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Protein

Basic leucine zipper and W2 domain-containing protein 2

Gene

BZW2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in neuronal differentiation.By similarity

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136261-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper and W2 domain-containing protein 2
Gene namesi
Name:BZW2
ORF Names:HSPC028, MSTP017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:18808. BZW2.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: BHF-UCL
  • membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi28969.
OpenTargetsiENSG00000136261.
PharmGKBiPA38690.

Polymorphism and mutation databases

BioMutaiBZW2.
DMDMi74762077.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002546181 – 419Basic leucine zipper and W2 domain-containing protein 2Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117N6-acetyllysineCombined sources1
Modified residuei412PhosphoserineCombined sources1
Modified residuei414PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y6E2.
PaxDbiQ9Y6E2.
PeptideAtlasiQ9Y6E2.
PRIDEiQ9Y6E2.

PTM databases

iPTMnetiQ9Y6E2.
PhosphoSitePlusiQ9Y6E2.
SwissPalmiQ9Y6E2.

Expressioni

Gene expression databases

BgeeiENSG00000136261.
CleanExiHS_BZW2.
ExpressionAtlasiQ9Y6E2. baseline and differential.
GenevisibleiQ9Y6E2. HS.

Organism-specific databases

HPAiHPA022813.
HPA026709.

Interactioni

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi118793. 60 interactors.
IntActiQ9Y6E2. 6 interactors.
MINTiMINT-5010259.
STRINGi9606.ENSP00000258761.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6E2.
SMRiQ9Y6E2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini248 – 415W2PROSITE-ProRule annotationAdd BLAST168

Sequence similaritiesi

Belongs to the BZW family.Curated
Contains 1 W2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2297. Eukaryota.
ENOG410XR08. LUCA.
GeneTreeiENSGT00390000012561.
HOGENOMiHOG000252932.
HOVERGENiHBG080940.
InParanoidiQ9Y6E2.
OMAiFMNKHQK.
OrthoDBiEOG091G090E.
PhylomeDBiQ9Y6E2.
TreeFamiTF324313.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR016021. MIF4-like.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y6E2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKHQKPVLT GQRFKTRKRD EKEKFEPTVF RDTLVQGLNE AGDDLEAVAK
60 70 80 90 100
FLDSTGSRLD YRRYADTLFD ILVAGSMLAP GGTRIDDGDK TKMTNHCVFS
110 120 130 140 150
ANEDHETIRN YAQVFNKLIR RYKYLEKAFE DEMKKLLLFL KAFSETEQTK
160 170 180 190 200
LAMLSGILLG NGTLPATILT SLFTDSLVKE GIAASFAVKL FKAWMAEKDA
210 220 230 240 250
NSVTSSLRKA NLDKRLLELF PVNRQSVDHF AKYFTDAGLK ELSDFLRVQQ
260 270 280 290 300
SLGTRKELQK ELQERLSQEC PIKEVVLYVK EEMKRNDLPE TAVIGLLWTC
310 320 330 340 350
IMNAVEWNKK EELVAEQALK HLKQYAPLLA VFSSQGQSEL ILLQKVQEYC
360 370 380 390 400
YDNIHFMKAF QKIVVLFYKA DVLSEEAILK WYKEAHVAKG KSVFLDQMKK
410
FVEWLQNAEE ESESEGEEN
Length:419
Mass (Da):48,162
Last modified:November 1, 1999 - v1
Checksum:i7ABFE7A51501E721
GO
Isoform 2 (identifier: Q9Y6E2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-201: IAASFAVKLFKAWMAEKDAN → NEAPVFSPVRQQKKNKVTDS
     202-419: Missing.

Note: No experimental confirmation available.
Show »
Length:201
Mass (Da):22,819
Checksum:i894B75B91E22764F
GO

Sequence cautioni

The sequence AAI07758 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203V → G in AAG39278 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03364244D → A.Corresponds to variant rs35233079dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055568182 – 201IAASF…EKDAN → NEAPVFSPVRQQKKNKVTDS in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_055569202 – 419Missing in isoform 2. 1 PublicationAdd BLAST218

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110323 mRNA. Translation: AAG39278.1.
AF083246 mRNA. Translation: AAD39844.1.
AK001218 mRNA. Translation: BAA91562.1.
AK027837 mRNA. Translation: BAB55401.1.
CH236948 Genomic DNA. Translation: EAL24285.1.
CH471073 Genomic DNA. Translation: EAW93675.1.
CH471073 Genomic DNA. Translation: EAW93678.1.
BC003056 mRNA. Translation: AAH03056.1.
BC008453 mRNA. Translation: AAH08453.1.
BC009597 mRNA. Translation: AAH09597.1.
BC107757 mRNA. Translation: AAI07758.1. Sequence problems.
CCDSiCCDS5362.1. [Q9Y6E2-1]
RefSeqiNP_001153239.1. NM_001159767.1. [Q9Y6E2-1]
NP_054757.1. NM_014038.2. [Q9Y6E2-1]
XP_006715769.1. XM_006715706.1. [Q9Y6E2-1]
XP_006715770.1. XM_006715707.1. [Q9Y6E2-1]
XP_006715771.1. XM_006715708.1. [Q9Y6E2-1]
UniGeneiHs.487635.

