Q9Y6F6 (MRVI1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein MRVI1

Alternative name(s):
Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate
JAW1-related protein MRVI1

Gene names

Name:	MRVI1
Synonyms:	IRAG, JAW1L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	885 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation. Ref.6
Subunit structure	Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 By similarity. Interacts with PRKG1/cGKI-beta and ITPR1/IP3R type I. Ref.7
Subcellular location	Cytoplasm › perinuclear region. Sarcoplasmic reticulum By similarity. Membrane; Single-pass membrane protein Potential.
Tissue specificity	Expressed in the colon, rectum, and cultured colonic smooth muscle. Detected in various cancer cell lines. Ref.1 Ref.6
Induction	By silencing of the transcription factor BTF3. Ref.8
Post-translational modification	Phosphorylated by PRKG1/cGKI-beta; Ser-367 showed constitutive phosphorylation in platelets Whereas Ser-657 is only phosphorylated in presence of cGMP and nitric oxide (NO); Ser-670 is phosphorylated in resting platelets but increases in presence of cGMP and NO. PRKG1 inhibitor prevents phosphorylation of Ser-657 and Ser-670 in response to NO and cGMP. Ref.7
Sequence caution	The sequence AAD25922.1 differs from that shown. Reason: Frameshift at position 1. The sequence AAD25923.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane Sarcoplasmic reticulum
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Transmembrane Transmembrane helix
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	blood coagulation Traceable author statement. Source: Reactome
Cellular_component	endoplasmic reticulum membrane Traceable author statement Ref.1. Source: ProtInc integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell platelet dense tubular network membrane Traceable author statement. Source: Reactome sarcoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y6F6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y6F6-2)

Also known as: MRVI1A;

The sequence of this isoform differs from the canonical sequence as follows:
     65-65: G → GQ

Isoform 3 (identifier: Q9Y6F6-3)

Also known as: MRVI1B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: MGMDLTCPFG...SCSPTPTIVL → M

Isoform 4 (identifier: Q9Y6F6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     209-209: D → GLDVCSGPPSPLPGAPPQK

Isoform 5 (identifier: Q9Y6F6-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: MGMDLTCPFG...SCSPTPTIVL → M
     209-209: D → GLDVCSGPPSPLPGAPPQK

Note: No experimental confirmation available.

Isoform 6 (identifier: Q9Y6F6-6)

The sequence of this isoform differs from the canonical sequence as follows:
     1-288: Missing.

Note: No experimental confirmation available.

Isoform 7 (identifier: Q9Y6F6-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MGMDLTCPFGISP → MVKAPQSEERLARGGKENNSVL
     209-209: D → GLDVCSGPPSPLPGAPPQK

Note: No experimental confirmation available.

