Q9Y6F8 (CDY1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Testis-specific chromodomain protein Y 1
EC=2.3.1.48

Gene names

Name:	CDY1
Synonyms:	CDY1A
AND
Name:	CDY1B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	540 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Has histone acetyltransferase activity, with a preference for histone H4. Ref.4
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subcellular location	Nucleus By similarity.
Tissue specificity	Testis-specific. Detected in spermatids (at protein level). Ref.4
Sequence similarities	Contains 1 chromo domain.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Molecular function	Acyltransferase Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone acetylation Inferred from electronic annotation. Source: GOC spermatogenesis Traceable author statement Ref.1. Source: ProtInc
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y6F8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y6F8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     532-540: YVENKIDEF → IPLLGYKAAFPPRKTQNDQRWCP

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 540

540

Testis-specific chromodomain protein Y 1

PRO_0000080219

Regions

Domain

6 – 66

61

Chromo

Natural variations

Alternative sequence

532 – 540

9

YVENKIDEF → IPLLGYKAAFPPRKTQNDQR WCP in isoform 2.

VSP_001079

Secondary structure

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540

Helix Strand Turn

Details...

Beta strand

284 – 290

7

Beta strand

292 – 299

8

Beta strand

302 – 305

4

Helix

311 – 326

16

Beta strand

330 – 336

7

Helix

347 – 356

10

Helix

358 – 378

21

Beta strand

383 – 387

5

Helix

394 – 397

4

Helix

399 – 401

3

Beta strand

402 – 408

7

Beta strand

412 – 414

3

Helix

417 – 420

4

Helix

428 – 436

9

Helix

438 – 445

8

Beta strand

450 – 452

3

Helix

453 – 458

6

Beta strand

463 – 466

4

Helix

472 – 482

11

Helix

487 – 498

12

Turn

499 – 501

3

Helix

502 – 520

19

Helix

523 – 530

8

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 5B7AEB789092A265	FASTA	540	60,473
	10 20 30 40 50 60 MASQEFEVEA IVDKRQDKNG NTQYLVRWKG YDKQDDTWEP EQHLMNCEKC VHDFNRRQTE 70 80 90 100 110 120 KQKKLTWTTT SRIFSNNARR RTSRSTKANY SKNSPKTPVT DKHHRSKNRK LFAASKNVRR 130 140 150 160 170 180 KAASILSDTK NMEIINSTIE TLAPDSPFDH KTVSGFQKLE KLDPIAADQQ DTVVFKVTEG 190 200 210 220 230 240 KLLRDPLSRP GAEQTGIQNK TQIHPLMSQM SGSVTASMAT GSATRKGIVV LIDPLAANGT 250 260 270 280 290 300 TDMHTSVPRV KGGQRNITDD SRDQPFIKKM HFTIRLTESA STYRDIVVKK EDGFTQIVLS 310 320 330 340 350 360 TRSTEKNALN TEVIKEIVNA LNSAAADDSK LVLFSAAGSV FCCGLDFGYF VKHLRNNRNT 370 380 390 400 410 420 ASLEMVDTIK NFVNTFIQFK KPIVVSVNGP AIGLGASILP LCDLVWANEK AWFQTPYTTF 430 440 450 460 470 480 GQSPDGCSSI TFPKMMGKAS ANEMLIAGRK LTAREACAKG LVSQVFLTGT FTQEVMIQIK 490 500 510 520 530 540 ELASYNPIVL EECKALVRCN IKLELEQANE RECEVLRKIW SSAQGIESML KYVENKIDEF
	Isoform 2 [UniParc]. Checksum: 84D4036A68AF8300	FASTA	554	62,017
	10 20 30 40 50 60 MASQEFEVEA IVDKRQDKNG NTQYLVRWKG YDKQDDTWEP EQHLMNCEKC VHDFNRRQTE 70 80 90 100 110 120 KQKKLTWTTT SRIFSNNARR RTSRSTKANY SKNSPKTPVT DKHHRSKNRK LFAASKNVRR 130 140 150 160 170 180 KAASILSDTK NMEIINSTIE TLAPDSPFDH KTVSGFQKLE KLDPIAADQQ DTVVFKVTEG 190 200 210 220 230 240 KLLRDPLSRP GAEQTGIQNK TQIHPLMSQM SGSVTASMAT GSATRKGIVV LIDPLAANGT 250 260 270 280 290 300 TDMHTSVPRV KGGQRNITDD SRDQPFIKKM HFTIRLTESA STYRDIVVKK EDGFTQIVLS 310 320 330 340 350 360 TRSTEKNALN TEVIKEIVNA LNSAAADDSK LVLFSAAGSV FCCGLDFGYF VKHLRNNRNT 370 380 390 400 410 420 ASLEMVDTIK NFVNTFIQFK KPIVVSVNGP AIGLGASILP LCDLVWANEK AWFQTPYTTF 430 440 450 460 470 480 GQSPDGCSSI TFPKMMGKAS ANEMLIAGRK LTAREACAKG LVSQVFLTGT FTQEVMIQIK 490 500 510 520 530 540 ELASYNPIVL EECKALVRCN IKLELEQANE RECEVLRKIW SSAQGIESML KIPLLGYKAA 550 FPPRKTQNDQ RWCP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Functional coherence of the human Y chromosome." Lahn B.T., Page D.C. Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (CDY1) (ISOFORM 2).
[2]	"Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome." Lahn B.T., Page D.C. Nat. Genet. 21:429-433(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (CDY1A) (ISOFORM 1). Tissue: Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (CDY1B) (ISOFORM 2).
[4]	"Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis." Lahn B.T., Tang Z.L., Zhou J., Barndt R.J., Parvinen M., Allis C.D., Page D.C. Proc. Natl. Acad. Sci. U.S.A. 99:8707-8712(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[5]	"Crystal structures of human CDY proteins reveal a crotonase-like fold." Wu H., Min J., Antoshenko T., Plotnikov A.N. Proteins 76:1054-1061(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 281-531.
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF000981 mRNA. Translation: AAC52116.1.
AF080597 mRNA. Translation: AAD22732.1.
BC132929 mRNA. Translation: AAI32930.1.
BC132955 mRNA. Translation: AAI32956.1.

