ID   MTCH2_HUMAN    STANDARD;      PRT;   303 AA.
AC   Q9Y6C9;
DT   13-SEP-2005 (Rel. 48, Created)
DT   13-SEP-2005 (Rel. 48, Last sequence update)
DT   13-SEP-2005 (Rel. 48, Last annotation update)
DE   Mitochondrial carrier homolog 2 (Met-induced mitochondrial protein).
GN   Name=MTCH2; Synonyms=MIMP; ORFNames=HSPC032;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=22294842; PubMed=12407445; DOI=10.1038/sj.neo.7900272;
RA   Yerushalmi G.M., Leibowitz-Amit R., Shaharabany M., Tsarfaty I.;
RT   "Met-HGF/SF signal transduction induces mimp, a novel mitochondrial
RT   carrier homologue, which leads to mitochondrial depolarization.";
RL   Neoplasia 4:510-522(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Jang J.S., Hahn Y., Park C., Chung J.H.;
RT   "Identification of an evolutionary conserved mitochondrial carrier
RT   family from various organisms.";
RL   Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Umbilical cord blood;
RX   MEDLINE=20499367; PubMed=11042152; DOI=10.1101/gr.140200;
RA   Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA   Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA   Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT   "Cloning and functional analysis of cDNAs with open reading frames for
RT   300 previously undefined genes expressed in CD34+ hematopoietic
RT   stem/progenitor cells.";
RL   Genome Res. 10:1546-1560(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cervix;
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
RN   [5]
RP   PROTEIN SEQUENCE OF 78-90; 112-122; 132-155 AND 281-287, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=B-cell lymphoma;
RA   Bienvenut W.V.;
RL   Unpublished observations (JUN-2005).
CC   -!- FUNCTION: The substrate tranported is not yet known. Induces
CC       mitochondrial depolarization.
CC   -!- SUBCELLULAR LOCATION: Integral membrane protein. Mitochondrial
CC       inner membrane (Potential).
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier family.
CC   -!- SIMILARITY: Contains 2 Solcar repeats.
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DR   EMBL; AY380792; AAQ88168.1; -; mRNA.
DR   EMBL; AF176008; AAD52646.1; -; mRNA.
DR   EMBL; AF085361; AAD40196.1; -; mRNA.
DR   EMBL; BC000875; AAH00875.1; -; mRNA.
DR   Ensembl; ENSG00000109919; Homo sapiens.
DR   HGNC; HGNC:17587; MTCH2.
DR   InterPro; IPR001993; Mitoch_carrier.
DR   Pfam; PF00153; Mito_carr; 1.
DR   PROSITE; PS50920; SOLCAR; 2.
KW   Direct protein sequencing; Inner membrane; Membrane; Mitochondrion;
KW   Repeat; Transmembrane; Transport.
FT   TRANSMEM      8     28       Potential.
FT   TRANSMEM    175    195       Potential.
FT   TRANSMEM    224    244       Potential.
FT   REPEAT        2     98       Solcar 1.
FT   REPEAT      118    206       Solcar 2.
SQ   SEQUENCE   303 AA;  33331 MW;  339087A8AF4A4508 CRC64;
     MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ LPGLFSYAQH
     IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQHYQESDK GEELGPGNVQ KEVSSSFDHV
     IKETTREMIA RSAATLITHP FHVITLRSMV QFIGRESKYC GLCDSIITIY REEGILGFFA
     GLVPRLLGDI LSLWLCNSLA YLVNTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV
     SNLMAVNNCG LAGGCPPYSP IYTSWIDCWC MLQKEGNMSR GNSLFFRKVP FGKTYCCDLK
     MLI
//