Isoform 8 (identifier: Q9Y6F6-8)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MGMDLTCPFGISP → MVKAPQSEERLARGGKENNSVL
     209-209: D → GLDVCSGPPSPLPGAPPQK
     210-241: GDEADVSSPHPGEPNVPKGLADRKQNDQRKVS → GDEADVSSPHPGEP
     242-429: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 885	885	Protein MRVI1		PRO_0000305292
Regions
	Transmembrane	825 – 845	21	Helical; Potential
	Region	144 – 176	33	Interaction with PRKG1 By similarity
	Region	508 – 554	47	Interaction with ITPR1 By similarity
	Coiled coil	521 – 619	99	Potential
	Compositional bias	742 – 809	68	Glu-rich
Amino acid modifications
	Modified residue	110	1	Phosphoserine By similarity
	Modified residue	367	1	Phosphoserine Ref.7
	Modified residue	657	1	Phosphoserine Ref.7
	Modified residue	670	1	Phosphoserine Ref.7
Natural variations
	Alternative sequence	1 – 288	288	Missing in isoform 6.		VSP_040452
	Alternative sequence	1 – 83	83	MGMDL…PTIVL → M in isoform 3 and isoform 5.		VSP_028341
	Alternative sequence	1 – 13	13	MGMDL…FGISP → MVKAPQSEERLARGGKENNS VL in isoform 7 and isoform 8.		VSP_046361
	Alternative sequence	65	1	G → GQ in isoform 2.		VSP_028342
	Alternative sequence	209	1	D → GLDVCSGPPSPLPGAPPQK in isoform 4, isoform 5, isoform 7 and isoform 8.		VSP_040453
	Alternative sequence	210 – 241	32	GDEAD…QRKVS → GDEADVSSPHPGEP in isoform 8.		VSP_046362
	Alternative sequence	242 – 429	188	Missing in isoform 8.		VSP_046363
	Natural variant	11	1	I → V. Ref.1 Ref.2 Corresponds to variant rs4909945 [ dbSNP | Ensembl ].		VAR_056942
	Natural variant	28	1	A → T. Corresponds to variant rs34302310 [ dbSNP | Ensembl ].		VAR_056943
	Natural variant	70	1	A → T. Ref.1 Ref.2 Corresponds to variant rs2162044 [ dbSNP | Ensembl ].		VAR_056944
	Natural variant	186	1	P → S. Corresponds to variant rs35857561 [ dbSNP | Ensembl ].		VAR_056945
	Natural variant	270	1	Q → H. Corresponds to variant rs34398944 [ dbSNP | Ensembl ].		VAR_056946
	Natural variant	334	1	Q → H. Corresponds to variant rs34398944 [ dbSNP | Ensembl ].		VAR_058298
Experimental info
	Sequence conflict	42	1	A → G in AAD25922. Ref.1
	Sequence conflict	57	1	P → S in AAD25922. Ref.1
	Sequence conflict	174	1	R → M in BAH12320. Ref.2
	Sequence conflict	209	1	D → E in AAD25922. Ref.1
	Sequence conflict	209	1	D → E in AAD25923. Ref.1
	Sequence conflict	493	1	S → G in BAH12320. Ref.2
	Sequence conflict	607	1	E → G in BAH12320. Ref.2
	Sequence conflict	650	1	P → L in AAD25922. Ref.1
	Sequence conflict	650	1	P → L in AAD25923. Ref.1
