    HGNCiHGNC:1809. CDY1.
    HGNC:23920. CDY1B.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26354.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 540540Testis-specific chromodomain protein Y 1PRO_0000080219Add
    BLAST

    Proteomic databases

    PaxDbiQ9Y6F8.
    PRIDEiQ9Y6F8.

    PTM databases

    PhosphoSiteiQ9Y6F8.

    Expressioni

    Tissue specificityi

    Testis-specific. Detected in spermatids (at protein level).1 Publication

    Gene expression databases

    BgeeiQ9Y6F8.
    CleanExiHS_CDY1.
    HS_CDY1B.
    GenevestigatoriQ9Y6F8.

    Interactioni

    Subunit structurei

    Interacts (via chromo domain) with histone H3K9me3.1 Publication

    Protein-protein interaction databases

    BioGridi128959. 1 interaction.
    STRINGi9606.ENSP00000302968.

    Structurei

    Secondary structure

    1
    540
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi284 – 2907
    Beta strandi292 – 2998
    Beta strandi302 – 3054
    Helixi311 – 32616
    Beta strandi330 – 3367
    Helixi347 – 35610
    Helixi358 – 37821
    Beta strandi383 – 3875
    Helixi394 – 3974
    Helixi399 – 4013
    Beta strandi402 – 4087
    Beta strandi412 – 4143
    Helixi417 – 4204
    Helixi428 – 4369
    Helixi438 – 4458
    Beta strandi450 – 4523
    Helixi453 – 4586
    Beta strandi463 – 4664
    Helixi472 – 48211
    Helixi487 – 49812
    Turni499 – 5013
    Helixi502 – 52019
    Helixi523 – 5308

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2FBMX-ray2.28A/B/C281-531[»]
    ProteinModelPortaliQ9Y6F8.
    SMRiQ9Y6F8. Positions 1-64, 282-531.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y6F8.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 6661ChromoPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 chromo domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1024.
    HOGENOMiHOG000111507.
    HOVERGENiHBG006723.
    KOiK00653.
    OMAiNERECEM.
    OrthoDBiEOG72RN06.
    PhylomeDBiQ9Y6F8.
    TreeFamiTF313375.

    Family and domain databases

    Gene3Di3.90.226.10. 1 hit.
    InterProiIPR017984. Chromo_dom_subgr.
    IPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR023779. Chromodomain_CS.
    IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    [Graphical view]
    PfamiPF00385. Chromo. 1 hit.
    PF00378. ECH. 1 hit.
    [Graphical view]
    PRINTSiPR00504. CHROMODOMAIN.
    SMARTiSM00298. CHROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF52096. SSF52096. 1 hit.
    SSF54160. SSF54160. 1 hit.
    PROSITEiPS00598. CHROMO_1. 1 hit.
    PS50013. CHROMO_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y6F8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASQEFEVEA IVDKRQDKNG NTQYLVRWKG YDKQDDTWEP EQHLMNCEKC    50
    VHDFNRRQTE KQKKLTWTTT SRIFSNNARR RTSRSTKANY SKNSPKTPVT 100
    DKHHRSKNRK LFAASKNVRR KAASILSDTK NMEIINSTIE TLAPDSPFDH 150
    KTVSGFQKLE KLDPIAADQQ DTVVFKVTEG KLLRDPLSRP GAEQTGIQNK 200
    TQIHPLMSQM SGSVTASMAT GSATRKGIVV LIDPLAANGT TDMHTSVPRV 250
    KGGQRNITDD SRDQPFIKKM HFTIRLTESA STYRDIVVKK EDGFTQIVLS 300
    TRSTEKNALN TEVIKEIVNA LNSAAADDSK LVLFSAAGSV FCCGLDFGYF 350
    VKHLRNNRNT ASLEMVDTIK NFVNTFIQFK KPIVVSVNGP AIGLGASILP 400
    LCDLVWANEK AWFQTPYTTF GQSPDGCSSI TFPKMMGKAS ANEMLIAGRK 450
    LTAREACAKG LVSQVFLTGT FTQEVMIQIK ELASYNPIVL EECKALVRCN 500
    IKLELEQANE RECEVLRKIW SSAQGIESML KYVENKIDEF 540
    Length:540
    Mass (Da):60,473
    Last modified:November 1, 1999 - v1
    Checksum:i5B7AEB789092A265
    GO
    Isoform 2 (identifier: Q9Y6F8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         532-540: YVENKIDEF → IPLLGYKAAFPPRKTQNDQRWCP

    Show »
    Length:554
    Mass (Da):62,017
    Checksum:i84D4036A68AF8300
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei532 – 5409YVENKIDEF → IPLLGYKAAFPPRKTQNDQR WCP in isoform 2. 2 PublicationsVSP_001079

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000981 mRNA. Translation: AAC52116.1.
    AF080597 mRNA. Translation: AAD22732.1.
    BC132929 mRNA. Translation: AAI32930.1.
    BC132955 mRNA. Translation: AAI32956.1.
    CCDSiCCDS14801.1. [Q9Y6F8-2]
    CCDS14802.1. [Q9Y6F8-1]
    CCDS35486.1. [Q9Y6F8-2]
    CCDS35487.1. [Q9Y6F8-1]
    RefSeqiNP_001003894.1. NM_001003894.1. [Q9Y6F8-1]
    NP_001003895.1. NM_001003895.1. [Q9Y6F8-2]
    NP_004671.1. NM_004680.2. [Q9Y6F8-2]
    NP_733841.1. NM_170723.1. [Q9Y6F8-1]
    UniGeneiHs.159281.
    Hs.562095.

