Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9Y6F8 (CDY1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Testis-specific chromodomain protein Y 1

EC=2.3.1.48
Gene names
Name:CDY1
Synonyms:CDY1A
AND
Name:CDY1B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has histone acetyltransferase activity, with a preference for histone H4. Ref.4

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subunit structure

Interacts (via chromo domain) with histone H3K9me3. Ref.5

Subcellular location

Nucleus Ref.5.

Tissue specificity

Testis-specific. Detected in spermatids (at protein level). Ref.4

Sequence similarities

Contains 1 chromo domain.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   Molecular functionAcyltransferase
Transferase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processspermatogenesis

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentnucleus

Inferred from direct assay Ref.5. Source: UniProtKB

   Molecular_functionhistone acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

methylated histone binding

Inferred from direct assay Ref.5. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y6F8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y6F8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     532-540: YVENKIDEF → IPLLGYKAAFPPRKTQNDQRWCP

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 540540Testis-specific chromodomain protein Y 1
PRO_0000080219

Regions

Domain6 – 6661Chromo

Natural variations

Alternative sequence532 – 5409YVENKIDEF → IPLLGYKAAFPPRKTQNDQR WCP in isoform 2.
VSP_001079

Secondary structure

........................................... 540
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 5B7AEB789092A265

FASTA54060,473
        10         20         30         40         50         60 
MASQEFEVEA IVDKRQDKNG NTQYLVRWKG YDKQDDTWEP EQHLMNCEKC VHDFNRRQTE 

        70         80         90        100        110        120 
KQKKLTWTTT SRIFSNNARR RTSRSTKANY SKNSPKTPVT DKHHRSKNRK LFAASKNVRR 

       130        140        150        160        170        180 
KAASILSDTK NMEIINSTIE TLAPDSPFDH KTVSGFQKLE KLDPIAADQQ DTVVFKVTEG 

       190        200        210        220        230        240 
KLLRDPLSRP GAEQTGIQNK TQIHPLMSQM SGSVTASMAT GSATRKGIVV LIDPLAANGT 

       250        260        270        280        290        300 
TDMHTSVPRV KGGQRNITDD SRDQPFIKKM HFTIRLTESA STYRDIVVKK EDGFTQIVLS 

       310        320        330        340        350        360 
TRSTEKNALN TEVIKEIVNA LNSAAADDSK LVLFSAAGSV FCCGLDFGYF VKHLRNNRNT 

       370        380        390        400        410        420 
ASLEMVDTIK NFVNTFIQFK KPIVVSVNGP AIGLGASILP LCDLVWANEK AWFQTPYTTF 

       430        440        450        460        470        480 
GQSPDGCSSI TFPKMMGKAS ANEMLIAGRK LTAREACAKG LVSQVFLTGT FTQEVMIQIK 

       490        500        510        520        530        540 
ELASYNPIVL EECKALVRCN IKLELEQANE RECEVLRKIW SSAQGIESML KYVENKIDEF 

« Hide

Isoform 2 [UniParc].

Checksum: 84D4036A68AF8300
Show »

FASTA55462,017

References

« Hide 'large scale' references
[1]"Functional coherence of the human Y chromosome."
Lahn B.T., Page D.C.
Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (CDY1) (ISOFORM 2).
[2]"Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome."
Lahn B.T., Page D.C.
Nat. Genet. 21:429-433(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (CDY1A) (ISOFORM 1).
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (CDY1B) (ISOFORM 2).
[4]"Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis."
Lahn B.T., Tang Z.L., Zhou J., Barndt R.J., Parvinen M., Allis C.D., Page D.C.
Proc. Natl. Acad. Sci. U.S.A. 99:8707-8712(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[5]"Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs."
Fischle W., Franz H., Jacobs S.A., Allis C.D., Khorasanizadeh S.
J. Biol. Chem. 283:19626-19635(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HISTONE H3K9ME3, SUBCELLULAR LOCATION.
[6]"Crystal structures of human CDY proteins reveal a crotonase-like fold."
Wu H., Min J., Antoshenko T., Plotnikov A.N.
Proteins 76:1054-1061(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 281-531.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF000981 mRNA. Translation: AAC52116.1.
AF080597 mRNA. Translation: AAD22732.1.
BC132929 mRNA. Translation: AAI32930.1.
BC132955 mRNA. Translation: AAI32956.1.
CCDSCCDS14801.1. [Q9Y6F8-2]
CCDS14802.1. [Q9Y6F8-1]
CCDS35486.1. [Q9Y6F8-2]
CCDS35487.1. [Q9Y6F8-1]
RefSeqNP_001003894.1. NM_001003894.1. [Q9Y6F8-1]
NP_001003895.1. NM_001003895.1. [Q9Y6F8-2]
NP_004671.1. NM_004680.2. [Q9Y6F8-2]
NP_733841.1. NM_170723.1. [Q9Y6F8-1]
UniGeneHs.159281.
Hs.562095.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2FBMX-ray2.28A/B/C281-531[»]
ProteinModelPortalQ9Y6F8.
SMRQ9Y6F8. Positions 1-64, 282-531.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128959. 1 interaction.
STRING9606.ENSP00000302968.

PTM databases

PhosphoSiteQ9Y6F8.

Polymorphism databases

DMDM20138089.

Proteomic databases

PaxDbQ9Y6F8.
PRIDEQ9Y6F8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306609; ENSP00000302968; ENSG00000172288. [Q9Y6F8-2]
ENST00000306882; ENSP00000303178; ENSG00000172352. [Q9Y6F8-2]
ENST00000361963; ENSP00000354799; ENSG00000172288. [Q9Y6F8-1]
ENST00000382407; ENSP00000371844; ENSG00000172352. [Q9Y6F8-1]
GeneID253175.
9085.
KEGGhsa:253175.
hsa:9085.
UCSCuc004fvz.3. human. [Q9Y6F8-2]
uc004fwa.3. human. [Q9Y6F8-1]

Organism-specific databases

CTD253175.
9085.
GeneCardsGC0YM026191.
GC0YP027768.
GeneReviewsCDY1.
HGNCHGNC:1809. CDY1.
HGNC:23920. CDY1B.
MIM400016. gene.
neXtProtNX_Q9Y6F8.
PharmGKBPA26354.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1024.
HOGENOMHOG000111507.
HOVERGENHBG006723.
KOK00653.
OMANERECEM.
OrthoDBEOG72RN06.
PhylomeDBQ9Y6F8.
TreeFamTF313375.

Gene expression databases

BgeeQ9Y6F8.
CleanExHS_CDY1.
HS_CDY1B.
GenevestigatorQ9Y6F8.

Family and domain databases

Gene3D3.90.226.10. 1 hit.
InterProIPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view]
PfamPF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
PRINTSPR00504. CHROMODOMAIN.
SMARTSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMSSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9Y6F8.
GeneWikiCDY1.
NextBio34041.
PROQ9Y6F8.
SOURCESearch...

Entry information

Entry nameCDY1_HUMAN
AccessionPrimary (citable) accession number: Q9Y6F8
Secondary accession number(s): A2RUK1, O14600
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome Y

Human chromosome Y: entries, gene names and cross-references to MIM