ID MTCH2_HUMAN Reviewed; 303 AA. AC Q9Y6C9; B2R7L8; DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1999, sequence version 1. DT 02-MAR-2010, entry version 70. DE RecName: Full=Mitochondrial carrier homolog 2; DE AltName: Full=Met-induced mitochondrial protein; GN Name=MTCH2; Synonyms=MIMP; ORFNames=HSPC032; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=22294842; PubMed=12407445; DOI=10.1038/sj.neo.7900272; RA Yerushalmi G.M., Leibowitz-Amit R., Shaharabany M., Tsarfaty I.; RT "Met-HGF/SF signal transduction induces mimp, a novel mitochondrial RT carrier homologue, which leads to mitochondrial depolarization."; RL Neoplasia 4:510-522(2002). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Jang J.S., Hahn Y., Park C., Chung J.H.; RT "Identification of an evolutionary conserved mitochondrial carrier RT family from various organisms."; RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Umbilical cord blood; RX MEDLINE=20499367; PubMed=11042152; DOI=10.1101/gr.140200; RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.; RT "Cloning and functional analysis of cDNAs with open reading frames for RT 300 previously undefined genes expressed in CD34+ hematopoietic RT stem/progenitor cells."; RL Genome Res. 10:1546-1560(2000). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Amygdala; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Cervix; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP PROTEIN SEQUENCE OF 78-90; 112-122; 132-155 AND 281-287, AND MASS RP SPECTROMETRY. RC TISSUE=B-cell lymphoma; RA Bienvenut W.V.; RL Submitted (JUN-2005) to UniProtKB. RN [8] RP IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY. RA Colinge J., Superti-Furga G., Bennett K.L.; RL Submitted (OCT-2008) to UniProtKB. RN [9] RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY. RX PubMed=19413330; DOI=10.1021/ac9004309; RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., RA Mohammed S.; RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in RT a refined SCX-based approach."; RL Anal. Chem. 81:4493-4501(2009). CC -!- FUNCTION: The substrate transported is not yet known. Induces CC mitochondrial depolarization. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass CC membrane protein (Potential). CC -!- SIMILARITY: Belongs to the mitochondrial carrier family. CC -!- SIMILARITY: Contains 2 Solcar repeats. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY380792; AAQ88168.1; -; mRNA. DR EMBL; AF176008; AAD52646.1; -; mRNA. DR EMBL; AF085361; AAD40196.1; -; mRNA. DR EMBL; AK313032; BAG35865.1; -; mRNA. DR EMBL; CH471064; EAW67892.1; -; Genomic_DNA. DR EMBL; BC000875; AAH00875.1; -; mRNA. DR IPI; IPI00003833; -. DR RefSeq; NP_055157.1; -. DR UniGene; Hs.269944; -. DR STRING; Q9Y6C9; -. DR TCDB; 2.A.29.25.2; mitochondrial carrier (MC) family. DR PhosphoSite; Q9Y6C9; -. DR PeptideAtlas; Q9Y6C9; -. DR PRIDE; Q9Y6C9; -. DR Ensembl; ENST00000302503; ENSP00000303222; ENSG00000109919; Homo sapiens. DR GeneID; 23788; -. DR KEGG; hsa:23788; -. DR UCSC; uc001ngd.1; human. DR CTD; 23788; -. DR GeneCards; GC11M047595; -. DR H-InvDB; HIX0009621; -. DR HGNC; HGNC:17587; MTCH2. DR PharmGKB; PA134951260; -. DR HOGENOM; HBG716616; -. DR HOVERGEN; HBG058632; -. DR InParanoid; Q9Y6C9; -. DR OMA; REGNMSR; -. DR OrthoDB; EOG9CVJT0; -. DR PhylomeDB; Q9Y6C9; -. DR NextBio; 46797; -. DR ArrayExpress; Q9Y6C9; -. DR Bgee; Q9Y6C9; -. DR CleanEx; HS_MTCH2; -. DR Genevestigator; Q9Y6C9; -. DR GermOnline; ENSG00000109919; Homo sapiens. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005488; F:binding; IEA:InterPro. DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro. DR InterPro; IPR001993; Mitochondria_substrate_carrier. DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier. DR Pfam; PF00153; Mito_carr; 1. DR SUPFAM; SSF103506; Mitoch_carrier; 1. DR PROSITE; PS50920; SOLCAR; 2. PE 1: Evidence at protein level; KW Acetylation; Complete proteome; Direct protein sequencing; Membrane; KW Mitochondrion; Mitochondrion inner membrane; Polymorphism; Repeat; KW Transmembrane; Transport. FT INIT_MET 1 1 Removed. FT CHAIN 2 303 Mitochondrial carrier homolog 2. FT /FTId=PRO_0000090637. FT TRANSMEM 8 28 Potential. FT TRANSMEM 175 195 Potential. FT TRANSMEM 224 244 Potential. FT REPEAT 2 98 Solcar 1. FT REPEAT 118 206 Solcar 2. FT MOD_RES 2 2 N-acetylalanine. FT MOD_RES 158 158 N6-acetyllysine (By similarity). FT VARIANT 68 68 R -> S (in dbSNP:rs34072236). FT /FTId=VAR_050128. FT VARIANT 290 290 P -> A (in dbSNP:rs1064608). FT /FTId=VAR_050129. SQ SEQUENCE 303 AA; 33331 MW; 339087A8AF4A4508 CRC64; MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ LPGLFSYAQH IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQHYQESDK GEELGPGNVQ KEVSSSFDHV IKETTREMIA RSAATLITHP FHVITLRSMV QFIGRESKYC GLCDSIITIY REEGILGFFA GLVPRLLGDI LSLWLCNSLA YLVNTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV SNLMAVNNCG LAGGCPPYSP IYTSWIDCWC MLQKEGNMSR GNSLFFRKVP FGKTYCCDLK MLI //