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Protein

Mitochondrial carrier homolog 2

Gene

MTCH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The substrate transported is not yet known. Induces mitochondrial depolarization.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109919-MONOMER.
SIGNORiQ9Y6C9.

Protein family/group databases

TCDBi2.A.29.25.2. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carrier homolog 2
Alternative name(s):
Met-induced mitochondrial protein
Gene namesi
Name:MTCH2
Synonyms:MIMP
ORF Names:HSPC032
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17587. MTCH2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrial outer membrane Source: Ensembl
  • mitochondrion Source: GO_Central
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23788.
OpenTargetsiENSG00000109919.
PharmGKBiPA134951260.

Polymorphism and mutation databases

BioMutaiMTCH2.
DMDMi67461088.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000906372 – 303Mitochondrial carrier homolog 2Add BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y6C9.
MaxQBiQ9Y6C9.
PaxDbiQ9Y6C9.
PeptideAtlasiQ9Y6C9.
PRIDEiQ9Y6C9.
TopDownProteomicsiQ9Y6C9.

PTM databases

iPTMnetiQ9Y6C9.
PhosphoSitePlusiQ9Y6C9.
SwissPalmiQ9Y6C9.

Expressioni

Gene expression databases

BgeeiENSG00000109919.
CleanExiHS_MTCH2.
ExpressionAtlasiQ9Y6C9. baseline and differential.
GenevisibleiQ9Y6C9. HS.

Organism-specific databases

HPAiHPA038385.
HPA038390.

Interactioni

Protein-protein interaction databases

BioGridi117287. 80 interactors.
IntActiQ9Y6C9. 16 interactors.
MINTiMINT-4657883.
STRINGi9606.ENSP00000303222.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6C9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 98Solcar 1Add BLAST97
Repeati118 – 206Solcar 2Add BLAST89

Sequence similaritiesi

Contains 2 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2745. Eukaryota.
ENOG410XSXF. LUCA.
GeneTreeiENSGT00390000000020.
HOGENOMiHOG000231394.
HOVERGENiHBG058632.
InParanoidiQ9Y6C9.
KOiK17885.
OMAiFAYAKHI.
OrthoDBiEOG091G0DU5.
PhylomeDBiQ9Y6C9.
TreeFamiTF313721.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ
60 70 80 90 100
LPGLFSYAQH IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQHYQESDK
110 120 130 140 150
GEELGPGNVQ KEVSSSFDHV IKETTREMIA RSAATLITHP FHVITLRSMV
160 170 180 190 200
QFIGRESKYC GLCDSIITIY REEGILGFFA GLVPRLLGDI LSLWLCNSLA
210 220 230 240 250
YLVNTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV SNLMAVNNCG
260 270 280 290 300
LAGGCPPYSP IYTSWIDCWC MLQKEGNMSR GNSLFFRKVP FGKTYCCDLK

MLI
Length:303
Mass (Da):33,331
Last modified:November 1, 1999 - v1
Checksum:i339087A8AF4A4508
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05012868R → S.Corresponds to variant rs34072236dbSNPEnsembl.1
Natural variantiVAR_050129290P → A.Corresponds to variant rs1064608dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY380792 mRNA. Translation: AAQ88168.1.
AF176008 mRNA. Translation: AAD52646.1.
AF085361 mRNA. Translation: AAD40196.1.
AK313032 mRNA. Translation: BAG35865.1.
CH471064 Genomic DNA. Translation: EAW67892.1.
BC000875 mRNA. Translation: AAH00875.1.
CCDSiCCDS7943.1.
RefSeqiNP_001304160.1. NM_001317231.1.
NP_001304161.1. NM_001317232.1.
NP_001304162.1. NM_001317233.1.
NP_055157.1. NM_014342.3.
UniGeneiHs.269944.

Genome annotation databases

EnsembliENST00000302503; ENSP00000303222; ENSG00000109919.
GeneIDi23788.
KEGGihsa:23788.
UCSCiuc010rho.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY380792 mRNA. Translation: AAQ88168.1.
AF176008 mRNA. Translation: AAD52646.1.
AF085361 mRNA. Translation: AAD40196.1.
AK313032 mRNA. Translation: BAG35865.1.
CH471064 Genomic DNA. Translation: EAW67892.1.
BC000875 mRNA. Translation: AAH00875.1.
CCDSiCCDS7943.1.
RefSeqiNP_001304160.1. NM_001317231.1.
NP_001304161.1. NM_001317232.1.
NP_001304162.1. NM_001317233.1.
NP_055157.1. NM_014342.3.
UniGeneiHs.269944.

3D structure databases

ProteinModelPortaliQ9Y6C9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117287. 80 interactors.
IntActiQ9Y6C9. 16 interactors.
MINTiMINT-4657883.
STRINGi9606.ENSP00000303222.

Protein family/group databases

TCDBi2.A.29.25.2. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiQ9Y6C9.
PhosphoSitePlusiQ9Y6C9.
SwissPalmiQ9Y6C9.

Polymorphism and mutation databases

BioMutaiMTCH2.
DMDMi67461088.

Proteomic databases

EPDiQ9Y6C9.
MaxQBiQ9Y6C9.
PaxDbiQ9Y6C9.
PeptideAtlasiQ9Y6C9.
PRIDEiQ9Y6C9.
TopDownProteomicsiQ9Y6C9.

Protocols and materials databases

DNASUi23788.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302503; ENSP00000303222; ENSG00000109919.
GeneIDi23788.
KEGGihsa:23788.
UCSCiuc010rho.3. human.

Organism-specific databases

CTDi23788.
DisGeNETi23788.
GeneCardsiMTCH2.
HGNCiHGNC:17587. MTCH2.
HPAiHPA038385.
HPA038390.
MIMi613221. gene.
neXtProtiNX_Q9Y6C9.
OpenTargetsiENSG00000109919.
PharmGKBiPA134951260.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2745. Eukaryota.
ENOG410XSXF. LUCA.
GeneTreeiENSGT00390000000020.
HOGENOMiHOG000231394.
HOVERGENiHBG058632.
InParanoidiQ9Y6C9.
KOiK17885.
OMAiFAYAKHI.
OrthoDBiEOG091G0DU5.
PhylomeDBiQ9Y6C9.
TreeFamiTF313721.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000109919-MONOMER.
SIGNORiQ9Y6C9.

Miscellaneous databases

ChiTaRSiMTCH2. human.
GeneWikiiMTCH2.
GenomeRNAii23788.
PROiQ9Y6C9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000109919.
CleanExiHS_MTCH2.
ExpressionAtlasiQ9Y6C9. baseline and differential.
GenevisibleiQ9Y6C9. HS.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTCH2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6C9
Secondary accession number(s): B2R7L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.