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Q9Y6B7

- AP4B1_HUMAN

UniProt

Q9Y6B7 - AP4B1_HUMAN

Protein

AP-4 complex subunit beta-1

Gene

AP4B1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.

    GO - Molecular functioni

    1. protein transporter activity Source: InterPro
    2. transporter activity Source: ProtInc

    GO - Biological processi

    1. intracellular protein transport Source: InterPro
    2. vesicle-mediated transport Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_19400. Golgi Associated Vesicle Biogenesis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AP-4 complex subunit beta-1
    Alternative name(s):
    AP-4 adaptor complex subunit beta
    Adaptor-related protein complex 4 subunit beta-1
    Beta subunit of AP-4
    Beta4-adaptin
    Gene namesi
    Name:AP4B1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:572. AP4B1.

    Subcellular locationi

    Golgi apparatustrans-Golgi network 1 Publication. Membranecoated pit By similarity
    Note: Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells.

    GO - Cellular componenti

    1. clathrin adaptor complex Source: InterPro
    2. coated pit Source: UniProtKB-SubCell
    3. membrane coat Source: InterPro
    4. trans-Golgi network Source: ProtInc

    Keywords - Cellular componenti

    Coated pit, Golgi apparatus, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Cerebral palsy, spastic quadriplegic 5 (CPSQ5) [MIM:614066]: A neurodevelopmental disorder characterized by neonatal hypotonia that progresses to hypertonia and spasticity, and severe mental retardation with poor or absent speech development.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi614066. phenotype.
    Orphaneti280763. Severe intellectual disability and progressive spastic paraplegia.
    PharmGKBiPA24864.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 739739AP-4 complex subunit beta-1PRO_0000193750Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y6B7.
    PaxDbiQ9Y6B7.
    PRIDEiQ9Y6B7.

    PTM databases

    PhosphoSiteiQ9Y6B7.

    Expressioni

    Tissue specificityi

    Widely expressed.

    Gene expression databases

    ArrayExpressiQ9Y6B7.
    BgeeiQ9Y6B7.
    CleanExiHS_AP4B1.
    GenevestigatoriQ9Y6B7.

    Organism-specific databases

    HPAiHPA028162.
    HPA028399.
    HPA028652.

    Interactioni

    Subunit structurei

    Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1). Interacts with ENTHD2; this interaction requires the presence of a functional AP-4 complex.1 Publication

    Protein-protein interaction databases

    BioGridi115943. 5 interactions.
    DIPiDIP-24209N.
    IntActiQ9Y6B7. 1 interaction.
    STRINGi9606.ENSP00000256658.

    Structurei

    Secondary structure

    1
    739
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi628 – 63710
    Beta strandi641 – 6477
    Helixi654 – 66310
    Beta strandi667 – 6715
    Beta strandi677 – 68711
    Beta strandi692 – 6998
    Beta strandi701 – 7033
    Beta strandi705 – 71410
    Helixi717 – 73519