	Sequence conflict	869	1	R → K in AAD25922. Ref.1
	Sequence conflict	869	1	R → K in AAD25923. Ref.1
Isoform 7:
	Sequence conflict	9	1	E → G in BAH12320. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 2, 2007. Version 2. Checksum: 2C9C2390BA527D28	FASTA	885	96,145
	10 20 30 40 50 60 MGMDLTCPFG ISPACGAQAS WSIFGADAAE VPGTRGHSQQ EAAMPHIPED EEPPGEPQAA 70 80 90 100 110 120 QSPAGQGPPA AGVSCSPTPT IVLTGDATSP EGETDKNLAN RVHSPHKRLS HRHLKVSTAS 130 140 150 160 170 180 LTSVDPAGHI IDLVNDQLPD ISISEEDKKK NLALLEEAKL VSERFLTRRG RKSRSSPGDS 190 200 210 220 230 240 PSAVSPNLSP SASPTSSRSN SLTVPTPPDG DEADVSSPHP GEPNVPKGLA DRKQNDQRKV 250 260 270 280 290 300 SQGRLAPRPP PVEKSKEIAI EQKENFDPLQ YPETTPKGLA PVTNSSGKMA LNSPQPGPVE 310 320 330 340 350 360 SELGKQLLKT GWEGSPLPRS PTQDAAGVGP PASQGRGPAG EPMGPEAGSK AELPPTVSRP 370 380 390 400 410 420 PLLRGLSWDS GPEEPGPRLQ KVLAKLPLAE EEKRFAGKAG GKLAKAPGLK DFQIQVQPVR 430 440 450 460 470 480 MQKLTKLREE HILMRNQNLV GLKLPDLSEA AEQEKGLPSE LSPAIEEEES KSGLDVMPNI 490 500 510 520 530 540 SDVLLRKLRV HRSLPGSAPP LTEKEVENVF VQLSLAFRND SYTLESRINQ AERERNLTEE 550 560 570 580 590 600 NTEKELENFK ASITSSASLW HHCEHRETYQ KLLEDIAVLH RLAARLSSRA EVVGAVRQEK 610 620 630 640 650 660 RMSKATEVMM QYVENLKRTY EKDHAELMEF KKLANQNSSR SCGPSEDGVP RTARSMSLTL 670 680 690 700 710 720 GKNMPRRRVS VAVVPKFNAL NLPGQTPSSS SIPSLPALSE SPNGKGSLPV TSALPALLEN 730 740 750 760 770 780 GKTNGDPDCE ASAPALTLSC LEELSQETKA RMEEEAYSKG FQEGLKKTKE LQDLKEEEEE 790 800 810 820 830 840 QKSESPEEPE EVEETEEEEK GPRSSKLEEL VHFLQVMYPK LCQHWQVIWM MAAVMLVLTV 850 860 870 880 VLGLYNSYNS CAEQADGPLG RSTCSAAQRD SWWSSGLQHE QPTEQ
	Isoform 2 (MRVI1A) [UniParc]. Checksum: 0F530C9C898ACC2C	FASTA	886	96,273
	10 20 30 40 50 60 MGMDLTCPFG ISPACGAQAS WSIFGADAAE VPGTRGHSQQ EAAMPHIPED EEPPGEPQAA 70 80 90 100 110 120 QSPAGQQGPP AAGVSCSPTP TIVLTGDATS PEGETDKNLA NRVHSPHKRL SHRHLKVSTA 130 140 150 160 170 180 SLTSVDPAGH IIDLVNDQLP DISISEEDKK KNLALLEEAK LVSERFLTRR GRKSRSSPGD 190 200 210 220 230 240 SPSAVSPNLS PSASPTSSRS NSLTVPTPPD GDEADVSSPH PGEPNVPKGL ADRKQNDQRK 250 260 270 280 290 300 VSQGRLAPRP PPVEKSKEIA IEQKENFDPL QYPETTPKGL APVTNSSGKM ALNSPQPGPV 310 320 330 340 350 360 ESELGKQLLK TGWEGSPLPR SPTQDAAGVG PPASQGRGPA GEPMGPEAGS KAELPPTVSR 370 380 390 400 410 420 PPLLRGLSWD SGPEEPGPRL QKVLAKLPLA EEEKRFAGKA GGKLAKAPGL KDFQIQVQPV 430 440 450 460 470 480 RMQKLTKLRE EHILMRNQNL VGLKLPDLSE AAEQEKGLPS ELSPAIEEEE SKSGLDVMPN 490 500 510 520 530 540 ISDVLLRKLR VHRSLPGSAP PLTEKEVENV