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Protein

Testis-specific chromodomain protein Y 2

Gene

CDY2A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May have histone acetyltransferase activity.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. spermatogenesis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific chromodomain protein Y 2 (EC:2.3.1.48)
Gene namesi
Name:CDY2A
Synonyms:CDY2
AND
Name:CDY2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome Y

Organism-specific databases

HGNCiHGNC:1810. CDY2A.
HGNC:23921. CDY2B.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26355.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Testis-specific chromodomain protein Y 2PRO_0000080220Add
BLAST

Proteomic databases

PaxDbiQ9Y6F7.
PRIDEiQ9Y6F7.

PTM databases

PhosphoSiteiQ9Y6F7.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiQ9Y6F7.
CleanExiHS_CDY2A.
HS_CDY2B.
GenevestigatoriQ9Y6F7.

Interactioni

Protein-protein interaction databases

BioGridi114819. 1 interaction.
128481. 1 interaction.
STRINGi9606.ENSP00000372319.

Structurei

Secondary structure

1
541
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi286 – 2927Combined sources
Beta strandi295 – 3006Combined sources
Beta strandi303 – 3064Combined sources
Helixi312 – 32716Combined sources
Beta strandi331 – 3377Combined sources
Helixi348 – 35710Combined sources
Helixi359 – 37921Combined sources
Beta strandi384 – 3885Combined sources
Helixi395 – 3984Combined sources
Helixi400 – 4023Combined sources
Beta strandi403 – 4097Combined sources
Beta strandi413 – 4153Combined sources
Helixi418 – 4214Combined sources
Helixi429 – 4379Combined sources
Helixi439 – 4468Combined sources
Beta strandi451 – 4533Combined sources
Helixi454 – 4596Combined sources
Beta strandi464 – 4674Combined sources
Helixi472 – 48312Combined sources
Helixi488 – 52134Combined sources
Helixi524 – 53512Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FW2X-ray2.20A/B/C/D/E/F282-541[»]
ProteinModelPortaliQ9Y6F7.
SMRiQ9Y6F7. Positions 1-64, 282-541.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y6F7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 6661ChromoPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 chromo domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1024.
GeneTreeiENSGT00760000119100.
HOGENOMiHOG000111507.
HOVERGENiHBG006723.
InParanoidiQ9Y6F7.
KOiK00653.
OrthoDBiEOG72RN06.
PhylomeDBiQ9Y6F7.
TreeFamiTF313375.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR000953. Chromo/shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y6F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQEFEVEA IVDKRQDKNG NTQYLVRWKG YDKQDDTWEP EQHLMNCEKC
60 70 80 90 100
VHDFNRRQTE KQKKLTWTTT SRIFSNNARR RTSRSTKANY SKNSPKTPVT
110 120 130 140 150
DKHHRSKNCK LFAASKNVRR KAASTLSDTK NMEIINSTIE TLAPDSPFDH
160 170 180 190 200
KKTVSGFQKL EKLDPIAADQ QDTVVFKVTE GKLLRDPLSH PGAEQTGIQN
210 220 230 240 250
KTQMHPLMSQ MSGSVTASMA TGSATRKGIV VLIDPLAANG TTDMHTSVPR
260 270 280 290 300
VKGGQRNITD DSRGQPFIKK MHFTIRLTES AITYRDIVVK KEDGFTQIVL
310 320 330 340 350
STRSTEKNAL NTEVIKEMVN ALNSAAADDS KLVLFSAAGS VFCCGLDFGY
360 370 380 390 400
FVRHLRNDRN TASLEMVDTI KNFVNTFIQF KKPIVVSVNG PAIGLGASIL
410 420 430 440 450
PLCDLVWANE KAWFQTPYTT FGQSPDGCSS ITFPKMMGKA SANEMLIAGR
460 470 480 490 500
KLTAREACAK GLVSQVFLTG TFTQEVMIQI KELASYNAIV LEECKALVRC
510 520 530 540
NIKLELEQAN ERECEVLRKI WSSAQGIESM LKYVENKIDE F
Length:541
Mass (Da):60,524
Last modified:November 1, 1999 - v1
Checksum:i53F31A6603829E85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080598 mRNA. Translation: AAD22733.1.
AK292233 mRNA. Translation: BAF84922.1.
BC069087 mRNA. Translation: AAH69087.1.
CCDSiCCDS14789.1.
CCDS35473.1.
RefSeqiNP_001001722.1. NM_001001722.1.
NP_004816.1. NM_004825.2.
UniGeneiHs.251375.
Hs.532657.

Genome annotation databases

EnsembliENST00000250838; ENSP00000250838; ENSG00000182415.
ENST00000382867; ENSP00000372319; ENSG00000129873.
ENST00000622951; ENSP00000485368; ENSG00000279820.
ENST00000623992; ENSP00000485314; ENSG00000280290.
GeneIDi203611.
9426.
KEGGihsa:203611.
hsa:9426.
UCSCiuc004ftl.1. human.

Polymorphism databases

DMDMi20138088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080598 mRNA. Translation: AAD22733.1.
AK292233 mRNA. Translation: BAF84922.1.
BC069087 mRNA. Translation: AAH69087.1.
CCDSiCCDS14789.1.
CCDS35473.1.
RefSeqiNP_001001722.1. NM_001001722.1.
NP_004816.1. NM_004825.2.
UniGeneiHs.251375.
Hs.532657.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FW2X-ray2.20A/B/C/D/E/F282-541[»]
ProteinModelPortaliQ9Y6F7.
SMRiQ9Y6F7. Positions 1-64, 282-541.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114819. 1 interaction.
128481. 1 interaction.
STRINGi9606.ENSP00000372319.

PTM databases

PhosphoSiteiQ9Y6F7.

Polymorphism databases

DMDMi20138088.

Proteomic databases

PaxDbiQ9Y6F7.
PRIDEiQ9Y6F7.

Protocols and materials databases

DNASUi203611.
9426.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250838; ENSP00000250838; ENSG00000182415.
ENST00000382867; ENSP00000372319; ENSG00000129873.
ENST00000622951; ENSP00000485368; ENSG00000279820.
ENST00000623992; ENSP00000485314; ENSG00000280290.
GeneIDi203611.
9426.
KEGGihsa:203611.
hsa:9426.
UCSCiuc004ftl.1. human.

Organism-specific databases

CTDi203611.
9426.
GeneCardsiGC0YM019990.
GC0YP020137.
GeneReviewsiCDY2A.
HGNCiHGNC:1810. CDY2A.
HGNC:23921. CDY2B.
MIMi400018. gene.
neXtProtiNX_Q9Y6F7.
PharmGKBiPA26355.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1024.
GeneTreeiENSGT00760000119100.
HOGENOMiHOG000111507.
HOVERGENiHBG006723.
InParanoidiQ9Y6F7.
KOiK00653.
OrthoDBiEOG72RN06.
PhylomeDBiQ9Y6F7.
TreeFamiTF313375.

Miscellaneous databases

EvolutionaryTraceiQ9Y6F7.
NextBioi35314.
PROiQ9Y6F7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y6F7.
CleanExiHS_CDY2A.
HS_CDY2B.
GenevestigatoriQ9Y6F7.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR000953. Chromo/shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome."
    Lahn B.T., Page D.C.
    Nat. Genet. 21:429-433(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Crystal structures of human CDY proteins reveal a crotonase-like fold."
    Wu H., Min J., Antoshenko T., Plotnikov A.N.
    Proteins 76:1054-1061(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 282-541.

Entry informationi

Entry nameiCDY2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6F7
Secondary accession number(s): A8K868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: April 1, 2015
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.