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Protein

Testis-specific chromodomain protein Y 1

Gene

CDY1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has histone acetyltransferase activity, with a preference for histone H4.1 Publication

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  • histone acetyltransferase activity Source: UniProtKB-EC
  • methylated histone binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:HS10499-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific chromodomain protein Y 1 (EC:2.3.1.48)
Gene namesi
Name:CDY1
Synonyms:CDY1A
AND
Name:CDY1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

HGNCiHGNC:1809. CDY1.
HGNC:23920. CDY1B.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi253175.
9085.
OpenTargetsiENSG00000172288.
ENSG00000172352.
PharmGKBiPA26354.

Polymorphism and mutation databases

BioMutaiCDY1.
DMDMi20138089.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802191 – 540Testis-specific chromodomain protein Y 1Add BLAST540

Proteomic databases

EPDiQ9Y6F8.
PaxDbiQ9Y6F8.
PeptideAtlasiQ9Y6F8.
PRIDEiQ9Y6F8.

PTM databases

iPTMnetiQ9Y6F8.
PhosphoSitePlusiQ9Y6F8.

Expressioni

Tissue specificityi

Testis-specific. Detected in spermatids (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000172288.
CleanExiHS_CDY1.
HS_CDY1B.
GenevisibleiQ9Y6F8. HS.

Interactioni

Subunit structurei

Interacts (via chromo domain) with histone H3K9me3.1 Publication

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi114541. 1 interactor.
128959. 1 interactor.
STRINGi9606.ENSP00000303178.

Structurei

Secondary structure

1540
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi284 – 290Combined sources7
Beta strandi292 – 299Combined sources8
Beta strandi302 – 305Combined sources4
Helixi311 – 326Combined sources16
Beta strandi330 – 336Combined sources7
Helixi347 – 356Combined sources10
Helixi358 – 378Combined sources21
Beta strandi383 – 387Combined sources5
Helixi394 – 397Combined sources4
Helixi399 – 401Combined sources3
Beta strandi402 – 408Combined sources7
Beta strandi412 – 414Combined sources3
Helixi417 – 420Combined sources4
Helixi428 – 436Combined sources9
Helixi438 – 445Combined sources8
Beta strandi450 – 452Combined sources3
Helixi453 – 458Combined sources6
Beta strandi463 – 466Combined sources4
Helixi472 – 482Combined sources11
Helixi487 – 498Combined sources12
Turni499 – 501Combined sources3
Helixi502 – 520Combined sources19
Helixi523 – 530Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FBMX-ray2.28A/B/C281-531[»]
ProteinModelPortaliQ9Y6F8.
SMRiQ9Y6F8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y6F8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 66ChromoPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Contains 1 chromo domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0016. Eukaryota.
KOG1911. Eukaryota.
COG1024. LUCA.
GeneTreeiENSGT00760000119100.
HOGENOMiHOG000111507.
HOVERGENiHBG006723.
InParanoidiQ9Y6F8.
KOiK00653.
OMAiNERECEM.
OrthoDBiEOG091G0T5I.
PhylomeDBiQ9Y6F8.
TreeFamiTF313375.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR000953. Chromo/shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF00378. ECH_1. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y6F8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASQEFEVEA IVDKRQDKNG NTQYLVRWKG YDKQDDTWEP EQHLMNCEKC
60 70 80 90 100
VHDFNRRQTE KQKKLTWTTT SRIFSNNARR RTSRSTKANY SKNSPKTPVT
110 120 130 140 150
DKHHRSKNRK LFAASKNVRR KAASILSDTK NMEIINSTIE TLAPDSPFDH
160 170 180 190 200
KTVSGFQKLE KLDPIAADQQ DTVVFKVTEG KLLRDPLSRP GAEQTGIQNK
210 220 230 240 250
TQIHPLMSQM SGSVTASMAT GSATRKGIVV LIDPLAANGT TDMHTSVPRV
260 270 280 290 300
KGGQRNITDD SRDQPFIKKM HFTIRLTESA STYRDIVVKK EDGFTQIVLS
310 320 330 340 350
TRSTEKNALN TEVIKEIVNA LNSAAADDSK LVLFSAAGSV FCCGLDFGYF
360 370 380 390 400
VKHLRNNRNT ASLEMVDTIK NFVNTFIQFK KPIVVSVNGP AIGLGASILP
410 420 430 440 450
LCDLVWANEK AWFQTPYTTF GQSPDGCSSI TFPKMMGKAS ANEMLIAGRK
460 470 480 490 500
LTAREACAKG LVSQVFLTGT FTQEVMIQIK ELASYNPIVL EECKALVRCN
510 520 530 540
IKLELEQANE RECEVLRKIW SSAQGIESML KYVENKIDEF
Length:540
Mass (Da):60,473
Last modified:November 1, 1999 - v1
Checksum:i5B7AEB789092A265
GO
Isoform 2 (identifier: Q9Y6F8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     532-540: YVENKIDEF → IPLLGYKAAFPPRKTQNDQRWCP