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2MJ7NMR-A610-739[»]
    ProteinModelPortaliQ9Y6B7.
    SMRiQ9Y6B7. Positions 37-537, 609-739.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5096.
    HOGENOMiHOG000294128.
    HOVERGENiHBG050521.
    InParanoidiQ9Y6B7.
    KOiK12401.
    OMAiRPWKAYL.
    PhylomeDBiQ9Y6B7.
    TreeFamiTF354235.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    3.30.310.10. 1 hit.
    InterProiIPR026739. AP_beta.
    IPR016342. AP_complex_bsu_1_2_4.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR015151. B-adaptin_app_sub_C.
    IPR012295. Beta2_adaptin/TBP_C_dom.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    [Graphical view]
    PANTHERiPTHR11134. PTHR11134. 1 hit.
    PfamiPF01602. Adaptin_N. 1 hit.
    PF09066. B2-adapt-app_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002291. AP_complex_beta. 1 hit.
    SMARTiSM01020. B2-adapt-app_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y6B7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPYLGSEDVV KELKKALCNP HIQADRLRYR NVIQRVIRYM TQGLDMSGVF    50
    MEMVKASATV DIVQKKLVYL YMCTYAPLKP DLALLAINTL CKDCSDPNPM 100
    VRGLALRSMC SLRMPGVQEY IQQPILNGLR DKASYVRRVA VLGCAKMHNL 150
    HGDSEVDGAL VNELYSLLRD QDPIVVVNCL RSLEEILKQE GGVVINKPIA 200
    HHLLNRMSKL DQWGQAEVLN FLLRYQPRSE EELFDILNLL DSFLKSSSPG 250
    VVMGATKLFL ILAKMFPHVQ TDVLVRVKGP LLAACSSESR ELCFVALCHV 300
    RQILHSLPGH FSSHYKKFFC SYSEPHYIKL QKVEVLCELV NDENVQQVLE 350
    ELRGYCTDVS ADFAQAAIFA IGGIARTYTD QCVQILTELL GLRQEHITTV 400
    VVQTFRDLVW LCPQCTEAVC QALPGCEENI QDSEGKQALI WLLGVHGERI 450
    PNAPYVLEDF VENVKSETFP AVKMELLTAL LRLFLSRPAE CQDMLGRLLY 500
    YCIEEEKDMA VRDRGLFYYR LLLVGIDEVK RILCSPKSDP TLGLLEDPAE 550
    RPVNSWASDF NTLVPVYGKA HWATISKCQG AERCDPELPK TSSFAASGPL 600
    IPEENKERVQ ELPDSGALML VPNRQLTADY FEKTWLSLKV AHQQVLPWRG 650
    EFHPDTLQMA LQVVNIQTIA MSRAGSRPWK AYLSAQDDTG CLFLTELLLE 700
    PGNSEMQISV KQNEARTETL NSFISVLETV IGTIEEIKS 739
    Length:739
    Mass (Da):83,260
    Last modified:February 20, 2007 - v2
    Checksum:iB6FC92215BDA5EDC
    GO
    Isoform 2 (identifier: Q9Y6B7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         113-205: Missing.
         373-395: GIARTYTDQCVQILTELLGLRQE → RCLLLFLLENLDQPARKLWLEEP
         396-739: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:302
    Mass (Da):34,403
    Checksum:i4B5F9E603C76C5B5
    GO

    Sequence cautioni

    The sequence BAD93054.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti140 – 1401A → V in AAD20448. (PubMed:10066790)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti480 – 4801L → S.2 Publications
    Corresponds to variant rs1217401 [ dbSNP | Ensembl ].
    VAR_030804

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei113 – 20593Missing in isoform 2. 1 PublicationVSP_055787Add
    BLAST
    Alternative sequencei373 – 39523GIART…GLRQE → RCLLLFLLENLDQPARKLWL EEP in isoform 2. 1 PublicationVSP_055788Add
    BLAST
    Alternative sequencei396 – 739344Missing in isoform 2. 1 PublicationVSP_055789Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF092094 mRNA. Translation: AAD20448.1.
    AK298037 mRNA. Translation: BAH12709.1.
    AB209817 mRNA. Translation: BAD93054.1. Different initiation.
    AL137856 Genomic DNA. Translation: CAI19072.1.
    BC014146 mRNA. Translation: AAH14146.1.
    CCDSiCCDS865.1.
    RefSeqiNP_001240781.1. NM_001253852.1.
    NP_001240782.1. NM_001253853.1.
    NP_006585.2. NM_006594.3.
    UniGeneiHs.515048.

    Genome annotation databases

    EnsembliENST00000256658; ENSP00000256658; ENSG00000134262. [Q9Y6B7-1]
    ENST00000369569; ENSP00000358582; ENSG00000134262. [Q9Y6B7-1]
    GeneIDi10717.
    KEGGihsa:10717.
    UCSCiuc001eeb.3. human.

    Polymorphism databases

    DMDMi126302520.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF092094 mRNA. Translation: AAD20448.1 .
    AK298037 mRNA. Translation: BAH12709.1 .
    AB209817 mRNA. Translation: BAD93054.1 . Different initiation.
    AL137856 Genomic DNA. Translation: CAI19072.1 .
    BC014146 mRNA. Translation: AAH14146.1 .
    CCDSi CCDS865.1.
    RefSeqi NP_001240781.1. NM_001253852.1.
    NP_001240782.1. NM_001253853.1.
    NP_006585.2. NM_006594.3.
    UniGenei Hs.515048.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2MJ7 NMR - A 610-739 [» ]
    ProteinModelPortali Q9Y6B7.
    SMRi Q9Y6B7. Positions 37-537, 609-739.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115943. 5 interactions.
    DIPi DIP-24209N.
    IntActi Q9Y6B7. 1 interaction.
    STRINGi 9606.ENSP00000256658.

