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Protein

Basic leucine zipper and W2 domain-containing protein 2

Gene

BZW2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in neuronal differentiation.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper and W2 domain-containing protein 2
Gene namesi
Name:BZW2
ORF Names:HSPC028, MSTP017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18808. BZW2.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38690.

Polymorphism and mutation databases

BioMutaiBZW2.
DMDMi74762077.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 419419Basic leucine zipper and W2 domain-containing protein 2PRO_0000254618Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei117 – 1171N6-acetyllysineCombined sources
Modified residuei412 – 4121PhosphoserineCombined sources
Modified residuei414 – 4141PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y6E2.
MaxQBiQ9Y6E2.
PaxDbiQ9Y6E2.
PeptideAtlasiQ9Y6E2.
PRIDEiQ9Y6E2.

PTM databases

iPTMnetiQ9Y6E2.
PhosphoSiteiQ9Y6E2.
SwissPalmiQ9Y6E2.

Expressioni

Gene expression databases

BgeeiQ9Y6E2.
CleanExiHS_BZW2.
ExpressionAtlasiQ9Y6E2. baseline and differential.
GenevisibleiQ9Y6E2. HS.

Organism-specific databases

HPAiHPA022813.
HPA026709.

Interactioni

Protein-protein interaction databases

BioGridi118793. 60 interactions.
IntActiQ9Y6E2. 6 interactions.
MINTiMINT-5010259.
STRINGi9606.ENSP00000258761.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6E2.
SMRiQ9Y6E2. Positions 256-406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini248 – 415168W2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the BZW family.Curated
Contains 1 W2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2297. Eukaryota.
ENOG410XR08. LUCA.
GeneTreeiENSGT00390000012561.
HOGENOMiHOG000252932.
HOVERGENiHBG080940.
InParanoidiQ9Y6E2.
OMAiFMNKHQK.
PhylomeDBiQ9Y6E2.
TreeFamiTF324313.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR016021. MIF4-like.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y6E2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKHQKPVLT GQRFKTRKRD EKEKFEPTVF RDTLVQGLNE AGDDLEAVAK
60 70 80 90 100
FLDSTGSRLD YRRYADTLFD ILVAGSMLAP GGTRIDDGDK TKMTNHCVFS
110 120 130 140 150
ANEDHETIRN YAQVFNKLIR RYKYLEKAFE DEMKKLLLFL KAFSETEQTK
160 170 180 190 200
LAMLSGILLG NGTLPATILT SLFTDSLVKE GIAASFAVKL FKAWMAEKDA
210 220 230 240 250
NSVTSSLRKA NLDKRLLELF PVNRQSVDHF AKYFTDAGLK ELSDFLRVQQ
260 270 280 290 300
SLGTRKELQK ELQERLSQEC PIKEVVLYVK EEMKRNDLPE TAVIGLLWTC
310 320 330 340 350
IMNAVEWNKK EELVAEQALK HLKQYAPLLA VFSSQGQSEL ILLQKVQEYC
360 370 380 390 400
YDNIHFMKAF QKIVVLFYKA DVLSEEAILK WYKEAHVAKG KSVFLDQMKK
410
FVEWLQNAEE ESESEGEEN
Length:419
Mass (Da):48,162
Last modified:November 1, 1999 - v1
Checksum:i7ABFE7A51501E721
GO
Isoform 2 (identifier: Q9Y6E2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-201: IAASFAVKLFKAWMAEKDAN → NEAPVFSPVRQQKKNKVTDS
     202-419: Missing.

Note: No experimental confirmation available.
Show »
Length:201
Mass (Da):22,819
Checksum:i894B75B91E22764F
GO

Sequence cautioni

The sequence AAI07758.1 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031V → G in AAG39278 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441D → A.
Corresponds to variant rs35233079 [ dbSNP | Ensembl ].
VAR_033642

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei182 – 20120IAASF…EKDAN → NEAPVFSPVRQQKKNKVTDS in isoform 2. 1 PublicationVSP_055568Add
BLAST
Alternative sequencei202 – 419218Missing in isoform 2. 1 PublicationVSP_055569Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110323 mRNA. Translation: AAG39278.1.
AF083246 mRNA. Translation: AAD39844.1.
AK001218 mRNA. Translation: BAA91562.1.
AK027837 mRNA. Translation: BAB55401.1.
CH236948 Genomic DNA. Translation: EAL24285.1.
CH471073 Genomic DNA. Translation: EAW93675.1.
CH471073 Genomic DNA. Translation: EAW93678.1.
BC003056 mRNA. Translation: AAH03056.1.
BC008453 mRNA. Translation: AAH08453.1.
BC009597 mRNA. Translation: AAH09597.1.
BC107757 mRNA. Translation: AAI07758.1. Sequence problems.
CCDSiCCDS5362.1. [Q9Y6E2-1]
RefSeqiNP_001153239.1. NM_001159767.1. [Q9Y6E2-1]
NP_054757.1. NM_014038.2. [Q9Y6E2-1]
XP_006715769.1. XM_006715706.1. [Q9Y6E2-1]
XP_006715770.1. XM_006715707.1. [Q9Y6E2-1]
XP_006715771.1. XM_006715708.1. [Q9Y6E2-1]
UniGeneiHs.487635.

