SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Y6F7

- CDY2_HUMAN

UniProt

Q9Y6F7 - CDY2_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Testis-specific chromodomain protein Y 2

Gene
CDY2A, CDY2
CDY2B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May have histone acetyltransferase activity By similarity.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. spermatogenesis Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
Testis-specific chromodomain protein Y 2 (EC:2.3.1.48)
Gene namesi
Name:CDY2A
Synonyms:CDY2
AND
Name:CDY2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome Y
HGNCiHGNC:1810. CDY2A.
HGNC:23921. CDY2B.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26355.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Testis-specific chromodomain protein Y 2PRO_0000080220Add
BLAST

Proteomic databases

PaxDbiQ9Y6F7.
PRIDEiQ9Y6F7.

PTM databases

PhosphoSiteiQ9Y6F7.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiQ9Y6F7.
CleanExiHS_CDY2A.
HS_CDY2B.
GenevestigatoriQ9Y6F7.

Interactioni

Protein-protein interaction databases

BioGridi114819. 1 interaction.
128481. 1 interaction.
STRINGi9606.ENSP00000372319.

Structurei

Secondary structure

1
541
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi286 – 2927
Beta strandi295 – 3006
Beta strandi303 – 3064
Helixi312 – 32716
Beta strandi331 – 3377
Helixi348 – 35710
Helixi359 – 37921
Beta strandi384 – 3885
Helixi395 – 3984
Helixi400 – 4023
Beta strandi403 – 4097
Beta strandi413 – 4153
Helixi418 – 4214
Helixi429 – 4379
Helixi439 – 4468
Beta strandi451 – 4533
Helixi454 – 4596
Beta strandi464 – 4674
Helixi472 – 48312
Helixi488 – 52134
Helixi524 – 53512

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FW2X-ray2.20A/B/C/D/E/F282-541[»]
ProteinModelPortaliQ9Y6F7.
SMRiQ9Y6F7. Positions 1-64, 282-541.

Miscellaneous databases

EvolutionaryTraceiQ9Y6F7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 6661ChromoAdd
BLAST

Sequence similaritiesi

Contains 1 chromo domain.

Phylogenomic databases

eggNOGiCOG1024.
HOGENOMiHOG000111507.
HOVERGENiHBG006723.
InParanoidiQ9Y6F7.
KOiK00653.
OrthoDBiEOG72RN06.
PhylomeDBiQ9Y6F7.
TreeFamiTF313375.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y6F7-1 [UniParc]FASTAAdd to Basket

« Hide

MASQEFEVEA IVDKRQDKNG NTQYLVRWKG YDKQDDTWEP EQHLMNCEKC    50
VHDFNRRQTE KQKKLTWTTT SRIFSNNARR RTSRSTKANY SKNSPKTPVT 100
DKHHRSKNCK LFAASKNVRR KAASTLSDTK NMEIINSTIE TLAPDSPFDH 150
KKTVSGFQKL EKLDPIAADQ QDTVVFKVTE GKLLRDPLSH PGAEQTGIQN 200
KTQMHPLMSQ MSGSVTASMA TGSATRKGIV VLIDPLAANG TTDMHTSVPR 250
VKGGQRNITD DSRGQPFIKK MHFTIRLTES AITYRDIVVK KEDGFTQIVL 300
STRSTEKNAL NTEVIKEMVN ALNSAAADDS KLVLFSAAGS VFCCGLDFGY 350
FVRHLRNDRN TASLEMVDTI KNFVNTFIQF KKPIVVSVNG PAIGLGASIL 400
PLCDLVWANE KAWFQTPYTT FGQSPDGCSS ITFPKMMGKA SANEMLIAGR 450
KLTAREACAK GLVSQVFLTG TFTQEVMIQI KELASYNAIV LEECKALVRC 500
NIKLELEQAN ERECEVLRKI WSSAQGIESM LKYVENKIDE F 541
Length:541
Mass (Da):60,524
Last modified:November 1, 1999 - v1
Checksum:i53F31A6603829E85
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF080598 mRNA. Translation: AAD22733.1.
AK292233 mRNA. Translation: BAF84922.1.
BC069087 mRNA. Translation: AAH69087.1.
CCDSiCCDS14789.1.
CCDS35473.1.
RefSeqiNP_001001722.1. NM_001001722.1.
NP_004816.1. NM_004825.2.
UniGeneiHs.251375.
Hs.532657.

Genome annotation databases

EnsembliENST00000250838; ENSP00000250838; ENSG00000182415.
ENST00000382867; ENSP00000372319; ENSG00000129873.
GeneIDi203611.
9426.
KEGGihsa:203611.
hsa:9426.
UCSCiuc004ftl.1. human.

Polymorphism databases

DMDMi20138088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF080598 mRNA. Translation: AAD22733.1 .
AK292233 mRNA. Translation: BAF84922.1 .
BC069087 mRNA. Translation: AAH69087.1 .
CCDSi CCDS14789.1.
CCDS35473.1.
RefSeqi NP_001001722.1. NM_001001722.1.
NP_004816.1. NM_004825.2.
UniGenei Hs.251375.
Hs.532657.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2FW2 X-ray 2.20 A/B/C/D/E/F 282-541 [» ]
ProteinModelPortali Q9Y6F7.
SMRi Q9Y6F7. Positions 1-64, 282-541.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114819. 1 interaction.
128481. 1 interaction.
STRINGi 9606.ENSP00000372319.

PTM databases

PhosphoSitei Q9Y6F7.

Polymorphism databases

DMDMi 20138088.

Proteomic databases

PaxDbi Q9Y6F7.
PRIDEi Q9Y6F7.

Protocols and materials databases

DNASUi 203611.
9426.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000250838 ; ENSP00000250838 ; ENSG00000182415 .
ENST00000382867 ; ENSP00000372319 ; ENSG00000129873 .
GeneIDi 203611.
9426.
KEGGi hsa:203611.
hsa:9426.
UCSCi uc004ftl.1. human.

Organism-specific databases

CTDi 203611.
9426.
GeneCardsi GC0YM019990.
GC0YP020137.
GeneReviewsi CDY2A.
HGNCi HGNC:1810. CDY2A.
HGNC:23921. CDY2B.
MIMi 400018. gene.
neXtProti NX_Q9Y6F7.
PharmGKBi PA26355.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1024.
HOGENOMi HOG000111507.
HOVERGENi HBG006723.
InParanoidi Q9Y6F7.
KOi K00653.
OrthoDBi EOG72RN06.
PhylomeDBi Q9Y6F7.
TreeFami TF313375.

Miscellaneous databases

EvolutionaryTracei Q9Y6F7.
NextBioi 35314.
PROi Q9Y6F7.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y6F7.
CleanExi HS_CDY2A.
HS_CDY2B.
Genevestigatori Q9Y6F7.

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
InterProi IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view ]
Pfami PF00385. Chromo. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view ]
PRINTSi PR00504. CHROMODOMAIN.
SMARTi SM00298. CHROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEi PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome."
    Lahn B.T., Page D.C.
    Nat. Genet. 21:429-433(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Crystal structures of human CDY proteins reveal a crotonase-like fold."
    Wu H., Min J., Antoshenko T., Plotnikov A.N.
    Proteins 76:1054-1061(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 282-541.

Entry informationi

Entry nameiCDY2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6F7
Secondary accession number(s): A8K868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi