Q9Y6F7 (CDY2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Testis-specific chromodomain protein Y 2
EC=2.3.1.48

Gene names

Name:	CDY2A
Synonyms:	CDY2
AND
Name:	CDY2B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	541 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May have histone acetyltransferase activity By similarity.
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Subcellular location	Nucleus By similarity.
Tissue specificity	Testis specific.
Sequence similarities	Contains 1 chromo domain.

Ontologies

Keywords
Cellular component	Nucleus
Molecular function	Acyltransferase Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	histone acetylation Inferred from electronic annotation. Source: GOC spermatogenesis Traceable author statement PubMed 9381176. Source: ProtInc
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 541

541

Testis-specific chromodomain protein Y 2

PRO_0000080220

Regions

Domain

6 – 66

61

Chromo

Secondary structure

1

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541

Helix Strand Turn

Details...

Beta strand

286 – 292

7

Beta strand

295 – 300

6

Beta strand

303 – 306

4

Helix

312 – 327

16

Beta strand

331 – 337

7

Helix

348 – 357

10

Helix

359 – 379

21

Beta strand

384 – 388

5

Helix

395 – 398

4

Helix

400 – 402

3

Beta strand

403 – 409

7

Beta strand

413 – 415

3

Helix

418 – 421

4

Helix

429 – 437

9

Helix

439 – 446

8

Beta strand

451 – 453

3

Helix

454 – 459

6

Beta strand

464 – 467

4

Helix

472 – 483

12

Helix

488 – 521

34

Helix

524 – 535

12

Sequences

	Sequence		Length	Mass (Da)
	Q9Y6F7 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 53F31A6603829E85	FASTA	541	60,524
	10 20 30 40 50 60 MASQEFEVEA IVDKRQDKNG NTQYLVRWKG YDKQDDTWEP EQHLMNCEKC VHDFNRRQTE 70 80 90 100 110 120 KQKKLTWTTT SRIFSNNARR RTSRSTKANY SKNSPKTPVT DKHHRSKNCK LFAASKNVRR 130 140 150 160 170 180 KAASTLSDTK NMEIINSTIE TLAPDSPFDH KKTVSGFQKL EKLDPIAADQ QDTVVFKVTE 190 200 210 220 230 240 GKLLRDPLSH PGAEQTGIQN KTQMHPLMSQ MSGSVTASMA TGSATRKGIV VLIDPLAANG 250 260 270 280 290 300 TTDMHTSVPR VKGGQRNITD DSRGQPFIKK MHFTIRLTES AITYRDIVVK KEDGFTQIVL 310 320 330 340 350 360 STRSTEKNAL NTEVIKEMVN ALNSAAADDS KLVLFSAAGS VFCCGLDFGY FVRHLRNDRN 370 380 390 400 410 420 TASLEMVDTI KNFVNTFIQF KKPIVVSVNG PAIGLGASIL PLCDLVWANE KAWFQTPYTT 430 440 450 460 470 480 FGQSPDGCSS ITFPKMMGKA SANEMLIAGR KLTAREACAK GLVSQVFLTG TFTQEVMIQI 490 500 510 520 530 540 KELASYNAIV LEECKALVRC NIKLELEQAN ERECEVLRKI WSSAQGIESM LKYVENKIDE F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome." Lahn B.T., Page D.C. Nat. Genet. 21:429-433(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Crystal structures of human CDY proteins reveal a crotonase-like fold." Wu H., Min J., Antoshenko T., Plotnikov A.N. Proteins 76:1054-1061(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 282-541.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF080598 mRNA. Translation: AAD22733.1.
AK292233 mRNA. Translation: BAF84922.1.
BC069087 mRNA. Translation: AAH69087.1.

IPI

IPI00181285.

RefSeq

NP_001001722.1. NM_001001722.1.
NP_004816.1. NM_004825.2.

UniGene

Hs.251375.
Hs.532657.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2FW2	X-ray	2.20	A/B/C/D/E/F	282-541	[»]

ProteinModelPortal

Q9Y6F7.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000372319.

PTM databases

PhosphoSite

Q9Y6F7.

Proteomic databases

PaxDb

Q9Y6F7.

PRIDE

Q9Y6F7.

Protocols and materials databases

DNASU

203611.
9426.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000250838; ENSP00000250838; ENSG00000182415.
ENST00000382867; ENSP00000372319; ENSG00000129873.

GeneID

203611.
9426.

KEGG

hsa:203611.
hsa:9426.

UCSC

uc004ftl.1. human.

Organism-specific databases

CTD

203611.
9426.

GeneCards

GC0YM019990.
GC0YP020137.

HGNC

HGNC:1810. CDY2A.
HGNC:23921. CDY2B.

MIM

400018. gene.

neXtProt

NX_Q9Y6F7.

PharmGKB

PA26355.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG1024.

HOGENOM

HOG000111507.

HOVERGEN

HBG006723.

InParanoid

Q9Y6F7.

KO

K00653.

OrthoDB

EOG4640BP.

PhylomeDB

Q9Y6F7.

Gene expression databases

ArrayExpress

Q9Y6F7.

Bgee

Q9Y6F7.

CleanEx

HS_CDY2A.
HS_CDY2B.

Genevestigator

Q9Y6F7.

GermOnline

ENSG00000129873. Homo sapiens.
ENSG00000182415. Homo sapiens.

Family and domain databases

InterPro

IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR001753. Crotonase_core_superfam.
[Graphical view]

Pfam

PF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]

PRINTS

PR00504. CHROMODOMAIN.

SMART

SM00298. CHROMO. 1 hit.
[Graphical view]

SUPFAM

SSF54160. Chromodomain-like. 1 hit.

PROSITE

PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9Y6F7.

NextBio

35314.

SOURCE

Search...

Entry information

Entry name

CDY2_HUMAN

Accession

Primary (citable) accession number: Q9Y6F7
Secondary accession number(s): A8K868

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.