FVQLSLAFRN DSYTLESRIN QAERERNLTE 550 560 570 580 590 600 ENTEKELENF KASITSSASL WHHCEHRETY QKLLEDIAVL HRLAARLSSR AEVVGAVRQE 610 620 630 640 650 660 KRMSKATEVM MQYVENLKRT YEKDHAELME FKKLANQNSS RSCGPSEDGV PRTARSMSLT 670 680 690 700 710 720 LGKNMPRRRV SVAVVPKFNA LNLPGQTPSS SSIPSLPALS ESPNGKGSLP VTSALPALLE 730 740 750 760 770 780 NGKTNGDPDC EASAPALTLS CLEELSQETK ARMEEEAYSK GFQEGLKKTK ELQDLKEEEE 790 800 810 820 830 840 EQKSESPEEP EEVEETEEEE KGPRSSKLEE LVHFLQVMYP KLCQHWQVIW MMAAVMLVLT 850 860 870 880 VVLGLYNSYN SCAEQADGPL GRSTCSAAQR DSWWSSGLQH EQPTEQ
	Isoform 3 (MRVI1B) [UniParc]. Checksum: 21AE73B811DE409B	FASTA	803	88,026
	10 20 30 40 50 60 MTGDATSPEG ETDKNLANRV HSPHKRLSHR HLKVSTASLT SVDPAGHIID LVNDQLPDIS 70 80 90 100 110 120 ISEEDKKKNL ALLEEAKLVS ERFLTRRGRK SRSSPGDSPS AVSPNLSPSA SPTSSRSNSL 130 140 150 160 170 180 TVPTPPDGDE ADVSSPHPGE PNVPKGLADR KQNDQRKVSQ GRLAPRPPPV EKSKEIAIEQ 190 200 210 220 230 240 KENFDPLQYP ETTPKGLAPV TNSSGKMALN SPQPGPVESE LGKQLLKTGW EGSPLPRSPT 250 260 270 280 290 300 QDAAGVGPPA SQGRGPAGEP MGPEAGSKAE LPPTVSRPPL LRGLSWDSGP EEPGPRLQKV 310 320 330 340 350 360 LAKLPLAEEE KRFAGKAGGK LAKAPGLKDF QIQVQPVRMQ KLTKLREEHI LMRNQNLVGL 370 380 390 400 410 420 KLPDLSEAAE QEKGLPSELS PAIEEEESKS GLDVMPNISD VLLRKLRVHR SLPGSAPPLT 430 440 450 460 470 480 EKEVENVFVQ LSLAFRNDSY TLESRINQAE RERNLTEENT EKELENFKAS ITSSASLWHH 490 500 510 520 530 540 CEHRETYQKL LEDIAVLHRL AARLSSRAEV VGAVRQEKRM SKATEVMMQY VENLKRTYEK 550 560 570 580 590 600 DHAELMEFKK LANQNSSRSC GPSEDGVPRT ARSMSLTLGK NMPRRRVSVA VVPKFNALNL 610 620 630 640 650 660 PGQTPSSSSI PSLPALSESP NGKGSLPVTS ALPALLENGK TNGDPDCEAS APALTLSCLE 670 680 690 700 710 720 ELSQETKARM EEEAYSKGFQ EGLKKTKELQ DLKEEEEEQK SESPEEPEEV EETEEEEKGP 730 740 750 760 770 780 RSSKLEELVH FLQVMYPKLC QHWQVIWMMA AVMLVLTVVL GLYNSYNSCA EQADGPLGRS 790 800 TCSAAQRDSW WSSGLQHEQP TEQ
	Isoform 4 [UniParc]. Checksum: C8B39FFD1BAA30F0	FASTA	903	97,829
	10 20 30 40 50 60 MGMDLTCPFG ISPACGAQAS WSIFGADAAE VPGTRGHSQQ EAAMPHIPED EEPPGEPQAA 70 80 90 100 110 120 QSPAGQGPPA AGVSCSPTPT IVLTGDATSP EGETDKNLAN RVHSPHKRLS HRHLKVSTAS 130 140 150 160 170 180 LTSVDPAGHI IDLVNDQLPD ISISEEDKKK NLALLEEAKL VSERFLTRRG RKSRSSPGDS 190 200 210 220 230 240 PSAVSPNLSP SASPTSSRSN SLTVPTPPGL DVCSGPPSPL PGAPPQKGDE ADVSSPHPGE 250 260 270 280 290 300 PNVPKGLADR KQNDQRKVSQ GRLAPRPPPV EKSKEIAIEQ KENFDPLQYP ETTPKGLAPV 310 320 330 340 350 360 TNSSGKMALN SPQPGPVESE LGKQLLKTGW EGSPLPRSPT QDAAGVGPPA SQGRGPAGEP 370 380 390 400 410 420 MGPEAGSKAE