Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Testis-specific chromodomain protein Y 2

Gene

CDY2A

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May have histone acetyltransferase activity.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:HS05312-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Testis-specific chromodomain protein Y 2 (EC:2.3.1.48)
Gene namesi
Name:CDY2A
Synonyms:CDY2
AND
Name:CDY2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

HGNCiHGNC:1810. CDY2A.
HGNC:23921. CDY2B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi203611.
9426.
OpenTargetsiENSG00000129873.
ENSG00000182415.
PharmGKBiPA26355.

Polymorphism and mutation databases

BioMutaiCDY2A.
DMDMi20138088.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802201 – 541Testis-specific chromodomain protein Y 2Add BLAST541

Proteomic databases

MaxQBiQ9Y6F7.
PaxDbiQ9Y6F7.
PeptideAtlasiQ9Y6F7.
PRIDEiQ9Y6F7.

PTM databases

iPTMnetiQ9Y6F7.
PhosphoSitePlusiQ9Y6F7.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiENSG00000182415.
CleanExiHS_CDY2A.
HS_CDY2B.
GenevisibleiQ9Y6F7. HS.

Interactioni

Protein-protein interaction databases

BioGridi114819. 1 interactor.
128481. 1 interactor.
STRINGi9606.ENSP00000372319.

Structurei

Secondary structure

1541
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi286 – 292Combined sources7
Beta strandi295 – 300Combined sources6
Beta strandi303 – 306Combined sources4
Helixi312 – 327Combined sources16
Beta strandi331 – 337Combined sources7
Helixi348 – 357Combined sources10
Helixi359 – 379Combined sources21
Beta strandi384 – 388Combined sources5
Helixi395 – 398Combined sources4
Helixi400 – 402Combined sources3
Beta strandi403 – 409Combined sources7
Beta strandi413 – 415Combined sources3
Helixi418 – 421Combined sources4
Helixi429 – 437Combined sources9
Helixi439 – 446Combined sources8
Beta strandi451 – 453Combined sources3
Helixi454 – 459Combined sources6
Beta strandi464 – 467Combined sources4
Helixi472 – 483Combined sources12
Helixi488 – 521Combined sources34
Helixi524 – 535Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FW2X-ray2.20A/B/C/D/E/F282-541[»]
ProteinModelPortaliQ9Y6F7.
SMRiQ9Y6F7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y6F7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 66ChromoPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Contains 1 chromo domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0016. Eukaryota.
KOG1911. Eukaryota.
COG1024. LUCA.
GeneTreeiENSGT00760000119100.
HOGENOMiHOG000111507.
HOVERGENiHBG006723.
InParanoidiQ9Y6F7.
KOiK00653.
PhylomeDBiQ9Y6F7.
TreeFamiTF313375.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR000953. Chromo/shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF00378. ECH_1. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y6F7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQEFEVEA IVDKRQDKNG NTQYLVRWKG YDKQDDTWEP EQHLMNCEKC
60 70 80 90 100
VHDFNRRQTE KQKKLTWTTT SRIFSNNARR RTSRSTKANY SKNSPKTPVT
110 120 130 140 150
DKHHRSKNCK LFAASKNVRR KAASTLSDTK NMEIINSTIE TLAPDSPFDH
160 170 180 190 200
KKTVSGFQKL EKLDPIAADQ QDTVVFKVTE GKLLRDPLSH PGAEQTGIQN
210 220 230 240 250
KTQMHPLMSQ MSGSVTASMA TGSATRKGIV VLIDPLAANG TTDMHTSVPR
260 270 280 290 300
VKGGQRNITD DSRGQPFIKK MHFTIRLTES AITYRDIVVK KEDGFTQIVL
310 320 330 340 350
STRSTEKNAL NTEVIKEMVN ALNSAAADDS KLVLFSAAGS VFCCGLDFGY
360 370 380 390 400
FVRHLRNDRN TASLEMVDTI KNFVNTFIQF KKPIVVSVNG PAIGLGASIL
410 420 430 440 450
PLCDLVWANE KAWFQTPYTT FGQSPDGCSS ITFPKMMGKA SANEMLIAGR
460 470 480 490 500
KLTAREACAK GLVSQVFLTG TFTQEVMIQI KELASYNAIV LEECKALVRC
510 520 530 540
NIKLELEQAN ERECEVLRKI WSSAQGIESM LKYVENKIDE F
Length:541
Mass (Da):60,524
Last modified:November 1, 1999 - v1
Checksum:i53F31A6603829E85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080598 mRNA. Translation: AAD22733.1.
AK292233 mRNA. Translation: BAF84922.1.
BC069087 mRNA. Translation: AAH69087.1.
CCDSiCCDS14789.1.
CCDS35473.1.
RefSeqiNP_001001722.1. NM_001001722.1.
NP_004816.1. NM_004825.2.
UniGeneiHs.251375.
Hs.532657.

Genome annotation databases

EnsembliENST00000250838; ENSP00000250838; ENSG00000182415.
ENST00000382867; ENSP00000372319; ENSG00000129873.
GeneIDi203611.
9426.
KEGGihsa:203611.
hsa:9426.
UCSCiuc004ftl.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080598 mRNA. Translation: AAD22733.1.
AK292233 mRNA. Translation: BAF84922.1.
BC069087 mRNA. Translation: AAH69087.1.
CCDSiCCDS14789.1.
CCDS35473.1.
RefSeqiNP_001001722.1. NM_001001722.1.
NP_004816.1. NM_004825.2.
UniGeneiHs.251375.
Hs.532657.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FW2X-ray2.20A/B/C/D/E/F282-541[»]
ProteinModelPortaliQ9Y6F7.
SMRiQ9Y6F7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114819. 1 interactor.
128481. 1 interactor.
STRINGi9606.ENSP00000372319.

PTM databases

iPTMnetiQ9Y6F7.
PhosphoSitePlusiQ9Y6F7.

Polymorphism and mutation databases

BioMutaiCDY2A.
DMDMi20138088.

Proteomic databases

MaxQBiQ9Y6F7.
PaxDbiQ9Y6F7.
PeptideAtlasiQ9Y6F7.
PRIDEiQ9Y6F7.

Protocols and materials databases

DNASUi203611.
9426.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250838; ENSP00000250838; ENSG00000182415.
ENST00000382867; ENSP00000372319; ENSG00000129873.
GeneIDi203611.
9426.
KEGGihsa:203611.
hsa:9426.
UCSCiuc004ftl.2. human.

Organism-specific databases

CTDi203611.
9426.
DisGeNETi203611.
9426.
GeneCardsiCDY2A.
CDY2B.
GeneReviewsiCDY2A.
HGNCiHGNC:1810. CDY2A.
HGNC:23921. CDY2B.
MIMi400018. gene.
neXtProtiNX_Q9Y6F7.
OpenTargetsiENSG00000129873.
ENSG00000182415.
PharmGKBiPA26355.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0016. Eukaryota.
KOG1911. Eukaryota.
COG1024. LUCA.
GeneTreeiENSGT00760000119100.
HOGENOMiHOG000111507.
HOVERGENiHBG006723.
InParanoidiQ9Y6F7.
KOiK00653.
PhylomeDBiQ9Y6F7.
TreeFamiTF313375.

Enzyme and pathway databases

BioCyciZFISH:HS05312-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9Y6F7.
PROiQ9Y6F7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182415.
CleanExiHS_CDY2A.
HS_CDY2B.
GenevisibleiQ9Y6F7. HS.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR000953. Chromo/shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF00378. ECH_1. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDY2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6F7
Secondary accession number(s): A8K868
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.