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Protein

Signal peptidase complex subunit 1

Gene

SPCS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.By similarity

GO - Molecular functioni

GO - Biological processi

  • protein targeting to ER Source: GO_Central
  • proteolysis Source: UniProtKB
  • signal peptide processing Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114902-MONOMER.
ReactomeiR-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-HSA-400511. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
R-HSA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex subunit 1 (EC:3.4.-.-)
Alternative name(s):
Microsomal signal peptidase 12 kDa subunit
Short name:
SPase 12 kDa subunit
Gene namesi
Name:SPCS1
Synonyms:SPC12
ORF Names:HSPC033
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:23401. SPCS1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Topological domaini48ExtracellularSequence analysis1
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 102CytoplasmicSequence analysisAdd BLAST33

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: Reactome
  • integral component of endoplasmic reticulum membrane Source: UniProtKB
  • organelle membrane Source: UniProtKB-SubCell
  • signal peptidase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000114902.
PharmGKBiPA134972486.

Polymorphism and mutation databases

BioMutaiSPCS1.
DMDMi557952606.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002151541 – 102Signal peptidase complex subunit 1Add BLAST102

Proteomic databases

EPDiQ9Y6A9.
MaxQBiQ9Y6A9.
PaxDbiQ9Y6A9.
PeptideAtlasiQ9Y6A9.
PRIDEiQ9Y6A9.
TopDownProteomicsiQ9Y6A9.

PTM databases

iPTMnetiQ9Y6A9.
PhosphoSitePlusiQ9Y6A9.
SwissPalmiQ9Y6A9.

Expressioni

Gene expression databases

BgeeiENSG00000114902.
CleanExiHS_SPCS1.
ExpressionAtlasiQ9Y6A9. baseline and differential.
GenevisibleiQ9Y6A9. HS.

Organism-specific databases

HPAiHPA046091.

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Q99IB84EBI-8852196,EBI-6901449From a different organism.

Protein-protein interaction databases

BioGridi118796. 15 interactors.
IntActiQ9Y6A9. 3 interactors.
STRINGi9606.ENSP00000233025.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6A9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPCS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4112. Eukaryota.
ENOG411274V. LUCA.
GeneTreeiENSGT00390000018321.
HOGENOMiHOG000171962.
HOVERGENiHBG086276.
InParanoidiQ9Y6A9.
KOiK12946.
PhylomeDBiQ9Y6A9.
TreeFamiTF106122.

Family and domain databases

InterProiIPR009542. SPC12.
[Graphical view]
PANTHERiPTHR13202. PTHR13202. 1 hit.
PfamiPF06645. SPC12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y6A9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEHLSSLPT QMDYKGQKLA EQMFQGIILF SAIVGFIYGY VAEQFGWTVY
60 70 80 90 100
IVMAGFAFSC LLTLPPWPIY RRHPLKWLPV QESSTDDKKP GERKIKRHAK

NN
Length:102
Mass (Da):11,805
Last modified:November 13, 2013 - v4
Checksum:iEACCE988863E42A7
GO

Sequence cautioni

The sequence AAD40380 differs from that shown. Reason: Frameshift at position 2.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28I → Y in AAL31361 (PubMed:8632014).Curated1
Sequence conflicti61L → LAQ in AAH00884 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092138 mRNA. Translation: AAD40380.1. Frameshift.
AK027426 mRNA. Translation: BAG51320.1.
L38852 mRNA. Translation: AAL31361.1.
AC104446 Genomic DNA. No translation available.
BC000884 mRNA. Translation: AAH00884.1.
RefSeqiNP_054760.3. NM_014041.3.
UniGeneiHs.11125.
Hs.297304.

Genome annotation databases

EnsembliENST00000602728; ENSP00000473265; ENSG00000114902.
GeneIDi28972.
KEGGihsa:28972.
UCSCiuc062kpj.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092138 mRNA. Translation: AAD40380.1. Frameshift.
AK027426 mRNA. Translation: BAG51320.1.
L38852 mRNA. Translation: AAL31361.1.
AC104446 Genomic DNA. No translation available.
BC000884 mRNA. Translation: AAH00884.1.
RefSeqiNP_054760.3. NM_014041.3.
UniGeneiHs.11125.
Hs.297304.

3D structure databases

ProteinModelPortaliQ9Y6A9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118796. 15 interactors.
IntActiQ9Y6A9. 3 interactors.
STRINGi9606.ENSP00000233025.

PTM databases

iPTMnetiQ9Y6A9.
PhosphoSitePlusiQ9Y6A9.
SwissPalmiQ9Y6A9.

Polymorphism and mutation databases

BioMutaiSPCS1.
DMDMi557952606.

Proteomic databases

EPDiQ9Y6A9.
MaxQBiQ9Y6A9.
PaxDbiQ9Y6A9.
PeptideAtlasiQ9Y6A9.
PRIDEiQ9Y6A9.
TopDownProteomicsiQ9Y6A9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000602728; ENSP00000473265; ENSG00000114902.
GeneIDi28972.
KEGGihsa:28972.
UCSCiuc062kpj.1. human.

Organism-specific databases

CTDi28972.
GeneCardsiSPCS1.
H-InvDBHIX0003369.
HGNCiHGNC:23401. SPCS1.
HPAiHPA046091.
MIMi610358. gene.
neXtProtiNX_Q9Y6A9.
OpenTargetsiENSG00000114902.
PharmGKBiPA134972486.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4112. Eukaryota.
ENOG411274V. LUCA.
GeneTreeiENSGT00390000018321.
HOGENOMiHOG000171962.
HOVERGENiHBG086276.
InParanoidiQ9Y6A9.
KOiK12946.
PhylomeDBiQ9Y6A9.
TreeFamiTF106122.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000114902-MONOMER.
ReactomeiR-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-HSA-400511. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
R-HSA-422085. Synthesis, secretion, and deacylation of Ghrelin.

Miscellaneous databases

ChiTaRSiSPCS1. human.
GenomeRNAii28972.
PROiQ9Y6A9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000114902.
CleanExiHS_SPCS1.
ExpressionAtlasiQ9Y6A9. baseline and differential.
GenevisibleiQ9Y6A9. HS.

Family and domain databases

InterProiIPR009542. SPC12.
[Graphical view]
PANTHERiPTHR13202. PTHR13202. 1 hit.
PfamiPF06645. SPC12. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPCS1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6A9
Secondary accession number(s): B3KNF8, Q9BVW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 13, 2013
Last modified: November 30, 2016
This is version 140 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.