Genome annotation databases

EnsembliENST00000258761; ENSP00000258761; ENSG00000136261. [Q9Y6E2-1]
ENST00000433922; ENSP00000397249; ENSG00000136261. [Q9Y6E2-1]
GeneIDi28969.
KEGGihsa:28969.
UCSCiuc003stj.3. human. [Q9Y6E2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110323 mRNA. Translation: AAG39278.1.
AF083246 mRNA. Translation: AAD39844.1.
AK001218 mRNA. Translation: BAA91562.1.
AK027837 mRNA. Translation: BAB55401.1.
CH236948 Genomic DNA. Translation: EAL24285.1.
CH471073 Genomic DNA. Translation: EAW93675.1.
CH471073 Genomic DNA. Translation: EAW93678.1.
BC003056 mRNA. Translation: AAH03056.1.
BC008453 mRNA. Translation: AAH08453.1.
BC009597 mRNA. Translation: AAH09597.1.
BC107757 mRNA. Translation: AAI07758.1. Sequence problems.
CCDSiCCDS5362.1. [Q9Y6E2-1]
RefSeqiNP_001153239.1. NM_001159767.1. [Q9Y6E2-1]
NP_054757.1. NM_014038.2. [Q9Y6E2-1]
XP_006715769.1. XM_006715706.1. [Q9Y6E2-1]
XP_006715770.1. XM_006715707.1. [Q9Y6E2-1]
XP_006715771.1. XM_006715708.1. [Q9Y6E2-1]
UniGeneiHs.487635.

3D structure databases

ProteinModelPortaliQ9Y6E2.
SMRiQ9Y6E2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118793. 60 interactors.
IntActiQ9Y6E2. 6 interactors.
MINTiMINT-5010259.
STRINGi9606.ENSP00000258761.

PTM databases

iPTMnetiQ9Y6E2.
PhosphoSitePlusiQ9Y6E2.
SwissPalmiQ9Y6E2.

Polymorphism and mutation databases

BioMutaiBZW2.
DMDMi74762077.

Proteomic databases

EPDiQ9Y6E2.
PaxDbiQ9Y6E2.
PeptideAtlasiQ9Y6E2.
PRIDEiQ9Y6E2.

Protocols and materials databases

DNASUi28969.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258761; ENSP00000258761; ENSG00000136261. [Q9Y6E2-1]
ENST00000433922; ENSP00000397249; ENSG00000136261. [Q9Y6E2-1]
GeneIDi28969.
KEGGihsa:28969.
UCSCiuc003stj.3. human. [Q9Y6E2-1]

Organism-specific databases

CTDi28969.
DisGeNETi28969.
GeneCardsiBZW2.
HGNCiHGNC:18808. BZW2.
HPAiHPA022813.
HPA026709.
neXtProtiNX_Q9Y6E2.
OpenTargetsiENSG00000136261.
PharmGKBiPA38690.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2297. Eukaryota.
ENOG410XR08. LUCA.
GeneTreeiENSGT00390000012561.
HOGENOMiHOG000252932.
HOVERGENiHBG080940.
InParanoidiQ9Y6E2.
OMAiFMNKHQK.
OrthoDBiEOG091G090E.
PhylomeDBiQ9Y6E2.
TreeFamiTF324313.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136261-MONOMER.

Miscellaneous databases

ChiTaRSiBZW2. human.
GeneWikiiBZW2.
GenomeRNAii28969.
PROiQ9Y6E2.

Gene expression databases

BgeeiENSG00000136261.
CleanExiHS_BZW2.
ExpressionAtlasiQ9Y6E2. baseline and differential.
GenevisibleiQ9Y6E2. HS.

Family and domain databases

Gene3Di1.25.40.180. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR016021. MIF4-like.
IPR003307. W2_domain.
[Graphical view]
PfamiPF02020. W2. 1 hit.
[Graphical view]
SMARTiSM00515. eIF5C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS51363. W2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBZW2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6E2
Secondary accession number(s): A4D123
, Q3B779, Q96JW5, Q9H3F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.