Show »
Length:554
Mass (Da):62,017
Checksum:i84D4036A68AF8300
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001079532 – 540YVENKIDEF → IPLLGYKAAFPPRKTQNDQR WCP in isoform 2. 2 Publications9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000981 mRNA. Translation: AAC52116.1.
AF080597 mRNA. Translation: AAD22732.1.
BC132929 mRNA. Translation: AAI32930.1.
BC132955 mRNA. Translation: AAI32956.1.
CCDSiCCDS14801.1. [Q9Y6F8-2]
CCDS14802.1. [Q9Y6F8-1]
CCDS35486.1. [Q9Y6F8-2]
CCDS35487.1. [Q9Y6F8-1]
RefSeqiNP_001003894.1. NM_001003894.1. [Q9Y6F8-1]
NP_001003895.1. NM_001003895.1. [Q9Y6F8-2]
NP_004671.1. NM_004680.2. [Q9Y6F8-2]
NP_733841.1. NM_170723.1. [Q9Y6F8-1]
UniGeneiHs.159281.
Hs.562095.

Genome annotation databases

EnsembliENST00000306609; ENSP00000302968; ENSG00000172288. [Q9Y6F8-2]
ENST00000306882; ENSP00000303178; ENSG00000172352. [Q9Y6F8-2]
ENST00000361963; ENSP00000354799; ENSG00000172288. [Q9Y6F8-1]
ENST00000382407; ENSP00000371844; ENSG00000172352. [Q9Y6F8-1]
GeneIDi253175.
9085.
KEGGihsa:253175.
hsa:9085.
UCSCiuc004fvz.4. human. [Q9Y6F8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000981 mRNA. Translation: AAC52116.1.
AF080597 mRNA. Translation: AAD22732.1.
BC132929 mRNA. Translation: AAI32930.1.
BC132955 mRNA. Translation: AAI32956.1.
CCDSiCCDS14801.1. [Q9Y6F8-2]
CCDS14802.1. [Q9Y6F8-1]
CCDS35486.1. [Q9Y6F8-2]
CCDS35487.1. [Q9Y6F8-1]
RefSeqiNP_001003894.1. NM_001003894.1. [Q9Y6F8-1]
NP_001003895.1. NM_001003895.1. [Q9Y6F8-2]
NP_004671.1. NM_004680.2. [Q9Y6F8-2]
NP_733841.1. NM_170723.1. [Q9Y6F8-1]
UniGeneiHs.159281.
Hs.562095.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FBMX-ray2.28A/B/C281-531[»]
ProteinModelPortaliQ9Y6F8.
SMRiQ9Y6F8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114541. 1 interactor.
128959. 1 interactor.
STRINGi9606.ENSP00000303178.

PTM databases

iPTMnetiQ9Y6F8.
PhosphoSitePlusiQ9Y6F8.

Polymorphism and mutation databases

BioMutaiCDY1.
DMDMi20138089.

Proteomic databases

EPDiQ9Y6F8.
PaxDbiQ9Y6F8.
PeptideAtlasiQ9Y6F8.
PRIDEiQ9Y6F8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306609; ENSP00000302968; ENSG00000172288. [Q9Y6F8-2]
ENST00000306882; ENSP00000303178; ENSG00000172352. [Q9Y6F8-2]
ENST00000361963; ENSP00000354799; ENSG00000172288. [Q9Y6F8-1]
ENST00000382407; ENSP00000371844; ENSG00000172352. [Q9Y6F8-1]
GeneIDi253175.
9085.
KEGGihsa:253175.
hsa:9085.
UCSCiuc004fvz.4. human. [Q9Y6F8-1]

Organism-specific databases

CTDi253175.
9085.
DisGeNETi253175.
9085.
GeneCardsiCDY1.
CDY1B.
GeneReviewsiCDY1.
HGNCiHGNC:1809. CDY1.
HGNC:23920. CDY1B.
MIMi400016. gene.
neXtProtiNX_Q9Y6F8.
OpenTargetsiENSG00000172288.
ENSG00000172352.
PharmGKBiPA26354.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0016. Eukaryota.
KOG1911. Eukaryota.
COG1024. LUCA.
GeneTreeiENSGT00760000119100.
HOGENOMiHOG000111507.
HOVERGENiHBG006723.
InParanoidiQ9Y6F8.
KOiK00653.
OMAiNERECEM.
OrthoDBiEOG091G0T5I.
PhylomeDBiQ9Y6F8.
TreeFamiTF313375.

Enzyme and pathway databases

BioCyciZFISH:HS10499-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9Y6F8.
GeneWikiiCDY1.
PROiQ9Y6F8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172288.
CleanExiHS_CDY1.
HS_CDY1B.
GenevisibleiQ9Y6F8. HS.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR000953. Chromo/shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF00378. ECH_1. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDY1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6F8
Secondary accession number(s): A2RUK1, O14600
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.