ID   MTCH2_HUMAN             Reviewed;         303 AA.
AC   Q9Y6C9;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   11-SEP-2007, entry version 43.
DE   Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein).
GN   Name=MTCH2; Synonyms=MIMP; ORFNames=HSPC032;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=22294842; PubMed=12407445; DOI=10.1038/sj.neo.7900272;
RA   Yerushalmi G.M., Leibowitz-Amit R., Shaharabany M., Tsarfaty I.;
RT   "Met-HGF/SF signal transduction induces mimp, a novel mitochondrial
RT   carrier homologue, which leads to mitochondrial depolarization.";
RL   Neoplasia 4:510-522(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Jang J.S., Hahn Y., Park C., Chung J.H.;
RT   "Identification of an evolutionary conserved mitochondrial carrier
RT   family from various organisms.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Umbilical cord blood;
RX   MEDLINE=20499367; PubMed=11042152; DOI=10.1101/gr.140200;
RA   Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA   Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA   Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT   "Cloning and functional analysis of cDNAs with open reading frames for
RT   300 previously undefined genes expressed in CD34+ hematopoietic
RT   stem/progenitor cells.";
RL   Genome Res. 10:1546-1560(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cervix;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   PROTEIN SEQUENCE OF 78-90; 112-122; 132-155 AND 281-287, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=B-cell lymphoma;
RA   Bienvenut W.V.;
RL   Submitted (JUN-2005) to UniProtKB.
CC   -!- FUNCTION: The substrate transported is not yet known. Induces
CC       mitochondrial depolarization.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC       membrane protein (Potential).
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier family.
CC   -!- SIMILARITY: Contains 2 Solcar repeats.
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DR   EMBL; AY380792; AAQ88168.1; -; mRNA.
DR   EMBL; AF176008; AAD52646.1; -; mRNA.
DR   EMBL; AF085361; AAD40196.1; -; mRNA.
DR   EMBL; BC000875; AAH00875.1; -; mRNA.
DR   UniGene; Hs.269944; -.
DR   PeptideAtlas; Q9Y6C9; -.
DR   Ensembl; ENSG00000109919; Homo sapiens.
DR   KEGG; hsa:23788; -.
DR   HGNC; HGNC:17587; MTCH2.
DR   PharmGKB; PA134951260; -.
DR   LinkHub; Q9Y6C9; -.
DR   ArrayExpress; Q9Y6C9; -.
DR   GermOnline; ENSG00000109919; Homo sapiens.
DR   InterPro; IPR001993; Mitoch_carrier.
DR   Pfam; PF00153; Mito_carr; 1.
DR   PROSITE; PS50920; SOLCAR; 2.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; Inner membrane; Membrane;
KW   Mitochondrion; Repeat; Transmembrane; Transport.
FT   CHAIN         1    303       Mitochondrial carrier homolog 2.
FT                                /FTId=PRO_0000090637.
FT   TRANSMEM      8     28       Potential.
FT   TRANSMEM    175    195       Potential.
FT   TRANSMEM    224    244       Potential.
FT   REPEAT        2     98       Solcar 1.
FT   REPEAT      118    206       Solcar 2.
FT   MOD_RES     158    158       N6-acetyllysine (By similarity).
SQ   SEQUENCE   303 AA;  33331 MW;  339087A8AF4A4508 CRC64;
     MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ LPGLFSYAQH
     IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQHYQESDK GEELGPGNVQ KEVSSSFDHV
     IKETTREMIA RSAATLITHP FHVITLRSMV QFIGRESKYC GLCDSIITIY REEGILGFFA
     GLVPRLLGDI LSLWLCNSLA YLVNTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV
     SNLMAVNNCG LAGGCPPYSP IYTSWIDCWC MLQKEGNMSR GNSLFFRKVP FGKTYCCDLK
     MLI
//