LPPTVSRPPL LRGLSWDSGP EEPGPRLQKV LAKLPLAEEE KRFAGKAGGK 430 440 450 460 470 480 LAKAPGLKDF QIQVQPVRMQ KLTKLREEHI LMRNQNLVGL KLPDLSEAAE QEKGLPSELS 490 500 510 520 530 540 PAIEEEESKS GLDVMPNISD VLLRKLRVHR SLPGSAPPLT EKEVENVFVQ LSLAFRNDSY 550 560 570 580 590 600 TLESRINQAE RERNLTEENT EKELENFKAS ITSSASLWHH CEHRETYQKL LEDIAVLHRL 610 620 630 640 650 660 AARLSSRAEV VGAVRQEKRM SKATEVMMQY VENLKRTYEK DHAELMEFKK LANQNSSRSC 670 680 690 700 710 720 GPSEDGVPRT ARSMSLTLGK NMPRRRVSVA VVPKFNALNL PGQTPSSSSI PSLPALSESP 730 740 750 760 770 780 NGKGSLPVTS ALPALLENGK TNGDPDCEAS APALTLSCLE ELSQETKARM EEEAYSKGFQ 790 800 810 820 830 840 EGLKKTKELQ DLKEEEEEQK SESPEEPEEV EETEEEEKGP RSSKLEELVH FLQVMYPKLC 850 860 870 880 890 900 QHWQVIWMMA AVMLVLTVVL GLYNSYNSCA EQADGPLGRS TCSAAQRDSW WSSGLQHEQP TEQ
	Isoform 5 [UniParc]. Checksum: 188EAD2A24983B9A	FASTA	821	89,710
	10 20 30 40 50 60 MTGDATSPEG ETDKNLANRV HSPHKRLSHR HLKVSTASLT SVDPAGHIID LVNDQLPDIS 70 80 90 100 110 120 ISEEDKKKNL ALLEEAKLVS ERFLTRRGRK SRSSPGDSPS AVSPNLSPSA SPTSSRSNSL 130 140 150 160 170 180 TVPTPPGLDV CSGPPSPLPG APPQKGDEAD VSSPHPGEPN VPKGLADRKQ NDQRKVSQGR 190 200 210 220 230 240 LAPRPPPVEK SKEIAIEQKE NFDPLQYPET TPKGLAPVTN SSGKMALNSP QPGPVESELG 250 260 270 280 290 300 KQLLKTGWEG SPLPRSPTQD AAGVGPPASQ GRGPAGEPMG PEAGSKAELP PTVSRPPLLR 310 320 330 340 350 360 GLSWDSGPEE PGPRLQKVLA KLPLAEEEKR FAGKAGGKLA KAPGLKDFQI QVQPVRMQKL 370 380 390 400 410 420 TKLREEHILM RNQNLVGLKL PDLSEAAEQE KGLPSELSPA IEEEESKSGL DVMPNISDVL 430 440 450 460 470 480 LRKLRVHRSL PGSAPPLTEK EVENVFVQLS LAFRNDSYTL ESRINQAERE RNLTEENTEK 490 500 510 520 530 540 ELENFKASIT SSASLWHHCE HRETYQKLLE DIAVLHRLAA RLSSRAEVVG AVRQEKRMSK 550 560 570 580 590 600 ATEVMMQYVE NLKRTYEKDH AELMEFKKLA NQNSSRSCGP SEDGVPRTAR SMSLTLGKNM 610 620 630 640 650 660 PRRRVSVAVV PKFNALNLPG QTPSSSSIPS LPALSESPNG KGSLPVTSAL PALLENGKTN 670 680 690 700 710 720 GDPDCEASAP ALTLSCLEEL SQETKARMEE EAYSKGFQEG LKKTKELQDL KEEEEEQKSE 730 740 750 760 770 780 SPEEPEEVEE TEEEEKGPRS SKLEELVHFL QVMYPKLCQH WQVIWMMAAV MLVLTVVLGL 790 800 810 820 YNSYNSCAEQ ADGPLGRSTC SAAQRDSWWS SGLQHEQPTE Q
	Isoform 6 [UniParc]. Checksum: 944DEBF8A90C2AA6	FASTA	597	65,878
