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Q9Y6C9 (MTCH2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitochondrial carrier homolog 2
Alternative name(s):
Met-induced mitochondrial protein
Gene names
Name:MTCH2
Synonyms:MIMP
ORF Names:HSPC032
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length303 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The substrate transported is not yet known. Induces mitochondrial depolarization.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 2 Solcar repeats.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Transmembrane
Transmembrane helix
   PTMAcetylation
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

mitochondrial inner membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.8
Chain2 – 303302Mitochondrial carrier homolog 2
PRO_0000090637

Regions

Transmembrane8 – 2821Helical; Potential
Transmembrane175 – 19521Helical; Potential
Transmembrane224 – 24421Helical; Potential
Repeat2 – 9897Solcar 1
Repeat118 – 20689Solcar 2

Amino acid modifications

Modified residue21N-acetylalanine Ref.8

Natural variations

Natural variant681R → S.
Corresponds to variant rs34072236 [ dbSNP | Ensembl ].
VAR_050128
Natural variant2901P → A.
Corresponds to variant rs1064608 [ dbSNP | Ensembl ].
VAR_050129

Sequences

Sequence LengthMass (Da)Tools
Q9Y6C9 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 339087A8AF4A4508

FASTA30333,331
        10         20         30         40         50         60 
MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ LPGLFSYAQH 

        70         80         90        100        110        120 
IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQHYQESDK GEELGPGNVQ KEVSSSFDHV 

       130        140        150        160        170        180 
IKETTREMIA RSAATLITHP FHVITLRSMV QFIGRESKYC GLCDSIITIY REEGILGFFA 

       190        200        210        220        230        240 
GLVPRLLGDI LSLWLCNSLA YLVNTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV 

       250        260        270        280        290        300 
SNLMAVNNCG LAGGCPPYSP IYTSWIDCWC MLQKEGNMSR GNSLFFRKVP FGKTYCCDLK 


MLI 

« Hide

References

« Hide 'large scale' references
[1]"Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization."
Yerushalmi G.M., Leibowitz-Amit R., Shaharabany M., Tsarfaty I.
Neoplasia 4:510-522(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Identification of an evolutionary conserved mitochondrial carrier family from various organisms."
Jang J.S., Hahn Y., Park C., Chung J.H.
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Amygdala.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cervix.
[7]Bienvenut W.V.
Submitted (JUN-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 78-90; 112-122; 132-155 AND 281-287, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: B-cell lymphoma.
[8]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY380792 mRNA. Translation: AAQ88168.1.
AF176008 mRNA. Translation: AAD52646.1.
AF085361 mRNA. Translation: AAD40196.1.
AK313032 mRNA. Translation: BAG35865.1.
CH471064 Genomic DNA. Translation: EAW67892.1.
BC000875 mRNA. Translation: AAH00875.1.
RefSeqNP_055157.1. NM_014342.3.
UniGeneHs.269944.

3D structure databases

ProteinModelPortalQ9Y6C9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117287. 10 interactions.
IntActQ9Y6C9. 1 interaction.
MINTMINT-4657883.
STRING9606.ENSP00000303222.

Protein family/group databases

TCDB2.A.29.25.2. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteQ9Y6C9.

Polymorphism databases

DMDM67461088.

Proteomic databases

PaxDbQ9Y6C9.
PeptideAtlasQ9Y6C9.
PRIDEQ9Y6C9.

Protocols and materials databases

DNASU23788.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302503; ENSP00000303222; ENSG00000109919.
GeneID23788.
KEGGhsa:23788.
UCSCuc010rho.2. human.

Organism-specific databases

CTD23788.
GeneCardsGC11M048804.
HGNCHGNC:17587. MTCH2.
HPAHPA038385.
HPA038390.
MIM613221. gene.
neXtProtNX_Q9Y6C9.
PharmGKBPA134951260.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG311439.
HOGENOMHOG000231394.
HOVERGENHBG058632.
InParanoidQ9Y6C9.
KOK17885.
OMAQHYQECD.
OrthoDBEOG7966H6.
PhylomeDBQ9Y6C9.
TreeFamTF313721.

Gene expression databases

ArrayExpressQ9Y6C9.
BgeeQ9Y6C9.
CleanExHS_MTCH2.
GenevestigatorQ9Y6C9.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMSSF103506. SSF103506. 1 hit.
PROSITEPS50920. SOLCAR. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiMTCH2.
GenomeRNAi23788.
NextBio46797.
PROQ9Y6C9.
SOURCESearch...

Entry information

Entry nameMTCH2_HUMAN
AccessionPrimary (citable) accession number: Q9Y6C9
Secondary accession number(s): B2R7L8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM