Q9Y6F8 (CDY1_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 107.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Testis-specific chromodomain protein Y 1 EC=2.3.1.48 | |||||||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | |||||||
| Taxonomic identifier | 9606 [NCBI] | |||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 540 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Has histone acetyltransferase activity, with a preference for histone H4. Ref.4 |
| Catalytic activity | Acetyl-CoA + [histone] = CoA + acetyl-[histone]. |
| Subcellular location | Nucleus By similarity. |
| Tissue specificity | Testis-specific. Detected in spermatids (at protein level). Ref.4 |
| Sequence similarities | Contains 1 chromo domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Nucleus |
| Coding sequence diversity | Alternative splicing |
| Molecular function | Acyltransferase Transferase |
| Technical term | 3D-structure Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | histone acetylation Inferred from electronic annotation. Source: GOC spermatogenesisTraceable author statement Ref.1. Source: ProtInc |
| Cellular_component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | histone acetyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9Y6F8-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9Y6F8-2) The sequence of this isoform differs from the canonical sequence as follows: 532-540: YVENKIDEF → IPLLGYKAAFPPRKTQNDQRWCP |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 540 | 540 | Testis-specific chromodomain protein Y 1 | PRO_0000080219 | |||||||||||||||||||||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Domain | 6 – 66 | 61 | Chromo | ||||||||||||||||||||||||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Alternative sequence | 532 – 540 | 9 | YVENKIDEF → IPLLGYKAAFPPRKTQNDQR WCP in isoform 2. | VSP_001079 | |||||||||||||||||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 284 – 290 | 7 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 292 – 299 | 8 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 302 – 305 | 4 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 311 – 326 | 16 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 330 – 336 | 7 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 347 – 356 | 10 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 358 – 378 | 21 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 383 – 387 | 5 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 394 – 397 | 4 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 399 – 401 | 3 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 402 – 408 | 7 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 412 – 414 | 3 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 417 – 420 | 4 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 428 – 436 | 9 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 438 – 445 | 8 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 450 – 452 | 3 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 453 – 458 | 6 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 463 – 466 | 4 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 472 – 482 | 11 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 487 – 498 | 12 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Turn | 499 – 501 | 3 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 502 – 520 | 19 | |||||||||||||||||||||||||||||||||||||||||||||||||
| Helix | 523 – 530 | 8 | |||||||||||||||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Functional coherence of the human Y chromosome." Lahn B.T., Page D.C. Science 278:675-680(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (CDY1) (ISOFORM 2). |
| [2] | "Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome." Lahn B.T., Page D.C. Nat. Genet. 21:429-433(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (CDY1A) (ISOFORM 1). Tissue: Testis. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (CDY1B) (ISOFORM 2). |
| [4] | "Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis." Lahn B.T., Tang Z.L., Zhou J., Barndt R.J., Parvinen M., Allis C.D., Page D.C. Proc. Natl. Acad. Sci. U.S.A. 99:8707-8712(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY. |
| [5] | "Crystal structures of human CDY proteins reveal a crotonase-like fold." Wu H., Min J., Antoshenko T., Plotnikov A.N. Proteins 76:1054-1061(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 281-531. |
| + | Additional computationally mapped references. |
Web resources
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AF000981 mRNA. Translation: AAC52116.1. AF080597 mRNA. Translation: AAD22732.1. BC132929 mRNA. Translation: AAI32930.1. BC132955 mRNA. Translation: AAI32956.1. | ||||||||||||
| IPI | IPI00069208. IPI00218948. | ||||||||||||
| RefSeq | NP_001003894.1. NM_001003894.1. NP_001003895.1. NM_001003895.1. NP_004671.1. NM_004680.2. NP_733841.1. NM_170723.1. | ||||||||||||
| UniGene | Hs.159281. Hs.562095. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
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| ProteinModelPortal | Q9Y6F8. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| STRING | 9606.ENSP00000302968. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | Q9Y6F8. | ||||||||||||
Proteomic databases | |||||||||||||
| PaxDb | Q9Y6F8. | ||||||||||||
| PRIDE | Q9Y6F8. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000306609; ENSP00000302968; ENSG00000172288. ENST00000306882; ENSP00000303178; ENSG00000172352. ENST00000361963; ENSP00000354799; ENSG00000172288. ENST00000382407; ENSP00000371844; ENSG00000172352. | ||||||||||||
| GeneID | 253175. 9085. | ||||||||||||
| KEGG | hsa:253175. hsa:9085. | ||||||||||||
| UCSC | uc004fvz.3. human. uc004fwa.3. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 253175. 9085. | ||||||||||||
| GeneCards | GC0YM026191. GC0YP027768. | ||||||||||||
| HGNC | HGNC:1809. CDY1. HGNC:23920. CDY1B. | ||||||||||||
| MIM | 400016. gene. | ||||||||||||
| neXtProt | NX_Q9Y6F8. | ||||||||||||
| PharmGKB | PA26354. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | COG1024. | ||||||||||||
| HOGENOM | HOG000111507. | ||||||||||||
| HOVERGEN | HBG006723. | ||||||||||||
| KO | K00653. | ||||||||||||
| OMA | NERECEM. | ||||||||||||
| PhylomeDB | Q9Y6F8. | ||||||||||||
Gene expression databases | |||||||||||||
| Bgee | Q9Y6F8. | ||||||||||||
| CleanEx | HS_CDY1. HS_CDY1B. | ||||||||||||
| Genevestigator | Q9Y6F8. | ||||||||||||
| GermOnline | ENSG00000172288. Homo sapiens. ENSG00000172352. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR017984. Chromo_dom_subgr. IPR023780. Chromo_domain. IPR000953. Chromo_domain/shadow. IPR016197. Chromodomain-like. IPR023779. Chromodomain_CS. IPR001753. Crotonase_core_superfam. [Graphical view] | ||||||||||||
| Pfam | PF00385. Chromo. 1 hit. PF00378. ECH. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00504. CHROMODOMAIN. | ||||||||||||
| SMART | SM00298. CHROMO. 1 hit. [Graphical view] | ||||||||||||
| SUPFAM | SSF54160. Chromodomain-like. 1 hit. | ||||||||||||
| PROSITE | PS00598. CHROMO_1. 1 hit. PS50013. CHROMO_2. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| EvolutionaryTrace | Q9Y6F8. | ||||||||||||
| NextBio | 34041. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | CDY1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9Y6F8 Secondary accession number(s): A2RUK1, O14600 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome Y Human chromosome Y: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with