    PTM databases

    PhosphoSitei Q9Y6B7.

    Polymorphism databases

    DMDMi 126302520.

    Proteomic databases

    MaxQBi Q9Y6B7.
    PaxDbi Q9Y6B7.
    PRIDEi Q9Y6B7.

    Protocols and materials databases

    DNASUi 10717.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256658 ; ENSP00000256658 ; ENSG00000134262 . [Q9Y6B7-1 ]
    ENST00000369569 ; ENSP00000358582 ; ENSG00000134262 . [Q9Y6B7-1 ]
    GeneIDi 10717.
    KEGGi hsa:10717.
    UCSCi uc001eeb.3. human.

    Organism-specific databases

    CTDi 10717.
    GeneCardsi GC01M114437.
    HGNCi HGNC:572. AP4B1.
    HPAi HPA028162.
    HPA028399.
    HPA028652.
    MIMi 607245. gene.
    614066. phenotype.
    neXtProti NX_Q9Y6B7.
    Orphaneti 280763. Severe intellectual disability and progressive spastic paraplegia.
    PharmGKBi PA24864.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5096.
    HOGENOMi HOG000294128.
    HOVERGENi HBG050521.
    InParanoidi Q9Y6B7.
    KOi K12401.
    OMAi RPWKAYL.
    PhylomeDBi Q9Y6B7.
    TreeFami TF354235.

    Enzyme and pathway databases

    Reactomei REACT_19400. Golgi Associated Vesicle Biogenesis.

    Miscellaneous databases

    GeneWikii AP4B1.
    GenomeRNAii 10717.
    NextBioi 40689.
    PROi Q9Y6B7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y6B7.
    Bgeei Q9Y6B7.
    CleanExi HS_AP4B1.
    Genevestigatori Q9Y6B7.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    3.30.310.10. 1 hit.
    InterProi IPR026739. AP_beta.
    IPR016342. AP_complex_bsu_1_2_4.
    IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR015151. B-adaptin_app_sub_C.
    IPR012295. Beta2_adaptin/TBP_C_dom.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    [Graphical view ]
    PANTHERi PTHR11134. PTHR11134. 1 hit.
    Pfami PF01602. Adaptin_N. 1 hit.
    PF09066. B2-adapt-app_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002291. AP_complex_beta. 1 hit.
    SMARTi SM01020. B2-adapt-app_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "AP-4, a novel protein complex related to clathrin adaptors."
      Dell'Angelica E.C., Mullins C., Bonifacino J.S.
      J. Biol. Chem. 274:7278-7285(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-480.
      Tissue: Skeletal muscle.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lung.
    3. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-480.
      Tissue: Brain.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    6. "Adaptor protein complex 4 deficiency causes severe autosomal-recessive intellectual disability, progressive spastic paraplegia, shy character, and short stature."
      Abou Jamra R., Philippe O., Raas-Rothschild A., Eck S.H., Graf E., Buchert R., Borck G., Ekici A., Brockschmidt F.F., Nothen M.M., Munnich A., Strom T.M., Reis A., Colleaux L.
      Am. J. Hum. Genet. 88:788-795(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN CPSQ5.
    7. "Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles."
      Borner G.H., Antrobus R., Hirst J., Bhumbra G.S., Kozik P., Jackson L.P., Sahlender D.A., Robinson M.S.
      J. Cell Biol. 197:141-160(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ENTHD2, SUBCELLULAR LOCATION.
    8. "Solution NMR structure of beta-adaptin appendage domain of human adapter protein complex 4 subunit beta, Northeast structural genomics consortium (NESG) target HR8998C."
      Northeast structural genomics consortium (NESG)
      Submitted (JAN-2014) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 610-739.

    Entry informationi

    Entry nameiAP4B1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y6B7
    Secondary accession number(s): B7Z4X3, Q59EJ4, Q96CL6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3