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Protein

Selenoprotein K

Gene

SELENOK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for Ca2+ flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (PubMed:22016385). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Plays a role in protection of cells from ER stress-induced apoptosis (PubMed:20692228). Protects cells from oxidative stress when overexpressed in cardiomyocytes (PubMed:16962588).By similarity4 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct

GO - Biological processi

Keywordsi

Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein K1 Publication
Short name:
SelK1 Publication
Gene namesi
Name:SELENOK1 PublicationImported
Synonyms:SELK1 Publication
ORF Names:HSPC030Imported, HSPC297Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:30394 SELENOK
MIMi607916 gene
neXtProtiNX_Q9Y6D0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 42HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi58515
OpenTargetsiENSG00000113811

Polymorphism and mutation databases

BioMutaiSELK
DMDMi190352222

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000976692 – 94Selenoprotein KAdd BLAST93

Post-translational modificationi

Cleaved by CAPN2/m-calpain in resting macrophages but not in activated macrophages. Macrophage activation up-regulates expression of the calpain inhibitor CAST/calpastatin, resulting in inhibition of CAPN2 activity (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei81 – 82Cleavage; by CAPN2By similarity2

Proteomic databases

EPDiQ9Y6D0
MaxQBiQ9Y6D0
PaxDbiQ9Y6D0
PeptideAtlasiQ9Y6D0
PRIDEiQ9Y6D0

PTM databases

iPTMnetiQ9Y6D0
PhosphoSitePlusiQ9Y6D0

Expressioni

Tissue specificityi

Highly expressed in heart.1 Publication

Inductioni

By ER stress (at protein level). Displays a slow increase with a lag phase of 6 hours but exhibits a dramatic increase after incubation with ER stress agents for more than 12 hours with maximum induction at 24 hours. Also induced by accumulation of misfolded proteins in the ER.2 Publications

Gene expression databases

ExpressionAtlasiQ9Y6D0 baseline and differential

Organism-specific databases

HPAiHPA008196

Interactioni

Subunit structurei

Interacts with DERL1, DERL2, DERL3 and SELENOS (PubMed:22016385). The SELENOK-SELENOS complex interacts with VCP (PubMed:22016385). Interacts with ZDHHC6 (PubMed:25368151).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-9679163,EBI-9679163

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi121841, 5 interactors
CORUMiQ9Y6D0
IntActiQ9Y6D0, 4 interactors
MINTiQ9Y6D0
STRINGi9606.ENSP00000418813

Structurei

3D structure databases

ProteinModelPortaliQ9Y6D0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the selenoprotein K family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0AZ Eukaryota
ENOG410XWKI LUCA
GeneTreeiENSGT00390000016119
HOGENOMiHOG000013002
HOVERGENiHBG108467
InParanoidiQ9Y6D0
OMAiMGRINHW
PhylomeDBiQ9Y6D0

Family and domain databases

InterProiView protein in InterPro
IPR024491 Se_SelK/SelG
PfamiView protein in Pfam
PF10961 SelK_SelG, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6D0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYISNGQVL DSRSQSPWRL SLITDFFWGI AEFVVLFFKT LLQQDVKKRR
60 70 80 90
SYGNSSDSRY DDGRGPPGNP PRRMGRINHL RGPSPPPMAG GUGR
Length:94
Mass (Da):10,645
Last modified:February 26, 2008 - v3
Checksum:iD26F13E90BEC6807
GO

Sequence cautioni

The sequence AAD40194 differs from that shown. Reason: Erroneous termination at position 92. Translated as Sec.Curated
The sequence AAF28975 differs from that shown. Reason: Erroneous termination at position 92. Translated as Sec.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05392150R → S. Corresponds to variant dbSNP:rs11562Ensembl.1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei92Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF537132 mRNA Translation: AAN61473.1
AF085359 mRNA Translation: AAD40194.1 Sequence problems.
AF161415 mRNA Translation: AAF28975.1 Sequence problems.
BC013162 mRNA Translation: AAH13162.2
CCDSiCCDS54597.1
RefSeqiNP_067060.2, NM_021237.4
UniGeneiHs.58471
Hs.640242

Genome annotation databases

EnsembliENST00000495461; ENSP00000418813; ENSG00000113811
GeneIDi58515
KEGGihsa:58515

Keywords - Coding sequence diversityi

Polymorphism, Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiSELK_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6D0
Secondary accession number(s): Q8IZQ3, Q9P085
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 26, 2008
Last modified: April 25, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health