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Protein

Mitochondrial carrier homolog 2

Gene

MTCH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The substrate transported is not yet known. Induces mitochondrial depolarization.

GO - Biological processi

  1. hepatocyte apoptotic process Source: Ensembl
  2. protein localization to mitochondrion Source: MGI
  3. regulation of mitochondrial membrane permeability involved in apoptotic process Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.29.25.2. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial carrier homolog 2
Alternative name(s):
Met-induced mitochondrial protein
Gene namesi
Name:MTCH2
Synonyms:MIMP
ORF Names:HSPC032
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17587. MTCH2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821HelicalSequence AnalysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence AnalysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: UniProtKB
  4. mitochondrial inner membrane Source: UniProtKB-SubCell
  5. mitochondrial outer membrane Source: Ensembl
  6. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134951260.

Polymorphism and mutation databases

BioMutaiMTCH2.
DMDMi67461088.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 303302Mitochondrial carrier homolog 2PRO_0000090637Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9Y6C9.
PaxDbiQ9Y6C9.
PeptideAtlasiQ9Y6C9.
PRIDEiQ9Y6C9.

PTM databases

PhosphoSiteiQ9Y6C9.

Expressioni

Gene expression databases

BgeeiQ9Y6C9.
CleanExiHS_MTCH2.
ExpressionAtlasiQ9Y6C9. baseline and differential.
GenevestigatoriQ9Y6C9.

Organism-specific databases

HPAiHPA038385.
HPA038390.

Interactioni

Protein-protein interaction databases

BioGridi117287. 19 interactions.
IntActiQ9Y6C9. 1 interaction.
MINTiMINT-4657883.
STRINGi9606.ENSP00000303222.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6C9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 9897Solcar 1Add
BLAST
Repeati118 – 20689Solcar 2Add
BLAST

Sequence similaritiesi

Contains 2 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311439.
GeneTreeiENSGT00390000000020.
HOGENOMiHOG000231394.
HOVERGENiHBG058632.
InParanoidiQ9Y6C9.
KOiK17885.
OMAiLCDSIVT.
OrthoDBiEOG7966H6.
PhylomeDBiQ9Y6C9.
TreeFamiTF313721.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6C9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADAASQVLL GSGLTILSQP LMYVKVLIQV GYEPLPPTIG RNIFGRQVCQ
60 70 80 90 100
LPGLFSYAQH IASIDGRRGL FTGLTPRLCS GVLGTVVHGK VLQHYQESDK
110 120 130 140 150
GEELGPGNVQ KEVSSSFDHV IKETTREMIA RSAATLITHP FHVITLRSMV
160 170 180 190 200
QFIGRESKYC GLCDSIITIY REEGILGFFA GLVPRLLGDI LSLWLCNSLA
210 220 230 240 250
YLVNTYALDS GVSTMNEMKS YSQAVTGFFA SMLTYPFVLV SNLMAVNNCG
260 270 280 290 300
LAGGCPPYSP IYTSWIDCWC MLQKEGNMSR GNSLFFRKVP FGKTYCCDLK

MLI
Length:303
Mass (Da):33,331
Last modified:November 1, 1999 - v1
Checksum:i339087A8AF4A4508
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681R → S.
Corresponds to variant rs34072236 [ dbSNP | Ensembl ].
VAR_050128
Natural varianti290 – 2901P → A.
Corresponds to variant rs1064608 [ dbSNP | Ensembl ].
VAR_050129

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY380792 mRNA. Translation: AAQ88168.1.
AF176008 mRNA. Translation: AAD52646.1.
AF085361 mRNA. Translation: AAD40196.1.
AK313032 mRNA. Translation: BAG35865.1.
CH471064 Genomic DNA. Translation: EAW67892.1.
BC000875 mRNA. Translation: AAH00875.1.
CCDSiCCDS7943.1.
RefSeqiNP_055157.1. NM_014342.3.
UniGeneiHs.269944.

Genome annotation databases

EnsembliENST00000302503; ENSP00000303222; ENSG00000109919.
GeneIDi23788.
KEGGihsa:23788.
UCSCiuc010rho.2. human.

Polymorphism and mutation databases

BioMutaiMTCH2.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY380792 mRNA. Translation: AAQ88168.1.
AF176008 mRNA. Translation: AAD52646.1.
AF085361 mRNA. Translation: AAD40196.1.
AK313032 mRNA. Translation: BAG35865.1.
CH471064 Genomic DNA. Translation: EAW67892.1.
BC000875 mRNA. Translation: AAH00875.1.
CCDSiCCDS7943.1.
RefSeqiNP_055157.1. NM_014342.3.
UniGeneiHs.269944.

3D structure databases

ProteinModelPortaliQ9Y6C9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117287. 19 interactions.
IntActiQ9Y6C9. 1 interaction.
MINTiMINT-4657883.
STRINGi9606.ENSP00000303222.

Protein family/group databases

TCDBi2.A.29.25.2. the mitochondrial carrier (mc) family.

PTM databases

PhosphoSiteiQ9Y6C9.

Polymorphism and mutation databases

BioMutaiMTCH2.
DMDMi67461088.

Proteomic databases

MaxQBiQ9Y6C9.
PaxDbiQ9Y6C9.
PeptideAtlasiQ9Y6C9.
PRIDEiQ9Y6C9.

Protocols and materials databases

DNASUi23788.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302503; ENSP00000303222; ENSG00000109919.
GeneIDi23788.
KEGGihsa:23788.
UCSCiuc010rho.2. human.

Organism-specific databases

CTDi23788.
GeneCardsiGC11M049909.
HGNCiHGNC:17587. MTCH2.
HPAiHPA038385.
HPA038390.
MIMi613221. gene.
neXtProtiNX_Q9Y6C9.
PharmGKBiPA134951260.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG311439.
GeneTreeiENSGT00390000000020.
HOGENOMiHOG000231394.
HOVERGENiHBG058632.
InParanoidiQ9Y6C9.
KOiK17885.
OMAiLCDSIVT.
OrthoDBiEOG7966H6.
PhylomeDBiQ9Y6C9.
TreeFamiTF313721.

Miscellaneous databases

ChiTaRSiMTCH2. human.
GeneWikiiMTCH2.
GenomeRNAii23788.
NextBioi46797.
PROiQ9Y6C9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y6C9.
CleanExiHS_MTCH2.
ExpressionAtlasiQ9Y6C9. baseline and differential.
GenevestigatoriQ9Y6C9.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization."
    Yerushalmi G.M., Leibowitz-Amit R., Shaharabany M., Tsarfaty I.
    Neoplasia 4:510-522(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of an evolutionary conserved mitochondrial carrier family from various organisms."
    Jang J.S., Hahn Y., Park C., Chung J.H.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cervix.
  7. Bienvenut W.V.
    Submitted (JUN-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 78-90; 112-122; 132-155 AND 281-287, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiMTCH2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6C9
Secondary accession number(s): B2R7L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 1, 1999
Last modified: April 29, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.