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Q9Y6F8

- CDY1_HUMAN

UniProt

Q9Y6F8 - CDY1_HUMAN

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Protein
Testis-specific chromodomain protein Y 1
Gene
CDY1, CDY1A
CDY1B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Has histone acetyltransferase activity, with a preference for histone H4.1 Publication

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
  2. methylated histone binding Source: UniProtKB

GO - Biological processi

  1. spermatogenesis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
Testis-specific chromodomain protein Y 1 (EC:2.3.1.48)
Gene namesi
Name:CDY1
Synonyms:CDY1A
AND
Name:CDY1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome Y
HGNCiHGNC:1809. CDY1.
HGNC:23920. CDY1B.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26354.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 540540Testis-specific chromodomain protein Y 1
PRO_0000080219Add
BLAST

Proteomic databases

PaxDbiQ9Y6F8.
PRIDEiQ9Y6F8.

PTM databases

PhosphoSiteiQ9Y6F8.

Expressioni

Tissue specificityi

Testis-specific. Detected in spermatids (at protein level).1 Publication

Gene expression databases

BgeeiQ9Y6F8.
CleanExiHS_CDY1.
HS_CDY1B.
GenevestigatoriQ9Y6F8.

Interactioni

Subunit structurei

Interacts (via chromo domain) with histone H3K9me3.1 Publication

Protein-protein interaction databases

BioGridi128959. 1 interaction.
STRINGi9606.ENSP00000302968.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi284 – 2907
Beta strandi292 – 2998
Beta strandi302 – 3054
Helixi311 – 32616
Beta strandi330 – 3367
Helixi347 – 35610
Helixi358 – 37821
Beta strandi383 – 3875
Helixi394 – 3974
Helixi399 – 4013
Beta strandi402 – 4087
Beta strandi412 – 4143
Helixi417 – 4204
Helixi428 – 4369
Helixi438 – 4458
Beta strandi450 – 4523
Helixi453 – 4586
Beta strandi463 – 4664
Helixi472 – 48211
Helixi487 – 49812
Turni499 – 5013
Helixi502 – 52019
Helixi523 – 5308

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FBMX-ray2.28A/B/C281-531[»]
ProteinModelPortaliQ9Y6F8.
SMRiQ9Y6F8. Positions 1-64, 282-531.

Miscellaneous databases

EvolutionaryTraceiQ9Y6F8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 6661Chromo
Add
BLAST

Sequence similaritiesi

Contains 1 chromo domain.

Phylogenomic databases

eggNOGiCOG1024.
HOGENOMiHOG000111507.
HOVERGENiHBG006723.
KOiK00653.
OMAiNERECEM.
OrthoDBiEOG72RN06.
PhylomeDBiQ9Y6F8.
TreeFamiTF313375.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y6F8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASQEFEVEA IVDKRQDKNG NTQYLVRWKG YDKQDDTWEP EQHLMNCEKC    50
VHDFNRRQTE KQKKLTWTTT SRIFSNNARR RTSRSTKANY SKNSPKTPVT 100
DKHHRSKNRK LFAASKNVRR KAASILSDTK NMEIINSTIE TLAPDSPFDH 150
KTVSGFQKLE KLDPIAADQQ DTVVFKVTEG KLLRDPLSRP GAEQTGIQNK 200
TQIHPLMSQM SGSVTASMAT GSATRKGIVV LIDPLAANGT TDMHTSVPRV 250
KGGQRNITDD SRDQPFIKKM HFTIRLTESA STYRDIVVKK EDGFTQIVLS 300
TRSTEKNALN TEVIKEIVNA LNSAAADDSK LVLFSAAGSV FCCGLDFGYF 350
VKHLRNNRNT ASLEMVDTIK NFVNTFIQFK KPIVVSVNGP AIGLGASILP 400
LCDLVWANEK AWFQTPYTTF GQSPDGCSSI TFPKMMGKAS ANEMLIAGRK 450
LTAREACAKG LVSQVFLTGT FTQEVMIQIK ELASYNPIVL EECKALVRCN 500
IKLELEQANE RECEVLRKIW SSAQGIESML KYVENKIDEF 540
Length:540
Mass (Da):60,473
Last modified:November 1, 1999 - v1
Checksum:i5B7AEB789092A265
GO
Isoform 2 (identifier: Q9Y6F8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     532-540: YVENKIDEF → IPLLGYKAAFPPRKTQNDQRWCP

Show »
Length:554
Mass (Da):62,017
Checksum:i84D4036A68AF8300
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei532 – 5409YVENKIDEF → IPLLGYKAAFPPRKTQNDQR WCP in isoform 2.
VSP_001079

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF000981 mRNA. Translation: AAC52116.1.
AF080597 mRNA. Translation: AAD22732.1.
BC132929 mRNA. Translation: AAI32930.1.
BC132955 mRNA. Translation: AAI32956.1.
CCDSiCCDS14801.1. [Q9Y6F8-2]
CCDS14802.1. [Q9Y6F8-1]
CCDS35486.1. [Q9Y6F8-2]
CCDS35487.1. [Q9Y6F8-1]
RefSeqiNP_001003894.1. NM_001003894.1. [Q9Y6F8-1]
NP_001003895.1. NM_001003895.1. [Q9Y6F8-2]
NP_004671.1. NM_004680.2. [Q9Y6F8-2]
NP_733841.1. NM_170723.1. [Q9Y6F8-1]
UniGeneiHs.159281.
Hs.562095.

Genome annotation databases

EnsembliENST00000306609; ENSP00000302968; ENSG00000172288. [Q9Y6F8-2]
ENST00000306882; ENSP00000303178; ENSG00000172352. [Q9Y6F8-2]
ENST00000361963; ENSP00000354799; ENSG00000172288. [Q9Y6F8-1]
ENST00000382407; ENSP00000371844; ENSG00000172352. [Q9Y6F8-1]
GeneIDi253175.
9085.
KEGGihsa:253175.
hsa:9085.
UCSCiuc004fvz.3. human. [Q9Y6F8-2]
uc004fwa.3. human. [Q9Y6F8-1]

Polymorphism databases

DMDMi20138089.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF000981 mRNA. Translation: AAC52116.1 .
AF080597 mRNA. Translation: AAD22732.1 .
BC132929 mRNA. Translation: AAI32930.1 .
BC132955 mRNA. Translation: AAI32956.1 .
CCDSi CCDS14801.1. [Q9Y6F8-2 ]
CCDS14802.1. [Q9Y6F8-1 ]
CCDS35486.1. [Q9Y6F8-2 ]
CCDS35487.1. [Q9Y6F8-1 ]
RefSeqi NP_001003894.1. NM_001003894.1. [Q9Y6F8-1 ]
NP_001003895.1. NM_001003895.1. [Q9Y6F8-2 ]
NP_004671.1. NM_004680.2. [Q9Y6F8-2 ]
NP_733841.1. NM_170723.1. [Q9Y6F8-1 ]
UniGenei Hs.159281.
Hs.562095.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2FBM X-ray 2.28 A/B/C 281-531 [» ]
ProteinModelPortali Q9Y6F8.
SMRi Q9Y6F8. Positions 1-64, 282-531.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128959. 1 interaction.
STRINGi 9606.ENSP00000302968.

PTM databases

PhosphoSitei Q9Y6F8.

Polymorphism databases

DMDMi 20138089.

Proteomic databases

PaxDbi Q9Y6F8.
PRIDEi Q9Y6F8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306609 ; ENSP00000302968 ; ENSG00000172288 . [Q9Y6F8-2 ]
ENST00000306882 ; ENSP00000303178 ; ENSG00000172352 . [Q9Y6F8-2 ]
ENST00000361963 ; ENSP00000354799 ; ENSG00000172288 . [Q9Y6F8-1 ]
ENST00000382407 ; ENSP00000371844 ; ENSG00000172352 . [Q9Y6F8-1 ]
GeneIDi 253175.
9085.
KEGGi hsa:253175.
hsa:9085.
UCSCi uc004fvz.3. human. [Q9Y6F8-2 ]
uc004fwa.3. human. [Q9Y6F8-1 ]

Organism-specific databases

CTDi 253175.
9085.
GeneCardsi GC0YM026191.
GC0YP027768.
GeneReviewsi CDY1.
HGNCi HGNC:1809. CDY1.
HGNC:23920. CDY1B.
MIMi 400016. gene.
neXtProti NX_Q9Y6F8.
PharmGKBi PA26354.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1024.
HOGENOMi HOG000111507.
HOVERGENi HBG006723.
KOi K00653.
OMAi NERECEM.
OrthoDBi EOG72RN06.
PhylomeDBi Q9Y6F8.
TreeFami TF313375.

Miscellaneous databases

EvolutionaryTracei Q9Y6F8.
GeneWikii CDY1.
NextBioi 34041.
PROi Q9Y6F8.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y6F8.
CleanExi HS_CDY1.
HS_CDY1B.
Genevestigatori Q9Y6F8.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
InterProi IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view ]
Pfami PF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view ]
PRINTSi PR00504. CHROMODOMAIN.
SMARTi SM00298. CHROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEi PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Functional coherence of the human Y chromosome."
    Lahn B.T., Page D.C.
    Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (CDY1) (ISOFORM 2).
  2. "Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome."
    Lahn B.T., Page D.C.
    Nat. Genet. 21:429-433(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (CDY1A) (ISOFORM 1).
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (CDY1B) (ISOFORM 2).
  4. "Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis."
    Lahn B.T., Tang Z.L., Zhou J., Barndt R.J., Parvinen M., Allis C.D., Page D.C.
    Proc. Natl. Acad. Sci. U.S.A. 99:8707-8712(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  5. "Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs."
    Fischle W., Franz H., Jacobs S.A., Allis C.D., Khorasanizadeh S.
    J. Biol. Chem. 283:19626-19635(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HISTONE H3K9ME3, SUBCELLULAR LOCATION.
  6. "Crystal structures of human CDY proteins reveal a crotonase-like fold."
    Wu H., Min J., Antoshenko T., Plotnikov A.N.
    Proteins 76:1054-1061(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 281-531.

Entry informationi

Entry nameiCDY1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6F8
Secondary accession number(s): A2RUK1, O14600
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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