Genome annotation databases

EnsembliENST00000258761; ENSP00000258761; ENSG00000136261. [Q9Y6E2-1]
ENST00000433922; ENSP00000397249; ENSG00000136261. [Q9Y6E2-1]
GeneIDi28969.
KEGGihsa:28969.
UCSCiuc003stj.3. human. [Q9Y6E2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110323 mRNA. Translation: AAG39278.1.
AF083246 mRNA. Translation: AAD39844.1.
AK001218 mRNA. Translation: BAA91562.1.
AK027837 mRNA. Translation: BAB55401.1.
CH236948 Genomic DNA. Translation: EAL24285.1.
CH471073 Genomic DNA. Translation: EAW93675.1.
CH471073 Genomic DNA. Translation: EAW93678.1.
BC003056 mRNA. Translation: AAH03056.1.
BC008453 mRNA. Translation: AAH08453.1.
BC009597 mRNA. Translation: AAH09597.1.
BC107757 mRNA. Translation: AAI07758.1. Sequence problems.
CCDSiCCDS5362.1. [Q9Y6E2-1]
RefSeqiNP_001153239.1. NM_001159767.1. [Q9Y6E2-1]
NP_054757.1. NM_014038.2. [Q9Y6E2-1]
XP_006715769.1. XM_006715706.1. [Q9Y6E2-1]
XP_006715770.1. XM_006715707.1. [Q9Y6E2-1]
XP_006715771.1. XM_006715708.1. [Q9Y6E2-1]
UniGeneiHs.487635.

3D structure databases

ProteinModelPortaliQ9Y6E2.
SMRiQ9Y6E2. Positions 256-406.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118793. 60 interactions.
IntActiQ9Y6E2. 6 interactions.
MINTiMINT-5010259.
STRINGi9606.ENSP00000258761.

PTM databases

iPTMnetiQ9Y6E2.
PhosphoSiteiQ9Y6E2.
SwissPalmiQ9Y6E2.

Polymorphism and mutation databases

BioMutaiBZW2.
DMDMi74762077.

Proteomic databases

EPDiQ9Y6E2.
MaxQBiQ9Y6E2.
PaxDbiQ9Y6E2.
PeptideAtlasiQ9Y6E2.
PRIDEiQ9Y6E2.

Protocols and materials databases

DNASUi28969.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258761; ENSP00000258761; ENSG00000136261. [Q9Y6E2-1]
ENST00000433922; ENSP00000397249; ENSG00000136261. [Q9Y6E2-1]
GeneIDi28969.
KEGGihsa:28969.
UCSCiuc003stj.3. human. [Q9Y6E2-1]

Organism-specific databases

CTDi28969.
GeneCardsiBZW2.
HGNCiHGNC:18808. BZW2.
HPAiHPA022813.
HPA026709.
neXtProtiNX_Q9Y6E2.
PharmGKBiPA38690.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2297. Eukaryota.
ENOG410XR08. LUCA.
GeneTreeiENSGT00390000012561.
HOGENOMiHOG000252932.
HOVERGENiHBG080940.
InParanoidiQ9Y6E2.
OMAiFMNKHQK.
PhylomeDBiQ9Y6E2.
TreeFamiTF324313.

Miscellaneous databases

ChiTaRSiBZW2. human.
GeneWikiiBZW2.
GenomeRNAii28969.
PROiQ9Y6E2.

Gene expression databases

BgeeiQ9Y6E2.
CleanExiHS_BZW2.
ExpressionAtlasiQ9Y6E2. baseline and differential.
GenevisibleiQ9Y6E2. HS.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR016021. MIF4-like.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Heart.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Placenta.
  4. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow, Kidney and Skeletal muscle.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412 AND SER-414, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412 AND SER-414, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-117, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412 AND SER-414, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412 AND SER-414, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBZW2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6E2
Secondary accession number(s): A4D123
, Q3B779, Q96JW5, Q9H3F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.