Reviewed, UniProtKB/Swiss-Prot Q9Y6E2 (BZW2_HUMAN)

Names and origin

Protein names

Recommended name:
    Basic leucine zipper and W2 domain-containing protein 2

Gene names

Name:	BZW2
ORF Names:	HSPC028, MSTP017

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May be involved in neuronal differentiation By similarity.
Sequence similarities	Belongs to the BZW family. Contains 1 W2 domain.
Sequence caution	The sequence AAI07758.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Coding sequence diversity	Polymorphism
Molecular function	Developmental protein
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW nervous system development Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BZW1	Q7L1Q6	1	EBI-1051021,EBI-1046727
PSTPIP1	O43586	1	EBI-1051021,EBI-1050964

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	Basic leucine zipper and W2 domain-containing protein 2		PRO_0000254618
Regions
	Domain	248 – 415	168	W2
Amino acid modifications
	Modified residue	117	1	N6-acetyllysine Ref.11
	Modified residue	412	1	Phosphoserine Ref.5 Ref.6 Ref.7
	Modified residue	414	1	Phosphoserine Ref.5 Ref.6 Ref.7
Natural variations
	Natural variant	44	1	D → A: dbSNP rs35233079.		VAR_033642
Experimental info
	Sequence conflict	203	1	V → G in AAG39278. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9Y6E2-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 7ABFE7A51501E721	FASTA	419	48,162
	10 20 30 40 50 60 MNKHQKPVLT GQRFKTRKRD EKEKFEPTVF RDTLVQGLNE AGDDLEAVAK FLDSTGSRLD 70 80 90 100 110 120 YRRYADTLFD ILVAGSMLAP GGTRIDDGDK TKMTNHCVFS ANEDHETIRN YAQVFNKLIR 130 140 150 160 170 180 RYKYLEKAFE DEMKKLLLFL KAFSETEQTK LAMLSGILLG NGTLPATILT SLFTDSLVKE 190 200 210 220 230 240 GIAASFAVKL FKAWMAEKDA NSVTSSLRKA NLDKRLLELF PVNRQSVDHF AKYFTDAGLK 250 260 270 280 290 300 ELSDFLRVQQ SLGTRKELQK ELQERLSQEC PIKEVVLYVK EEMKRNDLPE TAVIGLLWTC 310 320 330 340 350 360 IMNAVEWNKK EELVAEQALK HLKQYAPLLA VFSSQGQSEL ILLQKVQEYC YDNIHFMKAF 370 380 390 400 410 QKIVVLFYKA DVLSEEAILK WYKEAHVAKG KSVFLDQMKK FVEWLQNAEE ESESEGEEN

References

[1]	Zhao B., Xu Y.Y., Liu Y.Q., Wang X.Y., Liu B., Ye J., Song L., Zhao Y., Cao H.Q., Zhao X.W., Gao Y., Zhang C.L., Zhang J., Liu L.S., Ding J.F., Gao R.L., Wu Q.Y., Qiang B.Q. , Yuan J.G., Liew C.C., Zhao M.S., Hui R.T. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
[2]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed: 11042152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow, Kidney and Skeletal muscle.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412 AND SER-414, MASS SPECTROMETRY. Tissue: Epithelium.
[6]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412 AND SER-414, MASS SPECTROMETRY.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412 AND SER-414, MASS SPECTROMETRY.
[8]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[9]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412, MASS SPECTROMETRY.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412 AND SER-414, MASS SPECTROMETRY. Tissue: T-cell.
[11]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-117, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF110323 mRNA. Translation: AAG39278.1. AF083246 mRNA. Translation: AAD39844.1. AK001218 mRNA. Translation: BAA91562.1. BC003056 mRNA. Translation: AAH03056.1. BC008453 mRNA. Translation: AAH08453.1. BC009597 mRNA. Translation: AAH09597.1. BC107757 mRNA. Translation: AAI07758.1. Sequence problems.
IPI	IPI00022305.
RefSeq	NP_001153239.1. NP_054757.1.
UniGene	Hs.487635
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y6E2. 2 interactions.
STRING	Q9Y6E2.
PTM databases
PhosphoSite	Q9Y6E2.
Proteomic databases
PeptideAtlas	Q9Y6E2.
PRIDE	Q9Y6E2.
Genome annotation databases
Ensembl	ENST00000258761; ENSP00000258761; ENSG00000136261; Homo sapiens. [Genome view]
GeneID	28969.
KEGG	hsa:28969.
UCSC	uc003stj.1. human.
Organism-specific databases
CTD	28969.
GeneCards	GC07P016652.
HGNC	HGNC:18808. BZW2.
HPA	HPA022813.
PharmGKB	PA38690.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9Y6E2.
OMA	ECPIKEM
OrthoDB	EOG973S9J
Gene expression databases
ArrayExpress	Q9Y6E2.
Bgee	Q9Y6E2.
CleanEx	HS_BZW2.
Genevestigator	Q9Y6E2.
GermOnline	ENSG00000136261. Homo sapiens.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. IPR003307. eIF5C. [Graphical view]
Gene3D	G3DSA:1.25.40.230. eIF5C. 1 hit.
Pfam	PF02020. W2. 1 hit. [Graphical view]
SMART	SM00515. eIF5C. 1 hit. [Graphical view]
PROSITE	PS51363. W2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	51827.

Entry information

Entry name

BZW2_HUMAN

Accession

Primary (citable) accession number: Q9Y6E2
Secondary accession number(s): Q3B779, Q9H3F7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	November 1, 1999
Last modified:	November 24, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.