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Protein

Signal peptidase complex subunit 1

Gene

SPCS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.By similarity

GO - Molecular functioni

GO - Biological processi

  • protein targeting to ER Source: GO_Central
  • proteolysis Source: UniProtKB
  • signal peptide processing Source: GO_Central

Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

ReactomeiR-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
R-HSA-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex subunit 1 (EC:3.4.-.-)
Alternative name(s):
Microsomal signal peptidase 12 kDa subunit
Short name:
SPase 12 kDa subunit
Gene namesi
Name:SPCS1
Synonyms:SPC12
ORF Names:HSPC033
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114902.13
HGNCiHGNC:23401 SPCS1
MIMi610358 gene
neXtProtiNX_Q9Y6A9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Topological domaini48ExtracellularSequence analysis1
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 102CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi28972
OpenTargetsiENSG00000114902
PharmGKBiPA134972486

Polymorphism and mutation databases

BioMutaiSPCS1
DMDMi557952606

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002151541 – 102Signal peptidase complex subunit 1Add BLAST102

Proteomic databases

EPDiQ9Y6A9
MaxQBiQ9Y6A9
PaxDbiQ9Y6A9
PeptideAtlasiQ9Y6A9
PRIDEiQ9Y6A9
TopDownProteomicsiQ9Y6A9

PTM databases

iPTMnetiQ9Y6A9
PhosphoSitePlusiQ9Y6A9
SwissPalmiQ9Y6A9

Expressioni

Gene expression databases

BgeeiENSG00000114902
CleanExiHS_SPCS1
ExpressionAtlasiQ9Y6A9 baseline and differential
GenevisibleiQ9Y6A9 HS

Organism-specific databases

HPAiHPA046091

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Q99IB84EBI-8852196,EBI-6901449From Hepatitis C virus genotype 2a (isolate JFH-1).

Protein-protein interaction databases

BioGridi118796, 37 interactors
IntActiQ9Y6A9, 3 interactors
STRINGi9606.ENSP00000233025

Structurei

3D structure databases

ProteinModelPortaliQ9Y6A9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPCS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4112 Eukaryota
ENOG411274V LUCA
GeneTreeiENSGT00390000018321
HOGENOMiHOG000171962
HOVERGENiHBG086276
InParanoidiQ9Y6A9
KOiK12946
PhylomeDBiQ9Y6A9
TreeFamiTF106122

Family and domain databases

InterProiView protein in InterPro
IPR037713 Spc1
IPR009542 SPC12
PANTHERiPTHR13202 PTHR13202, 1 hit
PTHR13202:SF0 PTHR13202:SF0, 1 hit
PfamiView protein in Pfam
PF06645 SPC12, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y6A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEHLSSLPT QMDYKGQKLA EQMFQGIILF SAIVGFIYGY VAEQFGWTVY
60 70 80 90 100
IVMAGFAFSC LLTLPPWPIY RRHPLKWLPV QESSTDDKKP GERKIKRHAK

NN
Length:102
Mass (Da):11,805
Last modified:November 13, 2013 - v4
Checksum:iEACCE988863E42A7
GO

Sequence cautioni

The sequence AAD40380 differs from that shown. Reason: Frameshift at position 2.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28I → Y in AAL31361 (PubMed:8632014).Curated1
Sequence conflicti61L → LAQ in AAH00884 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092138 mRNA Translation: AAD40380.1 Frameshift.
AK027426 mRNA Translation: BAG51320.1
L38852 mRNA Translation: AAL31361.1
AC104446 Genomic DNA No translation available.
BC000884 mRNA Translation: AAH00884.1
RefSeqiNP_054760.3, NM_014041.3
UniGeneiHs.11125
Hs.297304

Genome annotation databases

EnsembliENST00000602728; ENSP00000473265; ENSG00000114902
GeneIDi28972
KEGGihsa:28972
UCSCiuc062kpj.1 human

Similar proteinsi

Entry informationi

Entry nameiSPCS1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6A9
Secondary accession number(s): B3KNF8, Q9BVW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 13, 2013
Last modified: May 23, 2018
This is version 148 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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