IPI

IPI00069208.
IPI00218948.

RefSeq

NP_001003894.1. NM_001003894.1.
NP_001003895.1. NM_001003895.1.
NP_004671.1. NM_004680.2.
NP_733841.1. NM_170723.1.

UniGene

Hs.159281.
Hs.562095.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2FBM	X-ray	2.28	A/B/C	281-531	[»]

ProteinModelPortal

Q9Y6F8.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000302968.

PTM databases

PhosphoSite

Q9Y6F8.

Proteomic databases

PaxDb

Q9Y6F8.

PRIDE

Q9Y6F8.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000306609; ENSP00000302968; ENSG00000172288.
ENST00000306882; ENSP00000303178; ENSG00000172352.
ENST00000361963; ENSP00000354799; ENSG00000172288.
ENST00000382407; ENSP00000371844; ENSG00000172352.

GeneID

253175.
9085.

KEGG

hsa:253175.
hsa:9085.

UCSC

uc004fvz.3. human.
uc004fwa.3. human.

Organism-specific databases

CTD

253175.
9085.

GeneCards

GC0YM026191.
GC0YP027768.

HGNC

HGNC:1809. CDY1.
HGNC:23920. CDY1B.

MIM

400016. gene.

neXtProt

NX_Q9Y6F8.

PharmGKB

PA26354.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG1024.

HOGENOM

HOG000111507.

HOVERGEN

HBG006723.

KO

K00653.

OMA

NERECEM.

PhylomeDB

Q9Y6F8.

Gene expression databases

Bgee

Q9Y6F8.

CleanEx

HS_CDY1.
HS_CDY1B.

Genevestigator

Q9Y6F8.

GermOnline

ENSG00000172288. Homo sapiens.
ENSG00000172352. Homo sapiens.

Family and domain databases

InterPro

IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR001753. Crotonase_core_superfam.
[Graphical view]

Pfam

PF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]

PRINTS

PR00504. CHROMODOMAIN.

SMART

SM00298. CHROMO. 1 hit.
[Graphical view]

SUPFAM

SSF54160. Chromodomain-like. 1 hit.

PROSITE

PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9Y6F8.

NextBio

34041.

SOURCE

Search...

Entry information

Entry name

CDY1_HUMAN

Accession

Primary (citable) accession number: Q9Y6F8
Secondary accession number(s): A2RUK1, O14600

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.