Testis-specific chromodomain protein Y 2

Contribute

Send feedback

Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q9Y6F7 (CDY2_HUMAN)

Last modified July 7, 2009. Version 67. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein names

Recommended name:
Testis-specific chromodomain protein Y 2
EC=2.3.1.48

Gene names

Name:	CDY2A
Synonyms:	CDY2
AND
Name:	CDY2B

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length	541 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Hide | Top

General annotation (Comments)

Function	May have histone acetyltransferase activity By similarity.
Catalytic activity	Acetyl-CoA + histone = CoA + acetylhistone.
Subcellular location	Nucleus By similarity.
Tissue specificity	Testis specific.
Sequence similarities	Contains 1 chromo domain.

Hide | Top

Ontologies

Keywords
Cellular component	Nucleus
Molecular function	Acyltransferase Transferase
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	chromatin assembly or disassembly Inferred from electronic annotation. Source: InterPro metabolic process Inferred from electronic annotation. Source: InterPro spermatogenesis Traceable author statement. Source: ProtInc
Cellular component	chromatin Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chromatin binding Inferred from electronic annotation. Source: InterPro histone acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 541

541

Testis-specific chromodomain protein Y 2

PRO_0000080220

Regions

Domain

6 – 66

Chromo

Secondary structure

541

Helix Strand Turn

Details...

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

Q9Y6F7-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 53F31A6603829E85
Show »

FASTA

541

60,524

        10         20         30         40         50         60 
MASQEFEVEA IVDKRQDKNG NTQYLVRWKG YDKQDDTWEP EQHLMNCEKC VHDFNRRQTE 

        70         80         90        100        110        120 
KQKKLTWTTT SRIFSNNARR RTSRSTKANY SKNSPKTPVT DKHHRSKNCK LFAASKNVRR 

       130        140        150        160        170        180 
KAASTLSDTK NMEIINSTIE TLAPDSPFDH KKTVSGFQKL EKLDPIAADQ QDTVVFKVTE 

       190        200        210        220        230        240 
GKLLRDPLSH PGAEQTGIQN KTQMHPLMSQ MSGSVTASMA TGSATRKGIV VLIDPLAANG 

       250        260        270        280        290        300 
TTDMHTSVPR VKGGQRNITD DSRGQPFIKK MHFTIRLTES AITYRDIVVK KEDGFTQIVL 

       310        320        330        340        350        360 
STRSTEKNAL NTEVIKEMVN ALNSAAADDS KLVLFSAAGS VFCCGLDFGY FVRHLRNDRN 

       370        380        390        400        410        420 
TASLEMVDTI KNFVNTFIQF KKPIVVSVNG PAIGLGASIL PLCDLVWANE KAWFQTPYTT 

       430        440        450        460        470        480 
FGQSPDGCSS ITFPKMMGKA SANEMLIAGR KLTAREACAK GLVSQVFLTG TFTQEVMIQI 

       490        500        510        520        530        540 
KELASYNAIV LEECKALVRC NIKLELEQAN ERECEVLRKI WSSAQGIESM LKYVENKIDE 


F

« Hide

Hide | Top

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome." Lahn B.T., Page D.C. Nat. Genet. 21:429-433(1999) [PubMed: 10192397] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The crystal structure of catalytic domain of human testis-specific chromodomain protein Y." Structural genomics consortium (SGC) Submitted (FEB-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 282-541.

Hide | Top

Cross-references

Sequence databases

AF080598 mRNA. Translation: AAD22733.1.
AK292233 mRNA. Translation: BAF84922.1.
BC069087 mRNA. Translation: AAH69087.1.

IPI

IPI00181285.

RefSeq

NP_001001722.1.
NP_004816.1.

UniGene

Hs.251375
Hs.532657

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2FW2	X-ray	2.20	A/B/C/D/E/F	282-541	[»]

SMR

Q9Y6F7. Positions 1-64.

ModBase

Search...

PTM databases

PhosphoSite

Q9Y6F7.

Proteomic databases

PRIDE

Q9Y6F7.

Genome annotation databases

Ensembl

ENSG00000129873. Homo sapiens. [Contig view]
ENSG00000182415. Homo sapiens. [Contig view]

GeneID

203611.
9426.

KEGG

hsa:203611.
hsa:9426.

UCSC

uc004ftl.1. human.

Organism-specific databases

GeneCards

GC0YM018499.
GC0YP018648.

H-InvDB

HIX0056665.
HIX0056697.

HGNC

HGNC:1810. CDY2A.
HGNC:23921. CDY2B.

MIM

400018. gene.

PharmGKB

PA26355.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q9Y6F7.

HOVERGEN

Q9Y6F7.

OMA

Q9Y6F7. MLKYVEN.

Enzyme and pathway databases

BRENDA

2.3.1.48. 247.

Gene expression databases

CleanEx

HS_CDY2A.
HS_CDY2B.

GermOnline

ENSG00000129873. Homo sapiens.
ENSG00000182415. Homo sapiens.

Family and domain databases

InterPro

IPR017984. Chromo_dom_subgr.
IPR000953. Chromodomain.
IPR001753. Crotonase_core.
[Graphical view]

Pfam

PF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]

PRINTS

PR00504. CHROMODOMAIN.

SMART

SM00298. CHROMO. 1 hit.
[Graphical view]

PROSITE

PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

90458.

SOURCE

Search...

Hide | Top

Entry information

Entry name

CDY2_HUMAN

Accession

Primary (citable) accession number: Q9Y6F7
Secondary accession number(s): A8K868

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	November 1, 1999
Last modified:	July 7, 2009
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Hide | Top