Q9Y6C9 (MTCH2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial carrier homolog 2

Alternative name(s):
Met-induced mitochondrial protein

Gene names

Name:	MTCH2
Synonyms:	MIMP
ORF Names:	HSPC032

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The substrate transported is not yet known. Induces mitochondrial depolarization.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification] Contains 2 Solcar repeats.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from direct assay. Source: HPA
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Mitochondrial carrier homolog 2		PRO_0000090637
Regions
	Transmembrane	8 – 28	21	Helical; Potential
	Transmembrane	175 – 195	21	Helical; Potential
	Transmembrane	224 – 244	21	Helical; Potential
	Repeat	2 – 98	97	Solcar 1
	Repeat	118 – 206	89	Solcar 2
Amino acid modifications
	Modified residue	158	1	N6-acetyllysine By similarity
Natural variations
	Natural variant	68	1	R → S. Corresponds to variant rs34072236 [ dbSNP | Ensembl ].		VAR_050128
	Natural variant	290	1	P → A. Corresponds to variant rs1064608 [ dbSNP | Ensembl ].		VAR_050129

Sequences

	Sequence		Length	Mass (Da)
	Q9Y6C9 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 339087A8AF4A4508	FASTA	303	33,331
	10 20 30 40 50 60 MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ LPGLFSYAQH 70 80 90 100 110 120 IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQHYQESDK GEELGPGNVQ KEVSSSFDHV 130 140 150 160 170 180 IKETTREMIA RSAATLITHP FHVITLRSMV QFIGRESKYC GLCDSIITIY REEGILGFFA 190 200 210 220 230 240 GLVPRLLGDI LSLWLCNSLA YLVNTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV 250 260 270 280 290 300 SNLMAVNNCG LAGGCPPYSP IYTSWIDCWC MLQKEGNMSR GNSLFFRKVP FGKTYCCDLK MLI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization." Yerushalmi G.M., Leibowitz-Amit R., Shaharabany M., Tsarfaty I. Neoplasia 4:510-522(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Identification of an evolutionary conserved mitochondrial carrier family from various organisms." Jang J.S., Hahn Y., Park C., Chung J.H. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Amygdala.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix.
[7]	Bienvenut W.V. Submitted (JUN-2005) to UniProtKB Cited for: PROTEIN SEQUENCE OF 78-90; 112-122; 132-155 AND 281-287, MASS SPECTROMETRY. Tissue: B-cell lymphoma.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY380792 mRNA. Translation: AAQ88168.1. AF176008 mRNA. Translation: AAD52646.1. AF085361 mRNA. Translation: AAD40196.1. AK313032 mRNA. Translation: BAG35865.1. CH471064 Genomic DNA. Translation: EAW67892.1. BC000875 mRNA. Translation: AAH00875.1.
IPI	IPI00003833.
RefSeq	NP_055157.1. NM_014342.3.
UniGene	Hs.269944.
3D structure databases
ProteinModelPortal	Q9Y6C9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y6C9. 1 interaction.
STRING	9606.ENSP00000303222.
Protein family/group databases
TCDB	2.A.29.25.2. mitochondrial carrier (MC) family.
PTM databases
PhosphoSite	Q9Y6C9.
Polymorphism databases
DMDM	67461088.
Proteomic databases
PaxDb	Q9Y6C9.
PeptideAtlas	Q9Y6C9.
PRIDE	Q9Y6C9.
Protocols and materials databases
DNASU	23788.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000302503; ENSP00000303222; ENSG00000109919.
GeneID	23788.
KEGG	hsa:23788.
UCSC	uc010rho.2. human.
Organism-specific databases
CTD	23788.
GeneCards	GC11M047746.
HGNC	HGNC:17587. MTCH2.
HPA	HPA038385. HPA038390.
MIM	613221. gene.
neXtProt	NX_Q9Y6C9.
PharmGKB	PA134951260.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG311439.
HOGENOM	HOG000231394.
HOVERGEN	HBG058632.
InParanoid	Q9Y6C9.
OMA	LCDSIVT.
OrthoDB	EOG4J9N0H.
PhylomeDB	Q9Y6C9.
Gene expression databases
ArrayExpress	Q9Y6C9.
Bgee	Q9Y6C9.
CleanEx	HS_MTCH2.
Genevestigator	Q9Y6C9.
GermOnline	ENSG00000109919. Homo sapiens.
Family and domain databases
Gene3D	1.50.40.10. 1 hit.
InterPro	IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom. [Graphical view]
Pfam	PF00153. Mito_carr. 1 hit. [Graphical view]
SUPFAM	SSF103506. Mitoch_carrier. 1 hit.
PROSITE	PS50920. SOLCAR. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	23788.
NextBio	46797.
SOURCE	Search...

Entry information

Entry name

MTCH2_HUMAN

Accession

Primary (citable) accession number: Q9Y6C9
Secondary accession number(s): B2R7L8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	November 1, 1999
Last modified:	April 3, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.