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Q9Y6F7

- CDY2_HUMAN

UniProt

Q9Y6F7 - CDY2_HUMAN

Protein

Testis-specific chromodomain protein Y 2

Gene

CDY2A

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    May have histone acetyltransferase activity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. spermatogenesis Source: ProtInc

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Testis-specific chromodomain protein Y 2 (EC:2.3.1.48)
    Gene namesi
    Name:CDY2A
    Synonyms:CDY2
    AND
    Name:CDY2B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome Y

    Organism-specific databases

    HGNCiHGNC:1810. CDY2A.
    HGNC:23921. CDY2B.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26355.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 541541Testis-specific chromodomain protein Y 2PRO_0000080220Add
    BLAST

    Proteomic databases

    PaxDbiQ9Y6F7.
    PRIDEiQ9Y6F7.

    PTM databases

    PhosphoSiteiQ9Y6F7.

    Expressioni

    Tissue specificityi

    Testis specific.

    Gene expression databases

    BgeeiQ9Y6F7.
    CleanExiHS_CDY2A.
    HS_CDY2B.
    GenevestigatoriQ9Y6F7.

    Interactioni

    Protein-protein interaction databases

    BioGridi114819. 1 interaction.
    128481. 1 interaction.
    STRINGi9606.ENSP00000372319.

    Structurei

    Secondary structure

    1
    541
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi286 – 2927
    Beta strandi295 – 3006
    Beta strandi303 – 3064
    Helixi312 – 32716
    Beta strandi331 – 3377
    Helixi348 – 35710
    Helixi359 – 37921
    Beta strandi384 – 3885
    Helixi395 – 3984
    Helixi400 – 4023
    Beta strandi403 – 4097
    Beta strandi413 – 4153
    Helixi418 – 4214
    Helixi429 – 4379
    Helixi439 – 4468
    Beta strandi451 – 4533
    Helixi454 – 4596
    Beta strandi464 – 4674
    Helixi472 – 48312
    Helixi488 – 52134
    Helixi524 – 53512

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2FW2X-ray2.20A/B/C/D/E/F282-541[»]
    ProteinModelPortaliQ9Y6F7.
    SMRiQ9Y6F7. Positions 1-64, 282-541.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y6F7.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 6661ChromoPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 chromo domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1024.
    HOGENOMiHOG000111507.
    HOVERGENiHBG006723.
    InParanoidiQ9Y6F7.
    KOiK00653.
    OrthoDBiEOG72RN06.
    PhylomeDBiQ9Y6F7.
    TreeFamiTF313375.

    Family and domain databases

    Gene3Di3.90.226.10. 1 hit.
    InterProiIPR017984. Chromo_dom_subgr.
    IPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR023779. Chromodomain_CS.
    IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    [Graphical view]
    PfamiPF00385. Chromo. 1 hit.
    PF00378. ECH. 1 hit.
    [Graphical view]
    PRINTSiPR00504. CHROMODOMAIN.
    SMARTiSM00298. CHROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF52096. SSF52096. 1 hit.
    SSF54160. SSF54160. 1 hit.
    PROSITEiPS00598. CHROMO_1. 1 hit.
    PS50013. CHROMO_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y6F7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASQEFEVEA IVDKRQDKNG NTQYLVRWKG YDKQDDTWEP EQHLMNCEKC    50
    VHDFNRRQTE KQKKLTWTTT SRIFSNNARR RTSRSTKANY SKNSPKTPVT 100
    DKHHRSKNCK LFAASKNVRR KAASTLSDTK NMEIINSTIE TLAPDSPFDH 150
    KKTVSGFQKL EKLDPIAADQ QDTVVFKVTE GKLLRDPLSH PGAEQTGIQN 200
    KTQMHPLMSQ MSGSVTASMA TGSATRKGIV VLIDPLAANG TTDMHTSVPR 250
    VKGGQRNITD DSRGQPFIKK MHFTIRLTES AITYRDIVVK KEDGFTQIVL 300
    STRSTEKNAL NTEVIKEMVN ALNSAAADDS KLVLFSAAGS VFCCGLDFGY 350
    FVRHLRNDRN TASLEMVDTI KNFVNTFIQF KKPIVVSVNG PAIGLGASIL 400
    PLCDLVWANE KAWFQTPYTT FGQSPDGCSS ITFPKMMGKA SANEMLIAGR 450
    KLTAREACAK GLVSQVFLTG TFTQEVMIQI KELASYNAIV LEECKALVRC 500
    NIKLELEQAN ERECEVLRKI WSSAQGIESM LKYVENKIDE F 541
    Length:541
    Mass (Da):60,524
    Last modified:November 1, 1999 - v1
    Checksum:i53F31A6603829E85
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF080598 mRNA. Translation: AAD22733.1.
    AK292233 mRNA. Translation: BAF84922.1.
    BC069087 mRNA. Translation: AAH69087.1.
    CCDSiCCDS14789.1.
    CCDS35473.1.
    RefSeqiNP_001001722.1. NM_001001722.1.
    NP_004816.1. NM_004825.2.
    UniGeneiHs.251375.
    Hs.532657.

    Genome annotation databases

    EnsembliENST00000250838; ENSP00000250838; ENSG00000182415.
    ENST00000382867; ENSP00000372319; ENSG00000129873.
    GeneIDi203611.
    9426.
    KEGGihsa:203611.
    hsa:9426.
    UCSCiuc004ftl.1. human.

    Polymorphism databases

    DMDMi20138088.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF080598 mRNA. Translation: AAD22733.1 .
    AK292233 mRNA. Translation: BAF84922.1 .
    BC069087 mRNA. Translation: AAH69087.1 .
    CCDSi CCDS14789.1.
    CCDS35473.1.
    RefSeqi NP_001001722.1. NM_001001722.1.
    NP_004816.1. NM_004825.2.
    UniGenei Hs.251375.
    Hs.532657.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2FW2 X-ray 2.20 A/B/C/D/E/F 282-541 [» ]
    ProteinModelPortali Q9Y6F7.
    SMRi Q9Y6F7. Positions 1-64, 282-541.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114819. 1 interaction.
    128481. 1 interaction.
    STRINGi 9606.ENSP00000372319.

    PTM databases

    PhosphoSitei Q9Y6F7.

    Polymorphism databases

    DMDMi 20138088.

    Proteomic databases

    PaxDbi Q9Y6F7.
    PRIDEi Q9Y6F7.

    Protocols and materials databases

    DNASUi 203611.
    9426.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000250838 ; ENSP00000250838 ; ENSG00000182415 .
    ENST00000382867 ; ENSP00000372319 ; ENSG00000129873 .
    GeneIDi 203611.
    9426.
    KEGGi hsa:203611.
    hsa:9426.
    UCSCi uc004ftl.1. human.

    Organism-specific databases

    CTDi 203611.
    9426.
    GeneCardsi GC0YM019990.
    GC0YP020137.
    GeneReviewsi CDY2A.
    HGNCi HGNC:1810. CDY2A.
    HGNC:23921. CDY2B.
    MIMi 400018. gene.
    neXtProti NX_Q9Y6F7.
    PharmGKBi PA26355.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1024.
    HOGENOMi HOG000111507.
    HOVERGENi HBG006723.
    InParanoidi Q9Y6F7.
    KOi K00653.
    OrthoDBi EOG72RN06.
    PhylomeDBi Q9Y6F7.
    TreeFami TF313375.

    Miscellaneous databases

    EvolutionaryTracei Q9Y6F7.
    NextBioi 35314.
    PROi Q9Y6F7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y6F7.
    CleanExi HS_CDY2A.
    HS_CDY2B.
    Genevestigatori Q9Y6F7.

    Family and domain databases

    Gene3Di 3.90.226.10. 1 hit.
    InterProi IPR017984. Chromo_dom_subgr.
    IPR023780. Chromo_domain.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR023779. Chromodomain_CS.
    IPR029045. ClpP/crotonase-like_dom.
    IPR001753. Crotonase_core_superfam.
    [Graphical view ]
    Pfami PF00385. Chromo. 1 hit.
    PF00378. ECH. 1 hit.
    [Graphical view ]
    PRINTSi PR00504. CHROMODOMAIN.
    SMARTi SM00298. CHROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52096. SSF52096. 1 hit.
    SSF54160. SSF54160. 1 hit.
    PROSITEi PS00598. CHROMO_1. 1 hit.
    PS50013. CHROMO_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome."
      Lahn B.T., Page D.C.
      Nat. Genet. 21:429-433(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Crystal structures of human CDY proteins reveal a crotonase-like fold."
      Wu H., Min J., Antoshenko T., Plotnikov A.N.
      Proteins 76:1054-1061(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 282-541.

    Entry informationi

    Entry nameiCDY2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y6F7
    Secondary accession number(s): A8K868
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome Y
      Human chromosome Y: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3