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Q9Y6C9

- MTCH2_HUMAN

UniProt

Q9Y6C9 - MTCH2_HUMAN

Protein

Mitochondrial carrier homolog 2

Gene

MTCH2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    The substrate transported is not yet known. Induces mitochondrial depolarization.

    GO - Biological processi

    1. protein localization to mitochondrion Source: MGI
    2. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.29.25.2. the mitochondrial carrier (mc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial carrier homolog 2
    Alternative name(s):
    Met-induced mitochondrial protein
    Gene namesi
    Name:MTCH2
    Synonyms:MIMP
    ORF Names:HSPC032
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:17587. MTCH2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: UniProtKB
    4. mitochondrial inner membrane Source: UniProtKB-SubCell
    5. nucleus Source: UniProt

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134951260.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 303302Mitochondrial carrier homolog 2PRO_0000090637Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9Y6C9.
    PaxDbiQ9Y6C9.
    PeptideAtlasiQ9Y6C9.
    PRIDEiQ9Y6C9.

    PTM databases

    PhosphoSiteiQ9Y6C9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y6C9.
    BgeeiQ9Y6C9.
    CleanExiHS_MTCH2.
    GenevestigatoriQ9Y6C9.

    Organism-specific databases

    HPAiHPA038385.
    HPA038390.

    Interactioni

    Protein-protein interaction databases

    BioGridi117287. 11 interactions.
    IntActiQ9Y6C9. 1 interaction.
    MINTiMINT-4657883.
    STRINGi9606.ENSP00000303222.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y6C9.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei175 – 19521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei224 – 24421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati2 – 9897Solcar 1Add
    BLAST
    Repeati118 – 20689Solcar 2Add
    BLAST

    Sequence similaritiesi

    Contains 2 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG311439.
    HOGENOMiHOG000231394.
    HOVERGENiHBG058632.
    InParanoidiQ9Y6C9.
    KOiK17885.
    OMAiQHYQECD.
    OrthoDBiEOG7966H6.
    PhylomeDBiQ9Y6C9.
    TreeFamiTF313721.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y6C9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ    50
    LPGLFSYAQH IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQHYQESDK 100
    GEELGPGNVQ KEVSSSFDHV IKETTREMIA RSAATLITHP FHVITLRSMV 150
    QFIGRESKYC GLCDSIITIY REEGILGFFA GLVPRLLGDI LSLWLCNSLA 200
    YLVNTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV SNLMAVNNCG 250
    LAGGCPPYSP IYTSWIDCWC MLQKEGNMSR GNSLFFRKVP FGKTYCCDLK 300
    MLI 303
    Length:303
    Mass (Da):33,331
    Last modified:November 1, 1999 - v1
    Checksum:i339087A8AF4A4508
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti68 – 681R → S.
    Corresponds to variant rs34072236 [ dbSNP | Ensembl ].
    VAR_050128
    Natural varianti290 – 2901P → A.
    Corresponds to variant rs1064608 [ dbSNP | Ensembl ].
    VAR_050129

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY380792 mRNA. Translation: AAQ88168.1.
    AF176008 mRNA. Translation: AAD52646.1.
    AF085361 mRNA. Translation: AAD40196.1.
    AK313032 mRNA. Translation: BAG35865.1.
    CH471064 Genomic DNA. Translation: EAW67892.1.
    BC000875 mRNA. Translation: AAH00875.1.
    CCDSiCCDS7943.1.
    RefSeqiNP_055157.1. NM_014342.3.
    UniGeneiHs.269944.

    Genome annotation databases

    EnsembliENST00000302503; ENSP00000303222; ENSG00000109919.
    GeneIDi23788.
    KEGGihsa:23788.
    UCSCiuc010rho.2. human.

    Polymorphism databases

    DMDMi67461088.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY380792 mRNA. Translation: AAQ88168.1 .
    AF176008 mRNA. Translation: AAD52646.1 .
    AF085361 mRNA. Translation: AAD40196.1 .
    AK313032 mRNA. Translation: BAG35865.1 .
    CH471064 Genomic DNA. Translation: EAW67892.1 .
    BC000875 mRNA. Translation: AAH00875.1 .
    CCDSi CCDS7943.1.
    RefSeqi NP_055157.1. NM_014342.3.
    UniGenei Hs.269944.

    3D structure databases

    ProteinModelPortali Q9Y6C9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117287. 11 interactions.
    IntActi Q9Y6C9. 1 interaction.
    MINTi MINT-4657883.
    STRINGi 9606.ENSP00000303222.

    Protein family/group databases

    TCDBi 2.A.29.25.2. the mitochondrial carrier (mc) family.

    PTM databases

    PhosphoSitei Q9Y6C9.

    Polymorphism databases

    DMDMi 67461088.

    Proteomic databases

    MaxQBi Q9Y6C9.
    PaxDbi Q9Y6C9.
    PeptideAtlasi Q9Y6C9.
    PRIDEi Q9Y6C9.

    Protocols and materials databases

    DNASUi 23788.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302503 ; ENSP00000303222 ; ENSG00000109919 .
    GeneIDi 23788.
    KEGGi hsa:23788.
    UCSCi uc010rho.2. human.

    Organism-specific databases

    CTDi 23788.
    GeneCardsi GC11M048804.
    HGNCi HGNC:17587. MTCH2.
    HPAi HPA038385.
    HPA038390.
    MIMi 613221. gene.
    neXtProti NX_Q9Y6C9.
    PharmGKBi PA134951260.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG311439.
    HOGENOMi HOG000231394.
    HOVERGENi HBG058632.
    InParanoidi Q9Y6C9.
    KOi K17885.
    OMAi QHYQECD.
    OrthoDBi EOG7966H6.
    PhylomeDBi Q9Y6C9.
    TreeFami TF313721.

    Miscellaneous databases

    GeneWikii MTCH2.
    GenomeRNAii 23788.
    NextBioi 46797.
    PROi Q9Y6C9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y6C9.
    Bgeei Q9Y6C9.
    CleanExi HS_MTCH2.
    Genevestigatori Q9Y6C9.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization."
      Yerushalmi G.M., Leibowitz-Amit R., Shaharabany M., Tsarfaty I.
      Neoplasia 4:510-522(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification of an evolutionary conserved mitochondrial carrier family from various organisms."
      Jang J.S., Hahn Y., Park C., Chung J.H.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Amygdala.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cervix.
    7. Bienvenut W.V.
      Submitted (JUN-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 78-90; 112-122; 132-155 AND 281-287, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: B-cell lymphoma.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMTCH2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y6C9
    Secondary accession number(s): B2R7L8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3