	10 20 30 40 50 60 MALNSPQPGP VESELGKQLL KTGWEGSPLP RSPTQDAAGV GPPASQGRGP AGEPMGPEAG 70 80 90 100 110 120 SKAELPPTVS RPPLLRGLSW DSGPEEPGPR LQKVLAKLPL AEEEKRFAGK AGGKLAKAPG 130 140 150 160 170 180 LKDFQIQVQP VRMQKLTKLR EEHILMRNQN LVGLKLPDLS EAAEQEKGLP SELSPAIEEE 190 200 210 220 230 240 ESKSGLDVMP NISDVLLRKL RVHRSLPGSA PPLTEKEVEN VFVQLSLAFR NDSYTLESRI 250 260 270 280 290 300 NQAERERNLT EENTEKELEN FKASITSSAS LWHHCEHRET YQKLLEDIAV LHRLAARLSS 310 320 330 340 350 360 RAEVVGAVRQ EKRMSKATEV MMQYVENLKR TYEKDHAELM EFKKLANQNS SRSCGPSEDG 370 380 390 400 410 420 VPRTARSMSL TLGKNMPRRR VSVAVVPKFN ALNLPGQTPS SSSIPSLPAL SESPNGKGSL 430 440 450 460 470 480 PVTSALPALL ENGKTNGDPD CEASAPALTL SCLEELSQET KARMEEEAYS KGFQEGLKKT 490 500 510 520 530 540 KELQDLKEEE EEQKSESPEE PEEVEETEEE EKGPRSSKLE ELVHFLQVMY PKLCQHWQVI 550 560 570 580 590 WMMAAVMLVL TVVLGLYNSY NSCAEQADGP LGRSTCSAAQ RDSWWSSGLQ HEQPTEQ
	Isoform 7 [UniParc]. Checksum: D3423E9FEDE8B2AA	FASTA	912	98,874
	10 20 30 40 50 60 MVKAPQSEER LARGGKENNS VLACGAQASW SIFGADAAEV PGTRGHSQQE AAMPHIPEDE 70 80 90 100 110 120 EPPGEPQAAQ SPAGQGPPAA GVSCSPTPTI VLTGDATSPE GETDKNLANR VHSPHKRLSH 130 140 150 160 170 180 RHLKVSTASL TSVDPAGHII DLVNDQLPDI SISEEDKKKN LALLEEAKLV SERFLTRRGR 190 200 210 220 230 240 KSRSSPGDSP SAVSPNLSPS ASPTSSRSNS LTVPTPPGLD VCSGPPSPLP GAPPQKGDEA 250 260 270 280 290 300 DVSSPHPGEP NVPKGLADRK QNDQRKVSQG RLAPRPPPVE KSKEIAIEQK ENFDPLQYPE 310 320 330 340 350 360 TTPKGLAPVT NSSGKMALNS PQPGPVESEL GKQLLKTGWE GSPLPRSPTQ DAAGVGPPAS 370 380 390 400 410 420 QGRGPAGEPM GPEAGSKAEL PPTVSRPPLL RGLSWDSGPE EPGPRLQKVL AKLPLAEEEK 430 440 450 460 470 480 RFAGKAGGKL AKAPGLKDFQ IQVQPVRMQK LTKLREEHIL MRNQNLVGLK LPDLSEAAEQ 490 500 510 520 530 540 EKGLPSELSP AIEEEESKSG LDVMPNISDV LLRKLRVHRS LPGSAPPLTE KEVENVFVQL 550 560 570 580 590 600 SLAFRNDSYT LESRINQAER ERNLTEENTE KELENFKASI TSSASLWHHC EHRETYQKLL 610 620 630 640 650 660 EDIAVLHRLA ARLSSRAEVV GAVRQEKRMS KATEVMMQYV ENLKRTYEKD HAELMEFKKL 670 680 690 700 710 720 ANQNSSRSCG PSEDGVPRTA RSMSLTLGKN MPRRRVSVAV VPKFNALNLP GQTPSSSSIP 730 740 750 760 770 780 SLPALSESPN GKGSLPVTSA LPALLENGKT NGDPDCEASA PALTLSCLEE LSQETKARME 790 800 810 820 830 840 EEAYSKGFQE GLKKTKELQD LKEEEEEQKS ESPEEPEEVE ETEEEEKGPR SSKLEELVHF 850 860 870 880 890 900 LQVMYPKLCQ HWQVIWMMAA VMLVLTVVLG LYNSYNSCAE QADGPLGRST CSAAQRDSWW 910 SSGLQHEQPT EQ
	Isoform 8 [UniParc]. Checksum: CD8963E32BBFC493	FASTA	706	76,892
	10 20 30 40 50 60 MVKAPQSEER LARGGKENNS VLACGAQASW SIFGADAAEV PGTRGHSQQE AAMPHIPEDE 70 80 90 100 110 120 EPPGEPQAAQ SPAGQGPPAA GVSCSPTPTI VLTGDATSPE GETDKNLANR VHSPHKRLSH 130 140 150 160 170 180 RHLKVSTASL TSVDPAGHII DLVNDQLPDI SISEEDKKKN LALLEEAKLV SERFLTRRGR 190 200 210 220 230 240 KSRSSPGDSP SAVSPNLSPS ASPTSSRSNS LTVPTPPGLD VCSGPPSPLP GAPPQKGDEA 250 260 270 280 290 300 DVSSPHPGEP EHILMRNQNL