    Genome annotation databases

    EnsembliENST00000306609; ENSP00000302968; ENSG00000172288. [Q9Y6F8-2]
    ENST00000306882; ENSP00000303178; ENSG00000172352. [Q9Y6F8-2]
    ENST00000361963; ENSP00000354799; ENSG00000172288. [Q9Y6F8-1]
    ENST00000382407; ENSP00000371844; ENSG00000172352. [Q9Y6F8-1]
    GeneIDi253175.
    9085.
    KEGGihsa:253175.
    hsa:9085.
    UCSCiuc004fvz.3. human. [Q9Y6F8-2]
    uc004fwa.3. human. [Q9Y6F8-1]

    Polymorphism databases

    DMDMi20138089.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000981 mRNA. Translation: AAC52116.1 .
    AF080597 mRNA. Translation: AAD22732.1 .
    BC132929 mRNA. Translation: AAI32930.1 .
    BC132955 mRNA. Translation: AAI32956.1 .
    CCDSi CCDS14801.1. [Q9Y6F8-2 ]
    CCDS14802.1. [Q9Y6F8-1 ]
    CCDS35486.1. [Q9Y6F8-2 ]
    CCDS35487.1. [Q9Y6F8-1 ]
    RefSeqi NP_001003894.1. NM_001003894.1. [Q9Y6F8-1 ]
    NP_001003895.1. NM_001003895.1. [Q9Y6F8-2 ]
    NP_004671.1. NM_004680.2. [Q9Y6F8-2 ]
    NP_733841.1. NM_170723.1. [Q9Y6F8-1 ]
    UniGenei Hs.159281.
    Hs.562095.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2FBM X-ray 2.28 A/B/C 281-531 [» ]
    ProteinModelPortali Q9Y6F8.
    SMRi Q9Y6F8. Positions 1-64, 282-531.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128959. 1 interaction.
    STRINGi 9606.ENSP00000302968.

    PTM databases

    PhosphoSitei Q9Y6F8.

    Polymorphism databases

    DMDMi 20138089.

    Proteomic databases

    PaxDbi Q9Y6F8.
    PRIDEi Q9Y6F8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306609 ; ENSP00000302968 ; ENSG00000172288 . [Q9Y6F8-2 ]
    ENST00000306882 ; ENSP00000303178 ; ENSG00000172352 . [Q9Y6F8-2 ]
    ENST00000361963 ; ENSP00000354799 ; ENSG00000172288 . [Q9Y6F8-1 ]
    ENST00000382407 ; ENSP00000371844 ; ENSG00000172352 . [Q9Y6F8-1 ]
    GeneIDi 253175.
    9085.
    KEGGi hsa:253175.
    hsa:9085.
    UCSCi uc004fvz.3. human. [Q9Y6F8-2 ]
    uc004fwa.3. human. [Q9Y6F8-1 ]

    Organism-specific databases

    CTDi 253175.
    9085.
    GeneCardsi GC0YM026191.
    GC0YP027768.
    GeneReviewsi CDY1.
    HGNCi HGNC:1809. CDY1.
    HGNC:23920. CDY1B.
    MIMi 400016. gene.
    neXtProti NX_Q9Y6F8.
    PharmGKBi PA26354.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1024.
    HOGENOMi HOG000111507.
    HOVERGENi HBG006723.
    KOi K00653.
    OMAi NERECEM.
    OrthoDBi EOG72RN06.
    PhylomeDBi Q9Y6F8.
    TreeFami TF313375.

    Miscellaneous databases

    EvolutionaryTracei Q9Y6F8.
    GeneWikii CDY1.
    NextBioi 34041.
    PROi Q9Y6F8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y6F8.
    CleanExi HS_CDY1.
    HS_CDY1B.
    Genevestigatori Q9Y6F8.

    Family and domain databases

    Gene3Di 3.90.226.10. 1 hit.
    InterProi IPR017984. Chromo_dom_subgr.
    IPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR023779. Chromodomain_CS.
    IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    [Graphical view ]
    Pfami PF00385. Chromo. 1 hit.
    PF00378. ECH. 1 hit.
    [Graphical view ]
    PRINTSi PR00504. CHROMODOMAIN.
    SMARTi SM00298. CHROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52096. SSF52096. 1 hit.
    SSF54160. SSF54160. 1 hit.
    PROSITEi PS00598. CHROMO_1. 1 hit.
    PS50013. CHROMO_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional coherence of the human Y chromosome."
      Lahn B.T., Page D.C.
      Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (CDY1) (ISOFORM 2).
    2. "Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome."
      Lahn B.T., Page D.C.
      Nat. Genet. 21:429-433(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (CDY1A) (ISOFORM 1).
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (CDY1B) (ISOFORM 2).
    4. "Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis."
      Lahn B.T., Tang Z.L., Zhou J., Barndt R.J., Parvinen M., Allis C.D., Page D.C.
      Proc. Natl. Acad. Sci. U.S.A. 99:8707-8712(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    5. "Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs."
      Fischle W., Franz H., Jacobs S.A., Allis C.D., Khorasanizadeh S.
      J. Biol. Chem. 283:19626-19635(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HISTONE H3K9ME3, SUBCELLULAR LOCATION.
    6. "Crystal structures of human CDY proteins reveal a crotonase-like fold."
      Wu H., Min J., Antoshenko T., Plotnikov A.N.
      Proteins 76:1054-1061(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 281-531.

    Entry informationi

    Entry nameiCDY1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y6F8
    Secondary accession number(s): A2RUK1, O14600
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome Y
      Human chromosome Y: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3