VGLKLPDLSE AAEQEKGLPS ELSPAIEEEE SKSGLDVMPN 310 320 330 340 350 360 ISDVLLRKLR VHRSLPGSAP PLTEKEVENV FVQLSLAFRN DSYTLESRIN QAERERNLTE 370 380 390 400 410 420 ENTEKELENF KASITSSASL WHHCEHRETY QKLLEDIAVL HRLAARLSSR AEVVGAVRQE 430 440 450 460 470 480 KRMSKATEVM MQYVENLKRT YEKDHAELME FKKLANQNSS RSCGPSEDGV PRTARSMSLT 490 500 510 520 530 540 LGKNMPRRRV SVAVVPKFNA LNLPGQTPSS SSIPSLPALS ESPNGKGSLP VTSALPALLE 550 560 570 580 590 600 NGKTNGDPDC EASAPALTLS CLEELSQETK ARMEEEAYSK GFQEGLKKTK ELQDLKEEEE 610 620 630 640 650 660 EQKSESPEEP EEVEETEEEE KGPRSSKLEE LVHFLQVMYP KLCQHWQVIW MMAAVMLVLT 670 680 690 700 VVLGLYNSYN SCAEQADGPL GRSTCSAAQR DSWWSSGLQH EQPTEQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1." Shaughnessy J.D. Jr., Largaespada D.A., Tian E., Fletcher C.F., Cho B.C., Vyas P., Jenkins N.A., Copeland N.G. Oncogene 18:2069-2084(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 4), TISSUE SPECIFICITY, VARIANTS VAL-11 AND THR-70.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 7 AND 8), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-170 (ISOFORM 1), VARIANTS VAL-11 AND THR-70. Tissue: Placenta, Thalamus and Uterus.
[3]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). Tissue: Brain.
[6]	"InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle." Fritsch R.M., Saur D., Kurjak M., Oesterle D., Schlossmann J., Geiselhoeringer A., Hofmann F., Allescher H.-D. J. Biol. Chem. 279:12551-12559(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, FUNCTION.
[7]	"IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation." Antl M., von Bruehl M.-L., Eiglsperger C., Werner M., Konrad I., Kocher T., Wilm M., Hofmann F., Massberg S., Schlossmann J. Blood 109:552-559(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH PRKG1 AND ITPR1, PHOSPHORYLATION AT SER-367; SER-657 AND SER-670.
[8]	"Basic transcription factor 3 (BTF3) regulates transcription of tumor-associated genes in pancreatic cancer cells." Kusumawidjaja G., Kayed H., Giese N., Bauer A., Erkan M., Giese T., Hoheise J.D., Friess H., Kleeff J. Cancer Biol. Ther. 6:367-376(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION BY BTF3.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF081249 mRNA. Translation: AAD25922.1. Frameshift. AF081250 mRNA. Translation: AAD25923.1. Sequence problems. AK296336 mRNA. Translation: BAH12320.1. AK300358 mRNA. Translation: BAH13268.1. AK304702 mRNA. Translation: BAH14239.1. DA857260 mRNA. No translation available. AC009532 Genomic DNA. No translation available. CH471064 Genomic DNA. Translation: EAW68559.1. CH471064 Genomic DNA. Translation: EAW68560.1. CH471064 Genomic DNA. Translation: EAW68561.1. CH471064 Genomic DNA. Translation: EAW68562.1. CH471064 Genomic DNA. Translation: EAW68563.1. BC117127 mRNA. Translation: AAI17128.1.
IPI	IPI00295313. IPI00867598. IPI00921916. IPI00922700. IPI00940764. IPI00973721. IPI00985272. IPI01018664.
RefSeq	NP_001092049.2. NM_001098579.2. NP_001093633.1. NM_001100163.2. NP_001093637.1. NM_001100167.2. NP_001193810.1. NM_001206881.1.
UniGene	Hs.501898. Hs.680194.
3D structure databases
ProteinModelPortal	Q9Y6F6.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y6F6. 1 interaction.
STRING	9606.ENSP00000414598.
PTM databases
PhosphoSite	Q9Y6F6.
Polymorphism databases
DMDM	158706131.
Proteomic databases
PaxDb	Q9Y6F6.
PRIDE	Q9Y6F6.
Protocols and materials databases
DNASU	10335.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000421747; ENSP00000414598; ENSG00000072952. ENST00000423302; ENSP00000412130; ENSG00000072952. ENST00000424001; ENSP00000401205; ENSG00000072952. ENST00000436272; ENSP00000412229; ENSG00000072952. ENST00000541483; ENSP00000437784; ENSG00000072952. ENST00000545852; ENSP00000441971; ENSG00000072952. ENST00000552103; ENSP00000446764; ENSG00000072952. ENST00000558540; ENSP00000453013; ENSG00000072952.
GeneID	10335.
KEGG	hsa:10335.
UCSC	uc001miw.2. human. uc001mix.3. human. uc001miz.2. human.
Organism-specific databases
CTD	10335.
GeneCards	GC11M010594.
HGNC	HGNC:7237. MRVI1.
HPA	HPA008704.
MIM	604673. gene.
neXtProt	NX_Q9Y6F6.
PharmGKB	PA31032.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG69910.
HOGENOM	HOG000113653.
HOVERGEN	HBG078204.
InParanoid	Q9Y6F6.
KO	K12337.
OrthoDB	EOG4JHCF9.
Enzyme and pathway databases
Reactome	REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	Q9Y6F6.
Bgee	Q9Y6F6.
CleanEx	HS_MRVI1.
Genevestigator	Q9Y6F6.
Family and domain databases
InterPro	IPR008677. MRVI1. [Graphical view]
PANTHER	PTHR15352. PTHR15352. 1 hit.
Pfam	PF05781. MRVI1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10335.
NextBio	39193.
SOURCE	Search...

Entry information

Entry name

MRVI1_HUMAN

Accession

Primary (citable) accession number: Q9Y6F6
Secondary accession number(s): B7Z3T4 , B7Z6I2, B7Z9A3, F5H6A1, J3KQZ7, Q17S00, Q9UNY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	May 1, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.